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| 1 | Effect of electroacupuncture on expression of Ang/Tie-2 mRNA and protein in rats with acute cerebral infarction显示文摘OBJECTIVE: To identify the intervention mechanism of the effect of electroacupuncture on the expression of Ang/Tie-2 m RNA and protein in rats with acute cerebral infarction induced by middle cerebral artery occlusion(MCAO).METHODS: Altogether 120 Wistar rats were subjected to MCAO by inserting a nylon filament, andthen divided into 3 groups: control group, injured group and electroacupuncture group. The injured and electroacupuncture groups were further divided into the following 7 subgroups according to the time after MCAO: 3, 6, 12, 24 h, 3, 7 and 12 d, with 8 rats in each subgroup. The electroacupuncture group was given electroacupuncture treatment at Shuigou(GV 26) instantly after operation. The rats were killed at different time points according to their groups, and then the expression levels of Ang/Tie-2 m RNA and protein were detected using Real-Time polymerase chain reaction and immunohistochemical staining.RESULTS: The m RNA and protein expression levels of Ang/Tie-2 in the electroacupuncture group were significant higher than that in the injured group.CONCLUSION: The results suggested that electroacupuncture could significantly regulate the expression of Ang/Tie-2 m RNA and protein in the rats with acute cerebral infarction induced by MCAO, and enhance angiogenesis after ischemic penumbra. | Li Jing Bai Zonglu Du Yuanhao Li Yongfeng Zhang Xuezhu Pang Bo Zhang Jingjing | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 17 |
| 2 | An update: the role of Nephrin inside and outside the kidney显示文摘Nephrin is a key molecule in podocytes to maintain normal slit diaphragm structure. Nephin interacts with many other podocyte and slit diaphragm protein and also mediates important cell signaling pathways in podocytes. Loss of nephrin during the development leads to the congenital nephrotic syndrome in children. Reduction of nephrin expression is often observed in adult kidney diseases including diabetic nephropathy and HIV-associated nephropathy. The critical role of nephrin has been confirmed by different animal models with nephrin knockout and knockdown. Recent studies demonstrate that knockdown of nephrin expression in adult mice aggravates the progression of unilateral nephrectomy and Adriamycin-induced kidney disease. In addition to its critical role in maintaining normal glomerular filtration unit in the kidney, nephrin is also expressed in other organs. However, the exact role of nephrin in kidney and extra-renal organs has not been well characterized. Future studies are required to determine whether nephrin could be developed as a drug target to treat patients with kidney disease. | LI XueZhu HE John Cijiang | 2015 | Science China(Life Sciences)2015，58，7： | 16 |
| 3 | Influences of nitrification inhibitor 3,4-dimethyl pyrazole phosphate on nitrogen and soil salt-ion leaching显示文摘一个没受到干扰的重黏土列实验被进行检验新硝化抑制剂的影响, 3,4- dimethylpyrazole 磷酸盐(DMPP ) ,在氮和土壤上咸离子的沥滤。常规脲在土壤作为氮来源被选择。结果证明在有 DMPP 的脲的处理下面的土壤 nitrate-N 的累积沥滤损失从没有 DMPP, 57.5% ~ 63.3% 脲的处理比那些降低。硝化抑制剂的使用当硝酸盐沥滤,延迟蚂蚁可以是在规定的一个建议阻止地下水沾染物。然而,与沥滤的 ammonium-N 上的 DMPP 处理脲和脲之间没有大差别。而且,土壤 Ca2+ , Mg2+ , K+ ,和 Na+ 的咸离子的沥滤损失分别地从 26.6% ~ 28.8% , 21.3% ~ 27.8% , 33.3% ~ 35.5% ,和 21.7% ~ 32.1% 被减少。那么,土壤的沥滤的损失咸离子为硝化抑制剂 DMPP 增加被拒绝,对浅地下水保护和庄稼的生长有益。这些结果显示了用硝化抑制剂 DMPP 生产混合物控制硝酸盐和滋养的阳离子沥滤损失的铵或铵的可能性,最小化在浅地下水的硝酸盐污染的风险。 | YU Qiaogang YE Xuezhu CHEN Yingxu ZHANG Zhijian TIAN Guangming | 2008 | Journal of Environmental Sciences2008，20，3： | 14 |
| 4 | Accurate authentication of Dendrobium officinale and its closely related species by comparative analysis of complete plastomes显示文摘Owing to its great medicinal and ornamental values, Dendrobium officinale is frequently adulterated with other Dendrobium species on the market. Unfortunately, the utilization of the common DNA markers ITS,ITS2, and mat Ktrbc L is unable to distinguish D. officinale from 5 closely related species of it(D. tosaense, D.shixingense, D. flexicaule, D. scoriarum and D. aduncum). Here, we compared 63 Dendrobium plastomes comprising 40 newly sequenced plastomes of the 6 species and 23 previously published plastomes. The plastomes of D. officinale and its closely related species were shown to have conserved genome structure and gene content. Comparative analyses revealed that small single copy region contained higher variation than large single copy and inverted repeat regions, which was mainly attributed to the loss/retention of ndh genes.Furthermore, the intraspecific sequence variability among different Dendrobium species was shown to be diversified, which necessitates a cautious evaluation of genetic markers specific for different Dendrobium species.By evaluating the maximum likelihood trees inferred from different datasets, we found that the complete plastome sequence dataset had the highest discriminatory power for D. officinale and its closely related species,indicating that complete plastome sequences can be used to accurately authenticate Dendrobium species.& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dh0qbwwwc5cnbu6kqx.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Shuying Zhu Zhitao Niu Qingyun Xue Hui Wang Xuezhu Xie Xiaoyu Ding | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 14 |
| 5 | Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months显示文摘A total of 29 patients were treated within 48 hours after acute subcortical cerebral infarction with Xuesaitong or Xuesaitong plus human urinary kallidinogenase for 14 days.Neurological deficits,activity of daily living,and evaluations of distal upper limb motor functions at the 6-month follow-up showed that patients treated with Xuesaitong plus human urinary kallidinogenase recovered better than with Xuesaitong alone.In addition,functional MRI revealed that activation sites were primarily at the ipsilesional side of injury in all patients.Human urinary kallidinogenase induced hyperactivation of the ipsilesional primary sensorimotor cortex,premotor cortex,supplementary motor area,and contralesional posterior parietal cortex.Results showed that human urinary kallidinogenase improved symptoms of neurological deficiency by enhancing remodeling of long-term cortical motor function in patients with acute cerebral infarction. | Xuezhu Song Lixin Han Yan Liu | 2012 | Neural Regeneration Research2012，7，11： | 10 |
| 6 | Coupled BEM-FEM Analysis of the Large-Diameter Cylinder Structure System显示文摘A method of coupled BEM-FEM analysis for the elastic spatial structure system is presented. It can be applied to the calculation of the stress and deformation of the large-diamater cylinder structure system and it is suitable for symmetric or non-symmetric structures under the distributed or concentrated load. Numerical examples show that the proposed method and computer program BEFEM are quite efficient in the analysis of the large-diameter cylinder structure problems in ocean engineering. | Zhou Xireng, Duan Xudong, Sang Xuezhu Zhang Rui and Dai Jialu 1 Professor, Tianjin University, Tianjin2 Engineer, Xiamen Port Office, Fujian3 Lecturer, Tianjin University, Tianjin4 Senior Engineer, Tianjin Port Office, Tianjin | 1992 | China Ocean Engineering1992，7，2： | 6 |
| 7 | Effect of electro-scalp acupuncture on acute ischemic stroke: a randomized, single blind, trial显示文摘OBJECTIVE: To determine the clinical efficacy and safety of electro-scalp acupuncture in the treatment of patients with acute ischemic stroke.METHODS: Totally 74 patients with acute ischemic stroke were enrolled and divided into either body acupuncture(Control) or electro-scalp acupuncture(ESA) groups according to randomized controlled principle. The patients in the control group weregiven body acupuncture treatment once daily for28 d, whereas except for the body acupuncture,electro-scalp acupuncture was additional treatment given to the ESA group. Neurological deficits,everyday motor function and muscle strength were evaluated at baseline and the 28 th d by NIH Stroke Scale(NIHSS), Fugl-Meyer Assessment(FMA) and Modified Barthel Index Score(MBI), respectively.RESULTS: There were not obvious between-group differences in the baseline efficacy parameters(NIHSS, FMA and MBI)(all P > 0.05), whereas significant between-group differences were found in post-treatment NIHSS, FMA-UE and MBI scores(all P < 0.05). After acupuncture treatment, systematic within-group improvements were found in the two groups for any of the efficacy parameters assessed(all P < 0.01), and the ESA group showed higher significant improvements in NIHSS, FMA-UE and MBI scores(all P < 0.05).CONCLUSION: Electro-scalp acupuncture was efficacious in the treatment of acute ischemic stroke,which resulted in meaningful improvements in neurologic function, motor function and activities of daily living of patients. | Liu Xiaoxi Zhang Xuezhu Nie Kun Jia Yujie Li Jing Ling Zhenzhen Wang Yao Chang Shichen | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 5 |
| 8 | Small RNAs,RNAi and the Inheritance of Gene Silencing in Caenorhabditis elegans显示文摘Invasive nucleic acids such as transposons and viruses usually exhibit aberrant characteristics,e.g.,unpaired DNA or abnormal doublestranded RNA.Organisms employ a variety of strategies to defend themselves by distinguishing self and nonself substances and disabling these invasive nucleic acids.Furthermore,they have developed ways to remember this exposure to invaders and transmit the experience to their descendants.The mechanism underlying this inheritance has remained elusive.Recent research has shed light on the initiation and maintenance of RNA-mediated inherited gene silencing.Small regulatory RNAs play a variety of crucial roles in organisms,including gene regulation,developmental timing,antiviral defense,and genome integrity,via a process termed as RNA interference(RNAi).Recent research has revealed that small RNAs and the RNAi machinery are engaged in establishing and promoting transgenerational gene silencing.Small RNAs direct the RNAi and chromatin modification machinery to the cognate nucleic acids to regulate gene expression and epigenetic alterations.Notably,these acquired small RNAs and epigenetic changes persist and are transmitted from parents to offspring for multiple generations.Thus,RNAi is a vital determinant of the inheritance of gene silencing and acts as a driving force of evolution. | Xuezhu Feng Shouhong Guang | 2013 | Journal of Genetics and Genomics2013，40，4： | 3 |
| 9 | PKM2-dependent glycolysis promotes the proliferation and migration of vascular smooth muscle cells during atherosclerosis显示文摘Increased glycolysis is involved in the proliferation and migration of vascular smooth muscle cells(VSMCs).Pyruvate kinase isoform M2(PKM2),a key rate-limiting enzyme in glycolysis,accelerates the proliferation and migration of tumor cells.Although the intracellular mecha nisms associated with oxidized low-density lipoprotein(oxLDL)-stimulated VSMC proliferation and migration have been extensively explored,it is still unclear whether oxLDL promotes the proliferation and migration of VSMCs by enhancing PKM2-dependent glycolysis.In the present study,we detected PKM2 expression and pyruvate kinase activity in oxLDL-treated VSMCs and explored the regulation of PKM2 in oxLDL-treated VSMCs and apoE^-/-mice.The results showed that PKM2 expression in VSMCs was higher in the intima than in the media in plaques from atherosclerotic rabbits.Moreover,PKM2 level in VSMCs was increased during atherosclerosis progression in apoE^-/-mice.Both PKM2 expression and pyruvate kinase activity were found to be upregulated by oxLDL stimulation in VSMCs.Shikonin(SKN),a specific inhibitor of PKM2,was found to inhibit the oxLDL-induced proliferation and migration in VSMCs,in addition to delaying the atherosclerosis progression in apoE^-/-mice.More importantly,oxLDL increased glucose uptake,ATP and lactate production,and the extracellular acidification rate in VSMCs,which could be reversed by SKN.Meanwhile,oxygen consumption rate was unchanged after oxLDL stimulation,suggesting that glycolysis is the main contributor to the energy supply in oxLDL-treated VSMCs.Our results suggest that oxLDL induces VSMC proliferation and migration by upregulating PKM2-dependent glycolysis,thereby contributing to the atherosclerosis progression.Thus,targeting PKM2-dependent glycolysis might provide a novel therapeutic approach for the treatment of atherosclerosis. | Xuezhu Zhao Fancheng Tan Xiaoru Cao Zhengyu Cao Bicheng Li Zhaoqian Shen Ye Tian | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 3 |
| 10 | Predictive Field-Oriented Control for Electric Drives显示文摘Model predictive field-oriented control(PFOC)is a novel control strategy belonging to the class of finite control set model predictive control(FCS-MPC)for electric drive systems.It is a direct control scheme which minimizes the cost function through the convergence of errors between the given and predictive stator currents.In this paper,PFOC is thoroughly presented and analyzed through its dynamics and steady state operations under wide range of speed and varying torque conditions.In light of PFOC’s model based characteristics,its robustness an d influence under model parameters’mismatch is also investigated.Experiments are conducted to show these performance and sensitivities. | Fengxiang Wang Xuezhu Mei Peng Tao Ralph Kennel Jose Rodriguez | 2017 | Chinese Journal of Electrical Engineering2017，3，1： | 3 |
| 11 | Effect of degree of deacetylation on physicochemical and gelation properties of konjac glucomannan显示文摘 | Xuezhu Du Jing Li Jian Chen Bin Li | 2011 | Food Research International2011，，1： | 3 |
| 12 | Synthesis of Amphiphilic Starch Derivatives Using One-pot Synthesis Procedure显示文摘Amphiphilic starch derivatives with high content of functional groups were prepared from potato starch using a one-pot synthesis method with a single reaction medium for the entire procedure. Potato starch was benzylated, followed by the introduction of hydroxypropyltrimethylammonium(HPMA) moieties without the purification of intermediates. The synthesis was performed under heterogeneous conditions, leading to the formation of benzyl 2-hydroxypropyltri methylammonium starch chloride(BnHPMAS) with a total degree of substitution(DS) of up to 1.4. This process improved the efficiency of the preparation of amphiphilic starch derivatives and reduced the time and resources consumed by avoiding a separation process and purification of the intermediate compounds.The DS of BnHPMAS was in the range of 0.36 to 1.4, which could be tuned by varying the molar ratio of the reagents to repeating unit or by changing the reaction temperature, time, and medium. The structure of the amphiphilic starches was characterized using elemental analysis, size exclusion chromatography,fourier transform infrared spectroscopy(FT-IR), and nuclear magnetic resonance(NMR) spectroscopy. Moreover, the surface tension and turbidity of the solutions of the products were measured for their potential application in the removal of dissolved and colloidal substances in paper cycling water. | Tao Song FengXia Yue XueZhu Xu ChunLin Xu Yi-Chen Li FaChuang Lu HaiSong Qi | 2018 | Paper And Biomaterials2018，3，1： | 3 |
| 13 | Study of the mechanism of cationic drug release increase coated with Sureleaseafter curing显示文摘This paper describes the investigation of the release mechanism of the cationic drug coated with Sureleaseafter curing compared with nonionic and anionic drug.The release rate of cured propafenone hydrochloride pellets coated with Sureleasewas increased significantly compared with uncured ones.The changes in release rate after seal-coating proved the migration of drug into the polymer film.Based on a comparative study of ammonia permeation tests and the impact of ammonia on drug with different properties,it was shown that the change in release of the cationic drug after curing was related to the combination of cationic drug and ammonia in Surelease.Also,the scanning electron microscopy results showed that curing and dissolution can both prevent polymer film coalescence.During coating,the evaporated ammonia combined with the cationic drug and the polymer film coalesced.However,the combined ammonia could be decomposed during curing and interrupt the coalescence of the polymer-coat,leading to increased release.In an optimized process,the ammonia in the Sureleasecan be evaporated quickly and the ionization of the drug will be reduced.All these factors can contribute to the formation of the polymer film. | Yanting Hou Huiying Wang Xuezhu Zhang Meijuan Zou Gang Cheng | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 1 |
| 14 | Fabrication of high strength PVA/SWCNT composite fibers by gel spinning显示文摘 | Xuezhu Xu Ahmed Jalal Uddin Kenta Aoki Yasuo Gotoh Takeshi Saito Motoo Yumura | 2010 | Carbon2010，，7： | 1 |
| 15 | Effect of Acupuncture treatment on vascular dementia显示文摘 | Yu Jianchun Zhang Xuezhu Liu Cunzhi | 2006 | Neurol Res2006，28，1： | 1 |
| 16 | Chromosome elimination and fragment introgressionand recombination producing intertribal partial hybrids from Brassica napus×Lesquerella fendleri crosses显示文摘 | Du Xuezhu Ge Xianhong Zhao Zhigang | 2008 | Plant Cell Rep2008，27，： | 1 |
| 17 | Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice显示文摘 | Guomin Li Haiyan Cheng Xuezhu Zhang Xuemei Shang Hui Xie Xin Zhang Jianchun Yu Jingxian Han | 2013 | Neurological Sciences2013，，6： | 1 |
| 18 | Effect of acupuncture treatment on vascular dementia显示文摘 | JIANCHUN YU XUEZHU ZHANG CUNZHI LIU | 2006 | Neurological Research2006，28，： | 1 |
| 19 | Design parameters of a six-bar linkage vibrating digger显示文摘 | Wen Xuezhu Kang W S | 2003 | Journal of the Korean Society for Agricultural Machinery2003，28，1： | 1 |
| 20 | Effect of Acupuncture Treatment on Vascular Dementia显示文摘 | Jianchun Yu Xuezhu Zhang Cunzhi Liu | 2006 | Neurological research2006，28，7： | 1 |
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