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| 1 | Recent progress in cationic polymeric gene carriers for cancer therapy显示文摘In recent years,various carriers for gene delivery nave been developed for biomedical applications.Among all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have received growing interests due to their improved high transfection efficiency with the relative safety.In particular,the advancement of novel polymeric gene carriers has gained much progress in the development of effective anticancer therapy.Herein,this review focused on the development of cationic polymeric carriers for cancer therapy,including polyethylenimine(PEI),polyamidoamine(PAMAM) dendrimers,polylysine(PLL),chitosan and modified cationic polymers.And recent progresses in the development of novel polymeric carriers for gene delivery,such as targeted gene carriers,responsive gene carriers and multifunctional gene carriers,were summarized.Finally,the future perspectives in the development of novel polymeric carriers for delivery gene were presented. | Caina Xu Huayu Tian Xuesi Chen | 2017 | Science China Chemistry2017，60，3： | 2 |
| 2 | Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment显示文摘肺的药和基因交货系统与最小的药损失,精确量子化,高本地的药集中和低副作用的优点在肺疾病的处理成为了一条吸引人的途径。然而,特殊注意应该对肺的生物障碍被给予。交货系统需要小心地被设计以便克服这些生物障碍并且最大化药和基因免职到肺。肺的药和基因交货系统能提供为把药和基因送到肺鼓励结果的一些。明确地,一些基于类脂化合物、基于聚合物的交货系统能与最小或可以忽略的毒性控制并且支撑药和基因的版本。这评论为各种各样的肺疾病的处理集中于药和基因的肺的交货的最近的发展。对肺,交货设备,管理的线路和为药和基因的交货系统的障碍肺的交货被描述。基于临床的要求的快速的开发,用为肺的交货药和基因的交货系统的新奇途径需要被构造,它被相信以后在肺疾病的治疗起一个重要作用。 | Caina Xu Huayu Tian Xuesi Chen | 2014 | Chinese Journal of Chemistry2014，32，1： | 1 |
| 3 | Isolation of high-purlty anthocyanin mixtures and monomers from blueberries using combined chromatographic techniques显示文摘 | Erlei Wang Yongguang Yin Caina Xu | 2014 | Journal of ChromatograpHy A2014，13，27： | 1 |
| 4 | Phosphopeptides (PPPs) from hen egg yolk phosvitin exert anti-inflammatory activity via modulation of cytokine expression显示文摘 | Xu Caina Yang Chengbo Yin Yongguang | 2012 | Journal of functional foods2012，4，4： | 1 |
| 5 | Dual Reactive Oxygen Species Generator Independent of Light and Oxygen for Tumor Imaging and Catalytic Therapy显示文摘Currently,reactive oxygen species(ROS)generation primarily depends upon light and O2,which hampers its further biomedical application.Here,we report that amanganese(Ⅲ)salen-based complex(MnS)can continuously catalyze overexpressed hydrogen peroxide(H_(2)O_(2))in the tumor microenvironment to ^(1)O_(2),while the nanocarrier(MIL-100)as a Fenton reagent can convert H_(2)O_(2) to hydroxyl radicals(·OH)through the Fenton reaction,inducing noticeable intracellular DNA strand scission and lipid peroxidation to provoke tumor cell apoptosis without the involvement of light and O_(2).Moreover,MIL-100 depleted the antioxidant glutathione,further amplifying intracellular oxidative pressure,which in turn led to the self-degradation of MIL-100,suggesting the long-term biosafety of the nanoplatform.Owing to the excellent magnetic resonance imaging performance of MnS,the diagnosis and specific treatment of tumors were eventually achieved.This work provides a novel approach for the realization of effective tumor catalytic therapy independent of light and O_(2) and a promising reference for the development of a wide range of catalytic therapeutic agents. | Shu Sheng Feng Liu Meng Meng Caina Xu Huayu Tian Xuesi Chen | 2022 | CCS Chemistry2022，4，7： | 0 |
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