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| 1 | Anti-cancer effect of iNOS inhibitor and its correlation with angiogenesis in gastric cancer显示文摘AIM: To observe the anti-cancer effect of iNOS selective inhibitor (aminoguanidine, AG) and investigate the relationship between iNOS inhibitor and angiogenesis, infiltration or metastasis in MFC gastric cancer xenografts.METHODS: Fifty athymic mice xenograft models were established by inoculating gastric cancer cell MFC subcutaneously. Twenty-four hours later, 0.9% sodium chloride solution, mitomycin, low dosage AG, high dosage AG, mitomycin and AG were administered by intraperitoneal injection respectively. Thus these mice were divided into five groups of 10 each randomly: control group, MMC group,AGL group, AGH group, MMC+AGH group. Two weeks later the mice were killed, and the tumor weight, inhibitory rate were evaluated. Greiss assay was used to detect the nitric oxide levels in plasma. HE and immunohistochemistry staining were used to examine microvessel density (MVD)and the expression of iNOS, VEGF, and PCNA. Apoptosis was detected by using TUNEL assay.RESULTS: The inhibitory rates in MMC+AGH group and AGH group were 52.9% and 47.1% respectively, which is significant statistically compared with that of control group (0). In treatment groups, the cell proliferation index (PI)was lower and apoptosis index was higher than those of control group. Microvessel density, iNOS, and VEGF in MMC+ AGH group were 8.8±2.6, 2.4±1.1, and 2.1±1.4respectively, which is significant statistically compared with those of control group (68.3±10.6, 11.3±1.3, and 10.3±1.6). The NO level in plasma of MMC+ AGH and AGH group were 12.7±2.1 and 12.9±2.0 μmol/L. Compared with that of control group (46.6±2.3 μmol/L), the difference is statistically significant.CONCLUSION: AG has anticancer effect on gastric cancer,and it has positive synergistic effect with chemotherapeutic drugs. It may play important inhibitory roles in angiogenesis of gastric cancer. The anticancer effect of iNOS inhibitors may include inducing cell apoptosis, suppressing cell proliferation and reducing angiogenesis. | Guang-YiWang BaiJi XuWang Jian-HuaGu | 2005 | World Journal of Gastroenterology2005，11，25： | 9 |
| 2 | Seasonal variations of soil bacterial communities in Suaeda wetland of Shuangtaizi River estuary, Northeast China显示文摘Estuarine wetland is the transitional interface linking terrestrial with marine ecosystems,and wetland microbes are crucial to the biogeochemical cycles of nutrients.The soil samples were collected in four seasons(spring,S1;summer,S2;autumn,S3;and winter,S4)from Suaeda wetland of Shuangtaizi River estuary,Northeast China,and the variations of bacterial community were evaluated by high-throughput sequencing.Soil properties presented a significant seasonal change,including p H,carbon(C)and total nitrogen(TN),and the microbial diversity,richness and structure also differed with seasons.Canonical correspondence analysis(CCA)and Mantel tests implied that soil p H,C and TN were the key factors structuring the microbial community.Gillisia(belonging to Bacteroidetes)and Woeseia(affiliating with Gammaproteobacteria)were the two primary components in the rhizosphere soils,displaying opposite variations with seasons.Based on PICRUSt(Phylogenetic Investigation of Communities by Reconstruction of Unobserved States)prediction,the xenobiotics biodegradation related genes exhibited a seasonal decline,while the majority of biomarker genes involved in nitrogen cycle showed an ascending trend.These findings could advance the understanding of rhizosphere microbiota of Suaeda in estuarine wetland. | Xuwang Zhang Zhe Ji Yating Shao Chaochen Guo Hao Zhou Lifen Liu Yuanyuan Qu | 2020 | Journal of Environmental Sciences2020，32，11： | 4 |
| 3 | Serological characterization of Haemophilus parasuis isolates from China显示文摘 | Xuwang Cai Huanchun Chen P.J. Blackall Zhengyan Yin Lei Wang Zhengfei Liu Meilin Jin | 2005 | Veterinary Microbiology2005，，3： | 3 |
| 4 | Performance and microbial community analysis of bioaugmented activated sludge for nitrogen-containing organic pollutants removal显示文摘Nitrogen-containing organic pollutants(quinoline,pyridine and indole)are widely distributed in coking wastewater,and bioaugmentation with specific microorganisms may enhance the removal of these recalcitrant pollutants.The bioaugmented system(group B)was constructed through inoculation of two aromatics-degrading bacteria,Comamonas sp.Z1(quinoline degrader)and Acinetobacter sp.JW(indole degrader),into the activated sludge for treatment of quinoline,indole and pyridine,and the non-bioaugmented activated sludge was used as the control(group C).Both groups maintained high efficiencies(>94%)for removal of nitrogen-containing organic pollutants and chemical oxygen demand(COD)during the long-term operation,and group B was highly effective at the starting period and the operation stage fed with raw wastewater.High-throughput sequencing analysis indicated that nitrogen-containing organic pollutants could shape the microbial community structure,and communities of bioaugmented group B were clearly separated from those of non-bioaugmented group C as observed in non-metric multidimensional scaling(NMDS)plot.Although the inoculants did not remain their dominance in group B,bioaugmentation could induce the formation of effective microbial community,and the indigenous microbes might play the key role in removal of nitrogen-containing organic pollutants,including Dokdonella,Comamonas and Pseudoxanthomonas.Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)analysis suggested that bioaugmentation could facilitate the enrichment of functional genes related to xenobiotics biodegradation and metabolism,probably leading to the improved performance in group B.This study indicated that bioaugmentation could promote the removal of nitrogen-containing organic pollutants,which should be an effective strategy for wastewater treatment. | Xuwang Zhang Zhaojian Song Qidong Tang Minghuo Wu Hao Zhou Lifen Liu Yuanyuan Qu | 2021 | Journal of Environmental Sciences2021，33，3： | 2 |
| 5 | Serological characterization of Haemophilus parasuis isolates from China 显示文摘 | Xuwang Cai Huanchun Chen Blackall P J | 2005 | Veterinary Microbiology2005，111，： | 1 |
| 6 | Recent advance of the hepatitis B virus inhibitors: a medicinal chemistry overview显示文摘 | Haiyong Jia Diwakar Rai Peng Zhan Xuwang Chen Xuemei Jiang Xinyong Liu | 2015 | Future Med. Chem2015，，5： | 1 |
| 7 | A deterministic and statistical energy analysis of tyre cavity resonance noise 显示文摘 | ZAMRI MOHAMED XUWANG | 2015 | Mechanical Systems and Signal Processing2015，，7071： | 1 |
| 8 | Biofilm formation by field isolates and reference strains of Haemophilus parasuis显示文摘 | Hui Jin Rui Zhou Mingsong Kang Rui Luo Xuwang Cai Huanchun Chen | 2006 | Veterinary Microbiology2006，，1： | 1 |
| 9 | Assessment ofecosystem health based on fish assemblages in the WeiRiver Basin,China显示文摘 | WU Wei XU Zongxue YIN Xuwang | 2014 | Environ Monit Assess2014，186，6： | 1 |
| 10 | Distribution of antimicrobial resistance among different serovars of Haemophilus parasuis isolates显示文摘 | Xueli Zhou Xiaojuan Xu Yaxin Zhao Pin Chen Xuan Zhang Huanchun Chen Xuwang Cai | 2009 | Veterinary Microbiology2009，，1： | 1 |
| 11 | Assessment of ecosystemhealth based on fish assemblages in the Wei River Basin, China显示文摘 | WU Wei XU Zongxue YIN Xuwang | 2014 | Environmental Monitoring and Assessment2014，186，6： | 1 |
| 12 | Two Types of Pressure Dependence of Residual Resistivity in Doped Kondo Insulators显示文摘The pressure dependence of the residual resistivity of the doped electron-type and hole-type Kondo insulators (KIs) are calculated within the framework of the slave-boson mean-field theory and the coherent potential approximation. It is shown that as the pressure increases, the resistivity increases and decreases for the dilute doping electron-type and hole-type KIs, respectively. These results are qualitatively in agreement with the experiments. | YUANYi-Zhe LIZheng-Zhong XIAOMing-Wen XUWang XUXiao-Hua | 2004 | Chinese Physics Letters2004，21，7： | 0 |
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