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| 1 | Mechanical(compressive)form of driving force triggers the phase transformation fromβtoω&α”phases in metastableβphase-field Ti-5553 alloy显示文摘Most of the structural alloys’applications are under static,dynamic,and cyclic forms of loading.Ti-5553 alloy in the beta phase field is being investigated to confirm the mechanism of deformation and phase transformation upon quasi-static and dynamic compression.The Ti-5553 alloy was heat-treated at 900℃ (almost 50℃ above beta transus temperature)for one hour of soaking time followed by air quenching to achieve a fullyβphase field.After that,Dynamic compression(DC)by Split Hopkinson Pressure Bar(SHPB)and Quasi-static compression(QSC)were performed at a strain rate of~10^3)/s and 10^(-3)/s,respectively.Recovered specimens were thoroughly examined by using different tools,such as an Optical microscope(OM),Scanning electron microscope(SEM),High-resolution transmission electron microscope(HRTEM),and Electron backscatter diffraction(EBSD)to get the reliable data for justification of logical conclusions.It is found that the dominating mode of deformation was dislocation slip along with twinning({332}<113>)to some extent in both of QSC and DC,but sliding&spalling of the grain boundary is observed more in the former.Stress-induced phase transformation,i.e.,βtoα'andβtoω,took place in the grains saturated with dislocation slips,where the former transformation occurred simultaneously with{332}<113>twinning,whileβtoωtransformation was completed when a set of two adjacent(110)_(β)planes covered±1/6th of the total separation distance between two(next to each other)(111)_(β)planes,by equal but opposite shear in(111)_(β)direction,and it caused 3%shrinkage of two closed packed(110)_(β)planes after transformation. | Tayyeb Ali Lin Wang Xingwang Cheng Huanwu Cheng Ying Yang Anjin Liu Xuefeng Xu Zhe Zhou Zixuan Ning Ziqi Xu Xinhua Min | 2021 | Journal of Materials Science & Technology2021，，19： | 2 |
| 2 | Texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr dual-phase alloy during cold rolling based on multiscale crystal plasticity finite element model显示文摘The complex micromechanical response among grains remains a persistent challenge to understand the deformation mechanism of titanium alloys during cold rolling.Therefore,in this work,a multiscale crystal plasticity finite element method of dual-phase alloy was proposed and secondarily developed based on LS-DYNA software.Afterward,the texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr alloy,based on the realistic 3D microstructure,during cold rolling(20%thickness reduction)were systematically investigated.The relative activity of the■slip system in theαphase gradually increased,and then served as the main slip mode at lower Schmid factor(<0.2).In contrast,the contribution of the■slip system to the overall plastic deformation was relatively limited.For theβphase,the relative activity of the<111>{110}slip system showed an upward tendency,indicating the important role of the critical resolved shear stress relationship in the relative activity evolutions.Furthermore,the abnormally high strain of very fewβgrains was found,which was attributed to their severe rotations compelled by the neighboring pre-deformedαgrains.The calculated pole figures,rotation axes,and compelled rotation behavior exhibited good agreement to the experimental results. | Duoduo Wang Qunbo Fan Xingwang Cheng Yu Zhou Ran Shi Yan Qian Le Wang Xinjie Zhu Haichao Gong Kai Chen Jingjiu Yuan Liu Yang | 2022 | Journal of Materials Science & Technology2022，，16： | 2 |
| 3 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 4 | Epitaxial growth of large area ZrS_(2)2D semiconductor films on sapphire for optoelectronics显示文摘Recently,group-IVB semiconducting transition metal dichalcogenides(TMDs)of ZrS_(2) have attracted significant research interest due to its layered nature,moderate band gap,and extraordinary physical properties.Most device applications require a deposition of high quality large-area uniform ZrS_(2) single crystalline films,which has not yet been achieved.In this work,for the first time,we demonstrate the epitaxial growth of high quality large-area uniform ZrS_(2) films on c-plane sapphire substrates by chemical vapor deposition.An atomically sharp interface is observed due to the supercell matching between ZrS_(2) and sapphire,and their epitaxial relationship is found to be ZrS_(2)(0001)[1010]||Al_(2)O_(3)(0001)[1120].The epitaxial ZrS_(2) film exhibits n-type semiconductor behavior with a room temperature mobility of 2.4 cm^(2)·V^(−1)·s^(−1),and the optical phonon is the dominant scattering mechanism at room temperature or above.Furthermore,the optoelectronic applications of ZrS_(2) films are demonstrated by fabricating photodetector devices.The ZrS_(2) photodetectors exhibit the excellent comprehensive performance,such as a light on/off ratio of 106 and a specific detectivity of 2.6×10^(12) Jones,which are the highest values compared with the photodetectors based on other group-IVB two-dimensional TMDs. | Yan Tian Yong Cheng Jidong Huang Siyu Zhang Hao Dong Gaokai Wang Jingren Chen Jinliang Wu Zhigang Yin Xingwang Zhang | 2022 | Nano Research2022，15，7： | 1 |
| 5 | Structural Modification of Al65Cu16.5Ti18.5 Amorphous Powder through Annealing and Post Milling: Improving Thermal Stability显示文摘To improve thermal stability of the Al65Cu16.5Ti18.5 amorphous powder,structural modification of the amorphous powder was performed through annealing and post milling.Annealing above the crystallization temperature(Tx) not only induced nanoscale intermetallics to precipitate in the amorphous powder,but also increased Cu atomic percentage within the residual amorphous phase.Post milling induced the amorphization of the nanocrystal intermetallics and the formation of Cu9Al4 from the residual amorphous phase.Thus,a mixed structure consisting of amorphous phase and Cu9Al4 was obtained in the powder after annealing and post milling(the APMed powder).The phase constituent in the APMed powder did not change during the post annealing,which exhibited significantly improved thermal stability in comparison with the as-milled amorphous powder. | Zhen Tan Lu Wang Yunfei Xue Xingwang Cheng Long Zhang | 2016 | Journal of Materials Science & Technology2016，32，12： | 1 |
| 6 | Using a novel pulsed high- voltage gas- liquid hybrid discharge continuous reactor for removal of organic pollutant in oxygen atmosphere显示文摘 | Le Cheng Yi Zhang Xingwang Zhang | 2008 | Journal of electrostatics2008，，66： | 1 |
| 7 | Ternary BCN Thin Films Deposited by Reactive Sputtering显示文摘 | Yue Jinshun Cheng Wenjuan Zhang Xingwang | 2000 | ThinSolid Films2000，375，12： | 1 |
| 8 | Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposureinduced anxiety-like behaviors in offspring显示文摘Pyridaben(PY)is a widely used organochlorine acaricide,which can be detected in the peripheral blood of pregnant women.Available evidence suggests that PY has reproductive toxicity.However,it remains uncertain whether prenatal PY exposure impacts neurobehavioral development in offspring.Here,we administered PY to pregnant mice at a dose of 0.5 and 5 mg kg^(-1)day^(-1)via gavage and observed anxietylike behaviors in PY offspring aged five weeks.We then integrated the metabolome and transcriptome of the offspring's brain to explore the underlying mechanism.Metabolome data indicated that the vitamin B6 metabolism pathway was significantly affected,and the pyridoxal 50-phosphate(PLP)concentration and the active form of vitamin B6 was significantly reduced.Moreover,the transcriptome data showed that both PLP generation-related Pdxk and anxiety-related Gad1 were significantly down-regulated.Meanwhile,there was a decreasing trend in the concentration of GABA in the hippocampal DG region.Next,we supplemented PLP at a dose of 20 mg kg^(-1)day^(-1)to the PY offspring via intraperitoneal injection at three weeks.We found up-regulated expression of Pdxk and Gad1 and restored anxiety-like behaviors.This study suggests that prenatal exposure to PY can disrupt vitamin B6 metabolism,reduce the concentration of PLP,down-regulate the expression levels of Pdxk and Gad1,inhibit the production of GABA,and ultimately lead to anxiety-like behaviors in offspring. | Xingwang Ding Ya Wen Xuan Ma Yuepei Zhang Yuting Cheng Zhaofeng Liu Weiyue Hu Yankai Xia | 2023 | Environmental Science and Ecotechnology2023，，1： | 0 |
| 9 | Cytochrome P450s in algae:Bioactive natural product biosynthesis and light-driven bioproduction显示文摘Algae are a large group of photo synthetic organisms responsible for approximately half of the earth’s total photosynthesis.In addition to their fundamental ecological roles as oxygen producers and as the food base for almost all aquatic life,algae are also a rich source of bioactive natural products,including several clinical drugs.Cytochrome P450 enzymes(P450s) are a superfamily of biocatalysts that are extensively involved in natural product biosynthesis by mediating various types of reactions.In the post-genome era,a growing number of P450 genes have been discovered from algae,indicating their important roles in algal life-cycle.However,the functional studies of algal P450s remain limited.Benefitting from the recent technical advances in algae cultivation and genetic manipulation,the researches on P450s in algal natural product biosynthesis have been approaching to a new stage.Moreover,some photoauto trophic algae have been developed into 'photo-bioreactors' for heterologous P450s to produce high-value added pharmaceuticals and chemicals in a carbon-neutral or carbon-negative manner.Here,we comprehensively review these advances of P450 studies in algae from 2000 to 2021. | Shanmin Zheng Jiawei Guo Fangyuan Cheng Zhengquan Gao Lei Du Chunxiao Meng Shengying Li Xingwang Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 0 |
| 10 | Dynamic response and damage evolution of Zr-based bulk metallic glass under shock loading显示文摘Dynamic response and damage evolution of Zr_(70)Cu_(13)Ni_(9.8)Al_(3.6)Nb_(3.4)Y_(0.2) bulk metallic glass(Zr-based BMG)under impact pressure ranging from 4.03 GPa to 27.22 GPa were studied.The Hugoniot Elastic Limit(HEL)and the spalling Strength(σ_(sp))were measured as 7.09 GPa and 2.28 GPa,and the curve of impact velocity(D)and particle velocity(u)were also obtained.Under the strain rate of~10^(5)s^(-1),local crystallization phenomenon was observed.As increasing the impact pressure,the failure mode of Zr-based BMG changed from spallation to fragmentation caused by the combination of spalling cracks and longitudinal cracks.Cone-cup structures were also observed in the internal spalling zone via nano-CT characterization.When increasing the impact pressure,the thickness of Zr-based BMG increased after impact and the remelting and cladding layers were also observed on the fracture surfaces.The fragments of the specimen were welded after impact due to the high temperature remelting,which causes plastic deformation of Zr-based BMG under shock loading. | Yan Li Xingwang Cheng Zhaolong Ma Xuhai Li Meng Wang | 2021 | Journal of Materials Science & Technology2021，，34： | 0 |
| 11 | Unraveling the advantages of Pd/CeO_(2)single-atom catalysts in the NO+CO reaction by model catalysts显示文摘Selective catalytic reduction of NO by CO is challenging in environmental catalysis but attractive owing to the advantage of simultaneous elimination of NO and CO.Here,model catalysts consisting of Pd nanoparticles(NPs)and single-atom Pd supported on a CeO_(2)(111)film grown on Cu(111)(denoted as Pd NPs/CeO_(2)and Pd_(1)/CeO_(2),respectively)were successfully prepared and characterized by synchrotron radiation photoemission spectroscopy(SRPES)and infrared reflection absorption spectroscopy(IRAS).The NO+CO adsorption/reaction on the Pd_(1)/CeO_(2)and Pd NPs/CeO_(2)catalysts were carefully investigated using SRPES,temperature-programmed desorption(TPD),and IRAS.It is found that the reaction products on both model catalysts are in good agreement with those on real catalysts,demonstrating the good reliability of using these model catalysts to study the reaction mechanism of the NO+CO reaction.On the Pd NPs/CeO_(2)surface,N_(2)is formed by the combination of atomic N coming from the dissociation of NO on Pd NPs at higher temperatures.N_(2)O formation occurs probably via chemisorbed NO combined with atomic N on the surface.While on the single-atom Pd_(1)/CeO_(2)surface,no N_(2)O is detected.The 100%N_(2)selectivity may stem from the formation of O-N-N-O^(*)intermediate on the surface.Through this study,direct experimental evidence for the reaction mechanisms of the NO+CO reaction is provided,which supports the previous density functional theory(DFT)calculations. | Qian Xu Xingwang Cheng Ningqiang Zhang Yi Tu Lihui Wu Haibin Pan Jun Hu Honghe Ding Junfa Zhu Yadong Li | 2023 | Nano Research2023，16，7： | 0 |
| 12 | Composition design of a novel Ti-6Mo-3.5Cr-1Zr alloy with high-strength and ultrahigh-ductility显示文摘The strength-elongation to fracture(εf)trade-off and low strain hardening rate have been a longstanding dilemma in titanium alloys.In this work,we innovatively manufactured a novel Ti-6Mo-3.5Cr-1Zr alloy via the introduction of a stress-induced strengthening phase into the material.Stress-inducedω(SIω)phase transformation was expected to replace theα''martensitic transformation that resulted in the low yield strength of titanium alloys.The obtained alloy exhibited an extremely high strain hardening rate of up to^1820 MPa.The true peak tensile strength andεfreached^1242 MPa and^40%,respectively.The intrinsic mechanisms underlying the simultaneous improvement of strength and ductility of the material were systematically investigated via in-situ and ex-situ characterizations.In-situ electron backscatter diffraction(EBSD)/digital image correlation(DIC)results showed that SIωphase transformation dominated the early stage of plastic deformation(1.5%–3%)and promoted the strain partitioning between the stress-induced bands andβmatrix.Subsequently,the formation of{332}<113>βtwins andωtwins was observed via ex-situ EBSD.In-situ transmission electron microscopy results revealed that dislocation pile-up(DPU)occurred at the SIω/βinterface.The coupling effects associated with the transformation induced plasticity(TRIP),twinning induced plasticity(TWIP),and DPU mechanisms contributed to the enhanced strength andεfof the designed titanium alloy. | Kai Chen Qunbo Fan Jiahao Yao Lin Yang Shun Xu Wei Lei Duoduo Wang Jingjiu Yuan Haichao Gong Xingwang Cheng | 2022 | Journal of Materials Science & Technology2022，，36： | 0 |
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