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| 1 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
| 2 | MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer显示文摘Objective:Menage a trois 1(MAT1)is a targeting subunit of cyclin-dependent kinase-activating kinase and general transcription factor IIH kinase,which modulates cell cycle,transcription and DNA repair.Its dysregulation is responsible for diseases including cancers.To further explore the role of MAT1 in breast cancer,we investigated the pathways in which MAT1 might be involved,the association between MAT1 and molecular subtypes,and the role of MAT1 in clinical outcomes of breast cancer patients.Methods:We conducted immunohistochemistry staining on tissue microarray and immunofluorescence staining on sections of MAT1 stable breast cancer cells.Also,we performed Kyoto Encyclopedia of Genes and Genomes pathway analysis,correlation analysis and prognosis analysis on public databases.Results:MAT1 was involved in multiple pathways including normal physiology signaling and disease-related signaling.Furthermore,MAT1 positively correlated with the protein status of estrogen receptor and progesterone receptor,and was enriched in luminal-type and human epidermal growth factor receptor 2-enriched breast cancer in comparison with basal-like subtype at both m RNA and protein levels.Correlation analysis revealed significant association between MAT1 m RNA amount and epithelial markers,mesenchymal markers,cancer stem cell markers,apoptosis markers,transcription markers and oncogenes.Consistently,the results of immunofluorescence stain indicated that MAT1 overexpression enhanced the protein abundance of epidermal growth factor receptor,vimentin,sex determining region Y-box 2 and sine oculis homeobox homolog 1.Importantly,Kaplan-Meier Plotter analysis reflected that MAT1 could serve as a prognostic biomarker predicting worse relapse-free survival and metastasis-free survival.Conclusions:MAT1 is correlated with molecular subtypes and is associated with unfavorable prognosis for breast cancer patients. | Hanxiao Xu Xianguang Bai Shengnan Yu Qian Liu Richard G Pestell Kongming Wu | 2018 | Chinese Journal of Cancer Research2018，30，3： | 2 |
| 3 | 显示文摘 | Yu J Wang E G Xu G C | 1998 | Chem Phys Lett1998，14，： | 1 |
| 4 | Breakage and re-growth of flocs formed by alum and PACl显示文摘 | Yu W Li G Xu Y | 2009 | Powder Technology2009，189，3： | 1 |
| 5 | High-accuracy TDOAbasedlocalization without time synchronization显示文摘 | XU B SUN G D YU R | 2013 | IEEETransactions on Parallel and Distributed Systems2013，24，8： | 1 |
| 6 | Effects of dimethyldicarbonate (DMDC) on the fermentation of litchi juice byLactobacillus casei as an alternative of heat treatment 显示文摘 | Yu Y S Xiao G S Xu Y J | 2014 | Journal of Food Science2014，79，： | 1 |
| 7 | Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid显示文摘 | Yu S B J X Li C G Xu | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 8 | Robust stabilization for uncertain discrete singular systems显示文摘 | Xu S Y Cheng W Y Yu G N James Lam | 2001 | Automatica2001，37，5： | 1 |
| 9 | A study on the seismic performance of steel-reinforced concrete frame concrete core wall high-rise mixed structure by large-scale shaking table tests and numerical simulations 显示文摘 | XU Z G YU P F XIAO C Z | 2013 | Earthquake Engineering and Structural Dynamic2013，42，13： | 1 |
| 10 | Supply chain coordination with CVaR criterion显示文摘 | Yang L Xu M Yu G | 2009 | Asia-Pacific J of Operation Research2009，26，1： | 1 |
| 11 | Increased expression ratio of Bcl-2/Bax is associated with crocin-mediated apoptosis in bovine aortic endothelial cells显示文摘 | Xu G Gong Z Yu W | | 0，，01： | 1 |
| 12 | Development a case- based classifier for predicting highly cited papers 显示文摘 | Wang M Y Yu G Xu J H | 2012 | Journal of Informetrics2012，6，4： | 1 |
| 13 | Polycyclic aromatic hydrocarbons in the surface sediments from Yellow River, China 显示文摘 | Xu J Yu Y Wang P Guo W F Dai S G Sun H W | 2007 | Chemosphere2007，67，： | 1 |
| 14 | Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid显示文摘 | YU S B LI J X XU C G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 15 | Green-light-emitting ZnSe nanowires fabricated via vapor phase growth显示文摘 | Xiang B Zhang H Z Li G H Yang F H Su F H Wang R M Xu J Lu G W Sun X C Zhao Q Yu D P | 2003 | Appl Phys Lett2003，82，19： | 1 |
| 16 | Characterization of petroporphyrins using ultraviolet visible spectroscopy and laser desorption ionization time-of-flight mass spectrometry 显示文摘 | XU H QUE G YU D | 2005 | Energy and Fuels2005，19，： | 1 |
| 17 | Normal and Oblique-slip of the 2008 Yutian Earthquake: Evidence for Eastward Block Motion, Northern Tibetan Plateau 显示文摘 | Xu X W Tan X B Yu G H | 2013 | Tectonophysics2013，584，： | 1 |
| 18 | Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid 显示文摘 | Yu S B Li J X Xu C G | 1997 | PNAS1997，94，： | 1 |
| 19 | Biochemical changes associated with fast fermentation of squid processing by-products for low salt fish sauce 显示文摘 | XU W YU G XUE C H | 2008 | Food Chemistry2008，107，4： | 1 |
| 20 | T lymphocytes plays a role in neuropathic pain following peripheral nerve injury in rats显示文摘 | G Moalem K Xu L Yu | 2004 | Neuroscience2004，129，： | 1 |
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