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| 1 | Impact of feeding flaxseed and microalgal residue on omega-3 fatty acids enrichment in hen eggs显示文摘To investigate the impact of dietary supplementation of different omega-3 polyunsaturated fatty acids (n-3 PUFAs) resources on PUFAs enrichment in hen eggs, two supplemental materials, flaxseed and oil-extracted microalgal residue of heterotrophic Schizochytrium, were added to the diet of laying hens in 3 groups. Results showed that supplementation with flaxseed and Schizochytrium residue gave rise to the increased, but different n-3 PUFAs levels in egg yolk, mainly α-linolenic acid (ALA) and docosahexaenoic acid (DHA). The ratio of n-6/n-3 PUFAs was reduced in all groups. After 14 days feeding of supplied PUFAs resources, n-3 PUFAs contents reached a plateau, and then remained constant during further supplementation in 3 experimental groups. Both the highest ALA level and DHA level were achieved in flaxseed group and microalgae group, reaching up to 353.69 (±68.15) mg/egg and 301.41 (± 26.76) mg/egg respectively. Moreover, the n-3 PUFAs enrichment efficiency was relatively low in flaxseed group when compared to other 2 groups. Laying rates of hens before entering peak production period could be improved by adding flaxseed but was not obviously affected by Schizochytrium residue. The egg weight, on the other hand, had no relationship with dietary supplementation. Thus, supplementation of flaxseed or Schizochytrium residue into standard feed offers an alternative choice for the production of n-3 PUFAs enriched eggs. | Bangfu Wu Xuyan Dong Fang Wei Jiqian Xiang Siew Young Quek Xin Lyu Lin Zhu Hong Chen | 2017 | Oil Crop Science2017，2，4： | 2 |
| 2 | Origins of black carbon from anthropogenic emissions and open biomass burning transported to Xishuangbanna, Southwest China显示文摘Black carbon(BC) has importance regarding aerosol composition, radiative balance, and human exposure. This study adopted a backward-trajectory approach to quantify the origins of BC from anthropogenic emissions(BCAn) and open biomass burning(BCBB) transported to Xishuangbanna in 2017. Haze months, between haze and clean months, and clean months in Xishuangbanna were defined according to daily PM_(2.5)concentrations of >75, 35–75, and<35 μg/m^(3), respectively. Results showed that the transport efficiency density(TED) of BC transported to Xishuangbanna was controlled by the prevailing winds in different seasons.The yearly contributions to the effective emission intensity of BCAnand BCBBtransported to Xishuangbanna were 52% and 48%, respectively. However, when haze occurred in Xishuangbanna, the average BCAnand BCBBcontributions were 23% and 77%, respectively. This suggests that open biomass burning(BB) becomes the dominant source in haze months. Myanmar, India, and Laos were the dominant source regions of BC transported to Xishuangbanna during haze months, accounting for 59%, 18%, and 13% of the total, respectively. Furthermore, India was identified as the most important source regions of BCAntransported to Xishuangbanna in haze months, accounting for 14%. The two countries making the greatest contributions to BCBBtransported to Xishuangbanna were Myanmar and Laos in haze months, accounting for 55% and 13%, respectively. BC emissions from Xishuangbanna had minimal effects on the results of the present study. It is suggested that open BB in Myanmar and Laos, and anthropogenic emissions in India were responsible for poor air quality in Xishuangbanna. | Xuyan Liu SiwenWang Qianqian Zhang Chunlai Jiang Linlin Liang Shihao Tang Xingying Zhang Xiuzhen Han Lin Zhu | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 3 | Xiaoaiping injection combined with cisplatin and gemcitabine for non-small cell lung cancer:a meta-analysis显示文摘目的:评价消癌平注射液辅助吉西他滨加顺铂(GP)化疗方案治疗晚期非小细胞肺癌(Nonsmall Cell Lung Cancer,NSCLC)的临床疗效。方法:计算机检索Cochrane Library,Pubmed,Embase,中国期刊全文数据库,中国生物医学文献数据库,中国科技期刊全文数据库和万方数据库中关于消癌平注射液辅助GP化疗方案治疗晚期非小细胞肺癌的随机对照试验(randomized controlled trial,RCT),检索时间限定为建库至2018年12月。Cochrane偏倚风险评估工具进行偏倚风险评估。Revman5.3.0进行数据分析。结果:最终纳入7个研究,共534例患者。Meta分析结果显示:与单纯GP化疗方案相比,消癌平注射液辅助GP化疗方案组的总有效率[OR=1.39,95%CI(0.97,1.98),P=0.07]和胃肠道反应发生率[OR=0.44,95%C I(0.16,1.23),P=0.12],差异无统计学意义;消癌平注射液辅助GP化疗方案组的血红蛋白的下降率[OR=0.49,95%CI(0.26,0.92),P=0.03]、白细胞的下降率[OR=0.40,95%CI(0.21,0.74),P=0.004]及血小板的下降率[OR=0.43,95%CI(0.22,0.87),P=0.02]均低于单纯GP化疗方案组,同时功能状态[OR=3.78,95%CI(2.24,6.38),P<0.0001]优于单纯GP化疗方案组。结论:消癌平注射液辅助GP化疗方案治疗晚期非小细胞肺癌有一定疗效,鉴于文献质量,仍需高质量随机对照试验的进行验证。 | Yue Ji Lin Wang Changying Chen Yihua Fan Xuyan Wang Hongtao Yang | 2019 | TMR Clinical Research2019，2，1： | 1 |
| 4 | Complexation of DNA with cationic surfactants as studied by small-angle X-ray scattering显示文摘建筑群的阶段行为由 didodecyldimethylammonium 溴化物( DDAB )和与 DNA 的三种不同类型交往的 cetyltrimethylammonium 溴化物( CTAB )形成了,大马哈鱼睾丸 DNA ( 2000 bp ), 21-bp 双stranded oligonucleotides ( oligo-dsDNA ),并且 21-nt 搁浅单人赛的 oligonucleotides ( oligo-ssDNA )被同步加速器学习散布的小角度的X光检查。和正电荷比率, DNA 长度和灵活性决定了最后的结构,这被发现。在更高的费用比率, DNA 长度展出了可以忽略的效果。oligo-dsDNA 和大马哈鱼 DNA 形成了与 DDAB 的与 CTAB,以及 bilayered 薄片的柱体的转换六角形的收拾行李。在更低的费用比率,然而, oligo-dsDNA 与 DDAB 与 CTAB 和新结构形成了一个弄歪的六角形的阶段,它与大马哈鱼 DNA 的行为不同。灵活 oligo-ssDNA 形成了服从于环境骚乱的富有的结构。运动学习也显示 oligo-ssDNA 形成的建筑群的结构花更长时间比 oligo-dsDNA 形成的结构成熟。我们在建筑群把这结果归因于 oligo-ssDNA 的 conformational 调整。 | NIU Lin YAN JingJing YANG XuYan BURGER Christian RONG LiXia HSIAO Benjamin LIANG DeHai | 2014 | Science China Chemistry2014，57，12： | 1 |
| 5 | 细菌效应蛋白揭示V-ATPase-ATG16L1通路介导异源自噬的研究显示文摘文章简介真核细胞通过选择性自噬的方式识别胞内病原体的过程称为异源自噬(xenophagy)。异源自噬在宿主天然免疫防御中发挥重要作用,但其触发机制仍不清楚。本研究通过对鼠伤寒沙门氏菌进行全基因组转座子突变筛选,鉴定出一个可强力阻断异源自噬的沙门氏菌III型分泌系统效应蛋白Sop F。更重要的是,Sop F可以抑制各种细菌感染引起的异源自噬,但不影响经典自噬通路。 | 许悦 Ping Zhou Sen Cheng Qiuhe Lu Kathrin Nowak Ann-Katrin Hopp Lin Li Xuyan Shi Zhiwei Zhou Wenqing Gao Da Li Huabin He Xiaoyun Liu Jingjin Ding Michael O.Hottiger 邵峰 | 2020 | 科学新闻2020，，2： | 0 |
| 6 | Enzyme-free photothermally amplified fluorescent immunosorbent assay(PAFISA)for sensitive cytokine quantification显示文摘Cytokine monitoring has attracted great attention due to its significance in the diagnosis and treatment of many diseases,such as tumors,microbial infections,and immunological diseases.Enzyme-linked immunosorbent assay(ELISA)is one of the most popular methods in cytokine detection,ascribing to the lavish signal amplification methods in the ELISA platform.In addition to classical enzymes,other signal amplifiers such as fluorescent probes,artificial nano-enzymes,and photothermal reagents have been applied to reduce the detection limit and produce more sensitive ELISA kits.Due to the accumulative effect of heat,photothermal reagents are promising materials in the signal amplification of ELISA.However,the lack of efficient photothermal generation material at an aggregate scale may delay the further development of this area.In this contribution,based on an efficient organic photothermal aggregate material,an enzyme-free photothermally amplified fluorescent immunosorbent assay system consisting of an assay microfluidic chip and detecting platform was developed.The photothermal nanoparticles with highly efficient photothermal conversion by harvesting energy via excited-state intramolecular motions and enlarging molar absorptivity were successfully prepared.The detection concentration at 50 pg/mL of interleukin-2 was achieved,realizing a signal improvement of detection limits by 20-fold compared to that of previously reported photothermal ELISA.The microscopic imaging integrated with plane sweeping technology provided high spatial resolution and precision,indicating the potential of achieving high throughput profiling at the microscale.Moreover,as an alternative excitation source,light-emitting diode not only provided a more affordable and miniaturized detection system but also revealed the great feasibility of intramolecular motion-induced photothermy nanoparticles for biological analyses. | Dian Li Wei He Xuyan Lin Xiaodong Cui Stefan Nagl Angela Ruohao Wu Ryan T.K.Kwok Renhua Wu Ben Zhong Tang | 2023 | Aggregate2023，4，6： | 0 |
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