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| 1 | 基于FLAC3D软件的魏家峁露天煤矿边坡稳定性破坏模式分析显示文摘为了研究魏家峁露天煤矿边坡稳定性破坏模式,介绍了该露天煤矿的工程地质条件,利用FLAC^3D软件构建工程地质模型,分析了工作帮边坡、内排土场、东一排土场、西南排土场、非工作帮的稳定性破坏模式,得出的结论对该露天煤矿边坡稳定性分析与评价提供了技术基础。 | 张永贵 WANG Guojie LIU Hongyu HAN Yichao | 2019 | 露天采矿技术2019，34，4： | 5 |
| 2 | MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness显示文摘Asthma is one of the most common heterogeneous airway diseases.Worldwide,the prevale nee of doctor-diagnosed asthma in adults was reported to be 4.3%in 2OO3.^(1)In China,the overall prevalence of asthma duri nq 2012 a nd 2015 was 4.2%,represe nting 45.7 million Chinese adults.^(2)Although comprehensive approaches have been used in clinical practice,a considerable number of people are still hospitalized for acute exacerbation of asthma every year.In China,15.5%of asthmatics reported at least one emergency room visit and 7.2%reported at least one hospital admission due to exacerbation of respiratory symptoms.^(2)A need exists to clarify the mechanism of asthma's pathogenesis and to identify more appropriate and precise therapies for asthma. | Yahui Liu Juan Du Xinnan Liu Lingbiao Wang Yichao Han Chunrong Huang Rui Liang Fang Zheng Guochao Shi Bin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 3 | Development of Streptomyces sp. FR-008 as an emerging chassis显示文摘Microbial-derived natural products are important in both the pharmaceutical industry and academic research.As the metabolic potential of original producer especially Streptomyces is often limited by slow growth rate,complicated cultivation profile,and unfeasible genetic manipulation,so exploring a Streptomyces as a super industrial chassis is valuable and urgent.Streptomyces sp.FR-008 is a fast-growing microorganism and can also produce a considerable amount of macrolide candicidin via modular polyketide synthase.In this study,we evaluated Streptomyces sp.FR-008 as a potential industrial-production chassis.First,PacBio sequencing and transcriptome analyses indicated that the Streptomyces sp.FR-008 genome size is 7.26 Mb,which represents one of the smallest of currently sequenced Streptomyces genomes.In addition,we simplified the conjugation procedure without heat-shock and pre-germination treatments but with high conjugation efficiency,suggesting it is inherently capable of accepting heterologous DNA.In addition,a series of promoters selected from literatures was assessed based on GusA activity in Streptomyces sp.FR-008.Compared with the common used promoter ermE*-p,the strength of these promoters comprise a library with a constitutive range of 60e860%,thus providing the useful regulatory elements for future genetic engineering purpose.In order to minimum the genome,we also target deleted three endogenous polyketide synthase(PKS)gene clusters to generate a mutant LQ3.LQ3 is thus an“updated”version of Streptomyces sp.FR-008,producing fewer secondary metabolites profiles than Streptomyces sp.FR-008.We believe this work could facilitate further development of Streptomyces sp.FR-008 for use in biotechnological applications. | Qian Liu Liping Xiao Yuanjie Zhou Kunhua Deng Gaoyi Tan Yichao Han Xinhua Liu Zixin Deng Tiangang Liu | 2016 | Synthetic and Systems Biotechnology2016，1，3： | 2 |
| 4 | Reduc- ing Operational Costs in Cloud social TV: An Op- portunity for Cloud Cloning 显示文摘 | JIN Yichao WEN Yonggang HU Han | 2014 | IEEE Transactions on Multimedia2014，16，6： | 1 |
| 5 | Study on Winter Operation Process of the Surface Flow Constructed Wetland in Tianjin Area显示文摘[Objective] The research aimed to study winter operation process of the surface flow constructed wetland in Tianjin area.[Method] In view of climate characteristics in Tianjin,by the way of running under the ice,winter operation experiment of the surface flow constructed wetland in Tianjin was conducted,with the expectation to get some useful process parameters to run such systems in North China in winter.[Result] Although purification effect of the sewage by surface flow constructed wetland in winter was worse than that in other seasons(average reduction of about 20%),surface flow constructed wetland running under the ice was feasible in Tianjin area.When surface flow constructed wetland in North China ran under ice in winter,it was suggested that the outlet must be located in a low position to prevent to be completely frozen,and running water depth should not be less than 50-60 cm.The hydraulic load could be raised on the basis of reflux,and hydraulic retention time should maintain less than 4 d to keep water-soil interface not freezing.Inlet water depth should be increased as much as possible to improve temperature in the system.[Conclusion] The research could provide reference for promotion and application of the surface flow constructed wetland in North China. | Xiaodan Qin Yichao Sun Li Li Xiaolong Shao Dan Yu Qiongqiong Liu Honglei Liu Lin Han | 2013 | Meteorological and Environmental Research2013，4，7： | 0 |
| 6 | The diverse role of RNA methylation in esophageal cancer显示文摘Esophageal cancer is one of the major life-threatening diseases in the world.RNA methylation is the most common post-transcriptional modification and a wide-ranging regulatory system controlling gene expression.Numerous studies have revealed that dysregulation of RNA methylation is critical for cancer development and progression.However,the diverse role of RNA methylation and its regulators in esophageal cancer remains to be elucidated and summarized.In this review,we focus on the regulation of major RNA methylation,including m6A,m5C,and m7G,as well as the expression patterns and clinical implications of its regulators in esophageal cancer.We systematically summarize how these RNA modifications affect the'life cycle'of target RNAs,including mRNA,microRNA,long non-coding RNA,and tRNA.The downstream signaling pathways associated with RNA methylation during the development and treatment of esophageal cancer are also discussed in detail.Further studies on how these modifications function together in the microenvironment of esophageal cancer will draw a clearer picture of the clinical application of novel and specific therapeutic strategies. | Wangyang Meng Yichao Han Bin Li Hecheng Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 0 |
| 7 | Inhibition of lysine-specific demethylase 1(LSD1)prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma显示文摘Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear. | Pengxing He Linna Du Pan Hao Han Yang Yufei Ren Huiqin Kang Yanli Ding Wen Zhao Yichao Xu Hongmin Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 8 | Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors显示文摘Pituitary neuroendocrine tumor(PitNET)is one of the most common intracranial tumors.Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery,the causative molecular mechanisms are far from being fully defined.Therefore,more studies are needed to improve the current clinicopathological classification system,and advanced treatment strategies such as targeted therapy and immunotherapy are yet to be explored.Here,we performed the largest integrative genomics,transcriptomics,proteomics,and phosphoproteomics analysis reported to date for a cohort of 200 PitNET patients.Genomics data indicate that GNAS copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage.Proteomics-based classification of PitNETs identified 7 clusters,among which,tumors overexpressing epithelial-mesenchymal transition(EMT)markers clustered into a more invasive subgroup.Further analysis identified potential therapeutic targets,including CDK6,TWIST1,EGFR,and VEGFR2,for different clusters.Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion,and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration.These identified molecular markers and alternations in various clusters/subtypes were further confirmed in an independent cohort of 750 PitNET patients.This proteogenomic analysis across traditional histological boundaries improves our current understanding of PitNET pathophysiology and suggests novel therapeutic targets and strategies. | Fan Zhang Qilin Zhang Jiajun Zhu Boyuan Yao Chi Ma Nidan Qiao Shiman He Zhao Ye Yunzhi Wang Rui Han Jinwen Feng Yongfei Wang Zhaoyu Qin Zengyi Ma Kai Li Yichao Zhang Sha Tian Zhengyuan Chen Subei Tan Yue Wu Peng Ran Ye Wang Chen Ding Yao Zhao | 2022 | Cell Research2022，32，12： | 0 |
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