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| 1 | Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, in vitro and in vivo evaluation显示文摘Meloxicam(MLX) is efficient in relieving pain and inflammatory symptoms, which, however, is limited by the poor solubility and gastrointestinal side effects. The objective of this study is to develop a nanocrystal formulation to enhance transdermal delivery of MLX. MLX nanocrystals were successfully prepared by the nanoprecipitation technique based on acidbase neutralization. With poloxamer 407 and Tween 80(80/20, w/w) as mixed stabilizers,MLX nanocrystals with particle size of 175 nm were obtained. The crystalline structure of MLX nanocrystals was confirmed by both differential scanning calorimetry and X-ray powder diffractometry. However, the nanoprecipitation process reduced the crystallinity of MLX.Nanocrystals increased both in vitro and in vivo transdermal permeation of MLX compared with the solution and suspension counterparts. Due to the enhanced apparent solubility and dissolution as well as the facilitated hair follicular penetration, nanocrystals present a high and prolonged plasma MLX concentration. And 2.58-and 4.4-fold increase in AUC0 →2 4 h was achieved by nanocrystals comparing with solution and suspension, respectively. In conclusion, nanocrystal is advantageous for transdermal delivery of MLX. | Qina Yu Xiying Wu Quangang Zhu Wei Wu Zhongjian Chen Ye Li Yi Lu | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 2 | B7-H3 was Highly Expressed in Human Primary Hepatocellular Carcinoma and Promoted Tumor Progression显示文摘 | Feifei Wang Guoyan Wang Tongshen Liu Guohua Yu Guangbo Zhang Xiying Luan | 2014 | Cancer Investigation2014，，6： | 1 |
| 3 | MicroRNA‐1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma显示文摘 | Tengfei Zhang Dan Zhao Qiming Wang Xiying Yu Yaling Cui Liping Guo Shih Hsin Lu | 2013 | Mol Carcinog2013，，8： | 1 |
| 4 | Water use efficiency and evapotranspiration of winter wheat and its response to irrigation regime in the north China plain显示文摘 | Guo Yu Qiu Liming Wang Xinhua He Xiying Zhang Suying Chen Jin Chen Yonghui Yang | 2008 | Agricultural and Forest Meteorology2008，，11： | 1 |
| 5 | DUSP6, a tumor suppressor, is involved in differentiation and apoptosisin esophageal squamous cell carcinoma显示文摘 | Jianjuan Ma Xiying Yu Liping Guo Shih Lu | 2013 | Oncology Letters2013，，6： | 1 |
| 6 | Study on Mechanism of Explosive Spalling of ULC Castables During Rapid Drying显示文摘Inner vapor pressure and temperature of vulnerable explosive spalling positions in refractory castables during rapid drying were measured by embedding pressure transmitting pipes and thermocouples during casting. The measured vapor pressure, temperature, and tensile strength of the castables were analyzed and discussed. A hollow sphere shell model was used to analyze the stress induced by the vapor pressure based on the structure of refractory castables. The mechanism of refractory castables explosive spalling caused by vapor-induced pore split was proposed. By comparing the vapor-induced stress and the tensile strength of the castables,the explosive spalling mechanism was validated quantitatively. | WANG Zhanmin ZHAO Jin CAO Xiying YU Lingyan ZHANG Sanhua SHI Gan HUANG Yufei ZHU Zhu | 2015 | China's Refractories2015，24，4： | 0 |
| 7 | Identification of natural allelic variation in TTL1 controlling thermotolerance and grain size by a rice super pan-genome∞显示文摘Continuously increasing global temperatures present great challenges to food security.Grain size,one of the critical components determining grain yield in rice(Oryza sativa L.),is a prime target for genetic breeding.Thus,there is an immediate need for genetic improvement in rice to maintain grain yield under heat stress.However,quantitative trait loci(QTLs)endowing heat stress tolerance and grain size in rice are extremely rare.Here,we identified a novel negative regulator with pleiotropic effects,Thermo‐Tolerance and grain Length 1(TTL1),from the super pan‐genomic and transcriptomic data.Loss‐of‐function mutations in TTL1 enhanced heat tolerance,and caused an increase in grain size by coordinating cell expansion and proliferation.TTL1 was shown to function as a transcriptional regulator and localized to the nucleus and cell membrane.Furthermore,haplotype analysis showed that hapL and hapS of TTL1 were obviously correlated with variations of thermotolerance and grain size in a core collection of cultivars.Genome evolution analysis of available rice germplasms suggested that TTL1 was selected during domestication of the indica and japonica rice subspecies,but still had much breeding potential for increasing grain length and thermotolerance.These findings provide insights into TTL1 as a novel potential target for the development of high‐yield and thermotolerant rice varieties. | Yarong Lin Yiwang Zhu Yuchao Cui Hongge Qian Qiaoling Yuan Rui Chen Yan Lin Jianmin Chen Xishi Zhou Chuanlin Shi Huiying He Taijiao Hu Chenbo Gu Xiaoman Yu Xiying Zhu Yuexing Wang Qian Qian Cuijun Zhang Feng Wang Lianguang Shang | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 8 | Status and Progress of Refraetories for Aluminum Smelting Furnaces显示文摘Status and state-of-the-art progress on research,development and application of refractories for aluminum smelting furnaces and holding furnaces were reviewed and discussed in the present paper. The main types of aluminum smelting furnaces and smelting processes,and the service conditions of refractories and the requirements for refractory lining were also described and discussed. | WANG Zhanmin CAO Xiying ZHANG Sanhua YU Lingyan ZHANG Xiaohui | 2014 | China's Refractories2014，23，1： | 0 |
| 9 | Contrasting sources and enrichment mechanisms in lithium-rich salt lakes:A Li-H-O isotopic and geochemical study from northern Tibetan Plateau显示文摘Lithium(Li),a crucial mineral resource for modern high-tech industries,is notably abundant in the northern Tibetan Plateau,primarily within lithium-rich salt lakes.However,the exploration and development of these resources are hindered due to an incomplete understanding of their nature and origin.Here we present results from a comprehensive study on the hydrochemical parameters,whole-rock geochemistry,H-O isotopes,and Li concentrations in surface brine,river water,geothermal springs,and associated rocks from two representative lithium-enriched salt lakes,the Laguo Co(LGC)and Cangmu Co(CMC)in Tibet to understand the genetic mechanisms.Our water-salt balance calculations and H-O isotopic analysis reveal that Li in LGC and CMC primarily originates from the Suomei Zangbo(SMZB,~91%)and Donglong Zangbo(DLZB,~75%)rivers,respectively.It is estimated that the LGC and CMC took a minimum of 6.0 ka and 3.0 ka to accumulate their current lithium resources,respectively.The distinct geological characteristics reflect evolutionary differences between the two lakes,suggesting diverse lithium sources and enrichment processes.The high lithium ion concentration and light lithium isotope composition in the SMZB river waters indicate the genetic relationship with lithium-enriched geothermal springs in the Tibetan Plateau.Our results suggest that lithium in the LGC originates from lithium-enriched geothermal springs and is primarily supplied through the small-scale SMZB river.In contrast,the formation and evolution of CMC are influenced by the northern Lunggar rifts,receiving a prolonged and stable input from the DLZB,resulting in high lithium concentrations and isotopic values.The absence of lithium-enriched geothermal springs and the prevalence of silicate rocks in the CMC catchment suggest that lithium may be sourced from the weathering of silicate rocks,such as granitic pegmatite veins containing lithium-rich beryl,widely distributed in the upstream area of DLZB.The forward modeling approach,quantifying the contribution fractions of different reservoirs(atmospheric precipitation,silicate,carbonate,and evaporite),indicates that the distinct lithium concentrations in the mainstream(>1 mg/L)and tributaries(<0.1 mg/L)are positively correlated with the ratio of silicate contributions to carbonate contributions,suggesting that dissolved lithium in river waters primarily originates from the weathering and dissolution of silicate rocks.The distinct sources and enrichment mechanisms of lithium in these two salt lakes are attributed to various evolutionary processes,topographical features,hydrological factors,fundamental geological settings,and tectonic histories,despite their spatial proximity.Furthermore,our study highlights the significant role of rivers in the formation of young salt lakes,in addition to geothermal springs. | Fei Xue Hongbing Tan Xiying Zhang MSantosh Peixin Cong Lu Ge Chao Li Guohui Chen Yu Zhang | 2024 | Geoscience Frontiers2024，15，2： | 0 |
| 10 | Research on Residents’Willingness to Protect Privacy in the Context of the Personal Information Protection Law:A Survey Based on Foshan Residents’Data显示文摘The Personal Information Protection Law,as the first law on personal information protection in China,hits the people’s most concerned,realistic and direct privacy and information security issues,and plays an extremely important role in promoting the development of the digital economy,the legalization of socialism with Chinese characteristics and social public security,and marks a new historical development stage in the protection of personal information in China.However,the awareness of privacy protection and privacy protection behavior of the public in personal information privacy protection is weak.Based on the literature review and in-depth understanding of current legal regulations,this study integrates the relevant literature and theoretical knowledge of the Personal Protection Law to construct a conceptual model of“privacy information protection willingness-privacy information protection behavior”.Taking the residents of Foshan City as an example,this paper conducts a questionnaire survey on their attitudes toward the Personal Protection Law,analyzes the factors influencing their willingness to protect their privacy and their behaviors,and explores the mechanisms of their influencing variables,to provide advice and suggestions for promoting the protection of privacy information and building a security barrier for the high-quality development of public information security. | Xiying Huang Qizhao Xie Xunxun Jiang Zhihang Zhou Xiao Zhang Yiyuan Cheng Yu’nan Wang Chien Chi Chu | 2023 | Journal of Sustainable Business and Economics2023，6，3： | 0 |
| 11 | Identification and characterization of stem cells in mammalian esophageal stratified squamous epithelia显示文摘Somatic stem cells are essential for the maintenance of tissue homeostasis. Despite its importance, how the esophageal stratified squamous epithelium executes its self-renewal and maintenance remains elusive. In this study, using 5-bromo-2′-deoxyuridine label-chase in rats in vivo and rat esophageal organoids in vitro together with genome-wide DNA methylation and single-cell RNA sequencing, we identified a slow-cycling/quiescent stem cell population that contained high levels of hemidesmosomes (HDs) and low levels of Wnt signaling localized spatially and randomly at the basal layer of the esophageal epithelium. Pseudotime cell trajectory analysis indicated that tissue cells originated from quiescent basal stem cells in the basal layer. Perturbations of HD component expression and/or Wnt signaling reduced the stem cell population in the basal layer of esophageal keratinocyte organoids, resulting in alterations in the organoid formation rate, size, morphogenesis, and proliferation–differentiation homeostasis. Furthermore, not only high levels of HDs and low levels of Wnt signaling but also an interplay between HD and Wnt signaling defined the stem cells of the basal layer. Hence, HDs and Wnt signaling are critical determinants for defining the stem cells of the basal layer required for tissue homeostasis in mammalian esophagi. | Yanan Yang Guodong Deng Lili Qiao Hui Yuan Xiaohong Yu Lei Xu Shih-Hsin Lu Wei Jiang Xiying Yu | 2022 | Journal of Molecular Cell Biology2022，14，6： | 0 |
| 12 | Solid–Liquid Composites with High Impact Resistance显示文摘Solid–liquid composites(SLCs)with novel thermal/electronic/mechanical properties imparted by programmable and functional liquid inclusions have attracted considerable research interest in recent years,and are widely used in smart electronics and soft robotics.The feasible application of SLCs requires that they exhibit excellent static physical properties as well as dynamic impact resistance to satisfy complex service conditions,such as drops and impacts.This paper examined the impact resistance of SLCs fabricated by using microfluidic 3D printing.The results of dynamic split-Hopkinson pressure bar(SHPB)tests showed that the performance of the fabricated SLCs improved in terms of energy dissipation and impact resistance compared with pristine materials.In case of dynamic impact in the strain rates ranging from 100 to 400s−1,the SLC specimen deformed without fracture,and its energy dissipation was dominated by the viscosity of the liquid inclusions.For dynamic impact in the strain rates ranging from 500 to 800s−1,the SLC specimen fractured and its energy dissipation was determined by the volume fraction of the liquid inclusions.Thus,the energy dissipation of the SLCs could be tuned by regulating the viscosity and volume fraction of the liquid inclusions to satisfy the requirements of protection against different strain rates.Furthermore,the process of fracture of the SLCs under the dynamic SHPB tests was recorded and analyzed by using a high-speed camera.The results showed that distributed liquid inclusions changed the paths of crack propagation to enhance energy dissipation in the SLCs.This study experimentally verified the enhancement in the energy dissipation of SLCs,and provided design strategies for developing multifunctional SLCs with high impact resistance. | Miao Yu Xiying Li Pengyu Lv Huiling Duan | 2021 | Acta Mechanica Solida Sinica2021，34，6： | 0 |
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