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| 1 | Microstructure, Mechanical Properties, Corrosion Behavior and Biocompatibility of As-Extruded Biodegradable Mg–3Sn–1Zn–0.5Mn Alloy显示文摘The microstructure evolution and mechanical properties of biodegradable Mg–3Sn–1Zn–0.5Mn alloys were investigated by the optical microscopy, X-ray diffractometer and a universal material testing machine.The corrosion and degradation behaviors were studied by potentiodynamic polarization method and immersion test in a simulated body fluid(SBF). It was found that the as-extruded Mg–3Sn–1Zn–0.5Mn alloy has the fine equiaxed grains which underwent complete dynamic recrystallization during the hot extrusion process, with the second phase particles of Mg_2Sn precipitated on the grain boundaries and inside the grains. The tensile strength and elongation of as-extruded Mg–3Sn–1Zn–0.5Mn alloys were 244 ± 3.7 MPa and 19.3% ± 1.7%, respectively. The potentiodynamic polarization curves in SBF solution indicated the better corrosion resistance of the as-extruded Mg–3Sn–1Zn–0.5Mn alloy in the SBF solution. Immersion test in the SBF solution for 720 h revealed that the corrosion rate of as-extruded Mg–3Sn–1Zn–0.5Mn alloy was nearly 4 ± 0.33 mm/year. The hemolysis rate of as-extruded Mg–3Sn–1Zn–0.5Mn alloy was lower than the safe value of 5% according to ISO 10993-4. As-extruded Mg–3Sn–1Zn–0.5Mn alloy showed good biocompatibility after being implanted into the dorsal muscle and the femoral shaft of the rabbit, and no abnormalities were found after short-term implantation. It was revealed that the as-extruded Mg–3Sn–1Zn–0.5Mn alloy is a promising material for biodegradable implants,which possesses an interesting combination of preferred mechanical properties, better corrosion resistance and biocompatibility. | Lida Hou Zhen Li Hong Zhao Yu Pan Sergey Pavlinich Xiwei Liu Xinlin Li Yufeng Zheng Li Li | 2016 | Journal of Materials Science & Technology2016，32，9： | 10 |
| 2 | Cyber-physical-social System in Intelligent Transportation显示文摘A cyber-physical system(CPS) is composed of a physical system and its corresponding cyber systems that are tightly fused at all scales and levels.CPS is helpful to improve the controllability,efficiency and reliability of a physical system,such as vehicle collision avoidance and zero-net energy buildings systems.It has become a hot R&D and practical area from US to EU and other countries.In fact,most of physical systems and their cyber systems are designed,built and used by human beings in the social and natural environments.So,social systems must be of the same importance as their CPSs.The indivisible cyber,physical and social parts constitute the cyber-physical-social system(CPSS),a typical complex system and it’s a challengeable problem to control and manage it under traditional theories and methods.An artificial systems,computational experiments and parallel execution(ACP) methodology is introduced based on which data-driven models are applied to social system.Artificial systems,i.e.,cyber systems,are applied for the equivalent description of physical-social system(PSS).Computational experiments are applied for control plan validation.And parallel execution finally realizes the stepwise control and management of CPSS.Finally,a CPSS-based intelligent transportation system(ITS) is discussed as a case study,and its architecture,three parts,and application are described in detail. | Gang Xiong Fenghua Zhu Xiwei Liu Xisong Dong Wuling Huang Songhang Chen Kai Zhao | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，3： | 8 |
| 3 | Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin显示文摘 | Xia Ding Feng Yan Phil Yao Zhihong Yang Weihong Wan Xiwei Wang Jing Liu Xinjiao Gao Ariane Abrieu Tongge Zhu Jiancun Zhang Zhen Dou Xuebiao Yao | 2010 | Cell Research2010，20，12： | 8 |
| 4 | Is new American Thyroid Association risk classification for hereditary medullary thyroid carcinoma applicable to Chinese patients? A single-center study显示文摘Objective: The American Thyroid Association(ATA) proposed a new risk classification for hereditary medullary thyroid carcinoma(MTC) in 2015. This study aimed to assess whether the new guidelines are suitable for the Chinese population, and reported our experience on prophylactic thyroidectomy.Methods: A total of 73 patients from 22 families were screened as rearranged during transfection(RET) mutation carriers from 2010 to 2016 in Cancer Hospital, Chinese Academy of Medical Science; the medical history for each patient was collected. Based on the initial treatment, we identified the risk factors for poor prognosis by univariate and multivariate logistic regression. Then, 4 RET mutation carriers were enrolled for prophylactic thyroidectomy,and their pathological data and follow-up outcomes were recorded.Results: In univariate and multivariate logistic regression analyses, age at initial surgery and risk classification were significant risk factors for stage Ⅲ/Ⅳ hereditary MTC at initial diagnosis. The likelihood was increased by 11.6% per year of age at initial surgery [95% confidence interval(95% CI), 1.040–1.198; P=0.002). It was 7.888 times more likely to have Ⅲ/Ⅳ stage disease for ATA highest risk patients, compared to ATA moderate risk individuals(95% CI, 1.607–38.717; P=0.003). Postoperative pathological results showed all 4 multiple endocrine neoplasia type 2A(MEN2A) patients had C-cell hyperplasia(CCH); multifocal malignancies were detected in 3 of them. All 4 patients were cured biochemically, and none developed permanent hypoparathyroidism.Conclusions: In Chinese individuals, hereditary MTC aggressiveness is in line with the new ATA risk classification. Germline RET gene mutation carriers should undergo prophylactic thyroidectomy according to basal serum calcitonin levels. | Xiwei Zhang Dangui Yan Junyi Wang Hanfeng Wan Yongxia Zhang Yabing Zhang Yuqin He Wensheng Liu Bin Zhang | 2017 | Chinese Journal of Cancer Research2017，29，3： | 5 |
| 5 | Optimization of Grouping Evacuation Strategy in High-rise Building Fires Based on Graph Theory and Computational Experiments显示文摘It is difficult to rescue people from outside, and emergency evacuation is still a main measure to decrease casualties in high-rise building fires. To improve evacuation efficiency, a valid and easily manipulated grouping evacuation strategy is proposed. Occupants escape in groups according to the shortest evacuation route is determined by graph theory. In order to evaluate and find the optimal grouping, computational experiments are performed to design and simulate the evacuation processes. A case study shown the application in detail and quantitative research conclusions is obtained. The thoughts and approaches of this study can be used to guide actual high-rise building evacuation processes in future. | Yuling Hu Xiwei Liu | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，6： | 5 |
| 6 | Controlling effects of differential swelling index on evolution of coal permeability显示文摘Coal permeability measurements are normally conducted under the assumption that gas pressure in the matrix is equalized with that in fracture and that gas sorption-induced swelling/shrinking strain is uniformly distributed within the coal.However,the validity of this assumption has long been questioned and differential strain between the fracture strain and the bulk strain has long been considered as the primary reason for the inconsistency between experimental data and poroelasticity solutions.Although efforts have been made to incorporate the impact into coal permeability models,the fundamental nature of those efforts to split the matrix strain between fracture and coal bulk remains questionable.In this study,a new concept of differential swelling index(DSI)was derived to theoretically define the relation among sorption-induced strains of the coal bulk,fracture,and coal matrix at the equilibrium state.DSI was a function of the equilibrium pressure and its magnitudes were regulated by the Langmuir constants of both the matrix and the coal bulk.Furthermore,a spectrum of DSI-based coal permeability models was developed to explicitly consider the effect of differential strains.These models were verified with the experimental data under the conditions of uniaxial strain,constant confining pressure,and constant effective stress. | Chuanzhong Jiang Zhenfeng Zhao Xiwei Zhang Jishan Liu Derek Elsworth Guanglei Cui | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，3： | 5 |
| 7 | Imbalance between subpopulations of regulatory T cells in COPD显示文摘 | Jia Hou Yongchang Sun Yu Hao Jie Zhuo Xiaofang Liu Peng Bai Junyan Han Xiwei Zheng Hui Zeng | 2013 | Thorax2013，，12： | 2 |
| 8 | Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes显示文摘Patients with type 2 diabetes mellitus(T2DM)have an increased risk of cancer.The effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain unknown.Here,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in patients.Strikingly,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T cells.These results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance. | Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 9 | Pinning complexnetworks by a single controller 显示文摘 | Chen Tianping Liu Xiwei Lu Wenlian | 2007 | IEEE Transctions onCircuits and Systems2007，54，6： | 1 |
| 10 | CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus显示文摘Influenza epidemics and pandemics are constant threats to global public health.Although strategies including vaccines and antiviral drugs have achieved great advances in controlling influenza virus infection,the efficacy of these strategies is limited by the highly frequent mutations in the viral genome and the emergence of drug-resistant strains.Our previous study indicated that boosting the immunity of human Vγ9Vδ2-T cells with the phosphoantigen pamidronate could be a therapeutic strategy to treat seasonal and avian influenza virus infections.However,one notable drawback ofγδ-T cell-based immunotherapy is the rapid exhaustion of proliferation and effector responses due to repeated treatments with phosphoantigens.Here,we found that the expression of CD137 was inducible in Vγ9Vδ2-T cells following antigenic stimulation.CD137^(+)Vγ9Vδ2-T cells displayed more potent antiviral activity against influenza virus than their CD137−counterparts in vitro and in Rag2^(-/-)γc^(-/-)mice.We further demonstrated that CD137 costimulation was essential for Vγ9Vδ2-T cell activation,proliferation,survival and effector functions.In humanized mice reconstituted with human peripheral blood mononuclear cells,CD137 costimulation with a recombinant human CD137L protein boosted the therapeutic effects of pamidronate against influenza virus.Our study provides a novel strategy of targeting CD137 to improve the efficacy of Vγ9Vδ2-T cell-based immunotherapy. | Yujun Pei Kun Wen Zheng Xiang Chunyu Huang Xiwei Wang Xiaofeng Mu Liyan Wen Yinping Liu Wenwei Tu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 11 | Evaluation of plant alarm systems by behavior simulation using a virtual subject显示文摘 | Liu Xiwei Masaru Noda Hirokazu Nishitani | | 0，，03： | 1 |
| 12 | Research on information technology of state monitoring and fault prediction for mechatronics system显示文摘The safety and reliability of mechatronics systems,particularly the high-end,large and key mechatronics equipment in service,can strongly influence on production efficiency,personnel safety,resources and environment.Based on the demands of development of modern industries and technologies such as international industry 4.0,Made-in-China 2025 and Internet + and so on,this paper started from revealing the regularity of evolution of running state of equipment and the methods of signal processing of low signal noise ratio,proposed the key information technology of state monitoring and earlyfault-warning for equipment,put forward the typical technical line and major technical content,introduced the application of the technology to realize modern predictive maintenance of equipment and introduced the development of relevant safety monitoring instruments.The technology will play an important role in ensuring the safety of equipment in service,preventing accidents and realizing scientific maintenance. | Xu Xiaoli Zuo Yunbo Meng Lingxia Zhao Xiwei Liu Xiuli | 2016 | 仪器仪表学报2016，37，S1： | 1 |
| 13 | Influence of ammonium sulfate on YAG nanopowders and Yb:YAG ceramics synthesized by a novel homogeneous co-precipitation method显示文摘Homogeneous and dispersed Y_3 Al_5 O_(12)(yttrium aluminum garnet,YAG) nanopowders were synthesized via a homogeneous co-precipitation method from the mixed solutions of yttrium nitrate,aluminum nitrate and a small amount of ammonium sulfate using hot urea as the precipitant.The method has the superiorities that co-precipitation of cations is ensured and continuous decomposition of the hot urea is achieved to obtain the narrow size distribution particles.The addition of small amount of ammonium sulfate surfactant,although has no influence on YAG garnet phase formation,has significant effect on dispersion,particles distribution and sinterability of the resultant YAG and Yb:YAG powders.Compared with the undoped sample,the green body of Yb:YAG doped with ammonium sulfate has higher total shrinkage,linear shrinkage rate and relative density through sintering at 1600 ℃.The resultant Yb:YAG powders can be sintered into transparent ceramics at 1700 ℃ through vacuum sintering.The influence of the sulfate ions on characteristics of the resultant powders was thoroughly studied. | Jinsheng Li Zhifa Liu Lei Wu Xiumei Han Xiwei Qi Xudong Sun | 2018 | Journal of Rare Earths2018，36，9： | 1 |
| 14 | Biomass Catalytic Pyrolysis with Ni Based Catalyst to Produce Hydrogen Rich Gas显示文摘Hydrogen rich gas was produced using rice husk as biomass material on the continuous biomass pyrolysis apparatus which consisted of continuous pyrolysis reactor and secondary catalytic cracking reactor. Ni based catalysts of different Ni/Al mass ratio and calcined temperature were prepared by impregnating method. The catalysts were characterized by X-ray diffraction (XRD), scan electron microscope (SEM) and FT-IR Spectrometer (FT-IR). Ni based catalyst showed good selectivity for H2 production from biomass. Catalysts prepared under different conditions had little influence on the yields of three states products when used at the same cracking temperature. Ni/Al mass ratio played an important role in products selectivity. However, the content of NiO increased further when Ni/Al mass ratio values reached 0.7 : 10, and the yield of H2 slightly increased. Hydrogen yield was greatly impacted by calcined temperature. Catalyst calcined at 550℃ performed best. When the catalyst was calcined at high temperature, NiO in the catalyst transformed into NiAl2O4, and the acid site also changed, which caused the deactivation of the catalyst. The hydrogen yield increased with the cracking temperature. The highest stable yield of hydrogen was about 30% without increasing with the cracking temperature. | WANG Mingfeng LIU Min XU Xiwei LI Bosong ZHANG Qiang JIAN Enchen | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，4： | 1 |
| 15 | Boosting lithium batteries under harsh operating conditions by a resilient ionogel with liquid-like ionic conductivity显示文摘New chemistries are being developed to increase the capacity and power of rechargeable batteries. However, the risk of safety issues increases when high-energy batteries using highly active materials encounter harsh operating conditions. Here we report on the synthesis of a unique ionogel electrolyte for abuse-tolerant lithium batteries. A hierarchically architected silica/polymer scaffold is designed and fabricated through a facile soft chemistry route, which is competent to confine ionic liquids with superior uptake ability (92.4 wt%). The monolithic ionogel exhibits high conductivity and thermal/mechanical stability, featuring high-temperature elastic modulus and dendrite-free lithium cycling. The Li/LiFePO_(4) pouch cells achieve outstanding cyclability at different temperatures up to 150 ℃, and can sustain cutting, crumpling, and even coupled thermal–mechanical abuses. Moreover, the solid-state lithium batteries with LiNi_(0.60)Co_(0.20)Mn_(0.20)O_(2), LiNi_(0.80)Co_(0.15)Al_(0.05)O_(2), and Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) cathodes demonstrate excellent cycle performances at 60 ℃. These results indicate that the resilient and high-conductivity ionogel electrolyte is promising to realize high-performance lithium batteries with high energy density and safety. | Le Yu Qing Liu Libin Wang Songtao Guo Qiaomei Hu Yaqian Li Xiwei Lan Zhifang Liu Xianluo Hu | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 16 | Pinning complex networks by a single controller显示文摘 | CHEN Tianping LIU Xiwei LU Wenlian | 2007 | IEEE Transactions on Circuits and Systems Ⅰ:Fundamental Theory and Applications2007，，06： | 1 |
| 17 | Pinning complex networks by a single controller 显示文摘 | CHEN Tianping LIU Xiwei LU Wenlian | 2007 | IEEE Transactions on Circuits and Systems L2007，54，6： | 1 |
| 18 | The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity显示文摘Cell polarity is essential for spatially regulating of physiological processes in metazoans by which hormonal stimulation‒secretion coupling is precisely coupled for tissue homeostasis and organ communications.However,the molecular mechanisms underlying epithelial cell polarity establishment remain elusive.Here,we show that septin cytoskeleton interacts with catenin complex to organize a functional domain to separate apical from basal membranes in polarized epithelial cells.Using polarized epithelial cell monolayer as a model system with transepithelial electrical resistance as functional readout,our studies show that septins are essential for epithelial cell polarization.Our proteomic analyses discovered a novel septin‒catenin complex during epithelial cell polarization.The functional relevance of septin‒catenin complex was then examined in three-dimensional(3D)culture in which suppression of septins resulted in deformation of apical lumen in cysts,a hallmark seen in polarity-deficient 3D cultures and animals.Mechanistically,septin cytoskeleton stabilizes the association of adherens catenin complex with actin cytoskeleton,and depletion or disruption of septin cytoskeleton liberates adherens junction and polarity complexes into the cytoplasm.Together,these findings reveal a previously unrecognized role for septin cytoskeleton in the polarization of the apical‒basal axis and lumen formation in polarized epithelial cells. | Xueying Wang Wenwen Wang Xiwei Wang Ming Wang Lijuan Zhu Fatima Garba Chuanhai Fu Barbara Zieger Xu Liu Xing Liu Xuebiao Yao | 2021 | Journal of Molecular Cell Biology2021，13，6： | 1 |
| 19 | Velocity structure and radial anisotropy beneath the northeastern Tibetan Plateau revealed by eikonal equation-based teleseismic P-wave traveltime tomography显示文摘The northeastern Tibetan Plateau serves as the frontier for the northeastward expansion of the plateau.In this area,the Tibetan Plateau interacts with the surrounding blocks,such as the Alxa Block,the Ordos Block,the Kunlun-West Qinling belt and the Sichuan Basin.Because of this expansion and interaction,this area suffers from intense deformation.At present,the evolution and deformation mechanisms of the northeastern Tibetan Plateau remain controversial.To provide new insights into these mechanisms,in this study,we conduct tomography of the P-wave velocity and radial anisotropy structures beneath the northeastern Tibetan Plateau.We choose a total of 667 teleseismic earthquakes from August 2006 to October 2020.Waveforms of these earthquakes were recorded by 921 broadband seismic stations in the northeastern Tibetan Plateau and surrounding areas.We first perform cross-correlation on waveforms of each station pair and obtain 770,749 P-wave traveltime differences.Then,we invert the differential traveltime data by applying eikonal equation-based teleseismic tomography.Finally,the P-wave velocity and radial anisotropy structures at depths from 30 to 800 km below the northeastern Tibetan Plateau are obtained.Our tomographic model shows clear low-velocity anomalies and positive radial anisotropy in the lower crust under the northeastern Qilian orogen,the northeastern Songpan-Ganzi belt and the western Qinling fold zone.These features are integrated to demonstrate the existence of lower crustal flow in the study area.Prominent low-velocity anomalies and positive radial anisotropy are found in the uppermost mantle beneath the Qilian orogen,the northeastern Songpan-Ganzi belt and western Qinling fold zone.These characteristics are combined to infer a weak lithosphere and horizontal asthenospheric flow under these tectonic units.Both the Ordos Block and the Sichuan Basin exhibit clear high-velocity anomalies and negative radial anisotropy in the uppermost mantle,thereby reflecting the high mechanical strength of the lithosphere beneath these blocks.High-velocity anomalies are also present in the upper mantle under the northern Chuandian block,potentially implying the northward subduction of the Indian plate.Furthermore,the front of the subducted Indian plate is imaged close to the Xianshuihe fault rather than the Kunlun fault. | Mengyang LI Shaolin LIU Dinghui YANG Xiwei XU Wenhao SHEN Chaodi XIE Wenshuai WANG Shuxin YANG | 2022 | Science China Earth Sciences2022，65，5： | 1 |
| 20 | Imbalance between subpopulations of regulatory T cells in COPD显示文摘 | Jia Hou Yongchang Sun Yu Hao Jie Zhuo Xiaofang Liu Peng Bai Junyan Han Xiwei Zheng Hui Zeng | 2013 | Thorax2013，，12： | 1 |
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