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| 1 | Cosmogenic ^(10)Be dating of Guxiang and Baiyu Glaciations显示文摘Guxiang and Baiyu Glaciations are two previously recognized local glaciations of the Tibetan Plateau. They have been widely used as the reference standard for classifying Late Quaternary glaciations on the Tibetan Plateau and its surrounding mountains. However, the numerical chronologies of both glaciations have been lacking. In this study, cosmogenic 10Be dating was undertaken to define the timing of these two glaciations. The surface boulders deposited by the glaciers of the Guxiang and Baiyu Glaciations have exposure ages of 112.9±16.7―136.5±15.8 ka BP and 11.1±1.9―18.5±2.2 ka BP, respectively. It is likely that the Guxiang and Baiyu Glaciations correspond to marine isotope stages 6 and 2, respectively. | ZHOU ShangZhe XU LiuBing PATRICK M. Colgan DAVID M. Mickelson WANG XiaoLi WANG Jie ZHONG Wei | 2007 | Chinese Science Bulletin2007，52，10： | 28 |
| 2 | Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features显示文摘The aim of this study was to compare the structure of gut microbiota in Parkinson's disease(PD) patients and healthy controls;and to explore correlations between gut microbiota and PD clinical features. We analyzed fecal bacterial composition of 24 PD patients and 14 healthy volunteers by using 16 S rRNA sequencing. There were significant differences between PD and healthy controls, as well as among different PD stages. The putative cellulose degrading bacteria from the genera Blautia(P=0.018),Faecalibacterium(P=0.048) and Ruminococcus(P=0.019) were significantly decreased in PD compared to healthy controls.The putative pathobionts from the genera Escherichia-Shigella(P=0.038), Streptococcus(P=0.01), Proteus(P=0.022), and Enterococcus(P=0.006) were significantly increased in PD subjects. Correlation analysis indicated that disease severity and PD duration negatively correlated with the putative cellulose degraders, and positively correlated with the putative pathobionts. The results suggest that structural changes of gut microbiota in PD are characterized by the decreases of putative cellulose degraders and the increases of putative pathobionts, which may potentially reduce the production of short chain fatty acids, and produce more endotoxins and neurotoxins; and these changes is potentially associated with the development of PD pathology. | Wei Li Xiaoli Wu Xu Hu Tao Wang Shan Liang Yunfeng Duan Feng Jin Bin Qin | 2017 | Science China(Life Sciences)2017，60，11： | 26 |
| 3 | Prevalence of HIV Indeterminate Western Blot Tests and Follow-up of HIV Antibody Sero-Conversion in Southeastern China显示文摘HIV-indeterminate Western blotting(WB)results are typically obtained in WB confirmatory assays,and the number of indeterminate samples may increase with the detection of HIV infections,which will present considerable challenges for the management of HIV/AIDS.Nucleic acid detection has been used as a laboratory test for screening suspected or indeterminate samples.However,the effectiveness of these assays for the differential diagnosis of HIV-indeterminate WB samples remained undetermined.In this study,210 subjects with HIV-indeterminate WB results were detected from 6360 positive HIV screening samples between 2015 and 2016 in southeastern China,in which HIV-indeterminate WB results accounted for 3.30%.The highest proportion of indeterminate results was observed in pregnant and lying-in women receiving physical examinations(16.67%),followed by that in voluntary blood donors(8.82%).The most common WB band patterns were p24,gpl60 and p24,and gpl60.The follow-up study revealed that the highest negative and positive conversion rates of HIV antibodies were in samples with a single p24 band(80.28%),and with gpl60 and p24 bands(86.21%),respectively.Among the Env,Gag,and Pol antibodies,samples with a Gag band showed the highest negative conversion rate(81.25%),whereas the highest positive conversion rate was observed in samples with an Env band(56.76%).In addition,quantitative and qualitative HIV nucleic acid testing exhibited the highest sensitivity(96.3%)and specificity(97.85%),respectively.Our results indicate a lower proportion of HIV indeterminate WB results in southeastern China compared to previous reports,and the follow-up re-examination of patients with HIV indeterminate results should be performed.Nucleic acid testing facilitates the identification of HIV infections. | Shouli Wu Min Gao Jian Zheng Pingping Yan Wei Wang Xiaoli Lu Yuefeng Qiu Yansheng Yan | 2019 | Virologica Sinica2019，34，4： | 15 |
| 4 | Prediction of permafrost changes in Northeastern China under a changing climate显示文摘Northeastern China has the second largest expanse of permafrost in China,primarily known as Xing'an-Baikal permafrost.Located on the southeastern edges of the Eurasian cryolithozone,the permafrost is thermally unstable and ecologically sensitive to external changes.The combined impacts of climatic,environmental,and anthropogenic changes cause 3-dimensional degradation of the permafrost.To predict these changes on the southern limit and ground temperature of permafrost in Northeastern China,an equivalent latitude model (ELM) for the mean annual ground surface temperature (MAGSTs) was proposed,and further improved to take into account of the influences of vegetation and snow-cover based on observational data and using the SHAW model.Using the finite element method and assuming a climate warming rate of 0.048°C a-1,the ELM was combined with the unsteady-state heat conduction model to simulate permafrost temperatures at present,and to predict those after 50 and 100 a.The results indicate that at present,sporadic permafrost occurs in the zones with MAGSTs of 1.5°C or colder,and there would still be a significant presence of permafrost in the zones with the present MAGSTs of 0.5°C or colder after 50 a,and in those of-0.5°C or colder after 100 a.Furthermore,the total areal extent of permafrost would decrease from 2.57×105 km2 at present to 1.84×105 km2 after 50 a and to 1.29×105 km2 after 100 a,i.e.,a reduction of 28.4% and 49.8% in the permafrost area,respectively.Also the permafrost would degrade more substantially in the east than in the west.Regional warming and thinning of permafrost would also occur.The area of stable permafrost (mean annual ground temperature,or MAGT≤-1.0°C) would decrease from present 1.07×105 to 8.8×104 km2 after 50 a,and further decrease to 5.6×104 km2 after 100 a.As a result,the unstable permafrost and seasonally frozen ground would expand,and the southern limit of permafrost would shift significantly northwards.The changes in the permafrost environment may adversely affect on ecological environments and engineering infrastructures in cold regions.Avoidance of unnecessary anthropogenic changes in permafrost conditions is a practical approach to protect the permafrost environment. | WEI Zhi JIN HuiJun ZHANG JianMing YU ShaoPeng HAN XuJun JI YanJun HE RuiXia CHANG XiaoLi | 2011 | Science China Earth Sciences2011，54，6： | 15 |
| 5 | Brain tumor-targeted drug delivery strategies显示文摘Despite the application of aggressive surgery,radiotherapy and chemotherapy in clinics,brain tumors are still a difficult health challenge due to their fast development and poor prognosis.Brain tumor-targeted drug delivery systems,which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue,are a promising new approach to brain tumor treatments.Since brain tumors exhibit many distinctive characteristics relative to tumors growing in peripheral tissues,potential targets based on continuously changing vascular characteristics and the microenvironment can be utilized to facilitate effective brain tumor-targeted drug delivery.In this review,we briefly describe the physiological characteristics of brain tumors,including blood–brain/brain tumor barriers,the tumor microenvironment,and tumor stem cells.We also review targeted delivery strategies and introduce a systematic targeted drug delivery strategy to overcome the challenges. | Xiaoli Wei Xishan Chen Man Ying Weiyue Lu | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 14 |
| 6 | Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages显示文摘肿瘤微型环境(TME ) 在肿瘤房间的生长起一个突出的作用。作为 TME 的主要煽动性的部件, M2d 巨噬细胞被 TME 教育以便他们采用支持肿瘤转移和前进的一个抑制免疫力的角色。有 6 月的 Fra-1 形式使活跃之物 protein-1 heterodimers 合伙并且驾驶基因抄写。Fra-1 被认为急速地导致 tumorigenesis 和前进。然而,在 M2d 巨噬细胞的产生的 Fra-1 的功能的角色糟糕迄今为止被理解。这里,我们表明那 4T1 乳房的癌房间与 RAW264.7 巨噬细胞房间 co 有教养,扭曲 RAW264.7 巨噬细胞房间区别进 M2d 巨噬细胞。4T1 房间在 RAW264.7 房间,然后 Fra-1 刺激 Fra-1 的 de novo overexpression 绑在 interleukin 6 (IL-6 ) 在 RAW264.7 房间增加 cytokine IL-6 的生产的倡导者。在 autocrine 的 IL-6 幕塑造扭曲 RAW264.7 巨噬细胞房间区别进 M2d 巨噬细胞。这些调查结果开的新卓见进怎么颠倒 M2d 导致巨噬细胞的有免疫力的忍耐改进 immunotherapeutic 途径的功效。 | Qingshan Wang Hong Ni Lan Lan Xiaoli Wei Rong Xiang Yue Wang | 2010 | Cell Research2010，20，6： | 12 |
| 7 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 8 | Modification of Costanza's model of valuing ecosystem services and its application in China显示文摘In the past,evaluations of ecosystem functions were mostly based on Costanza's model,whereas the spatial,quality and temporal characteristics of regional ecosystems were not considered in the model.Focusing on these issues,coefficients of regional difference,spatial heterogeneity and willingness-to-pay(WTP)were established to modify Costanza's model,and a new comprehensive valuation model of ecosystem functions is proposed.The analytical results indicate that the comprehensive model could evaluate regional ecosystem functions in China accurately and provide more helpful information for decision-making.The empirical study on Zhangbei County in Hebei Province shows that the intensive human activities could limit the provision of ecosystem functions while the planned ecological programs might promote the restoration of ecosystem functions. | Shi Xiaoli Wang Wei | 2009 | Ecological Economy2009，5，4： | 10 |
| 9 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 10 | A NAC transcription factor, NOR-like1, is a new positive regulator of tomato fruit ripening显示文摘Ripening of the model fruit tomato(Solanum lycopersicum)is controlled by a transcription factor network including NAC(NAM,ATAF1/2,and CUC2)domain proteins such as No-ripening(NOR),SlNAC1,and SlNAC4,but very little is known about the NAC targets or how they regulate ripening.Here,we conducted a systematic search of fruit-expressed NAC genes and showed that silencing NOR-like1(Solyc07g063420)using virus-induced gene silencing(VIGS)inhibited specific aspects of ripening.Ripening initiation was delayed by 14 days when NOR-like1 function was inactivated by CRISPR/Cas9 and fruits showed obviously reduced ethylene production,retarded softening and chlorophyll loss,and reduced lycopene accumulation.RNA-sequencing profiling and gene promoter analysis suggested that genes involved in ethylene biosynthesis(SlACS2,SlACS4),color formation(SlGgpps2,SlSGR1),and cell wall metabolism(SlPG2a,SlPL,SlCEL2,and SlEXP1)are direct targets of NOR-like1.Electrophoretic mobility shift assays(EMSA),chromatin immunoprecipitation-quantitative PCR(ChIP-qPCR),and dual-luciferase reporter assay(DLR)confirmed that NOR-like1 bound to the promoters of these genes both in vitro and in vivo,and activated their expression.Our findings demonstrate that NOR-like1 is a new positive regulator of tomato fruit ripening,with an important role in the transcriptional regulatory network. | Ying Gao Wei Wei Xiaodan Zhao Xiaoli Tan Zhongqi Fan Yiping Zhang Yuan Jing Lanhuan Meng Benzhong Zhu Hongliang Zhu Jianye Chen Cai-Zhong Jiang Donald Grierson Yunbo Luo Da-Qi Fu | 2018 | Horticulture Research2018，5，1： | 9 |
| 11 | Dipeptidyl peptidase Ⅳ(DPP Ⅳ):a novel emerging target for thetreatment of type 2 diabetes显示文摘The enzyme, dipeptidyl peptidase Ⅳ(DPP Ⅳ), is a novel target for the treatment of type 2 diabetes. Dipeptidyl peptidase Ⅳ inhibition improves the impaired insulin secretion and decrease postprandial concentrations of glucagon by enhancing the incretin hormone levels lucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide(GIP). Recently, DPP Ⅳ inhibitors have attracted more and more attention, several of which have entered pre-clinical and clinical trials, and one has received approval for use as an anti-diabetic agent. Among the DPP Ⅳ inhibitors, two leading agents(sitagliptin and vildagliptin) have been shown to be effective in reducing glycosylated hemoglobin(HbA1c) and fasting plasma glucose(FPG) in patients with type 2 diabetes. This review summarizes the evidence supporting DPP IV inhibitors as potential antidiabetic agents. | Jing Wu Yiding Chen Xiaoli Shi Wei Gu | 2009 | Journal of Nanjing Medical University2009，23，4： | 9 |
| 12 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
| 13 | Correcting ionospheric effects and monitoring two-dimensional displacement fields with multiple-aperture InSAR technology with application to the Yushu earthquake显示文摘Differential synthetic aperture radar interferometry (D-InSAR) can only measure one-dimensional surface displacements along the line-of-sight (LOS) direction which greatly inhibits its development and application.In this paper, we introduce a novel approach to measuring two-dimensional (2-D) surface displacements by exploiting a single InSAR pair, which is called multi-aperture InSAR (MAI) technology.We study the effects of baseline errors and the ionosphere on MAI technology and develop a directional filter and interpolator to minimize the ionospheric effects.A PALSAR image pair covering the 2010 Yushu earthquake is used to estimate the 2-D displacement fields of the earthquake using the MAI approach.The experimental results show that MAI is superior to conventional Offset-Tracking and therefore has great potential in co-seismic displacement measurement and source parameter inversion. | HU Jun LI ZhiWei ZHANG Lei DING XiaoLi ZHU JianJun SUN Qian DING Wei | 2012 | Science China Earth Sciences2012，55，12： | 9 |
| 14 | V4C3Tx MXene:A promising active substrate for reactive surface modification and the enhanced electrocatalytic oxygen evolution activity显示文摘Presented are the synthesis,characterizations,and reactive surface modification(RSM)of a novel nine atomic layered V4C3Tx MXene.With the advantages of the multilayered V4C3Tx MXene that can simultaneously support the RSM reaction and keep the inner skeleton stable,a series of amorphous Ni/Fe/Vternary oxide hydroxides thin layer can be successfully modified on the surface of the V4C3Tx MXene(denoted as MOOH@V4C3Tx,M=Ni,Fe,and V)without disrupting its original structure.Attributed to the in situ reconstruction of highly active oxide hydroxide layer,the nanohybrids exhibited an enhanced oxygen evolution reaction(OER)activity and excellent long-time stability over 70 hours.In particular,a current density of 10 mA cm−2 can be reached by the nanohybrid with the optimized Ni/Fe ratio at an overpotential(η)as low as 275.2 mV,which is comparable to most of the state-of-the-art OER catalysts and better than other MXene-based derivatives.Demonstrated by the tunable physicochemical properties and excellent structural stability of these nanohybrids,we may envision the promising role of the M4X3-based MXenes as substrates for a wide range of energy conversion and storage materials. | Cheng-Feng Du Xiaoli Sun Hong Yu Wei Fang Yao Jing Yonghui Wang Shuiqing Li Xianhu Liu Qingyu Yan | 2020 | InfoMat2020，2，5： | 8 |
| 15 | Optimal Operation for Baoying Pumping Station in East Route Project of South-to-North Water Transfer显示文摘Baoying pumping station is a part of source pumping stations in East Route Project of South-to-North Water Transfer in China.Aiming at the characteristics of head varying, and making use of the function of pump adjustable blade, mathematical models of pumping station optimal operation are established and solved with genetic algorithm.For different total pumping discharge and total pumping volume of water per day, in order to minimize pumping station operation cost, the number and operation duties of running pump units are respectively determined at different periods of time in a day.The results indicate that the saving of electrical cost is significantly effected by the schemes of adjusting blade angles and time-varying electrical price when pumping certain water volume of water per day, and compared with conventional operation schemes(namely, the schemes of pumping station operation at design blade angles based on certain pumping discharge), the electrical cost is saved by 4.73%?31.27%.Also, compared with the electrical cost of conventional operation schemes, the electrical cost is saved by 2.03%?5.79% by the schemes of adjusting blade angles when pumping certain discharge. | FENG Xiaoli QIU Baoyun CAO Haihong WEI Qianglin TENG Haibo | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 7 |
| 16 | Highly Efficient and Stable Hydrogen Production in All pH Range by Two-Dimensional Structured Metal-Doped Tungsten Semicarbides显示文摘Transition-metal-doped tungsten semicarbide nanosheets(M-doped W_(2)C NSs,M=Fe,Co,and Ni)have been synthesized through carburization of the mixture of tungsten trioxide,polyvinylpyrrolidone,and metal dopant.Te nanosheets grow directly on the W mesh and have the lateral dimension of several hundreds of nm to a few�m with a thickness of few tens nm.It is demonstrated that the M-doped W_(2)C NSs exhibit superior electrocatalytic activity for hydrogen evolution reaction(HER).Impressively,the Nidoped W_(2)C NSs(2 at%Ni)with the optimized HER activity show extremely low onset overpotentials of 4,9,and 19 mV and modest Tafel slopes of 39,51,and 87 mV dec−1 in acidic(pH=0),neutral(pH=7.2),and basic(pH=14)solutions,respectively,which is close to the commercial Pt/C catalyst.Density functional theory(DFT)calculations also demonstrate that the Gibbs free energy for H adsorption of Ni-W_(2)C is much closer to the optimal valueG_(H∗)=-0.073 eV as compared to-0.16 eV of W_(2)C.Furthermore,nearly 100%Faradaic efciency and long-term stability are obtained in those environments.Tis realization of highly tolerant metal semicarbide catalyst performing on par with commercial Pt/C in all range of pH ofers a key step towards industrially electrochemical water splitting. | Edison H.Ang Khang N.Dinh Xiaoli Sun Ying Huang Jun Yang Zhili Dong Xiaochen Dong Wei Huang Zhiguo Wang Hua Zhang Qingyu Yan | 2019 | Research2019，，1： | 7 |
| 17 | Synergetic Effect of Y Zeolite and ZSM-5 Zeolite Ratios on Cracking, Oligomerization and Hydrogen Transfer Reactions显示文摘The objective of this study is to explore the optimum composition of Y and ZSM-5 zeolites to develop novel catalysts for obtaining lower gasoline olefins content and higher propylene yield. Five composite zeolite catalysts with varying Y zeolite/ZSM-5 zeolite ratios have been prepared in this work to investigate the synergy between the Y zeolite and ZSM-5 zeolite on the selectivity to protolytic cracking, β-scission, oligomerization, and hydrogen transfer reactions using a FCC naphtha feedstock at 480 ℃ in a confined fluidized bed reactor. Experimental results showed that the composite catalyst with a Y zeolite/ZSM-5 zeolite ratio of 1:4 had the highest protolytic cracking and β-scission ability, which was even higher than that of pure ZSM-5 catalyst. On the other hand, the catalyst with a Y zeolite/ZSM-5 zeolite ratio of 3:2 exhibited the strongest hydrogen transfer functionality while the pure Y zeolite based catalyst had the highest oligomerization ability. For all the catalysts tested, increasing conversion enhanced the selectivity to protolytic cracking and hydrogen transfer reactions but reduced the selectivity to β-scission reaction. However, no clear trend was identified for the selectivity to oligomerization when an increased conversion was experienced. | Gong Jianhong Xu Youhao Long Jun Wei Xiaoli | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，3： | 7 |
| 18 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 19 | Single-Crystalline In Ga As Nanowires for Room-Temperature High-Performance Near-Infrared Photodetectors显示文摘In Ga As is an important bandgap-variable ternary semiconductor which has wide applications in electronics and optoelectronics. In this work, single-crystal In Ga As nanowires were synthesized by a chemical vapor deposition method.Photoluminescence measurements indicate the In Ga As nanowires have strong light emission in near-infrared region. For the first time, photodetector based on as-grown In Ga As nanowires was also constructed. It shows good light response over a broad spectral range in infrared region with responsivity of 6.5×10~3 AW^(-1) and external quantum efficiency of 5.04×10~5%. This photodetector may have potential applications in integrated optoelectronic devices and systems. | Huang Tan Chao Fan Liang Ma Xuehong Zhang Peng Fan Yankun Yang Wei Hu Hong Zhou Xiujuan Zhuang Xiaoli Zhu Anlian Pan | 2016 | Nano-Micro Letters2016，8，1： | 6 |
| 20 | 乙肝病毒X蛋白对肝细胞生物钟基因的影响及其意义(英文)显示文摘Objective:The aim of this study was to investigate the influence of hepatitis B virus X protein (HBx) on the clock genes in LO2 cells and its significance.Methods:A cell line LO2-HBx,Stably transfected with HBx gene,was established.The levels of mRNA and protein expression of CLOCK and BMAL1 were detected by real-time PCR and western blot.Results:The expression of CLOCK mRNA and protein were increased in cell line LO2-HBx (P<0.05),while the expression of BMAL1 mRNA and protein were decreased in cell line LO2-HBx (P<0.05).Conclusion:The expressions of core clock gene CLOCK and BMAL1 have been changed by HBx,which breaks down the previous circadian rhythm of liver cells.This maybe one of the reasons leads to the formation of liver cancer. | Shengli Yang Xiaoli Pan Zhifan Xiong Bo Wei Hongyi Yao | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 6 |
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