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| 1 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，6： | 11 |
| 2 | 根据血压等级确定脑卒中和冠状动脉粥样硬化性心脏病死亡的终生风险:日本EPOCH(观察队列的心血管预防证据)研究显示文摘在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本人(男性占42.4%,平均年龄55.1岁)。在平均(15.2±5.3)年(1 559 136人年)的随访期.1922人死于脑卒中,913人死于CHDO研究者在调整其他死亡危险因素后估计风险。 | 陈嘉睿(译) 练桂丽(审校) Satoh M Ohkubo T Asayama K Murakami Y Sugiyama D Yamada M Saitoh S Sakata K Irie F Sairenchi T Ishikawa S Kiyama M Ohnishi H Miura K Imai Y Ueshima H Okamura T EPOCH-JAPAN research group | 2019 | 中华高血压杂志2019，27，4： | 9 |
| 3 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 4 | Administration of Glucocorticoids to Ovarian Cancer Patients Is Associated with Expression of theAnti-apoptotic Genes SGK1 and MKP1/DUSP1 in OvarianTissues显示文摘 | Melhem A Yamada S D Fleming G F | 2009 | Clin Cancer Res2009，15，9： | 1 |
| 5 | Age as a prognosticfactor for recurrence in patients with endometrial carcinoma 显示文摘 | Mundt AJ Waggoner S Yamada D | 2000 | Gynecol Oncol2000，79，1： | 1 |
| 6 | Production of tropane alkaoids in genetically engineered root cultures 显示文摘 | Hashimoto T Yun D J Yamada Y | 1993 | Phyto- chem1993，32，3： | 1 |
| 7 | Attitudes regarding tuberculosis in immigrants from the Philippines to the United States显示文摘 | YAMADA S CABALLERO J MATSUNAGA D S | 1999 | Faro IVied1999，31，： | 1 |
| 8 | Evidence-based public health: a critical perspective显示文摘 | Yamada S Slingsby B T Inada M K Derauf D | 2008 | J Public Health2008，16，： | 1 |
| 9 | Age as a prognostic factor for recurrence in patients with endometrial carcinoma显示文摘 | Mundt AL Waggoner S Yamada D | 2002 | Gynecol Oncol2002，79，： | 1 |
| 10 | Proteomic analysis of extracellular proteins from AspergiUus oryzae grown under submerged and solid-state culture conditions显示文摘 | Oda K Kakizono D Yamada O | | 0，，72： | 1 |
| 11 | Specific accumulation of polychlorinated biphenyls and organochlorine pesticides in Japanese common squid as a bioindicator显示文摘 | D Ueno S Inoue K Ikeda H Tanaka H Yamada S Tanabe | 2003 | Environmental Pollution2003，，2： | 1 |
| 12 | Production of tropane alkaloids in genetically engineered root cultures 显示文摘 | Hashimoto T Yun D J Yamada Y | 1993 | Phytochemistry1993，32，3： | 1 |
| 13 | Rate of reduction of nitric oxide by char 显示文摘 | Kunii D Yamada N | 1980 | International Chemical Engineering1980，20，： | 1 |
| 14 | Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides 显示文摘 | Klinman D M Yamada H Gursel M | 2003 | Ann N Y Acad Sci2003，1002，1： | 1 |
| 15 | Seismology constrains on the ultralow velocity zones at the lowermost mantle inferred from CMB reflected waves显示文摘 | Idehara K Yamada A Zhao D | | 0，，： | 1 |
| 16 | Proteomic analysis of extraceUular proteins from Aspergillus oryzae grown under submerged and solid-state culture conditions显示文摘 | ODA K KAKIZONO D YAMADA O | 2006 | Appl Environ Microbiol2006，72，： | 1 |
| 17 | Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis显示文摘 | Shimizu A Yamada K Sachs D et a1 | 2002 | Kidney Int2002，61，5： | 1 |
| 18 | Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLCI/IGSF4, an immunoglobulin superfamily cell adhe-sion molecule 显示文摘 | Yamada D Yoshida M Williams YN | 2006 | Mol Cell Bio12006，26，9： | 1 |
| 19 | Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2El 显示文摘 | Ramdhan D H Kamijima M Yamada N | 2008 | Toxicol Appl Pharmacol2008，231，3： | 1 |
| 20 | Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/beta-tricalcium phosphate ratios显示文摘 | Yamada S Heymann D Bouler JM | | 0，，15： | 1 |
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