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| 1 | Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation显示文摘Trans-catheter arterial embolization(TAE)plays an important role in treating various diseases.The available embolic agents lack X-ray visibility and do not prevent the reflux phenomenon,thus hindering their application for TAE therapy.Herein,we aim to develop a multifunctional embolic agent that combines the X-ray radiopacity with local procoagulant activity.The barium sulfate nanoparticles(BaSO4 NPs)were synthesized and loaded into the polyvinyl alcohol/chitosan(PVA/CS)to prepare the radiopaque BaSO4/PVA/CS microspheres(MS).Thereafter,thrombin was immobilized onto the BaSO4/PVA/CS MS to obtain the thrombin@BaSO4/PVA/CS MS.The prepared BaSO4/PVA/CS MS were highly spherical with diameters ranging from 100 to 300μm.In vitro CT imaging showed increased X-ray visibility of BaSO4/PVA/CS MS with the increased content of BaSO4 NPs in the PVA/CS MS.The biocompatibility assessments demonstrated that the MS were non-cytotoxic and possessed permissible hemolysis rate.The biofunctionalized thrombin@BaSO4/PVA/CS MS showed improved hemostatic capacity and facilitated hemostasis in vitro.Additionally,in vivo study performed on a rabbit ear embolization model confirmed the excellent X-ray radiopaque stability of the BaSO4/PVA/CS MS.Moreover,both the BaSO4/PVA/CS and thrombin@BaSO4/PVA/CS MS achieved superior embolization effects with progressive ischemic necrosis on the ear tissue and induced prominent ultrastructural changes in the endothelial cells.The findings of this study suggest that the developed MS could act as a radiopaque and hemostatic embolic agent to improve the embolization efficiency. | Xiaohong Li Xiongfa Ji Kun Chen Muhammad Wajid Ullah Basen Li Jiameng Cao Lin Xiao Jun Xiao Guang Yang | 2021 | Bioactive Materials2021，6，7： | 6 |
| 2 | Room temperature polymerization of alkyl isocyanates catalyzed by rare earth Schiff base complexes显示文摘The polymerization of alkyl isocyanates catalyzed by rare earth chloride salen complexes/triisobutyl aluminum(Ln(H2salen)2Cl3·2C2H7OH/Al(i-Bu)3) at room temperature was investigated.The influences of ligand structure,catalyst composition,polymerization temperature,polymerization time,the concentration of catalyst and monomer,and the polymerization solvent on the polymerization of isocyanates were studied.It was found that under the polymerization conditions,examined La(H2salenA)2Cl3·2C2-H7OH/Al(i-Bu)3(H2salenA= N,N'-disalicylideneethylene diamine) is a fairly high efficient catalyst for the polymerization of n-hexyl isocyanate(n-HexNCO) to prepare high molecular weight poly(n-hexyl isocyanate)(PHNCO) with narrower molecular weight distribution at room temperature.PHNCO could be prepared with yield of 74.0%,number-average molecular weight(Mn) of 40.20×104 and MWD of 1.79 under the following optimum conditions:[Al]/[La]=30(molar ratio),[n-HexNCO]/[La]=100(molar ratio),[n-HexNCO]=3.43 mol/L polymerization at 20℃ for 12 h in toluene.In the same polymerization conditions,poly(n-octyl isocyanate)(PONCO) with yield of 67.3%,and poly(n-butyl isocyanate)(PBNCO) with yield of 45.5%,could be prepared respectively.The kinetics of the polymerization of n-HexNCO was also investigated and found to be first-order with respect to both monomer and catalyst concentrations. | XiongFa Yang XuFeng Ni ZhiQuan Shen | 2009 | Science China Chemistry2009，52，11： | 2 |
| 3 | Effect of structure and additives on thermal stability of silicone fluid显示文摘 | Wu Chuan Jin Jing Yang Xiongfa | 2010 | Journal of Applied Polymer Science2010，117，： | 1 |
| 4 | Measurement and correla- tion of the vapor pressure of methylethoxydichlorosilane 显示文摘 | Dong Hong Wu Chuan Yang Xiongfa | 2010 | Jour- nal of Chemical and Engineering Data2010，55，2： | 1 |
| 5 | Measurement and correlation of saturated vapor pressure of 2,4,6,8,10 - pentam- ethylcyclopentasiloxane by means of an inclined ebulliometer显示文摘 | Dong Hong Wu Chuan Yang Xiongfa | 2009 | Thermochimica Acta2009，483，12： | 1 |
| 6 | Measurement and correlation of saturated vapor pressure of 2, 4, 6, 8, 10pentamethylcyclopentasiloxane by means of an inclined ebulliometer 显示文摘 | Dong Hong Wu Chuan Yang Xiongfa | 2009 | Thermochimica Acta2009，483，12： | 1 |
| 7 | Measurement and correlation of the vapor pressure of methylethoxydichlorosilane显示文摘 | Dong Hong Wu Chuan Yang Xiongfa | 2010 | Journal of Chemical & Engineering Data2010，55，2： | 1 |
| 8 | Effect of structure and additives on thermal stability of silicone fluids显示文摘 | Wu Chuan JinJing Yang Xiongfa | 2010 | Journal of Appliedpolymer Science2010，117，5： | 1 |
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