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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 3 | Modern pollen rain in the Lake Qinghai basin, China显示文摘Lake Qinghai is the largest inland brackish lake in China and lies within the NE Tibetan Plateau. Our study shows that pollen assemblages in each vegetation belt are significantly correlated with the vegetation types of this area. Among the herbaceous and shrubby pollen assemblages, Artemisia is over-represented, while Poaceae, Cyperaceae and Polygonaceae are under-represented. Artemisia/ Chenopodiaceae (A/C) ratios with the regional vegetation characteristic can be used as a proper index to reconstruct the history of vegetation and climate in Lake Qinghai basin. Modern pollen in the lake mainly comes from the nearby vegetation, controlled by the directions and velocity of the wind. The distribution of modern pollen in Lake Qinghai tends to be similar in most part of the lake. The difference of pollen sedimentation process in the lake can be potentially influenced by the focusing function of the lake, river streams, and lake current. | SHANG Xue LI XiaoQiang AN ZhiSheng JI Ming ZHANG HongBin | 2009 | Science China Earth Sciences2009，52，10： | 15 |
| 4 | A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity显示文摘由调整 transcriptional 激活剂 Yorkie (Yki ) 的活动的河马(Hpo ) 小径控制织物生长和机关尺寸,它在原子核与抄写因素 Scalloped (Sd ) 联系下游地支持指向基因表示。这里,我们识别新奇蛋白质 Sd-Binding-Protein (SdBP )/Tgi,它直接通过它的 TDU 域为绑定与 Yki 竞争到 Sd 并且禁止 Sd-Yki transcriptional 活动。我们也发现 SdBP 经由它的 PPXY 主题与 Yki WW 领域通过协会在原子核保留 Yki。一起,我们作为 Hpo 小径的一个新奇部件识别 SdBP,否定地调整 Sd-Yki 的 transcriptional 活动限制织物生长。 | Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang | 2013 | Cell Research2013，23，10： | 13 |
| 5 | Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers显示文摘 | Li, Fei Feng, Yan Fang, Rong Fang, Zhaoyuan Xia, Jufeng Han, Xiangkun Liu, Xin-Yuan Chen, Haiquan Liu, Hongyan Ji, Hongbin | 2012 | Cell Research2012，22，5： | 11 |
| 6 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 7 | An Early Cretaceous Avialian Bird, Shenzhouraptor sinensis from Western Liaoning, China显示文摘This paper describes an avialian bird from the Early Cretaceous Jiufotang Formation in Yixian county,western Liaoning, China, which is named as Shenzhouraptor sinensis by Ji et al. on July 15, 2002. Shenzhouraptor sinensis is characterized by no teeth in its mouth, the forelimbs longer than the hindlimbs, a long tail with more than 23 caudal vertebrae, U-shaped wishbone, and remiges longer than the total length of ulna and manus. It is certain that the new avialian bird is really capable of powerful flight, representing a missing link between theropod dinosaurs and birds. | Ji Qiang, Ji Shu’an, You Hailu, Zhang Jianping,Zhang Hongbin, Zhang Nanjun, Yuan Chongxi and Ji XinxinDepartment of Earth Sciences, Nanjing University, Nanjing, Jiangsu 100093Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037 School of Earth and Space Sciences, Peking University, Beijing 100871China University of Geosciences, Beijing 100083 China Dinosaur Park of Changzhou, Changzhou, Jiangsu 213002 | 2003 | Acta Geologica Sinica(English Edition)2003，77，1： | 8 |
| 8 | Pathological transition as the arising mechanism for drug resistance in lung cancer显示文摘Despite the tremendous efforts for improving therapeutics of lung cancer patients,its prognosis remains disappoint-ing.This can be largely attributed to the lack of comprehensive understanding of drug resistance leading to insuf-ficient development of effective therapeutics in clinic.Based on the current progresses of lung cancer research,we classify drug resistance mechanisms into three different levels:molecular,cellular and pathological level.All these three levels have significantly contributed to the acquisition and evolution of drug resistance in clinic.Our under-standing on drug resistance mechanisms has begun to change the way of clinical practice and improve patient prognosis.In this review,we focus on discussing the pathological changes linking to drug resistance as this has been largely overlooked in the past decades. | Yueqing Chen Waiying Yvonne Tang Xinyuan Tong Hongbin Ji | 2019 | Cancer Communications2019，39，1： | 8 |
| 9 | LKB1 in lung cancerigenesis:a serine/threonine kinase as tumor suppressor显示文摘Lung cancer is featured with high mortality,with a 15%five-year survival rate worldwide.Genetic alterations,such as loss of function of tumor suppressor genes,frequently contribute to lung cancer initiation,progression and metastasis.Liver kinase B1(LKB1),as a serine/threonine kinase and tumor suppressor,is frequently mutated and inactivated in non-small cell lung cancer(NSCLC).Recent studies have provided strong evidences that LKB1 loss promotes lung cancerigenesis process,especially lung cancer progression and metastasis.This review will summarize recent progress on how LKB1 modulates the process of lung cancerigenesis,emphasizing on LKB1 downstream signaling pathways and biological functions.We will further discuss the potential development of prognostic biomarkers or therapeutic targets in lung cancer clinic based on the molecular alteration associated with deregulated LKB1 signaling. | Yijun Gao Gaoxiang Ge Hongbin Ji | 2011 | Protein & Cell2011，2，2： | 8 |
| 10 | miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells显示文摘在这研究,我们鉴别五 miRNAs 高度在小房间的肺癌症(SCLC ) 表示了房间线 NCI-H209。在他们之中, miR-375 的表示层次戏剧性地在检验的所有 SCLC 房间线被提高,与抄写因素 achaete 鳞甲建筑群相当或相同的事物的表示重合 1 (ASCL1 ) 。而且, miR-375 是 upregulated 并且在也从老鼠象 SCLC 一样肿瘤产生的房间线与 ASCL1 相关。双酶的试金进一步证明 ASCL1 在 miR-375 倡导者由绑定激活 miR-375 的表达式到三个电子盒子元素。这些结果经由 miR-375 的 upregulation 在 SCLC 暗示 ASCL1 的一个角色。 | Huijie Zhao Lei Zhu Yujuan Jin Hongbin Ji Xiumin Yan Xueliang Zhu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 6 |
| 11 | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer显示文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment. | Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 5 |
| 12 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 13 | Microstructure, cold rolling, heat treatment, and mechanical properties of Mg-Li alloys显示文摘The magnesium-lithium (Mg-Li) alloy exhibits two phase structures between 5.7wt% and 10.3wt% Li contents, consisting of the α (hcp) Mg-rich and the β (bcc) Li-rich phases, at room temperature. In the experiment, Mg-5Li-2Zn, Mg-9Li-2Zn, Mg-16Li-2Zn, Mg-22Li-2Zn, Mg-5Li-2Zn-2Ca, Mg-9Li-2Zn-2Ca, Mg-16Li-2Zn-2Ca, and Mg-22Li-2Zn-2Ca (wt%) were melted. During the melting process, the flux, which was composed of lithium chloride (LiCl) and lithium fluoride (LiF) in the proportion of 3:1 (mass ratio) and argon gas were used to protect the alloys from oxidation. The microstructure, mechanical properties, and cold-rolling workability of the wrought alloys were studied. The crystal grain of the alloys (adding Ga) is fine. The hardness of the studied alloys decreases with an increase in element Li. The density of the studied alloys is in the range of 1.187 to 1.617 g/cm3. The reduction of the Mg-16Li-2Zn and Mg-22Li-2Zn alloys can exceed 85% at room temperature. The Mg-9Li-2Zn-2Ca alloy was heat treated at 300°C for 8, 12, 16, and 24 h, respectively. The optimum heat treatment of the Mg-9Li-2Zn-2Ca alloy is 300°C×12h by metallographic observation and by studying the mechanical properties of the alloys. | Haibin Ji Guangchun Yao Hongbin Li | 2008 | Journal of University of Science and Technology Beijing2008，15，4： | 3 |
| 14 | Finding Deceptive Opinion Spam by Correcting the Mislabeled Instances显示文摘Assessing the trustworthiness of reviews is a key in natural language processing and computational linguistics. Previous work mainly focuses on some heuristic strategies or simple supervised learning methods, which limit the performance of this task. This paper presents a new approach, from the viewpoint of correcting the mislabeled instances, to find deceptive opinion spam. Partition a dataset into several subsets, construct a classifier set for each subset and select the best one to evaluate the whole dataset. Error variables are defined to compute the probability that the instances have been mislabeled. The mislabeled instances are corrected based on two threshold schemes, ma jority and non-objection. The results display significant improvements in our method in contrast to the existing baselines. | REN Yafeng JI Donghong YIN Lan ZHANG Hongbin | 2015 | Chinese Journal of Electronics2015，24，1： | 2 |
| 15 | A network-based gene-weighting approach for pathway analysis显示文摘古典算法瞄准与学习有关显著地识别生物小径调节经常减少的小径到基因集合,与对在一条定义小径以内的各种各样的基因的组成的非等价的明显的无知。我们这里设计了一个基于网络的方法以基因重量决定如此的非等价。决定的基因重量生物学上一致、柔韧联网不安。由把基因重量集成到古典基因设置分析,与为 “ 的随后的修正; over-counting”与多子单元蛋白质联系的偏爱,我们开发了一条新奇称基因的小径分析途径,在称为 “ 的一个 R 包裹实现了基因 Associaqtion 基于网络的小径 Analysis”(GANPA ) 。通过几 microarray 数据集的分析,包括 p53 数据集,气喘数据集和三乳癌数据集,我们证明我们的途径是生物学上可靠、可再现、对 microarray 因此有用的数据解释和假设产生。 | Zhaoyuan Fang Weidong Tian Hongbin Ji | 2012 | Cell Research2012，22，3： | 2 |
| 16 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 17 | Interferon-β-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells显示文摘干扰素 --(IFN-) 广泛地在癌症治疗被使用了,但是临床的试用结果通常是令人失望的。我们的以前的研究证明了带 IFN-(ZD55-IFN-) 的 oncolytic 侵入人体气管粘膜的病菌展出重要反肿瘤活动。然而,内在的机制不是清楚的。这里,我们由激活混乱毛细管扩张以一种 p53 依赖的方式显示出那 ZD55-IFN- 导致感染的 S 阶段房间周期拘捕变异依赖者的 DNA 损坏小径。另外, ZD55-IFN- 感染能在癌症房间开始 caspase 依赖的 apoptosis 和 necroptosis。更重要地, ZD55-IFN- 在癌症房间上看了 synergistic 效果什么时候与 doxorubicin 结合了。这些结果建议有 doxorubicin 的 ZD55-IFN- 的联合可以在癌症治疗代表有希望的临床的策略。 | Hongling Huang Tian Xiao Lingfeng He Hongbin Ji Xin-Yuan Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 1 |
| 18 | The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression显示文摘LKB1 是直接激活精力传感器的 serine/threonine kinase 响应 bioenergetic 应力的激活安培的蛋白质 kinase (AMPK ) ,并且主要充当控制房间极性和增长的肿瘤 suppressor。尽管 LKB1 包括胸腺和怒气在多重纸巾被表示,它在 T 房间开发和功能的角色仍然保持未知。这里,我们证明 LKB1 的那 T-cell-specific 删除导致了双 positive (DP ) 的减少的幸存 thymocytes 和 CD4 和 CD8 的损害产生单人赛积极的 thymocytes。LKB1 的混乱不仅阻止了 AMPK 的激活而且损害了 anti-apoptotic 蛋白质 Bcl-XL 的表示。重要地,任何一个 Bcl-XL 的宫外的表示或组成地活跃的 AMPK 异种显著地救了 DP thymocytes 免于 LKB1 导致缺乏的房间死亡。而且,组成地活跃的 AMPK 异种的宫外的表示被发现在 LKB1 缺乏的 DP thymocytes 恢复 Bcl-XL 的表示。这些调查结果通过 AMPK 激活和 Bcl-XL 表示的规定为 DP thymocytes 的幸存作为一个关键因素识别 LKB1。 | Yonghao Cao Hai Li Haifeng Liu Chao Zheng Hongbin Ji Xiaolong Liu | 2010 | Cell Research2010，20，1： | 1 |
| 19 | Investigating the function of Akt by tet-off inducible expression system显示文摘A tet-off inducible cell line named BBT derived from BA/F3β cell line was constructed and the effect of this inducible expression system was significant when detected by tet-off responded luciferase reporter gene assay. Then tet-off responded Akt expression plasmid was transfected into BBT cells, and the stable cell lines were screened. The result of Northern blot showed that the expression of akt was significantly inducible. The clone with the best inducible effect was selected and named BBA for investigating the function of Akt. We found that Akt could significantly inhibit zinc-induced decrease of cell viability when assayed by MTT method. And the flow cytometric analysis showed that Akt could markedly repress zinc-induced apoptosis. | Qiwei Zhai Hongbin Ji Zhongcheng Zheng Lanying Sun Xinyuan Liu | 2001 | Chinese Science Bulletin2001，46，3： | 1 |
| 20 | Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and overcomes Kinase Inhibitor Resistance显示文摘 | Takeshi Shimamura Danan Li Hongbin JI | 2008 | Cancer Res2008，68，14： | 1 |
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