|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 2 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 3 | A novel wet-spinning method of manufacturing continuous bio-inspired composites based on graphene oxide and sodium alginate显示文摘珠母贝是小、强壮、生硬、坚韧的材料,它为材料设计使它成为一个 mimicking 目标。由各种各样的方法模仿珠母贝的许多尝试与优秀性质导致了人工的珠母贝的合成。然而,制造过程由于顺序的步很勤劳、费时间,并且仅仅限制大小的材料能被获得。因此,与一致分层的结构启用高效的人工的珠母贝的可伸缩的生产的一个新奇图案着急地被需要。我们开发了一种新奇湿旋转的集会技术很快生产连续 nacremimic graphene 氧化物(去,砖) 钠 alginate (SA,臼) 有优秀机械性质的电影和纤维。在高集中, GO-SA 混合物自发地由于模板效果生产了液体晶体(LC ) 去,并且连续,长像珠母贝的 GO-SA 拍摄的 6 m 从获得的 GO-SA 液体是湿纺纱的水晶(LC ) 以多达 1.5 m/min 的速度做。装配宏观的 GO-SA composites 从 LC 阶段继承了 GO 表的排列,并且他们的机械性质被联合试验性计算的研究调查。张力的测试表明最大的力量() 并且当最大值珍视时,获得的电影的幼仔模量(E) 到达了 239.6 MPa 和 22.4 GPa,为纤维的 E 分别地是 784.9 MPa 和 58 GPa。描述的湿旋转的集会方法为高效的连续人工的珠母贝的大规模、快的生产是适用的。 | Xiaozhen Hu Sangeetha Rajendran Yuansi Yao Zheng Liu Karthikeyan Gopalsamy Li Peng Chao Gao | 2016 | Nano Research2016，9，3： | 4 |
| 4 | Role of chemerin/CMKLR1 in the maintenance of earlypregnancy显示文摘Chemerin is a cytokine that attracts much attention in the reproductive process. This study aimed toexplore the effects of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) on the maintenance of earlypregnancy. The expression levels of chemerin and CMKLR1 in the decidua tissues of 20 early normal pregnantwomen and 20 early spontaneous abortion women were examined by Western blot and real-time polymerase chainreaction analyses. CMKLR1 receptor antagonist (a-NETA) was then intrauterinely injected into normal pregnantmice model to assess its effect on the outcome of pregnancy and the phosphorylation rate of ERK1/2 in deciduatissues. We found that the expression level of chemerin in women who had experienced early spontaneous abortionwas lower than in those who had experienced normal early pregnancy (P 〈 0.01); conversely, CMKLR1expression was higher in the former than in the latter (P 〈 0.01). In a pregnant-mouse model, the embryoresorption rate of a-NETA group was higher than that in the negative control group (61.5% vs. 10.8%) (P 〈 0.001).Compared with the control group, ERK1/2 phosphorylation in decidua tissues decreased in the a-NETA-treatedgroup (P 〈 0.01). These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can leadto the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance ofearly pregnancy possibly by regulating ERK1/2 phosphorylation. | Xuezhou Yang Junning Yao Qipeng Wei Jinhai Ye Xiaofang Yin Xiaozhen Quan Yanli Lan Hui Xing | 2018 | Frontiers of Medicine2018，12，5： | 2 |
| 5 | Crucial function of histone lysine methylation in plant reproduction显示文摘Unlike animals, plants do not set aside germ cells early in development. In angiosperm species, reproduction occurs in the adult plant upon flowering. The multicellular male and female gametophytes differentiate from meiotic products within reproductive floral organs. Double fertilization is another remarkable feature of most angiosperm species. The zygote derived from fertilization of the egg cell by one of the sperm cells and the endosperm from fertilization of the central cell by the second sperm cell develop in a coordinated manner together and enclosed in the sporophytic maternal integuments, forming the seed. Understanding plant reproduction is biologically pertinent and agronomically and ecologically important. Here, we describe the known functions of histone lysine methylations in various steps of reproduction in the reference plant Arabidopsis thaliana. It is emerging that histone lysine methylation is key for understanding epigenetic regulation networks of genome function. | YAO XiaoZhen SHEN WenHui | 2011 | Chinese Science Bulletin2011，56，33： | 2 |
| 6 | Transformer Winding I)eformation Diagn(stie System U- sing Online High Frequency Signal Injection by Capacitive Coupling 显示文摘 | Yao Chenguo Zhao Zhongyang Chen Yn Zhao Xiaozhen Li Zhao- jiong | 2014 | IEEE Transaetion on Dielectrics and Electrical Insulation2014，21，4： | 1 |
| 7 | Development of a novel type of composite cathode material for proton - conducting solid oxide fuel cells 显示文摘 | LING YIHAN YAO XIAHUI ZHANG XIAOZHEN | 2012 | International Journal of Hydrogen Energy2012，37，7： | 1 |
| 8 | The contributions of sporophytic tapetum to pollen formation显示文摘Successful pollen formation is essential for plant reproduction.During anther development,microspore mother cells undergo meiosis to form tetrads.After being released from the tetrad,microspores develop into mature pollen.The tapetum is the innermost layer of anther somatic cells and forms a locule to provide nutrition,enzymes and pollen wall materials for microspore development.Based on the male sterile phenotype,many genes important for tapetum and pollen development have been cloned.In this review,we highlight the genetic pathway of DYT1-TDF1-AMS-MS188-MS1 which acts in tapetal development in Arabidopsis.We also compared this genetic pathway in different species such as Arabidopsis,rice and maize.Based on this pathway,we review recent findings and insights into the contribution of the tapetum to pollen formation at the molecular level.1)Tapetum provides nutrition for microspore development.2)Tapetum provides enzymes to dissolve pectin and callose to release microspores from tetrads.3)Tapetum synthesizes precursors for pollen wall formation via different molecular pathways.4)Tapetum provides precursors for pollen coat formation.5)Tapetum provides small RNAs to regulate genic methylation in the germline cells. | Xiaozhen Yao Wen Hu Zhong-Nan Yang | 2022 | Seed Biology2022，1，1： | 0 |
| 9 | Whirligig‑Inspired Hybrid Nanogenerator for Multi‑strategy Energy Harvesting显示文摘Portable energy solutions are highly desired in the era of the Internet of Things for powering various distributed micro-electronic devices.At the same time,the energy crisis and catastrophic global warming are becoming serious problems in the world,emphasizing the urgent need for clean and renewable energy.Here,we report a low-cost,high-performance,and portable hand-driven whirligig structured triboelectric–electromagnetic hybrid nanogenerator(whirligig-HNG)for multi-strategy energy harvesting.The whirligig-HNG comprises a dynamic supercoiling TENG via the pulling-strings and inner-distributed EMGs(variable number)in the rotator.The whirligig structure can readily convert linear displacement in low frequency into rotary motion in extremely high frequency.Based on this ingenious design,the whirligig-HNG is capable to harvest the triboelectric energy from the supercoiling/uncoiling process from the pulling strings and simultaneously utilize the high-frequency rotation energy via electromagnetic induction.We have systematically investigated the working mecha-nism of the whirligig-HNG for coupled energy harvesting and compared the individual characteristics of TENG and EMG.The whirligig-HNG is successfully demonstrated to light up more than 100 commercial light-emitting diodes(LEDs)and drive portable electronics.This research presents the enormous potential of whirligig-HNG as a manual and portable power supply for powering various portable electronics. | Xiaozhen Dan Ran Cao Xiaole Cao Yifei Wang Yao Xiong Jing Han Lan Luo Jiahong Yang Nuo Xu Jia Sun Qijun Sun Zhong Lin Wang | 2023 | Advanced Fiber Materials2023，5，1： | 0 |
| 10 | Utilizing dual-pathway energy transfer in upconversion nanoconjugates for reinforced photodynamic therapy显示文摘Enhancing the therapeutic effect of existing treatments or developing new non-invasive treatments are important measures to achieve high-efficiency treatment of malignant tumors.Photodynamic therapy(PDT)is an emerging treatment modality,and the key for achieving high-efficiency PDT is to select light with strong tissue penetration depth and enhance the generation of reactive oxygen species(ROS).Although the upconversion nanoparticles(UCNPs)modified with the photosensitizers could achieve PDT with strong penetration depth under near-infrared light irradiation,the ROS generated by traditional single-pathway PDT is still insufficient.Herein,we developed a novel nanoconjugate(UCNP-Ce6/AIEgen)for dual-pathway reinforced PDT,in which the UCNPs were co-modified with chlorin e6(Ce6)and luminogen with aggregation-induced emission(AIEgen).Due to the presence of AIEgen,UCNP-Ce6/AIEgen could avoid aggregation-caused luminescence quenching in biological water environments and convert upconversion luminescence(UCL)of UCNPs to Ce6-activatable fluorescence.Therefore,under the irradiation of 808 nm laser,UCNP-Ce6/AIEgen can not only undergo direct lanthanide-triplet energy transfer to activate Ce6,but also convert the UCL of UCNPs to the light that can activate Ce6 through Fӧrster resonance energy transfer to generate more ROS,thus promoting tumor cell apoptosis.This work broadens the applications of nanoconjugates of lanthanide-based inorganic materials and organic dyes,and provides a conception for reinforced PDT of tumors. | Ruohao Zhang Yu Lu Yifei Zhou Kehong Lv Xinyu Fu Jitong Gong Shuang Yao Xiaozhen Wang Jing Feng Hongjie Zhang | 2024 | Nano Research2024，17，4： | 0 |
| 11 | Dynamic Model of Thermal Fatigue Crack Propagation In 3Cr2W8V Steel显示文摘In this paper, the thermal fatigue test data in 3Cr2W8V steel are analyzed numerically. Then, on this basis a formula of thermal fatigue crack propagation rate with respect to stress intensiyt factor range is presented. Finally a dynamic equation of the control parameters for thermal fatigue crack propagationis derived according to evaluating the thermal strain relaxation property of the steel. | Liu Jianhong Yao Mei Feng Xiaozhen He Shiyu (Department of Metals and Technology) | 1990 | 哈尔滨工业大学学报1990，22，3： | 0 |
| 12 | Construction of coxsackievirus B5 viruses with luciferase reporters and their applications in vitro and in vivo显示文摘Coxsackievirus belongs to the Picornaviridae family and is one of the major pathogens that cause hand,foot and mouth disease(HFMD)in infants and children with potential serious complications and even deaths.The pathogenesis of this virus is not fully elucidated and no vaccine or antiviral drug has been approved.In this study,a full-length infectious cDNA clone of coxsackievirus B5 virus was assembled and the recombinant virus displayed similar growth kinetics and ability to cause cytopathic effects as the parental virus.Luciferase reporter was then incorporated to generate both full-length and subgenomic replicon(SGR)reporter viruses.The full-length reporter virus is suitable for high-throughput antiviral screening,while the SGR is a useful tool to study viral-host interactions.More importantly,the full-length reporter virus has also been shown to infect the suckling mouse model and the reporter gene could be detected using an in vivo imaging system,thus providing a powerful tool to track viruses in vivo.In summary,we have generated coxsackievirus B5 reporter viruses and provided unique tools for studying virus-host interactions in vitro and in vivo as well as for high-throughput screenings(HTS)to identify novel antivirals. | Shangrui Guo Meng Xun Tingting Fan Xinyu Li Haoyan Yao Xiaozhen Li Bo Wu Hang Yang Chaofeng Ma Hongliang Wang | 2023 | Virologica Sinica2023，38，4： | 0 |
| 13 | Gastric adenocarcinoma with hepatoid adenocarcinoma:A case report and literature review显示文摘Objective Hepatoid adenocarcinoma of the stomach is exceedingly rare. Only a few cases have been reported worldwide. In this report, we describe our pathological findings along with a review of the literature to improve our understanding of the disease and prevent misdiagnosis, as well as to provide evidence for its treatment and prognosis.Methods A 68-year-old male patient was admitted to our hospital(Dalian Municipal Central Hospital, Dalian, China) complaining of upper abdominal pain. Physical examination and regular laboratory blood tests showed no obvious abnormalities. A contrast-enhanced computed tomography scan displayed a 3.0 cm × 3.0 cm mass in the gastric antrum, but no metastasis was found in the adjacent organs.Results A radical gastrectomy was performed and postoperative histopathology showed a moderately differentiated adenocarcinoma with partial hepatoid adenocarcinoma.Conclusion Hepatoid adenocarcinoma of the stomach is a rare malignant neoplasm. The diagnostic criteria for hepatoid adenocarcinoma of the stomach depends mainly on the clinical, radiographic, and histopathological findings. Pathomorphology and immunohistochemical staining can be utilized to confirm the diagnosis. | Yao Han Lin Zhen Baiying Liu Xiaozhen Zhan Wenbin Li Taotao Zhang Xiangwen Zhang Guo Zu | 2018 | Oncology and Translational Medicine2018，4，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员