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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | ^(11)C-methionine (MET) and ^(18)F-fluorothymidine (FLT) PET in patients withnewly diagnosed glioma显示文摘Eur J Nucl Med Mol Imaging. 2008 Jun 10.PURPOSE: The purpose of this prospective study was to clarify the individual and combined role of L: -methyl-(11)C-methionine-positron emission tomography (MET-PET) and 3' -deoxy-3' -[(18)F]fluorothymidine (FLT)-PET in tumor detection,noninvasive grad-ing, and assessment of the cellular proliferation rate in newly diagnosed histologically verified gliomas of different grades. MATERI- | Hatakeyama T Kawai N Nishiyama Y Yamamoto Y Sasakawa Y Ichikawa T Tamiya T | 2008 | 中国神经肿瘤杂志2008，6，2： | 11 |
| 3 | Carbon catalyzed supercritical water oxidation of phenol 显示文摘 | Matsumura Y Urase T Yamamoto K | 2002 | Journal of Supercritical Fluids2002，22，3： | 2 |
| 4 | COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA显示文摘 | Yamamoto T Sakashita Y | 1998 | Neuroreport1998，9，17： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | 初产妇和经产妇妊娠期间的诊室和家庭血压显示文摘妊娠高血压可导致分娩时产生严重的并发症,如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法:入选初产妇和经产妇共575名,评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值,参与者妊娠期间每日清晨在家自测血压。 | Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K Sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori S Suzuki M Kuriyama S Imai Y 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，6： | 2 |
| 7 | Expression and localization of aquaporins in rat gastrointestinal tract显示文摘 | Koyama Y Yamamoto T Tani T | 1999 | Am physiol cell physiol1999，276，31： | 1 |
| 8 | Serial measurement of serum S - 100B protein as a marker of cerebral damage after cardiac surgery显示文摘 | Iguro Y Yamamoto H | 2003 | Ann Thorac Surg2003，75，6： | 1 |
| 9 | J Power Sources显示文摘 | Matsuoka O Hiwara A Omi T Toriida M Hayashi T Tanaka C Saito Y Ishida T Tan H Ono S S Yamamoto S | 2002 | 108:1282002，108，： | 1 |
| 10 | An integrated Monte Carlo dosimetric verification system for radiotherapy treatment planning显示文摘 | Yamamoto T Mizowaki T Miyabe Y | 2007 | Phys Med Biol2007，52，7： | 1 |
| 11 | Distribution and identification of actinomycetes lysing cyanobacteria in a eutrophic lake显示文摘 | Yamamoto Y Kouchiwal T Hodokil Y | 1998 | Journal of Applied Phycology1998，10，4： | 1 |
| 12 | IFATS collection:in vivo therapeutic potential of human adipose tis sue mesenchymal stem cells after transplantation into mice with liver injury显示文摘 | BANAS A TERATANI T YAMAMOTO Y | 2008 | Stem Cells2008，26，10： | 1 |
| 13 | Deep brain stimulation therapy for a persistent vegetative state 显示文摘 | Yamamoto T Katayama Y Oshima H | 2002 | Acta Neurochir Suppl2002，79，： | 1 |
| 14 | Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy显示文摘 | Moriwaki Y Yamamoto T Shibutani Y | 2003 | Metabolism2003，52，5： | 1 |
| 15 | The absorption of pirarubicin instilled intravesically immediately after transurethral resection of superficial bladder cancer显示文摘 | Yamamoto Y Nasu Y Saika T | 2000 | BJU Int2000，86，7： | 1 |
| 16 | SSRs isolated from apple can identify polymorphism and geneticdiversity in pear显示文摘 | YAMAMOTO T KIMURA T SAWAMURA Y | 2001 | Theor Appl Genet2001，102，： | 1 |
| 17 | Frequent immune response to a melanocyte-specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease显示文摘 | Otani S Sakurai T Yamamoto K Fujita T Matsuzaki Y Goto Y | 2006 | Br J Ophthalmol2006，90，6： | 1 |
| 18 | Synthesis of monodisperse platinum nanoparticles supported on carbon gel microspheres显示文摘 | YAMAMOTO T YOSHIMURA Y TOBA M | 2006 | Journal of Non-Crystalline Solids2006，352，2627： | 1 |
| 19 | Fabrication and characterization of anatase TiO2 thin film on glass substrate grown by pulsed laser deposition显示文摘 | CHOI Y YAMAMOTO S UMEBAYASHI T | 2004 | Solid State Ionics2004，172，： | 1 |
| 20 | Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid - responsive element 显示文摘 | Yamamoto T Nakahata Y Tanaka M | 2005 | J Biol Chem2005，280，42： | 1 |
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