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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Stereotactic aspiration for hypertensive intracerebral haemorrhage in a Chinese population:a retrospective cohort study显示文摘Objective We aimed to compare the therapeutic effects of stereotactic aspiration and best medical management in patients who developed supratentorial hypertensive intracerebral haemorrhage(HICH)with a volume of haemorrhage between 20 and 40 mL.Methods The clinical data of 220 patients with supratentorial HICH with a volume between 20 and 40 mL were retrospectively analysed.Among them,142 received stereotactic aspiration surgery(stereotactic aspiration group)and 78 received best medical management(conservative group).All were followed up for 6 months.Multivariate logistic regression and Kaplan-Meier survival curves were used to compare the outcome between the two groups.results The rebleeding rate was lower in the group that had stereotactic aspiration when compared with the group with medical treatment(6[4.2%]vs 9[11.5%],χ2=4.364,p=0.037).After 6 months,although the mortality rate did not differ significantly between the two groups(8 cases[5.6%]vs 10 cases[12.8%],χ2=3.461,p=0.063),the rate of a favourable outcome was higher in the group who received stereotactic aspiration(χ2=15.870,p=0.000).Logistic regression identified that medical treatment(OR=1.64,p=0.000)was an independent risk factor for an unfavourable outcome.The Kaplan-Meier curves indicated that the median favourable outcome time in the stereotactic aspiration group was 59.5 days compared with that in the medically treated group(87.0 days).The log-rank test indicated that the prognosis at 6 months was better for those treated with stereotactic haematoma aspiration(χ2=29.866,p=0.000).However,the 6-month survival rate was similar between the two groups(χ2=3.253,p=0.068).Conclusions Stereotactic haematoma aspiration significantly improved the quality of life,although did not effectively reduce the rate of mortality.When selected appropriately,patients with HICH may benefit from this type of surgical intervention. | Xuyang Zhang Shaolong Zhou Qiang Zhang Xudong Fu Yuehui Wu Jiasheng Liu Bo Liang Zhuo Yang Xinjun Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 19 |
| 3 | Effects of environmental variations on the abundance of western winter-spring cohort of neon flying squid(Ommastrephes bartramii) in the Northwest Pacific Ocean显示文摘During 1995–2011, annual production of winter-spring cohort of Ommastrephes bartramii for Chinese squidjigging fishery has greatly fluctuated, which is closely related to the environmental conditions on the spawning and fishing grounds. To better understand how squid recruitment and abundance were influenced by ocean environmental conditions, biological and physical environmental variables including sea surface temperature(SST), SST anomaly(SSTA), chlorophyll a(Chl a) concentration and the Kuroshio Current were examined during years with the highest(1999), intermediate(2005), and lowest(2009) catches. Catch per unit effort(CPUE) of the squid-jigging vessels was used as an indicator of squid abundance. The results indicated that high SST and Chl a concentration on the spawning ground in 1999 resulted in favorable incubation and feeding conditions for squid recruitment. Whereas the suitable spawning zone(SSZ) in 2009 shifted southward and coincided with low SST and Chl a concentration, resulting in a reduction in the squid recruitment. The small difference of SSZ area in the three years suggested the SSZ provided limited influences on the variability in squid recruitment. Furthermore,high squid abundance in 1999 and 2005 was associated with warm SSTA on the fishing ground. While the cool SSTA on the fishing ground in 2009 contributed to adverse habitat for the squid, leading to extremely low abundance. It was inferred that strengthened intensity of the Kuroshio force generally yielded favorable environmental conditions for O. bartramii. Future research are suggested to focus on the fundamental research on the early life stage of O. bartramii and mechanism of how the ocean-climate variability affects the squid abundance and spatial distribution by coupling physical model with squid biological process to explore transport path and abundance distribution. | YU Wei CHEN Xinjun CHEN Yong YI Qian ZHANG Yang | 2015 | Acta Oceanologica Sinica2015，34，8： | 10 |
| 4 | Apoptosis of Spodoptera litura larval hemocytes induced byheavy metal zinc显示文摘By adding different amount of zinc into the artificial medium of the insect larvae, the zinc-induced apoptosis of the larvae haemocytes of the herbivorous insect Spodoptera litura Fabricius was investigated with flow cy- tometer. The results showed that the increase of zinc dose in the artificial feed led to the accumulations of zinc in the lar- val hemolymph and fat body, and more zinc was accumu- lated in fat body than in hemolymph. The apoptosis of hemocytes was significantly induced at high zinc concentra- tion (1000 mg·kg?1) in the insect diet, and the apoptosis rate was 63.63%, which was remarkably higher than that at con- trol and lower concentrations (50―500 mg·kg?1). This sug- gests that the high dose of zinc in the artificial diet of S. litura larvae could induce the apoptosis of the larval hemocytes of S. litura. | XIA Qiang SUN Hongxia HU Xinjun SHU Yinghua GU Dexiang ZHANG Guren | 2005 | Chinese Science Bulletin2005，50，24： | 9 |
| 5 | Standardization of CPUE for Chilean Jack Mackerel (Trachurus murphyi) from Chinese Trawl Fleets in the High Seas of the Southeast Pacific Ocean显示文摘The generalized linear model(GLM) and generalized additive model(GAM) were applied to the standardization of catch per unit effort(CPUE) for Chilean jack mackerel from Chinese factory trawl fishing fleets in the Southeast Pacific Ocean from 2001 to 2010 by removing the operational,environmental,spatial and temporal impacts.A total of 9 factors were selected to build the GLM and GAM,i.e.,Year,Month,Vessel,La Ni a and El Ni o events(ELE),Latitude,Longitude,Sea surface temperature(SST),SST anomaly(SSTA),Nino3.4 index and an interaction term between Longitude and Latitude.The first 5 factors were significant components in the GLM,which in combination explained 27.34% of the total variance in nominal CPUE.In the stepwise GAM,all factors explained 30.78% of the total variance,with Month,Year and Vessel as the main factors influencing CPUE.The higher CPUE occurred during the period April to July at a SST range of 12-15℃ and a SSTA range of 0.2-1.0℃.The CPUE was significantly higher in normal years compared with that in La Ni a and El Ni o years.The abundance of Chilean jack mackerel declined during 2001 and 2010,with an increase in 2007.This work provided the relative abundance index of Chilean jack mackerel for stock assessment by standardizing catch and effort data of Chinese trawl fisheries and examined the influence of temporal,spatial,environmental and fisheries operational factors on Chilean jack mackerel CPUE. | LI Gang ZOU Xiaorong CHEN Xinjun ZHOU Yinqi ZHANG Min | 2013 | Journal of Ocean University of China2013，12，3： | 9 |
| 6 | Impacts of oceanographic factors on interannual variability of the winter-spring cohort of neon flying squid abundance in the Northwest Pacific Ocean显示文摘The neon flying squid Ommastrephes bartramii is an economically important species in the Northwest Pacific Ocean. The life cycle of O. bartramii is highly susceptible to climatic and oceanic factors. In this study, we have examined the impacts of climate variability and local biophysical environments on the interannual variability of the abundance of the western winter-spring cohort of O. bartramii over the period of 1995–2011. The results showed that the squid had experienced alternant positive and negative Pacific Decadal Oscillation(PDO) over the past 17 years during which five El Ni?o and eight La Ni?a events occurred. The catch per unit effort(CPUE) was positively correlated with the PDO index(PDOI) at a one-year time lag. An abnormally warm temperature during the La Ni?a years over the positive PDO phase provided favorable oceanographic conditions for the habitats of O.bartramii, whereas a lower temperature on the fishing ground during the El Ni?o years over the negative PDO phase generally corresponded to a low CPUE. The same correlation was also found between CPUE and Chl a concentration anomaly. A possible explanation was proposed that the CPUE was likely related to the climateinduced variability of the large-scale circulation in the Northwest Pacific Ocean: high squid abundance often occurred in a year with a significant northward meander of the Kuroshio Current. The Kuroshio Current advected the warmer and food-rich waters into the fishing ground, and multiple meso-scale eddies arising from current instability enhanced the food retention on the fishing ground, all of which were favorable for the life stage development of the western squid stocks. Our results help better understand the potential process that the climatic and oceanographic factors affect the abundance of the winter-spring cohort of O. bartramii in the Northwest Pacific Ocean. | YU Wei CHEN Xinjun CHEN Changsheng ZHANG Yu | 2017 | Acta Oceanologica Sinica2017，36，10： | 9 |
| 7 | Analysis of genetic diversity and population structure of Chinese yak breeds (Bos grunniens) using microsatellite markers显示文摘Nine Chinese yak breeds (Maiwa, Tianzhu White, Qinghai Plateau, Sibu, Zhongdian, Pali, Tibetan High Mountain, Jiulong, and Xin-jiang) and Gayal were analyzed by means of 16 microsatellite markers to determine the level of genetic variation within populations, genetic relationship between populations, and population structure for each breed. A total of 206 microsatellite alleles were observed. Mean F-statistics (0.056) for 9 yak breeds indicated that 94.4% of the genetic variation was observed within yak breeds and 5.6% of the genetic variation existed amongst breeds. The Neighbor-Joining phylogenetic tree was constructed based on Nei's standard genetic dis-tances and two clusters were obtained. The Gayal separated from the yaks far away and formed one cluster and 9 yak breeds were grouped together. The analysis of population structure for 9 yak breeds and the Gayal showed that they resulted in four clusters; one clus-ter includes yaks from Tibet Autonomous Region and Qinghai Province, one cluster combines Zhongdian, Maiwa, and Tianzhu White, and Jiulong and Xinjiang come into the third cluster. Pali was mainly in the first cluster (90%), Jiulong was mainly in the second cluster (87.1%), Zhongdian was primarily in the third cluster (83%), and the other yak breeds were distributed in two to three clusters. The Gayal was positively left in the fourth cluster (99.3%). | Guixiang Zhang Weisheng Chen Ming Xue Zhigang Wang Hong Chang Xu Han Xinjun Liao Donglei Wang | 2008 | Journal of Genetics and Genomics2008，35，4： | 8 |
| 8 | Response of winter cohort abundance of Japanese common squid Todarodes pacificus to the ENSO events显示文摘The Japanese common squid Todarodes pacificus is an economically important species with one year lifespan,which is significantly influenced by climatic and environmental variability. According to the fishery data of the winter cohort of T. pacificus from 2003 to 2012, as well as environmental data and the Oceanic Ni?o index(ONI,which was defined by the sea surface temperature(SST) anomaly in the Ni?o 3.4 region), variations in the SST,chlorophyll a(Chl a) concentration, suitable spawning area(SSA) and sea surface height anomaly(SSHA) on the spawning ground of T. pacificus were examined under the El Ni?o and La Ni?a conditions. Their influences on squid abundance(defined by catch per unit effort, CPUE) were further assessed. The results showed that seasonal changes were found in SST, Chl a and SSA on the spawning ground of T. pacificus. Correlation analysis suggested that annual CPUE was significantly positively correlated with Chl a and SSA(p<0.05), but had insignificant relationship with SST(p>0.05). Moreover, the El Ni?o and La Ni?a events tended to dominate the changes of SSA and Chl a concentration in the key area between 25°–29°N and 122.5°–130.5°E, driving the variability of squid abundance. However, this influence varied with the intensity of each anomalous climatic event: the weak El Ni?o event occurred, the spawning ground was occupied by waters with enlarged SSA but with extremely low Chl a concentration, leading to low squid recruitment, the CPUE then decreased; the moderate intensity of El Ni?o event resulted in shrunk SSA but with high Chl a concentration on the spawning ground, the squid recruitment and CPUE increased; the moderate intensity of La Ni?a events yielded elevated SSA and high Chl a concentration on the spawning ground, the squid recruitment and CPUE dramatically increased. Our findings suggested that the ENSO events played crucial effects on the incubating and feeding conditions of the winter cohort of T. pacificus during the spawning season and ultimately affected its abundance. | YU Wei ZHANG Yang CHEN Xinjun YI Qian QIAN Weiguo | 2018 | Acta Oceanologica Sinica2018，37，6： | 7 |
| 9 | Seasonal Variation of Biochemical Components in Clam (Saxidomuspurpuratus Sowerby 1852) in Relation to Its Reproductive Cycle and the Environmental Condition of Sanggou Bay, China显示文摘Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycle of clam.According to the histological analysis,the reproductive cycle of S.purpuratus includes two distinctive phases:a total spent and inactive stage from November to January,and a gametogenesis stage,including ripeness and spawning,during the rest of the year.Gametes were generated at a low temperature(2.1℃) in February.Spawning took place once a year from June to October.The massive spawning occurred in August when the highest water temperature and chlorophyll a level could be observed.The key biochemical components(glycogen,protein and lipid) in five tissues(gonad,foot,mantle,siphon and adductor muscle) were analyzed.The glycogen content was high before gametogenesis,and decreased significantly during the gonad development in the gonad,mantle and foot of both females and males,suggesting that glycogen was an important energy source for gonad development.The protein and lipid contents increased in the ovary during the gonad development,demonstrating that they are the major organic components of oocytes.The lipid and protein contents decreased in the testis,implying that they can provide energy and material for spermatogenesis.The results also showed that protein stored in the mantle and foot could support the reproduction after the glycogen was depleted. | BI Jinhong LI Qi ZHANG Xinjun ZHANG Zhixin TIAN Jinling XU Yushan LIU Wenguang | 2016 | Journal of Ocean University of China2016，15，2： | 6 |
| 10 | Design and experimental study of the SPKM165, a five-axis serial-parallel kinematic milling machine显示文摘A five-axis serial-parallel kinematic milling machine, the SPKM 165, is introduced. This machine consists of a three-degree of-freedom parallel module and a two-degree-of-freedom serial table. The SPKM 165 is capable of five-face machining. A discussion of the inverse kinematics of the five-axis control is provided. A dimensional synthesis procedure is presented in terms of motion/force transmissibility. Finite-element analysis was used to evaluate the stiffness of a CAD model before the machine was manufactured. Kinematic calibration was implemented to improve the accuracy of the end effector. The results of a calibration experiment are presented. The stiffness of the developed machine was then measured. Milling experiments were conducted, and the test piece showed that the developed machine has satisfactory performance. | XIE FuGui LIU XinJun ZHANG Hui WANG JinSong | 2011 | Science China(Technological Sciences)2011，54，5： | 6 |
| 11 | A β-glucosidase-producing M-2 strain: Isolation from cow dung and fermentation parameter optimization for flaxseed cake显示文摘Flaxseed cake contains cyanogenic glucosides, which can be metabolized into hydrocyanic acid in an animal's body, leading to asphyxia poisoning in cells. Beta-glucosidase is highly efficient in degrading cyanogenic glucosides. The Cattle may have b-glucosidase-producing strains in the intestinal tract after eating small amounts of flaxseed cake for a long time. This study aimed to isolate of a strain from cow dung that produces b-glucosidase with high activity and can significantly reduce the amount of cyanogenic glucosides. We used cow dung as the microflora source and an esculin agar as the selective medium. After screening with 0.05% esculin and 0.01% ferric citrate, we isolated 5 strains producing high amounts of b-glucosidase. In vitro flaxseed cake fermentation was fermented by these 5 strains, in which the strain M-2 exerted the best effect(P < 0.05). The strain M-2 was identified as Lichtheimia ramosa and used as the fermentation strain to optimize the fermentation parameters by a single factor analysis and orthogonal experimental design. The optimum condition was as follows: inoculum size3%, water content 60%, time 144 h, and temperature 32℃. Under this condition, the removal rate of cyanogenic glucosides reached 89%, and crude protein increment reached 44%. These results provided a theoretical basis for the removal of cyanogenic glucosides in flaxseed and the comprehensive utilization of flaxseed cake. | Chenhui Li Junshu Wei Yaping Jing Baoxia Teng Pingrong Yang Xinjun Chen Haiying Huang Tang Zhao Tuanjie Che Chunjiang Zhang | 2019 | Animal Nutrition2019，，1： | 5 |
| 12 | A comprehensive review of bio-oil, bio-binder and bio-asphalt materials: Their source, composition, preparation and performance显示文摘To promote the application of bio-materials and provide a direction for their further researches,this paper comprehensively summarizes the research progress of biomaterials in recent years.The review results show that bio-oil is a mixture obtained from different biomasses through pyrolysis,alcoholysis,acidolysis,high liquefaction,etc.,and those biomasses mainly include wood fiber type,waste oil type and animal manure type.Biobinder refers to the product of bio-oil processed by distillation,extraction oxidation and polymer modification,and it can be served as a modifier,diluent or substitute material of asphalt;the main chemical components of bio-oil include ethers,esters,aldehydes,ketones,phenols,organic acids,alcohols and sugars.Bio-asphalt is obtained by adding biobinder into the petroleum asphalt for modification or blending,and the shear temperature and shear rate of bio-asphalt derived from wood fiber type and waste oil type are usually higher than that of bio-asphalt derived from swine manure.Compared with petroleum asphalt,bio-asphalt binder usually shows lower high-temperature performance as well as higher low-temperature performance and aging resistance.Also,bio-asphalt mixture generally exhibits lower high-temperature stability,higher low-temperature crack resistance and water stability than petroleum asphalt mixture.Future studies should be conducted combining with the source,composition,preparation,properties and oil production rate of bio-oil.First,how to raise the bio-binder content in bio-asphalt as much as possible while ensuring the sufficient performance becomes the focus of future researches.Second,the micro reaction mechanism between bio-binder and petroleum asphalt should be illustrated in depth.Moreover,developing a complete and unifying technical standard and application specification of bio-asphalt technology is necessary for future researches.Furthermore,determining the optimum bio-binder potentially used as the substitute of petroleum asphalt is also an interesting topic. | Zhengqi Zhang Ying Fang Jianhua Yang Xinjun Li | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，2： | 5 |
| 13 | Colour compound lenses for a portable fluorescence microscope显示文摘In this article,we demonstrated a handheld smartphone fluorescence microscope(HSFM)that integrates dualfunctional polymer lenses with a smartphone.The HSFM consists of a smartphone,a field-portable illumination source,and a dual-functional polymer lens that performs both optical imaging and filtering.Therefore,compared with the existing smartphone fluorescence microscope,the HSFM does not need any additional optical filters.Although fluorescence imaging has traditionally played an indispensable role in biomedical and clinical applications due to its high specificity and sensitivity for detecting cells,proteins,DNAs/RNAs,etc.,the bulky elements of conventional fluorescence microscopes make them inconvenient for use in point-of-care diagnosis.The HSFM demonstrated in this article solves this problem by providing a multifunctional,miniature,small-form-factor fluorescence module.This multifunctional fluorescence module can be seamlessly attached to any smartphone camera for both bright-field and fluorescence imaging at cellular-scale resolutions without the use of additional bulky lenses/filters;in fact,the HSFM achieves magnification and light filtration using a single lens.Cell and tissue observation,cell counting,plasmid transfection evaluation,and superoxide production analysis were performed using this device.Notably,this lens system has the unique capability of functioning with numerous smartphones,irrespective of the smartphone model and the camera technology housed within each device.As such,this HSFM has the potential to pave the way for realtime point-of-care diagnosis and opens up countless possibilities for personalized medicine. | Bo Dai Ziao Jiao Lulu Zheng Hunter Bachman Yongfeng Fu Xinjun Wan Yule Zhang Yu Huang Xiaodian Han Chenglong Zhao Tony Jun Huang Songlin Zhuang Dawei Zhang | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 14 | Layered Fe(Ⅲ) doped TiO_2 thin-film electrodes for the photoelectrocatalytic oxidation of glucose and potassium hydrogen phthalate显示文摘Four types of TiO 2 thin-film electrodes were fabricated from TiO 2 and Fe(III) doped TiO 2 sols using a layer-by-layer dip-coating technique. Electrodes fabricated were TF (pure TiO 2 surface, Fe(III)-TiO 2 bottom layer), FT (Fe(III)-TiO 2 surface, pure TiO 2 bottom layer), TT (both layers pure TiO 2 ) and FF (both layers Fe(III)-TiO 2 ). The photoelectrochemical behavior of these electrodes was characterized using linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS) and steady-state photocurrent measurements in aqueous 0.1 mol L –1 NaNO 3 containing varying concentrations of glucose or potassium hydrogen phthalate (KHP). EIS and LSV results revealed that exciton separation efficiency followed the sequence of TF﹥TT﹥FT > FF. Under a constant potential of +0.3 V, steady-state photocurrent profiles were recorded with varying organic compound concentrations. The TF electrode possessed the greatest photocatalytic capacity for oxidizing glucose and KHP, and possessed a KHP anti-poisoning effect. Enhanced photoelectrochemical performance of the TF electrode was attributed to effective exciton separation because of the layered TF structure. | YU Hua WANG Jing ZHANG ShanQing LI XinJun ZHAO HuiJun | 2011 | Chinese Science Bulletin2011，56，23： | 3 |
| 15 | Mars Orbiter magnetometer of China’s First Mars Mission Tianwen-1显示文摘As one of the seven scientific payloads on board the Tianwen-1 orbiter,the Mars Orbiter Magnetometer(MOMAG)will measure the magnetic fields of and surrounding Mars to study its space environment and the interaction with the solar wind.The instrument consists of two identical triaxial fluxgate magnetometer sensors,mounted on a 3.19 meter-long boom with a seperation of about 90 cm.The dual-magnetometers configuration will help eliminate the magnetic field interference generated by the spacecraft platform and payloads.The sensors are controlled by an electric box mounted inside the orbiter.Each magnetometer measures the ambient vector magnetic field over a wide dynamic range(to 10,000 nT per axis)with a resolution of 1.19 pT.Both magnetometers sample the ambient magnetic field at an intrinsic frequency of 128 Hz,but will operate in a model with alternating frequency between 1 and 32 Hz to meet telemetry allocations. | Kai Liu XinJun Hao YiRen Li TieLong Zhang ZongHao Pan ManMing Chen XiaoWen Hu Xin Li ChengLong Shen YuMing Wang | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 16 | Experimental and numerical investigations on convective heat transfer of dual piezoelectric fans显示文摘An investigation is performed to study the convective heat transfer performance under dual piezoelectric fans. Three main aspects are involved in the current study. Firstly, vibration tests for dual specific piezoelectric fans actuating at the first-mode resonant frequency are conducted to illustrate the influence roles of vibrating phase difference and fan-to-fan pitch on the piezoelectric fan vibration amplitude. Secondly, heat transfer measurements are made to compare the heat transfer among single fan, dual fans in-phase and dual fans out-of-phase. Thirdly, three-dimensional numerical simulations are conducted to reveal the influence mechanism of dual piezoelectric fans on heat transfer. The results show that, the vibrating phase difference of dual fans has nearly no influence on the displacement velocity and amplitude of piezoelectric fan related to single fan once the dimensionless pitch(P/W) is beyond 1.2. The dual piezoelectric fans produce nearly the same peak heat transfer coefficient as that of single fan case.Of particular is that the dual fans operating in-phase produce more favorable heat transfer than the dual fans operating out-of-phase,especially in the gap zone between dual fans. Due to the interaction between dual fans, the streaming flow induced by one vibrating fan suffers the action of sweeping flow of another vibrating fan when they operate out-of-phase. While for the dual fans operating in-phase, the streaming flows induced by vibrating fans merge together to form stronger wall jet flow in the region between two fans. | li xinjun zhang jingzhou tan xiaoming | 2018 | Science China(Technological Sciences)2018，61，2： | 2 |
| 17 | Determination of physical properties for the mixtures of [BMIM]Cl with different organic solvents显示文摘Physical properties including refractive index, density, viscosity and conductivity for binary mixtures of 1-butyl-3-methyl imidazolium chloride([BMIM]Cl) and different organic solvents at 298.15 K have been investigated. Excess molar volumes have been calculated and obtained data has been fitted by the Redlich–Kister equation. The density and refractive index were found to increase with increasing concentration of [BMIM]Cl, however, exceptions do exist as in the case of dimethyl sulfoxide(DMSO)/[BMIM]Cl. For DMSO/[BMIM]Cl, the density decreases with increasing concentration. The addition of different organic solvents was able to disrupt the interactions within mixtures, leading to free mobility of ions. The free mobility of ions has been found to enhance conductivity and decrease viscosity to varying extents in all mixtures studied. It has been observed that solubility parameters,dielectric constants and composition of the solvents used play a vital role in determining the resultant properties.The data obtained will play an important role in understanding the effect of the addition of organic solvents in ILs to enhance their applicability. | Hina Saba Xinjun Zhu Ye Chen Yumei Zhang | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 2 |
| 18 | tRNA-derived small RNAs:Mechanisms and potential roles in cancers显示文摘Transfer RNAs(tRNAs)are essential for protein synthesis.Mature or pre-tRNAs may be cleaved to produce tRNA-derived small RNAs(tsRNAs).tsRNAs,divided into tRNA-derived stress-induced RNA(tiRNAs)and tRNA-derived fragments(tRFs),play versatile roles in a number of fundamental biological processes.tsRNAs not only play regulatory roles in gene silencing,RNA stability,reverse transcription,and translation,but are also closely related to cell proliferation,migration,cell cycle,and apoptosis.Their abnormal expression is associated with the occurrence and development of various human diseases,especially cancer.This paper reviews the classification,biogenesis,and mechanism of action of tsRNAs,and the research progress to date on tsRNAs in cancers.These findings provide new opportunities for diagnostic biomarkers and treatment targets of several types of cancers including gastric cancer,colorectal cancer,hepatocellular carcinomas,pancreatic cancer,breast cancer,prostate cancer,renal cell carcinoma,ovarian cancer,lung cancer,bladder cancer,thyroid cancer,oral cancer,and leukemia. | Yao Wang Qiuyan Weng Jiaxin Ge Xinjun Zhang Junming Guo Guoliang Ye | 2022 | Genes & Diseases2022，9，6： | 2 |
| 19 | Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers显示文摘 | Long Cui Yanru Lou Xinjun Zhang Hui Zhou Hongxia Deng Haojun Song Xiuchong Yu Bingxiu Xiao Weihua Wang Junming Guo | 2011 | Clinical Biochemistry2011，，13： | 2 |
| 20 | Effects of Climate Variability on Habitat Range and Distribution of Chub Mackerel in the East China Sea显示文摘Spatio-temporal distribution of chub mackerel Scomber japonicus is strongly susceptible to climate variability.In this study,a weighting-based habitat suitability index(HSI)model was established to assess the impacts of Pacific Decadal Oscillation(PDO)on habitat range and distribution of S.japonicus in the East China Sea(ECS)using vertical water temperature at depths of 2.5 m,25 m and 50 m.Results showed that the optimal HSI model selected from ten weighting scenarios can yield reliable predictions.Correlation analysis revealed a significant negative relationship between the PDO index and water temperature anomaly at different depths.The water temperatures at three different layers on the fishing ground of S.japonicus tended to be low in the warm PDO phase and high in the cold PDO phase,respectively.The range of suitable habitats and its spatial distribution exhibited large differences between the warm and cold PDO regimes.During a warm PDO phase,vertical water temperature became cool,and the monthly preferred water temperature at each depth for S.japonicus shifted southeastward.Consequently,habitat quality dramatically decreased,and suitable habitat ranges also reduced and moved southeastward.Conversely,in a cool PDO phase,with the warmer vertical water temperature and northwestward shift of the preferred water temperature,the suitable habitats enlarged and migrated in the same direction.Our findings indicate that the PDO produced significant impacts on habitat range and distribution of S.japonicus in the East China Sea. | YU Wei WEN Jian CHEN Xinjun LI Gang LI Yuesong ZHANG Zhong | 2021 | Journal of Ocean University of China2021，20，6： | 2 |
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