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| 1 | Comparative study of the net exchange of CO_(2) in 3 types of vegetation ecosystems on the Qinghai-Tibetan Plateau显示文摘Using the eddy covariance method,from 1 July2003 to 30 June 2004, we conducted the observation andanalysis of ecosystem CO2 flux in 3 types of alpine meadowvegetation (Kobresia humilis, Potentilla fruticosa shrub andKobresia tibetica swamp meadows) on the Qinghai-TibetanPlateau. The results show that the Kobresia humilis meadow,the shrub meadow and the swamp meadow’s highest CO2uptake rates are 16.78, 10.42 and 16.57 μmol·m?2·s?1respectively, while their highest CO2 release rates are 8.22,7.73 and 18.67 μmol·m?2·s?1 respectively. The Kobresiahumilis meadow and shrub meadow’s annual atmosphericuptakes are 282 g CO2/m2 and 53 g CO2/m2, respectively,while swamp meadow’s annual atmospheric release is 478 gCO2/m2. This proves that the Kobresia humilis meadow andthe shrub meadow on the Qinghai-Tibetan Plateau haverelatively low potential for CO2 uptake and release comparedto C4 grasslands, a number of lowland grasslands, andforests. Moreover, swamp meadow has relatively high releasepotential. This, in turn, reveals clear differences in carbonsource/sink between different types of vegetation in theQinghai-Tibetan Plateau alpine meadow ecosystem. Thesedifferences are mainly brought by differences in thevegetations’ photosynthetic capacity and soil respiration. | ZHAO Liang LI Yingnian ZHAO Xinquan XU Shixiao TANG Yanhong YU Guirui GU Song DU Mingyuan WANG Qinxue | 2005 | Chinese Science Bulletin2005，50，16： | 34 |
| 2 | STABILITY OF ALPINE MEADOW ECOSYSTEM ON THE QINGHAI-TIBETAN PLATEAU显示文摘The meadow ecosystem on the Qing- hai-Tibetan Plateau is considered to be sensitive to climate change. An understanding of the alpine meadow ecosystem is therefore important for pre- dicting the response of ecosystems to climate change. In this study, we use the coefficients of variation (Cv) and stability (E) obtained from the Haibei Alpine Meadow Ecosystem Research Station to characterize the ecosystem stability. The results suggest that the net primary production of the alpine meadow eco- system was more stable (Cv = 13.18%) than annual precipitation (Cv = 16.55%) and annual mean air temperature (Cv = 28.82%). The net primary produc- tion was insensitive to either the precipitation (E = 0.0782) or air temperature (E = 0.1113). In summary, the alpine meadow ecosystem on the Qinghai- Tibetan Plateau is much stable. Comparison of alpine meadow ecosystem stability with other five natural grassland ecosystems in Israel and southern African indicates that the alpine meadow ecosystem on the Qinghai-Tibetan Plateau is the most stable ecosys- tem. The alpine meadow ecosystem with relatively simple structure has high stability, which indicates that community stability is not only correlated with biodiversity and community complicity but also with environmental stability. An average oscillation cycles of 3―4 years existed in annual precipitation, annual mean air temperature, net primary production and the population size of consumers at the Haibei natural ecosystem. The high stability of the alpine meadow ecosystem may be resulting also from the adaptation of the ecosystem to the alpine environment. | ZHOU Huakun ZHOU Li ZHAO Xinquan LIU Wei LI Yingnian GU Song ZHOU Xinmin | 2006 | Chinese Science Bulletin2006，51，3： | 21 |
| 3 | Characterizing CO_2 fluxes for growing and non-growing seasons in a shrub ecosystem on the Qinghai-Tibet Plateau显示文摘To assess carbon budget for shrub ecosystems on the Qinghai-Tibet Plateau, CO2flux was measured with an open-path eddy covariance system for an alpine shrub ecosystem during growing and non-growing seasons. CO2 flux dynamics was distinct between the two seasons. During the growing season from May to September, the ecosystem exhibited net CO2uptake from 08:00 to 19:00 (Beijing Standard Time), but net CO2 emission from 19:00 to 08:00.Maximum CO2 uptake appeared around 12:00 with values of 0.71, 1.19, 1.46 and 0.67 g CO2m-2 h-1 for June, July, August and September, respectively. Diurnal fluctuation of CO2 flux showed higher correlation with photosynthetic photon flux density than temperature. The maximum net CO2 influx occurred in August with a value of 247 g CO2 m-2. The total CO2 uptake by the ecosystem was up to 583 g CO2 m-2 for the growing season. During the non-growing season from January to April and from October to December, CO2 flux showed small fluctuation with the largest net CO2 efflux of 0.30 g CO2 m-2 h-1 in April. The diurnal CO2 flux was close to zero during most time of the day, but showed a small net CO2 efflux from 11:00 to 18:00. Diurnal CO2 flux, is significantly correlated to diurnal temperature in the non-growing season. The maximum monthly net CO2 efflux appeared in April, with a value of 105 g CO2 m-2. The total net CO2 efflux for the whole non-growing season was 356 g CO2 m-2. | XU Shixiao, ZHAO Xinquan, FU Yuling, ZHAO Liang, LI Yingnian, CAO Guangmin, GU Song, WANG Qinxue & DU Mingyuan Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100136, China National Institute for Environmental Studies, Tsukuba 305-8569, Japan National Institute for Agro-Environmental Science, Tsukuba 305-8604, Japan | 2005 | Science China Earth Sciences2005，48，z1： | 12 |
| 4 | Long-term anodal block stimulation at sacral anterior roots promoted recovery of neurogenic bladder function in a rabbit model of complete spinal cord injury显示文摘A complete spinal cord injury model was established in experimental rabbits using the spinal cord clip compression method.Urodynamic examination was performed 2 weeks later to determine neurogenic bladder status.The rabbits were treated with anodal block stimulation at sacral anterior roots for 4 weeks.Electrical stimulation of sacral anterior roots improved urodynamic parameters of neurogenic bladder in rabbit models of complete spinal cord injury,effectively promoted urinary function,and relieved urinary retention.Immunohistochemistry results showed that a balance was achieved among expression of muscarinic receptor subunits M2,M3,ATP-gated ion channel P2X3 receptors,and β2-adrenergic receptor,and nerve growth factor expression decreased.These results suggested that long-term sacral anterior root stimulation of anodal block could be used to treat neurogenic bladder in a rabbit model of complete spinal cord injury. | Xiaoran Wang Qi Gao Xiaoyu Yang Weihua Wang Xinquan Gu Guifeng Liu Peng Yan Ge Gao Xin Yu Yongjie Wang Jihu Lian Chaoling Shi Yao Wang Li Fan | 2012 | Neural Regeneration Research2012，7，5： | 6 |
| 5 | Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration显示文摘The restoration of bone defects caused by osteoporosis remains a challenge for surgeons.Strontium ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium(Sr).In this study,we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass(MBG)and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat model.The results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable biocompatibility.Moreover,with the incorporation of Sr,osteogenic and angiogenic capacities were upregulated in vitro.The in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel formation.Furthermore,bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway,thus playing an anti-osteoporosis role while promoting osteogenesis.This study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis. | Qianju Wu Longwei Hu Ran Yan Junfeng Shi Hao Gu Yuwei Deng Ruixue Jiang Jin Wen Xinquan Jiang | 2022 | Bone Research2022，10，4： | 1 |
| 6 | Radiation partitioning and its relation to environmental factors above a meadow ecosystem on the Qinghai Tibetan Plateau显示文摘 | Zhang Xiaocun Gu Song Zhao Xinquan | | 0，，： | 1 |
| 7 | Diumal and seasonal variations of UV radiation on the northern edge of the Qinghai-Tibetan Plateau显示文摘 | Cui Xiaoyong Gu Song Zhao Xinquan | 2008 | Agricultural and Forest Meteorology2008，148，1： | 1 |
| 8 | High positive correlation between soil temperature and NDVI from 1982 to 2006 in alpine meadow of the Three-River Source Region on the Qinghai-Tibetan Plateau显示文摘 | Weixin Xu Song Gu XinQuan Zhao Jianshe Xiao Yanhong Tang Jingyun Fang Juan Zhang Sha Jiang | 2011 | International Journal of Applied Earth Observations and Geoinformation2011，，4： | 1 |
| 9 | Correlation between X-ray cross-complementing group 1 polymorphisms and the onset risk of glioma A meta-analysis显示文摘OBJECTIVE:To evaluate the association of X-ray cross-complementing group 1(XRCC1)Arg399Gln,Arg194Trp and Arg280His polymorphisms with the risk of glioma.DATA SOURCES:A systematic literature search of papers published from January 2000 to August2012 in PubMed,Embase,China National Knowledge Infrastructure database,and Wanfang database was performed.The key words used were'glioma','polymorphism',and'XRCC1 or X-ray repair cross-complementing group 1'.References cited in the retrieved articles were screened manually to identify additional eligible studies.STUDY SELECTION:Studies were identified according to the following inclusion criteria:case-control design was based on unrelated individuals;and genotype frequency was available to estimate an odds ratio(OR)and 95%confidence interval(CI).Meta-analysis was performed for the selected studies after strict screening.Dominant and recessive genetic models were used and the relationship between homozygous mutant genotype frequencies and mutant gene frequency and glioma incidence was investigated.We chose the fixed or random effect model according to the heterogeneity to calculate OR and 95%CI,and sensitivity analyses were conducted.Publication bias was examined using the inverted funnel plot and the Egger’s test using Stata 12.0 software.MAIN OUTCOME MEASURES:Association of XRCC1 Arg399Gln,Arg194Trp,and Arg280His polymorphisms with the risk of glioma,and subgroup analyses were performed according to different ethnicities of the subjects.RESULTS:Twelve articles were included in the meta-analysis.Eleven of the articles were concerned with the Arg399Gln polymorphism and glioma onset risk.Significantly increased glioma risks were found only in the dominant model(Gln/Gln+Gln/Arg versus Arg/Arg:OR=1.26,95%CI=1.03-1.54,P=0.02).In the subgroup analysis by ethnicity,significantly increased risk was found in Asian subjects in the recessive(OR=1.46,95%CI=1.04-2.45,P=0.03)and dominant models(OR=1.40,95%CI=1.10-1.78,P=0.007),and homozygote contrast(OR=1.69,95%CI=1.17-2.45,P=0.005),but not in Caucasian subjects.For association of the Arg194Trp(eight studies)and Arg280His(four studies)polymorphisms with glioma risk,the meta-analysis did not reveal a significant effect in the allele contrast,the recessive genetic model,the dominant genetic model,or homozygote contrast.CONCLUSION:The XRCC1 Arg399Gln polymorphism may be a biomarker of glioma susceptibility,especially in Asian populations.The Arg194Trp and Arg280His polymorphisms were not associated with overall glioma risk. | Xinquan Gu Hongyan Sun Liping Chang Ran Sun Hongfeng Yang Xuewen Zhang Xianling Cong | 2013 | Neural Regeneration Research2013，8，26： | 1 |
| 10 | Therapeutic safety evaluation of sodium glycididazole combined with ^(131)I radiotherapy for differentiated thyroid carcinoma显示文摘To evaluate safety and therapeutic efficacy of sodium glycididazole (CMNa) combined with 131I radiotherapy for differentiated thyroid carcinoma (DTC),the 60 patients of DTC therapeutic protocols were selected and divided into 3 groups of the DTC 4.44 GBq 131I,DTC 3.70 GBq 131I,and combination of DTC 3.70 GBq 131I with CMNa,and the 20 patients of Graves' Disease were selected as the control group.Peripheral blood was sampled at 131I pre-treatment of 1 day,and 131I post-treatment of 7,91,and 182 days,thus analyzing lymphocyte micronucleus scores and karyotyping profiles.Compared with the control group,the lymphocyte micronucleus and chromosome mutation rates in 131I treated DTC increased after post-treatment of 7 days,recovered after post-treatment of 91 days,and did not bounce after post-treatment of 182 days.The micronucleus and chromosome mutation rates in the combination of DTC 3.70 GBq 131I with CMNa showed less significant variation than other treated DTC groups.Our results demonstrate that micronucleus assay and karyotyping analysis are favorable to evaluate 131I radiotherapy for DTC.The combination of the CMNa with 131I radiotherapy was safe for DTC patients without affecting the long-term therapeutic outcomes. | SUN Wenwei GU Xinquan GAO Shi BAI Lin CUI Qu MA Qingjie Wang Qing Zhao Guoqing | 2011 | Nuclear Science and Techniques2011，22，4： | 0 |
| 11 | Biotinylated dextran amine is an ideal anterograde tracer for the corticospinal tract in a goat model of ischemic corticospinal tract injury显示文摘Existing visualized tracer studies of the corticospinal tract have been focused on rodents, which have markedly different spinal cord structures compared with humans. In this study, the segmental artery feeding the spinal cord was embolized with digital subtraction angiography to establish a goat model of ischemic spinal cord injury. Biotinylated dextran amine was injected into the motor function areas of the cortex in goats with ischemic spinal cord injury. The corticospinal tract originates from the cerebral cortex motor function area, and travels towards the lateral funiculus at the contralateral spinal dorsal horn after decussation at the pyramid. The number of corticospinal tract positive fibers was found to be gradually reduced. These findings indicate that digital subtraction angiography can be applied to a goat model of ischemic spinal cord injury. Biotinylated dextran amine visualizes the course of the goat corticospinal tract in the spinal cord, which is similar to the human spinal cord. Biotinylated dextran amine is an ideal tracer for the corticospinal tract. | Xiaoyu Yang Yufei Gao Zhigang Qin Xia Cao Xinquan Gu | 2011 | Neural Regeneration Research2011，6，25： | 0 |
| 12 | Relations between Carbon Dioxide Fluxes and Environmental Factors of Kobresia humilis Meadows and Potentilla fruticosa Meadows显示文摘Carbon dioxide fluxes of Kobresia humilis and Potentilla fruticosa shrub meadows,two typical ecosystems in the Qinghai-Tibet Plateau,were measured by eddy covari-ance technology and the data collected in August 2003 were employed to analyze the relations between carbon dioxide fluxes and environmental factors of the ecosystems.August is the time when the two ecosystems reach their peak leaf area indexes and stay stable,and also the period when the net carbon absorptions of Kobresia humilis and Potentilla fruticosa shrub meadows reach 56.2 g C·m^(-2)and 32.6 g C·m^(-2),with their highest daily carbon dioxide absorp-tions standing at 12.7μmol·m^(-2)·s^(-1)and 9.3μmol·m^(-2)·s^(-1),and their highest carbon discharges at 5.1μmol·m^(-2)·s^(-1)and 5.7μmol·m^(-2)·s^(-1),respectively.At the same photosynthetic photo flux densities(PPFD),the carbon dioxide-uptake rate of the Kobresia humilis meadow is higher than that of the Potentilla fruticosa shrub meadow;where the PPFD are higher than 1,200μmol·m^(-2)·s^(-1).The carbon dioxide uptake rates of the two ecosystems declined as air temperature increased,but the carbon dioxide uptake rate of the Kobresia humilis meadow decreased more quickly(-0.086)than that of the Potentilla fruticosa shrub meadow(-0.016).Soil moistures exert influence on the soil respirations and this varies with the vegetation type.The daily carbon dioxide absorptions of the ecosystems increase with increased diurnal temperature differences and higher diurnal temperature differences result in higher carbon dioxide exchanges.There exists a negative correlation between the vegetation albedos and the carbon dioxide fluxes. | ZHAO Liang XU Shixiao LI Yingnian TANG Yanhong ZHAO Xinquan GU Song DU Mingyuan YU Guirui | 2007 | Frontiers in Biology2007，2，3： | 0 |
| 13 | Hippocampal mitochondrial cytochrome C oxidase activity and gene expression in a rat model of chronic cerebral ischemia显示文摘The present study established a rat model of chronic cerebral ischemia using bilateral common carotid artery permanent ligation to analyze cytochrome C oxidase activity and mRNA expression in hippocampal mitochondria. Results showed significantly decreased cytochrome C oxidase activity and cytochrome C oxidase II mRNA expression with prolonged ischemia time. Further analysis re-vealed five mitochondrial cytochrome C oxidase II gene mutations, two newly generated mutations, and four absent mutational sites at 1 month after cerebral ischemia, as well as three mitochondrial cytochrome C oxidase III gene mutations, including two newly generating mutations, and one dis-appeared mutational site at 1 month after cerebral ischemia. Results demonstrated that decreased cytochrome C oxidase gene expression and mutations, as well as decreased cytochrome C oxidase activity, resulting in energy dysmetabolism, which has been shown to be involved in the pathological process of ischemic brain injury. | Qing Zhao Yingli Zhang Mingming Zhao Yu Wang Ming Ma Xinquan Gu Xia Cao | 2011 | Neural Regeneration Research2011，6，32： | 0 |
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