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| 1 | Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates显示文摘Huntington's disease(HD) is caused by abnormal CAG repeat expansion in the 5′-end of the Huntingtin(HTT) gene.In addition to the canonical C-terminal full-length huntingtin(htt) nuclear export signal,a cytoplasmic localization-related domain(CLRD) in the N-terminus of htt has recently been reported.Here,we analyzed this domain by introducing deletion and substitution mutations in a truncated N-terminal htt protein and subsequently monitored htt expression,aggregation and subcellular localization by immunocytochemistry and Western blot analysis.We demonstrated that Htt4-17 was the essential sequence for htt cytoplasmic localization.We also found that the subcellular distribution of htt was altered when Htt1-17 was mutated to contain amino acids of different charges,suggesting a structural requirement of Htt1-17 for the cytoplasmic localization of htt. Deletion of the first three amino acids did not affect its association with mitochondria.We observed that defective cytoplasmic localization resulted in a reduction of total htt aggregates and increased nuclear aggregates,indicating that the subcellular distribution of the protein might influence the aggregation process.These studies provide new insight into the molecular mechanism of htt aggregation in HD. | YAN YaPing PENG DanTao TIAN Jun CHI JingWei TAN JieQiong YIN XinZhen PU JiaLi XIA Kun ZHANG BaoRong | 2011 | Science China(Life Sciences)2011，54，4： | 4 |
| 2 | Photocatalytic H2 Evolution on TiO2 Assembled with Ti3C2 MXene and Metallic 1T-WS2 as Co-catalysts显示文摘The biggest challenging issue in photocatalysis is efficient separation of the photoinduced carriers and the aggregation of photoexcited electrons on photocatalyst’s surface.In this paper,we report that double metallic co-catalysts Ti3C2 MXene and metallic octahedral(1T)phase tungsten disulfide(WS2)act pathways transferring photoexcited electrons in assisting the photocatalytic H2 evolution.TiO2 nanosheets were in situ grown on highly conductive Ti3C2 MXenes and 1T-WS2 nanoparticles were then uniformly distributed on TiO2@Ti3C2 composite.Thus,a distinctive 1T-WS2@TiO2@Ti3C2 composite with double metallic co-catalysts was achieved,and the content of 1T phase reaches 73%.The photocatalytic H2 evolution performance of 1T-WS2@TiO2@Ti3C2 composite with an optimized 15 wt%WS2 ratio is nearly 50 times higher than that of TiO2 nanosheets because of conductive Ti3C2 MXene and 1T-WS2 resulting in the increase of electron transfer efficiency.Besides,the 1T-WS2 on the surface of TiO2@Ti3C2 composite enhances the Brunauer–Emmett–Teller surface area and boosts the density of active site. | Yujie Li Lei Ding Shujun Yin Zhangqian Liang Yanjun Xue Xinzhen Wang Hongzhi Cui Jian Tian | 2020 | Nano-Micro Letters2020，12，1： | 4 |
| 3 | Electromotive Force Calculation of Fifteen-phase Induction Motors With Non-sinusoidal Supply显示文摘非正弦供电十五相感应电机基波磁动势正幅值与3次谐波磁动势负幅值不在同一位置时的叠加磁动势波形称为常规磁动势波形,此种情况下感应电动势的计算是该种电机电磁性能分析与优化设计的前提。与正弦磁动势或理想叠加磁动势不同,常规磁动势下电机的感应电动势与激磁电流相位因磁路饱和不再相差/2,为此提出把感应电动势作为激磁电流流控电压源的处理方法。鉴于电机每半个极下气隙磁密波形不再相同的情况,提出基于电机1个极距区域的拓展分布磁路法计算气隙磁密,进而求出基波感应电动势与3次谐波感应电动势。非正弦供电十五相感应电机样机的感应电动势计算值与实测值相互吻合,说明了拓展分布磁路法计算感应电动势有效且具有较高的准确度。 | WANG Dong WU Xinzhen GUO Yunjun CHEN Junquan | 2013 | 中国电机工程学报2013，33，9： | 3 |
| 4 | Narrow distribution of cyanophage psbA genes observed in two paddy waters of Northeast China by an incubation experiment显示文摘Dear Editor,Cyanophages are viruses that infect cyanobacteria.They play an important role in shaping the genetic and functional diversity of themselves and their hosts through genetic exchange and shuffling(Lindell et al.,2005;Singh et al.,2012).The psb A gene of cyanophages is a'hostderived'gene,and its encoded D1 protein is capable | Xinzhen Wang Ruiyong Jing Junjie Liu Zhenhua Yu Jian Jin Xiaobing Liu Xiaojuan Wang Guanghua Wang | 2016 | Virologica Sinica2016，31，2： | 3 |
| 5 | Protective effect of sodium butyrate on the cell culture model of Huntington disease显示文摘这研究试图开发亨廷顿疾病的一个房间文化模型并且在这个房间文化模型上观察钠丁酸盐的效果。从有亨廷顿疾病的一个健康成年人和一个病人的 genomic DNA 的一种野类型和变异的 IT15 基因的 Exon 1 被放大并且克隆进真核细胞的表示向量 pEGFP-C1。人的 neuroblastoma SH-SY5Y 房间是短暂地有在钠丁酸盐(0.1,0.2,0.5,1.0 mmol L ) 的缺席和存在的这些 recombinant 原生质标志的 transfected。MTT 试金被用来测量房间生存能力。结果显示变异的狩猎的锡的 N 终端碎片形成了原子的仙子和 intranuclear 总数并且引起了一个减少 SH-SY5Y 房间生存能力。钠丁酸盐禁止了变异的狩猎的锡的 N 终端碎片引起的 SH-SY5Y 房间生存能力的减少。这建议钠丁酸盐在亨廷顿疾病的这个房间文化模型上有保护的效果。 | Zhang Baorong Tian Jun Yin Xinzhen Luo Wei Xia Kun | 2007 | Progress in Natural Science:Materials International2007，17，7： | 2 |
| 6 | Spectroscopic studies of interfacial structures of CeO 2 –TiO 2 mixed oxides显示文摘 | Jun Fang Xinzhen Bi Dejun Si Zhiquan Jiang Weixin Huang | 2007 | Applied Surface Science2007，，22： | 2 |
| 7 | Inorganic/organicmesoporous silica as a novel fiber coating of solid-phasemicroextraction显示文摘 | Hou Jingguo Ma Qian Du Xinzhen | 2004 | Talanta2004，62，24： | 1 |
| 8 | Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study显示文摘 | Chunping Wang Yinying Lu Yan Chen Yongyi Feng Linjing An Xinzhen Wang Shuhui Su Wenlin Bai Lin Zhou Yongping Yang Dongping Xu | 2009 | Clinical & Experimental Metastasis2009，，7： | 1 |
| 9 | Fending Off Hot Money显示文摘Amid uncertainties about the amount of hot money,the government strives to curb the harmful capital The benchmark Shanghai Composite Index was plagued by dips, climbs and dives as the stock market slumped from 3,186 to 2,838 | LAN XINZHEN | 2010 | Beijing Review2010，53，50： | 1 |
| 10 | Renewable production of a- crylic acid and its derivative:New insights into the aldol condensa- tion route over the vanadium phosphorus oxides 显示文摘 | Feng Xinzhen Sun Bo Yao Yae | 2014 | Journal of Ca- talysis2014，314，： | 1 |
| 11 | Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study显示文摘 | Chunping Wang Yinying Lu Yan Chen Yongyi Feng Linjing An Xinzhen Wang Shuhui Su Wenlin Bai Lin Zhou Yongping Yang Dongping Xu | 2009 | Clinical & Experimental Metastasis2009，，7： | 1 |
| 12 | That Internet of Things显示文摘China begins accelerating development of the Internet of Things, but has many technological obstacles to | LAN XINZHEN | 2011 | Beijing Review2011，54，29： | 1 |
| 13 | Come to China, find investment 显示文摘 | | 2003 | Beijing Review2003，，36： | 1 |
| 14 | Synthesis of nestlike ZnO hierarchically porous structures and analysis of their gas sensing properties显示文摘 | Wang Xinzhen Liu Wei Liu Jiurong | 2012 | ACS Appl Mater Interf2012，4，2： | 1 |
| 15 | Spectroscopic studies of interfacial structures of Ce02-TiO2mixed oxides 显示文摘 | Jun Fang Xinzhen Bi Dejun Si Zhiquan Jiang Weixin Huang | 2007 | Applied Surface Science2007，253，22： | 1 |
| 16 | Internet Plus Helps With Poverty Alleviation显示文摘The Chinese Government has been pushing forward its Internet Plus strategy in the form of promoting the combination of mobile Internet,cloud computing,big data and Internet of things together with modern manufacturing.It has also combined Internet Plus with poverty alleviation work.People living in poverty are connected by means of the Internet and big data to people willing to help them.In this way,those who have something to | Lan Xinzhen | 2017 | Beijing Review2017，60，32： | 1 |
| 17 | WHAT’S THE REAL INCOME GAP?显示文摘Gini coefficient figures arouse calls for reforming the income distribution system ’A journalist called me asking for comment on the macroeconomic figures releasedtoday. Am I crazy to say anything based on false facts? | Lan Xinzhen | 2013 | Beijing Review2013，56，6： | 1 |
| 18 | N-Methyl-aspartate receptor and L-type voltage-gated Ca^2+ channel activation mediate profilie - rich tyrosilie kirlase 2 phosphorylation during cerebral ischemia in rats 显示文摘 | Jun GHO Fanjie Meng Xinzhen Fu | 2004 | Neuroscience Letters2004，355，3： | 1 |
| 19 | Stud- ies on gas holdup in a bubble column operated at elevated temperatures 显示文摘 | ZOU Renjun JIANG Xinzhen LI Baozhang | 1988 | Industrial & Engineering Chemistry Research1988，27，10： | 1 |
| 20 | A practical method for computing the largest M-eigenvalue of a fourth-order partially symmetric tensor显示文摘 | Wang Yiju Qi Liqun Zhang Xinzhen | 2009 | Numerical Linear Algebra Appl2009，16，： | 1 |
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