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| 1 | Effect of Lingqi Huangban granule plus intravitreal ranibizumab on macular edema induced by retinal vein occlusion: a randomized controlled clinical trial显示文摘OBJECTIVE: To investigate the effect of Lingqi Huangban granule(LQHB) plus intravitreal ranibizumab in the treatment of macular edema(ME) induced by retinal vein occlusion(RVO).METHODS: A prospective, randomized controlled study was conducted. A total of 60 subjects with RVO induced ME were randomized into control group(CG)(30 eyes) and LQHB group(LQHBG)(30 eyes). CG patients underwent intravitreal ranibizumab(IVR) injections. LQHBG patients were treated with oral LQHB combined with IVR injections. In order to reduce the financial burden of the injections, we used one injection and pro re nata(PRN)regimen for both groups. The best-corrected visual acuity(BCVA), central macular thickness(CMT), and mean number of injections were evaluated at the beginning of treatment and 3, 6, 9 and 12 months afterward. All the subjects were followed up for 1 year.RESULTS: At the beginning of treatment, there were no statistically significant differences between the two groups in terms of the general condition of patients(P > 0.05). At 3, 6, 9 and 12 months after treatment, however, the BCVA scores improved and the CMT measurements decreased in all patients(P < 0.05), with the improvement of LQHBG significantly greater than that of CG(P <0.05). The mean numbers of ranibizumab injections were 1.8 ± 0.3 in LQHBG and 2.3 ± 0.6 in CG, respectively(P < 0.05). No adverse events were reported in both groups.CONCLUSION: LQHB plus intravitreal ranibizumab could be a much more effective and economic treatment for stabilizing and improving vision with fewer intravitreal injections in the treatment of RVO induced ME. This integrative therapy appears to be a promising option for this type of patient. | Lu Bingwen Wu Xingwei | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 4 |
| 2 | A Hyper-redundant Elephant’s Trunk Robot with an Open Structure:Design,Kinematics,Control and Prototype显示文摘As for the complex operational tasks in the unstructured environment with narrow workspace and numerous obstacles,the traditional robots cannot accomplish these mentioned complex operational tasks and meet the dexterity demands.The hyper-redundant bionic robots can complete complex tasks in the unstructured environments by simulating the motion characteristics of the elephant’s trunk and octopus tentacles.Compared with traditional robots,the hyper-redundant bionic robots can accomplish complex tasks because of their flexible structure.A hyper-redundant elephant’s trunk robot(HRETR)with an open structure is developed in this paper.The content includes mechanical structure design,kinematic analysis,virtual prototype simulation,control system design,and prototype building.This design is inspired by the flexible motion of an elephant’s trunk,which is expansible and is composed of six unit modules,namely,3UPS-PS parallel in series.First,the mechanical design of the HRETR is completed according to the motion characteristics of an elephant’s trunk and based on the principle of mechanical bionic design.After that,the backbone mode method is used to establish the kinematic model of the robot.The simulation software SolidWorks and ADAMS are combined to analyze the kinematic characteristics when the trajectory of the end moving platform of the robot is assigned.With the help of ANSYS,the static stiffness of each component and the whole robot is analyzed.On this basis,the materials of the weak parts of the mechanical structure and the hardware are selected reasonably.Next,the extensible structures of software and hardware control system are constructed according to the modular and hierarchical design criteria.Finally,the prototype is built and its performance is tested.The proposed research provides a method for the design and development for the hyper-redundant bionic robot. | Yongjie Zhao Xiaogang Song Xingwei Zhang Xinjian Lu | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 3 |
| 3 | Multi‑omics reveals that the host‑microbiome metabolism crosstalk of differential rumen bacterial enterotypes can regulate the milk protein synthesis of dairy cows显示文摘Background Dairy cows’lactation performance is the outcome of the crosstalk between ruminal microbial metabo-lism and host metabolism.However,it is still unclear to what extent the rumen microbiome and its metabolites,as well as the host metabolism,contribute to regulating the milk protein yield(MPY).Methods The rumen fluid,serum and milk of 12 Holstein cows with the same diet(45%coarseness ratio),parity(2–3 fetuses)and lactation days(120–150 d)were used for the microbiome and metabolome analysis.Rumen metabolism(rumen metabolome)and host metabolism(blood and milk metabolome)were connected using a weighted gene co-expression network(WGCNA)and the structural equation model(SEM)analyses.Results Two different ruminal enterotypes,with abundant Prevotella and Ruminococcus,were identified as type1 and type2.Of these,a higher MPY was found in cows with ruminal type2.Interestingly,[Ruminococcus]gauvreauii group and norank_f_Ruminococcaceae(the differential bacteria)were the hub genera of the network.In addition,differential ruminal,serum and milk metabolome between enterotypes were identified,where the cows with type2 had higher L-tyrosine of rumen,ornithine and L-tryptophan of serum,and tetrahydroneopterin,palmitoyl-L-carnitine,S-lactoylglutathione of milk,which could provide more energy and substrate for MPY.Further,based on the identi-fied modules of ruminal microbiome,as well as ruminal serum and milk metabolome using WGCNA,the SEM analysis indicated that the key ruminal microbial module1,which contains the hub genera of the network([Ruminococcus]gauvreauii group and norank_f_Ruminococcaceae)and high abundance of bacteria(Prevotella and Ruminococcus),could regulate the MPY by module7 of rumen,module2 of blood,and module7 of milk,which contained L-tyrosine and L-tryptophan.Therefore,in order to more clearly reveal the process of rumen bacterial regulation of MPY,we established the path of SEM based on the L-tyrosine,L-tryptophan and related components.The SEM based on the metabolites suggested that[Ruminococcus]gauvreauii group could inhibit the energy supply of serum tryptophan to MPY by milk S-lactoylglutathione,which could enhance pyruvate metabolism.Norank_f_Ruminococcaceae could increase the ruminal L-tyrosine,which could provide the substrate for MPY.Conclusion Our results indicated that the represented enterotype genera of Prevotella and Ruminococcus,and the hub genera of[Ruminococcus]gauvreauii group and norank_f_Ruminococcaceae could regulate milk protein synthesis by affecting the ruminal L-tyrosine and L-tryptophan.Moreover,the combined analysis of enterotype,WGCNA and SEM could be used to connect rumen microbial metabolism with host metabolism,which provides a fundamental understanding of the crosstalk between host and microorganisms in regulating the synthesis of milk composition. | Chenguang Zhang Mengya Wang Huifeng Liu Xingwei Jiang Xiaodong Chen Tao Liu Qingyan Yin Yue Wang Lu Deng Junhu Yao Shengru Wu | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 1 |
| 4 | Poly(I:C)preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway显示文摘Emerging evidence suggests that Toll-like receptors(TLRs)ligands pretreatment may play a vital role in the progress of myocardial ischemia/reperfusion(I/R)injury.As the ligand of TLR3,polyinosinic-polycytidylic acid(poly(I:C)),a synthetic double-stranded RNA,whether its preconditioning can exhibit a cardioprotective phenotype remains unknown.Here,we report the protective effect of poly(I:C)pretreatment in acute myocardial I/R injury by activating TLR3/PI3K/Akt signaling pathway.Poly(I:C)pretreatment leads to a significant reduction of infarct size,improvement of cardiac function,and downregulation of inflammatory cytokines and apoptotic molecules compared with controls.Subsequently,our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced,and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C)pretreatment,while knock out of TLR3 suppresses the cardioprotection of poly(I:C)preconditioning through a decreased activation of PI3K/Akt signaling.Moreover,inhibition of p85 PI3K by the administration of LY294002 in vivo and knockdown of Akt by siRNA in vitro significantly abolish poly(I:C)preconditioning-induced cardioprotective effect.In conclusion,our results reveal that poly(I:C)preconditioning exhibits essential protection in myocardial I/R injury via its modulation of TLR3,and the downstream PI3K/Akt signaling,which may provide a potential pharmacologic target for perioperative cardioprotection. | Erya Chen Chan Chen Zhendong Niu Lu Gan Qiao Wang Ming Li XingWei Cai Rui Gao Sruthi Katakam Hai Chen Shu Zhang Ronghua Zhou Xu Cheng Yanhua Qiu Hai Yu Tao Zhu Jin Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 5 | Role of microRNA-29b in angiotensin II-induced epithelial-mesenchymaltransition in renal tubular epithelial cells显示文摘 | Jialin Pan Juhong Zhang Xingwei Zhang Xi Zhou Shengyue Lu Xiaoyan Huang Jiayu Shao Guoqiang Lou Deye Yang Yong-Jian Geng | 2014 | International Journal of Molecular Medicine2014，，5： | 1 |
| 6 | The joint knowledge reasoning model based on knowledge representation learning for aviation assembly domain显示文摘Knowledge graph technology is widely applied in the domain of general knowledge reasoning with an excellent performance.For fine-grained professional fields,professional knowledge graphs can provide more accurate information in practical industrial scenarios.Based on an aviation assembly domain-specific knowledge graph,the article constructs a joint knowledge reasoning model,which combines a named entity recognition model and a subgraph embedding learning model.When performing knowledge reasoning tasks,the two models vectorize entities,relationships and entity attributes in the same space,so as to share parameters and optimize learning efficiency.The knowledge reasoning model,which provides intelligent question answering services,is able to reduce the assembly error rate and improve the assembly efficiency.The system can accurately solve general knowledge reasoning problems in the assembly process in actual industrial scenarios of general assembly and component assembly under interference-free conditions.Finally,this paper compares the proposed knowledge reasoning model based on knowledge representation learning and the question-answering system based on large-scale pre-trained models.In the application scenario of system functional testing in general assembly,the joint model attains an accuracy rate of 95%,outperforming GPT with 78%accuracy and enhanced representation through knowledge integration with 71%accuracy. | LIU PeiFeng QIAN Lu LU Hu XUE Lei ZHAO XingWei TAO Bo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 7 | Continuous,efficient and safe synthesis of 1-oxa-2-azaspiro[2.5]octane in a microreaction system显示文摘1-Oxa-2-azaspiro[2.5]octane,as one of N-H oxaziridines,is a selective electrophilic aminating agent for N-,S-,C-,and O-nucleophiles.It has the features of stereoselectivity and the absence of formation of strongly acidic or basic byproducts,leading to considerable interest in the development of organic synthetic methods.Currently,the economically feasible route of production of 1-oxa-2-azaspiro[2.5]octane is the reaction of cyclohexanone with ammonia and sodium hypochlorite.However,due to strong exothermic reactions,massive gas release and heterogeneous reaction,the controllability,efficiency and safety of the reaction are in great difficulty using batch technology.In this paper,a microreaction system containing predispersion,reaction and phase separation was introduced into the preparation of 1-oxa-2-azaspiro[2.5]octane.The research results showed that precise control of the process including droplet dispersion,temperature control,reaction time control and fast continuous phase separation,was the key to process intensification.Under optimal conditions,the concentration of 1-oxa-2-azaspiro[2.5]octane in product obtained by microreaciton system(~2.0 mol·L^(-1))was much higher than that obtained by batch technology(0.2-0.4 mol·L^(-1)),which demonstrated that the continuous-flow synthesis would be a more efficient substitute for batch synthesis.Meanwhile,the results of the derivation experiments also showed that the aminating agent solution with higher concentration was more advantageous in the applications. | Jinpei Huang Xingwei Lu Xuejing Zhang Yiqiang Jin Yifeng Zhou | 2023 | Chinese Journal of Chemical Engineering2023，61，9： | 0 |
| 8 | Human-Robot Collaboration Framework Based on Impedance Control in Robotic Assembly显示文摘Human–robot(HR)collaboration(HRC)is an emerging research field because of the complementary advantages of humans and robots.An HRC framework for robotic assembly based on impedance control is proposed in this paper.In the HRC framework,the human is the decision maker,the robot acts as the executor,while the assembly environment provides constraints.The robot is the main executor to perform the assembly action,which has the position control,drag and drop,positive impedance control,and negative impedance control modes.To reveal the characteristics of the HRC framework,the switch condition map of different control modes and the stability analysis of the HR coupled system are discussed.In the end,HRC assembly experiments are conducted,where the HRC assembly task can be accomplished when the assembling tolerance is 0.08 mm or with the interference fit.Experiments show that the HRC assembly has the complementary advantages of humans and robots and is efficient in finishing complex assembly tasks. | Xingwei Zhao Yiming Chen Lu Qian Bo Tao Han Ding | 2023 | Engineering2023，，11： | 0 |
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