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| 1 | Salicylic Acid Regulates Pollen Tip Growth :hrough an NPR3/NPR4-1ndependent Pathway显示文摘尖端生长是为到牧草的细胞的快速的延伸的普通策略环境或指向到长途的目的地。在 Arabidopsis 花粉试管的模型尖端生长系统,几小分子的荷尔蒙调整他们的延伸,但是这些很快扩散的分子怎么控制极其局部性的生长,仍然保持神秘。这里,我们证明可互相转的水杨酸酸(SA ) 和 methylated SA (方山) ,在植物防卫为他们的角色描绘的井,相对地与是禁止的 SA 和方山 stimulatory 调整 Arabidopsis 花粉尖端生长。SA 和方山的效果独立于已知的 NPR3/NPR4 SA 调停受体的发信号小径。SA 在在顶端的墙中与更少的可拉长的 demethylated 果胶的增加的累积联系的花粉试管禁止了调停 clathrin 的 endocytosis,而方山做了反面。而且, SA 和方山改变 ROP1 GTPase 的顶端的激活,在花粉试管的尖端生长的一个关键管理者,以一种相反的方式。有趣地,方山 methylesterase 和 SA methyltransferase,催化在 SA 和方山之间的互变现象,在花粉试管的顶端的区域是局部性的, SA 和方山的尖端局部性的生产显示并且与他们在顶端的细胞的活动的效果一致。这些调查结果建议一个高度可散开的信号的本地产生能调整极化的房间生长,除了包含蛋白质和 mRNA 极化的那提供房间极性控制的新奇机制。 | Duoyan Rong Nan Luo Jean Claude Mollet Xuanming Liu Zhenbiao Yang | 2016 | Molecular Plant2016，9，11： | 4 |
| 2 | Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes melitus: from pathophysiology to therapeutics显示文摘Type 2 diabetes mellitus(T2DM or T2D)is a devastating metabolic abnormality featured by insulin resistance,hyperglycemia,and hyperlipidemia.T2D provokes unique metabolic changes and compromises cardiovascular geometry and function.Meanwhile,T2D increases the overall risk for heart failure(HF)and acts independent of classical risk factors including coronary artery disease,hypertension,and valvular heart diseases.The incidence of HF is extremely high in patients with T2D and is manifested as HF with preserved,reduced,and midrange ejection fraction(HFpEF,HFrEF,and HFmrEF,respectively),all of which significantly worsen the prognosis for T2D.HFpEFis seen in approximately half of the HF cases and is defined as a heterogenous syndrome with discrete phenotypes,particularly in close association with metabolic syndrome.Nonetheless,management of HFpEF in T2D remains unclear,largely due to the poorly defined pathophysiology behind HFpEF.Here,in this review,we will summarize findings from multiple preclinical and clinical studies as well as recent clinical trials,mainly focusing on the pathophysiology,potential mechanisms,and therapies of HFpEF in T2D. | Miyesaier Abudureyimu Xuanming Luo Xiang Wang James R.Sowers Wenshuo Wang Junbo Ge Jun Ren Yingmei Zhang | 2022 | Journal of Molecular Cell Biology2022，14，5： | 1 |
| 3 | Evaluation and Renovation Strategy of Buildings in Mountainous Towns from the Perspectives of Nature and Culture显示文摘In recent years,as a new growth point of China's economic development,small towns are under construction in full swing[1].But with the rapid expansion,many problems that the city scholars and builders think about have emerged.The problems in the construction of small towns are mainly reflected in the over development of capital,insufficient understanding on culture,deviation of construction strategies,etc.In many small towns,there is an imbalance between the volume and color of buildings,the architectural form is single[2],and the expression of local culture is insufficient.From the perspectives of nature and culture,the architecture of Ciping Town,a mountainous town,is evaluated.In view of the problems found,this paper puts forward its thinking on the buildings in this type of small towns,so as to provide some reference for the development of architecture in this type of small towns. | Xuanming CHEN Qi LUO | 2020 | Asian Agricultural Research2020，12，11： | 0 |
| 4 | Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca^(2+)homeostasis in a murine model of HFpEF显示文摘Heart failure with preserved ejection fraction(HFpEF)displays normal or near-normal left ventricular ejection fraction,diastolic dysfunction,cardiac hypertrophy,and poor exercise capacity.Berberine,an isoquinoline alkaloid,possesses cardiovascular benefits.Adult male mice were assigned to chow or high-fat diet with L-NAME(“two-hit”model)for 15 weeks.Diastolic function was assessed using echocardiography and noninvasive Doppler technique.Myocardial morphology,mitochondrial ultrastructure,and cardiomyocyte mechanical properties were evaluated.Proteomics analysis,autophagic flux,and intracellular Ca^(2+)were also assessed in chow and HFpEF mice.The results show exercise intolerance and cardiac diastolic dysfunction in“two-hit”-induced HFpEF model,in which unfavorable geometric changes such as increased cell size,interstitial fibrosis,and mitochondrial swelling occurred in the myocardium.Diastolic dysfunction was indicated by the elevated E value,mitral E/A ratio,and E/e’ratio,decreased e’value and maximal velocity of re-lengthening(-dL/dt),and prolonged re-lengthening in HFpEF mice.The effects of these processes were alleviated by berberine.Moreover,berberine ameliorated autophagic flux,alleviated Drp1 mitochondrial localization,mitochondrial Ca^(2+)overload and fragmentation,and promoted intracellular Ca^(2+)reuptake into sarcoplasmic reticulum by regulating phospholamban and SERCA2a.Finally,berberine alleviated diastolic dysfunction in“two-hit”diet-induced HFpEF model possibly because of the promotion of autophagic flux,inhibition of mitochondrial fragmentation,and cytosolic Ca^(2+)overload. | Miyesaier Abudureyimu Mingjie Yang Xiang Wang Xuanming Luo Junbo Ge Hu Peng Yingmei Zhang Jun Ren | 2023 | Frontiers of Medicine2023，17，6： | 0 |
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