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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | The use of small titanium screws for orthodontic anchorage显示文摘 | Deguchi D Yamamoto TT Kanomi R | 2003 | Dent Res2003，82，5： | 1 |
| 4 | Xanthophyll cycle enzymes are members of the lipocalin family,the first identified from plants显示文摘 | Hieber A D Yamamoto H Y | 1998 | J Biochem1998，273，15： | 1 |
| 5 | Association between bone loss and promoter polymorphism in the IL-6 gene in elderly Japanese women with hip fracture 显示文摘 | Feng D Ishibashi H Yamamoto S | 2003 | J Bone Miner Metab2003，21，： | 1 |
| 6 | Anharmonicity and the equation of state for gold显示文摘 | Anderson O L Isaak D G Yamamoto S | 1989 | J Appl Phys1989，65，： | 1 |
| 7 | Whole-genome characterization of human group C rotaviruses:Identification of two lineages in the VP3 gene显示文摘 | Yamamoto D Ghosh S Kuzuya M | 2011 | J Gen Virol2011，92，： | 1 |
| 8 | Identification and Analysis of Cytochrome P450IID6 Antigenic Sites Recognized by Anti-liver-kidney Microsome Type-1 Antibodies(LKMI)显示文摘 | Yamamoto AM Cresteil D Boniface O | 1993 | European Journal of Immunology1993，23，5： | 1 |
| 9 | Cycloprodigiosin hydrochloride, a new H+/Cl- sympoter,induces apoptosis in human and rat hepatocellular cancer cell line in vitro and inhibits yhe growth of hepatocellular carcinoma xenografts in nude mice显示文摘 | Takemoto H Kuno K Yamamoto D Tsubura A Kamata H | 1999 | Hepatology1999，30，4： | 1 |
| 10 | Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells:significance of direct cell-to-cell contact in coculture system显示文摘 | Yamamoto Y Mochida J Sakai D | 2004 | Spine2004，29，14： | 1 |
| 11 | Sup- pression of aging in mice by the hormone Klotho显示文摘 | KUROSU H YAMAMOTO M CLARK J D | 2005 | Science2005，309，5742： | 1 |
| 12 | The use of small titanium screws for orthodontic anchorage 显示文摘 | Deguehi D Yamamoto Tr Kanomi R | 2003 | J Dent Res2003，82，6： | 1 |
| 13 | Nicotine overrides DNA damage-induced Gl/S restriction in lung cells显示文摘 | Nishioka T Yamamoto D Zhu T | 2011 | PLoS ONE2011，6，4： | 1 |
| 14 | Effect of seed size on germination, seedling vigor, electrolyte, and establishment of bird's--foot trefoil显示文摘 | Mckersie B D Tomes D T Yamamoto S | 1981 | Canadian Journal of Plant Science1981，61，： | 1 |
| 15 | Identification of putative me- tabolites of doeosabexaenoic acid as potent PPARgamma agonists and antidiabetic agents 显示文摘 | Yamamoto K Itoh T Abe D | 2005 | Bioorg Med Chem Lett2005，15，3： | 1 |
| 16 | Origin of the defect states at ZnS/Si interfaces显示文摘 | Zhao X D Yamamoto H Taniguchi K | 1995 | Appl Phys A1995，61，6： | 1 |
| 17 | Focal Adhesion Kinase:at the Cross-roads of Signal Transduction显示文摘 | llic D DAMSKEY C H YAMAMOTO T | 1997 | J Cell Sci1997，110，4： | 1 |
| 18 | Predictive factors for sur-gical indication in adhesive small bowel obstruction 显示文摘 | Tanaka S Yamamoto T Kubota D | 2008 | Am J Surg2008，196，1： | 1 |
| 19 | Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9显示文摘 | Yamamoto D Takai S Jin D | | 0，，06： | 1 |
| 20 | 查看详情显示文摘 | Pashkin Y A Yamamoto T Astafiev O Nakamara Y Averin D V Tsai J S | | 0，，： | 1 |
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