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您的检索式：作者名="Xingshen WEI"
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| 1 | Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure显示文摘Asthenozoospermia is the most common cause of male infertility.Dynein protein arms play a crucial role in the motility of both the cilia and flagella,and defects in these proteins generally impair the axoneme structure and cause primary ciliary dyskinesia.But relatively little is known about the influence of dynein protein arm defects on sperm flagella function.Here,we recruited 85 infertile patients with idiopathic asthenozoospermia and identified bi-allelic mutations in DNAH7(NM_018897.3)from three patients using whole-exome sequencing.These variants are rare,highly pathogenic,and very conserved.The spermatozoa from the patients with DNAH7 bi-allelic mutations showed specific losses in the inner dynein arms.The expression of DNAH7 in the spermatozoa from the DNAH7-defective patients was significantly decreased,but these patients were able to have their children via intra-cytoplasmic sperm injection treatment.Our study is the first to demonstrate that bi-allelic mutations in DNAH7 may impair the integrality of axoneme structure,affect sperm motility,and cause asthenozoospermia in humans.These findings may extend the spectrum of etiological genes and provide new clues for the diagnosis and treatment of patients with asthenozoospermia. | Xiaoli Wei Yanwei Sha Zijie Wei Xingshen Zhu Fengming He Xiaoya Zhang Wensheng Liu Yifeng Wang Zhongxian Lu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 2 | EdgeKeeper: a trusted edge computing framework for ubiquitous power Internet of Things显示文摘Ubiquitous power Internet of Things(IoT)is a smart service system oriented to all aspects of the power system,and has the characteristics of universal interconnection,human-computer interaction,comprehensive state perception,efficient information processing,and other convenient and flexible applications.It has become a hot topic in the field of IoT.We summarize some existing research work on the IoT and edge computing framework.Because it is difficult to meet the requirements of ubiquitous power IoT for edge computing in terms of real time,security,reliability,and business function adaptation using the general edge computing framework software,we propose a trusted edge computing framework,named“EdgeKeeper,”adapting to the ubiquitous power IoT.Several key technologies such as security and trust,quality of service guarantee,application management,and cloud-edge collaboration are desired to meet the needs of the edge computing framework.Experiments comprehensively evaluate EdgeKeeper from the aspects of function,performance,and security.Comparison results show that EdgeKeeper is the most suitable edge computing framework for the electricity IoT.Finally,future directions for research are proposed. | Weiyong YANG Wei LIU Xingshen WEI Zixin GUO Kangle YANG Hao HUANG Longyun QI | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，3： | 1 |
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