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| 1 | Solid-pseudopapillary tumor of the pancreas: Clinical experience and literature review显示文摘AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare disease.METHODS: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our institution.RESULTS: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant therapy.The mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow up.CONCLUSION: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable. | Hsueh-Lien Huang Shou-Chuan Shih Wen-Hsiung Chang Tsang-En Wang Ming-Jen Chen Yu-Jan Chan | 2005 | World Journal of Gastroenterology2005，11，9： | 57 |
| 2 | Large eddy simulation of a planar jet flow with nanoparticle coagulation显示文摘易于在一口平面喷气的大协调结构的 nanoparticles 的凝结和生长被使用大旋涡模拟探索了。粒子地被一片刻采用方法接近获得 nanoparticle 将军动态方程。在直径包含 1 nm 的粒子的不可压缩的液体被投射进一没有粒子周围。当喷气发展,结果证明协调结构统治 nanoparticle 数字紧张直径和多分散性分布的进化。另外,当配对的旋涡引起粒子分布成为制服时,增加粒子的散开的协调结构行为,和旋涡滚动起来做更不规则地散布的粒子。当喷气下游地旅行,平均时间的粒子数字集中在郊区在喷气核心并且更高变得更低,而在全部流动地上的平均时间的粒子团维持未改变,,并且他们的最大值在喷气区域的接口上并且周围。 | Mingzhou Yu Jianzhong Lin Lihua Chen Tatleung Chan | 2006 | Acta Mechanica Sinica2006，22，4： | 25 |
| 3 | Management Recommendations on Sleep Disturbance o Patients with Parkinson's Disease显示文摘INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD).Sleep disturbance affects 40-98% of PD patients in the world. In China, the prevalence of PD patients with sleep disturbance ranges from 47.66% to 89.10%. Sleep disturbance usually has adverse impact on the quality of life of PD patients. Apossible pathogenesis of PD with sleep disturbance include thalamocortical pathway degeneration and changes of neurotransmitter systems. The etiology of sleep disturbance is multifactorial,involving degeneration of areas regulating sleep,sleep structure affected by drugs,sleep disturbance induced by drug,and sleep fragmentation by multiple factors. | Chun-Feng Liu Tao Wang Shu-Qin Zhan De-Qin Geng Jian Wang Jun Liu Hui-Fang Shang Li-Juan Wang Piu Chan Hai-Bo Chen Sheng-Di Chen Yu-Ping Wang Zhong-Xin Zhao K Ray Chaudhuri | 2018 | Chinese Medical Journal2018，，24： | 26 |
| 4 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 5 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 6 | Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas显示文摘瞄准:为了学习 CDH1/E-cadherin (电子恶棍) 的角色,基因改变介绍在胃的癌(GC ) 在激活在 CDH1 的机制包括变化,杂合现象(LOH ) 的损失,倡导者多型性和 hypermethylation。方法:标本与 GC 从 70 个病人通过手术被收集。Allelotyping PCR 和定序的 LOH,使中毒的高压力液相色谱法和 DNA 的察觉,限制碎片长度多型性分析,甲基化 specific PCR,和免疫组织化学的染色被使用。结果:倡导者多型性不是在激活的电子恶棍的主要机制。仅仅一截断变化在一个弥漫的类型肿瘤(3%) 被发现。LOH 和倡导者 hypermethylation 是在激活的电子恶棍的主要机制,但是有趣地,在 CDH1 的肿瘤和 hypermethylation 在突变而产生之遗传的损失(LOH ) 的部分之间有一个否定协会。因此 LOH 和 hypermethylation 是涉及 GC 的二条不同致瘤的小径。结论:给体细胞突变是极其低的,在 LOH 和 hypermethylation 之间的关系是反的调查结果,这三个因素的任何二联合不能在激活完成 CDH1 的古典二点击的假设。因此,在 transcriptional 水平或在 translational 以后水平操作的另外的机制可能被要求在激活导致 E-cadherin。 | Yao-Chi Liu Chen-Yang Shen Hurng-Sheng Wu Tsai-Yuan Hsieh De-Chuan Chan Cheng-Jueng Chen Jyh-Cherng Yu Cheng-Ping Yu Horng-Jyh Harn Peng-Jen Chen Chung-Bao Hsieh Teng-Wei Chen Huan-Mieng Hsu | 2006 | World Journal of Gastroenterology2006，12，14： | 16 |
| 7 | Predictors of the outcomes of acute-on-chronic hepatitis B liver failure显示文摘AIM:To identify the risk factors in predicting the outcome of acute-on-chronic hepatitis B liver failure patients.METHODS:We retrospectively divided 113 patients with acute-on-chronic liver failure-hepatitis B virus(ACLF-HBV) and without concurrent hepatitis C or D virus infection and hepatocellular carcinoma into two groups according to their outcomes after anti-HBV therapy.Their demographic,clinical,and biochemical data on the day of diagnosis and after the first week of treatment were analyzed using the Mann-Whitney U test,Fisher's exact test,and a multiple logistic regression analysis.RESULTS:The study included 113 patients(87 men and 26 women) with a mean age of 49.84 years.Fiftytwo patients survived,and 61 patients died.Liver failure(85.2%),sepsis(34.4%),and multiple organ failure(39.3%) were the main causes of death.Multivariate analyses showed that Acute Physiology and Chronic Health Evaluation(APACHE) Ⅱ scores ≥ 12 [odds ratio(OR) = 7.160,95% CI:2.834-18.092,P < 0.001] and positive blood culture(OR = 13.520,95% CI:2.740-66.721,P = 0.001) on the day of diagnosis and model for end-stage liver disease(MELD) scores ≥ 28(OR = 8.182,95% CI:1.884-35.527,P = 0.005) after the first week of treatment were independent predictors of mortality.CONCLUSION:APACHE Ⅱ scores on the day of diagnosis and MELD scores after the first week of anti-HBV therapy are feasible predictors of outcome in ACLFHBV patients. | Hsiu-Lung Fan Po-Sheng Yang Hui-Wei Chen Teng-Wei Chen De-Chuan Chan Chi-Hong Chu Jyh-Cherng Yu Shih-Ming Kuo Chung-Bao Hsieh | 2012 | World Journal of Gastroenterology2012，18，36： | 16 |
| 8 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 9 | Acupuncture treatment of lung-spleen Qi deficiency in stable chronic obstructive pulmonary disease: a randomized, open-label, controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of acupuncture that reinforces the spleen to strengthen the lung in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a randomized,open-controlled trial in which the acupuncturist and the participants were not blinded,but the outcome evalu-ators and data analysts were blinded.One-hundred-and-two patients with stable COPD were randomly divided into two groups in a 1∶1 ratio.The acupuncture group received 30-minute sessions of acupuncture therapy at the same acupoints three times weekly for 6 weeks in addition to routine conventional Western Medicine treatment;the control group received routine conventional Western Medicine treatment alone.The primary outcome was the Borg scale score,which was assessed immediately after the 6-minute walk test.The secondary outcomes were the 6-minute walk distance,lung function,and oxygen saturation.Measurements were obtained at baseline and after 6 weeks of treatment.RESULTS:After 6 weeks of treatment,the Borg scale score in the acupuncture group was significantly better than that in the control group(2.02±0.71 versus 5.01±0.34,P<0.05).Furthermore,the post-treatment improvements in the 6-minute walk distance,lung function,and oxygen saturation were significantly greater in the acupuncture group than in the control group,showing that the acupuncture group had better exercise tolerance.CONCLUSION:The findings suggest that acupuncture that aims to reinforce the spleen to strengthen the lung is a safe and effective adjuvant therapy that effectively improves the exercise capacity of patients with stable COPD. | Li Yu Xiong Chan Zeng Yan Wei Hua Zhuang Guangtong Zhao Lihong Li Chenyi Li Lin Qin Erqi Chen Xiaoqin Fu Juanjuan | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 13 |
| 10 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 11 | Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong显示文摘氨基酸,器官的酸和丰满的酸氧化的新陈代谢(IEM ) 的古典先天的错误的背景数据大部分正在缺乏香港,在集体基于 spectrometry 的扩展新生儿为 IEM 屏蔽没被开始的地方。瞄准在香港评估近似发生,光谱和古典 IEM 的另外的特征的当前的学习,将在开发为实验室血浆氨基酸记录的本地 area.Methods 屏蔽节目的一个扩展新生儿重要,血浆 acylcarnitines 和尿从年 2005~2009 的器官的酸分析在为 IEM 提供生物化学、基因的诊断服务的三个地区性的化学病理实验室包括回顾地 reviewed.Resu 在香港的古典 IEM 的发生粗略地被估计每 1000live 出生每 4122 生活出生,或 0.243 个盒子是至少 1 个盒子。这发生类似于全球报导的那些,包括中国的大陆。hyperphenylalaninemia 的估计的发生在 29 542 实时 births.Conclusions 是 1 我们的数据显示它为在香港的扩展新生的屏蔽节目的介绍是无可争辩的。因为香港是一个大城市的城市,一个全面扩展新生的屏蔽程序和工作分派系统应该是可得到的服务在区域出生的出生不满一月的婴儿。 | Han-Chih Hencher Lee Chloe Miu Mak Ching-Wan Lam Yuet-Ping Yuen, Angel On-Kei Chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching Wai-Kwan Siu Sammy Pak-Lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam Albert Yan-Wo Chan | 2011 | Chinese Medical Journal2011，，7： | 12 |
| 12 | 新生代产业工人工作状况调查——基于汽车产业的实证数据显示文摘本文以6省市、12家汽车乘用车整车厂的新生代产业工人为调查对象,调研分析了他们的工作状况。调查显示,新生代产业工人在年龄、文化程度、政治素质、维权意识方面具有鲜明的群体特征。同时,新生代产业工人的工作收入不高,工作时间长,工作强度大,工作前景渺茫,工作满意度和组织承诺低。对于新生代产业工人工作状况中体现的问题,应该从提高产业工人收入,完善工作场所的管理,吸纳一线工人参与管理三方面予以改善。 | 谢玉华 肖巧玲 Anita Chan 赵炜 Yiu Por Chen | 2013 | 中国青年研究2013，，8： | 11 |
| 13 | Percutaneous transgastric computed tomography-guided biopsy of the pancreas using large needles显示文摘AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided biopsies in patients with pancreas mass,of whom 24(71%)had a direct path to the mass without passing through a major organ.The needle passed through the liver in one case(3%).Nine passes(26%)were made through the stomach.These nine transgastric biopsies which used a coaxial technique(i.e.a 17-gauge coaxial introducer needle and an 18-gauge biopsy needle)were the basis of this study.Immediate and late follow-up CT images to detect complications were obtained. RESULTS:Tumor tissues were obtained in nine pancreatic biopsies,and histologic specimens for diagnosis were obtained in all cases.One patient,who had a rare sarco-matoid carcinoma,received a second biopsy.One patient had a complication of transient pneumoperitoneum but no subjective complaints.An immediate imaging study and clinical follow-up detected neither hemorrhage nor peritonitis.No delayed procedure-related complication was seen during the survival period of our patients.CONCLUSION:Pancreatic biopsy can be obtained by a transgastric route using a large needle as an alternative method,without complications of peritonitis or bleeding. | Hsiuo-Shan Tseng Chia-Yuen Chen Wing P Chan Jen-Huey Chiang | 2009 | World Journal of Gastroenterology2009，15，47： | 11 |
| 14 | Roux-en-Y reconstruction does not require gastric decompression after radical distal gastrectomy显示文摘AIM: To determine whether routine nasogastric (NG) decompression benefitted patients undergoing radical gastric surgery. METHODS: Between January 1998 and December 2008, 519 patients who underwent distal gastrectomy for gastric cancer were retrospectively divided into 2 time-period cohorts; those treated with Billroth Ⅱ (BⅡ) reconstruction in the first 6 years and those with Roux-en-Y (RY) reconstruction in the last 5 years. In the latter group, the patients were further divided into 2 subgroups; with and without nasogastric decompression.RESULTS: Postoperatively, there were no significant differences in the number of anastomotic leaks between the 3 groups. In the tubeless RY group, time to semiliquid diet was significantly shorter than in the other 2 groups (4.4 d ± 1.4 d vs 7.2 d ± 1.3 d and 5.9 d ± 1.2 d, P = 0.005). The length of postoperative stay was significantly increased in patients with BⅡ reconstruction compared with patients with RY reconstruction with/without NG decompression (15.4 d ± 4.3 d in BⅡ group vs 12.6 d ± 3.1 d in decompressed RY and 11.4 d ± 3.4 d in the tubeless RY group, P = 0.035). The postoperative pneumonia rate was lowest in the tubeless group and highest in the BⅡ group (1.4% vs 4.6%, P = 0.01). Severe sore throat was noted in 59 (20.7%) members of the BⅡ group, 18 (17.4%) members of the decompressed RY group and 6 (4.2%) members of the tubeless RY group. Fewer patients in the tubeless group complained of severe sore throat (P = 0.001). CONCLUSION: This study provides support for abandoning routine NG decompression in patients undergoing subtotal gastrectomy with Roux-en-Y gastrojejunostomy. | Cheng-Jueng Chen Tsang-Pai Liu Jyh-Cherng Yu Sheng-Der Hsua Tsai-Yuan Hsieh Heng-Cheng Chu Chung-Bao Hsieh Teng-Wei Chen, De-Chuan Chan | 2012 | World Journal of Gastroenterology2012，18，3： | 11 |
| 15 | Effects of lactic acid bacteria isolated from fermented mustard on lowering cholesterol显示文摘Objective:To evaluate the ability of lactic acid bacteria(LAB)strains isolated from fermented mustard to lower the cholesterol in vitro.Methods:The ability of 50 LAB strains isolated from fermented mustard on lowering cholesterol in vitro was determined by modified o-phtshalaldehyde method.The LAB isolates were analyzed for their resistance to acid and bile salt.Strains with lowering cholesterol activity,were determined adherence to Caco-2 cells.Results:Strain B0007,B0006 and B0022 assimilated more cholesterol than BCRC10474 and BCRC17010.The isolated strains showed tolerance to pH 3.0 for 3h despite variations in the degree of viability and bile-tolerant strains,with more than 10~s CFU/mL after incubation for 24 h at 1%oxigall in MRS.In addition,strain B0007 and B0022 identified as Lactobacillus plantarum with 16S rDNA sequences were able to adhere to the Caco-2 cell lines.Conclusions:These strains B0007 and B0022 may be potential functional sources for cholesterollowering activities as well as adhering to Caco-2 cell lines. | Shu Chen Wang Chen Kai Chang Shu Chang Chan Jiunn Shiuh Shieh Chih Kwang Chiu Pin-Der Duh | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 10 |
| 16 | Inverted Internal Limiting Membrane Flap Technique for Repair of Large Macular Holes: A Short-term Follow-up of Anatomical and Functional Outcomes显示文摘 | Zhe Chen Chan Zhao Jun-Jie Ye Xu-Qian Wang Rui-Fang Sui | 2016 | Chinese Medical Journal2016，，5： | 10 |
| 17 | Evidence of compliance with and effectiveness of guidelines for noninvasive prenatal testing in China:a retrospective study of 189,809 cases显示文摘In China,the medical guidelines recommend performing noninvasive prenatal testing(NIPT)with caution for pregnant women aged 35 years or older.However,the Mother and Child Health Care Law suggests that all primiparous women whose age is older than 35 years undergo prenatal diagnosis.These two inconsistent suggestions/recommendations have made obstetricians confused about whether to offer NIPT to these older pregnant women.To face this issue and find out the solution we performed a retrospective study of 189,809 NIPT samples collected from 28 provincial-leveled administrative units in China.Of 1,564 women with high-risk pregnancies who underwent NIPT,459(29.3%)did not participate in follow-up.The compound sensitivity and specificity of NIPT for trisomies 21,18 and 13 detection was 99.1%(95%CI,98.0%–99.6%)and 99.9%(95%CI,98.8%–99.9%),respectively.In secundiparous women,NIPT showed high sensitivity and specificity similar to that in primiparous women.The observed risk for trisomies 21 and 18 significantly increased when the maternal age was 39 and older.After the publication of the current NIPT policy,the follow-up rate at our center was 97.9%;however,a large number of women are not in maternal and infant care networks nationwide,and that makes the follow-up rate outside our center relatively low.Our study shows that to balance the prevention of major aneuploidies and the limited resources for prenatal diagnosis,the cut-off age of 35 for invasive prenatal diagnosis might be unnecessary.Although the NIPT guidelines are well written,how to practice it effectively,especially in less industrialized areas,is worth discussing. | Chan Tian Tao Deng Xiuhuang Zhu Chen Gong Yangyu Zhao Yuan Wei Rong Li Xiufeng Xu Miaonan He Zhiwei Zhang Jing Cheng Mol BenWillem Jie Qiao | 2020 | Science China(Life Sciences)2020，63，3： | 10 |
| 18 | Reduction of the ages at diagnosis and operation of biliary atresia in Taiwan: A 15-year population-based cohort study显示文摘AIM: To describe the ages at diagnosis and operation of biliary atresia(BA) and its incidence over a 15-year period in Taiwan.METHODS: This was a population-based cohort study. BA cases were identified from the Taiwan National Health Insurance Research Database based on the International Classification of Diseases,Ninth Revision(ICD-9) code of BA 751.61 plus Kasai operation(ICD-9 procedure code 51.37) or liver transplantation(LT,ICD-9 procedure code 50.5). The patients' characteristics including sex,age at diagnosis,age at receiving Kasai operation and age at receiving LT were compared among three birth cohorts:(1) 1997 to 2001;(2) 2002 to 2006; and(3) 2007 to 2011.RESULTS: There were a total of 540 BA cases(275 females) with an incidence of 1.62 per 10000 live births. No seasonality of BA was noted. The mean ages at diagnosis of three cohorts were 57.9,55.6 and 52.6 d.A linear regression model demonstrated a decreasing trend of the mean age at diagnosis(1.27 d per year). The proportion of BA cases that received the Kasai operation within 60 d of age increased from 76% to 81%. A total of 189(35%) BA patients underwent LT. The mean age at LT was reduced from 3-year-old to 1-year-old. The rates of LT were 25.6% and 32.3% in patients who received the Kasai operation within 60 d or after 60 d of age,respectively. All patients who did not undergo a Kasai operation eventually required LT.CONCLUSION: The ages at diagnosis and operation in BA cases have decreased over time. Kasai operation performed at younger age reduces the need for LT. The incidence of BA in Taiwan fluctuates,but without certain trend. | Jen-Shyang Lin Solomon Chih-Cheng Chen Chin-Li Lu Hung-Chang Lee Chun-Yan Yeung Wai-Tao Chan | 2015 | World Journal of Gastroenterology2015，21，46： | 10 |
| 19 | Constraint-induced movement therapy enhances AMPA receptor-dependent synaptic plasticity in the ipsilateral hemisphere following ischemic stroke显示文摘Constraint-induced movement therapy(CIMT)can promote the recovery of motor function in injured upper limbs following stroke,which may be associated with upregulation ofα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)at synapses in the ipsilateral sensorimotor cortex in our previous study.However,AMPAR distribution is tightly regulated,and only AMPARs on the postsynaptic membrane can mediate synaptic transmission.We speculated that synaptic remodeling induced by movement-associated synaptic activity can promote functional recovery from stroke.To test this hypothesis,we compared AMPAR expression on the postsynaptic membrane surface in a rat model of ischemic stroke induced by middle cerebral artery occlusion(MCAO)with versus without CIMT,which consisted of daily running wheel training for 2 weeks starting on day 7 after MCAO.The results showed that CIMT increased the number of glutamate receptor(Glu R)2-containing functional synapses in the ipsilateral sensorimotor cortex,and reduced non-Glu R2 AMPARs in the ipsilateral sensorimotor cortex and hippocampal CA3 region.In addition,CIMT enhanced AMPAR expression on the surface of post-synaptic membrane in the ipsilateral sensorimotor cortex and hippocampus.Thus,CIMT promotes the recovery of motor function of injured upper limbs following stroke by enhancing AMPAR-mediated synaptic transmission in the ischemic hemisphere.These findings provide supporting evidence for the clinical value of CIMT for restoring limb movement in stroke patients.All experimental procedures and protocols were approved by the Department of Laboratory Animal Science of Fudan University,China(approval No.201802173 S)on March 3,2018. | Jian Hu Pei-Le Liu Yan Hua Bei-Yao Gao Yu-Yuan Wang Yu-Long Bai Chan Chen | 2021 | Neural Regeneration Research2021，16，2： | 9 |
| 20 | Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy显示文摘AIM: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC).METHODS: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization.RESULTS: Gender, the type of resection, operating time,blood loss, tumor status and amount of narcotics were connparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P= 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C(groups A and C vsgroup B, P<0.05). There was no significant difference in respect to the first flatus among the three groups. However, the time of tolerating oral intake with soft food in groups A and C patients was significantly shorter than that in group B patients. Levels of C-reactive protein (CRP) were significantly lower in group C and there was a more prominent and prolonged response in CRP level in patients undergoing IPC. The incidence of post-operative complications was similar in the three groups except for prolonged post-operative ileus. There was no increased risk of anastomotic leakage in patients receiving Met.CONCLUSION: The results suggest that a combination of intravenous Met and epidural pain control may be required to achieve a considerable decrease in time to resumption of oral soft diet in advanced gastric cancer patients who underwent gastrectomy and IPC. Furthermore,the administration of Met did not increase anastomotic leakage. Met has a role in the prevention of prolonged post-operative ileus. | De-Chuan Chan Yao-Chi Liu Cheng-Jueng Chen Jyh-Cherng Yu Heng-Cheng Chu Fa-Chang Chen Teng-Wei Chen Huan-Fa Hsieh Tzu-Ming Chang Kuo-Liang Shen | 2005 | World Journal of Gastroenterology2005，11，31： | 9 |
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