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3篇 您的检索式：作者名="Xinkui Fang"

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		题名	作者	年代	出处	被引量
	1	Evaluation of attenuated VSVs with mutated M or/and G proteins as vaccine vectors显示文摘	Xinkui Fang Shikuan Zhang Xiaodong Sun Jinjin Li Tao Sun	2011	Vaccine2011，，7：	1
	2	Evaluation of attenuated VSVs with mutated M or/and G proteins as vaccine vec- tors显示文摘	Fang Xinkui Zhang Shikuan Sun Xiaodong	2012	Vaccine2012，30，7：	1
	3	Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector(VSV_(MT))in golden syrian hamster显示文摘COVID-19 is caused by coronavirus SARS-CoV-2.Current systemic vaccines generally pro-vide limited protection against viral replication and shedding within the airway.Recombinant VSV(rVSV)is an effective vector which inducing potent and comprehensive immunities.Currently,there are two clinical trials investigating COVID-19vaccines based on VSV vectors.These vaccines were developed with spike protein of WA1 which administrated intramuscularly.Although intranasal route is ideal for activating mucosal immunity with VSV vector,safety is of concern.Thus,a highly attenuated rVSV with three amino acids mutations in matrix protein(VSV_(MT))was developed to construct safe mucosal vaccines against multiple SARS-CoV-2 variants of concern.It demonstrated that spike protein mutant lacking 21 amino acids in its cytoplasmic domain could rescue rVSV efficiently.VSV_(MT) indicated improved safeness compared with wild-type VSV as the vector encoding SARS-CoV-2 spike protein.With a single-dosed intranasal inoculation of rVSV_(ΔGMT)-S_(Δ21),potent SARS-CoV-2specific neutraliza-tion antibodies could be stimulated in animals,particularly in term of mucosal and cellular immunity.Strikingly,the chimeric VSV encoding S_(Δ21) of Delta-variant can induce more potent immune responses compared with those encoding S_(Δ21) of Omicron-or WA1-strain.VSV_(MT) is a promising platform to develop a mucosal vaccine for countering COVID-19.	Yong Ke En Zhang Jianming Guo Xiaoxiao Zhang Lei Wang Duo Chen Xinkui Fang Jianwei Zhu Feng Li Tao Sun Baohong Zhang	2023	Acta Pharmaceutica Sinica B2023，13，12：	0

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