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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Antidepressant principles of Valeriana fauriei roots显示文摘 | Yoshiteru O Setsu M Yasushi O | 1995 | Chem Pharm Bull1995，43，1： | 1 |
| 3 | Ultra-low sulfur non-oriented electrical steel sheets for highly efficient motors: NKB-CORE显示文摘 | Yoshihiko O Yasushi T Yamagami N | 2002 | NKK Technical Review2002，87，： | 1 |
| 4 | Transcatheter arterial infusion for uterine cervical cancer显示文摘 | Yasushi Kaoro O Jakashi L | 1996 | Cardiovascular Interventional Radiology1996，19，： | 1 |
| 5 | Role of RIS and PHIP on insulin-induced tyrosine phosphorylation and distribution of IRS proteins显示文摘 | Yasushi K Hitoshi O Shinobu S el al | 2007 | Cell Struct Funct2007，32，： | 1 |
| 6 | Synthesis ofrhodamine B-doped and monodispersed spherical particles of polyorganosiloxane using a W/O emulsion显示文摘 | TAICHI M YASUSHI T HIROAKI O | 2005 | Journal of the American Ceramic Society2005，88，12： | 1 |
| 7 | Pharmachkinetics and metabolism of miloxacin in cultured eel显示文摘 | Ryuji U Yasushi O Takuya T | 2001 | Aquaculture2001，193，： | 1 |
| 8 | transcatheter arterial infusion for uterine cervical cancer显示文摘 | Yasushi Kaoro O Jakashi L | 1996 | Cardiovascular Interventional Radiology1996，19，： | 1 |
| 9 | Total cadmium intake and mortality among residents in the Jinzu River Basin, Japan 显示文摘 | Kaori M Etsukok Yasushi O | 2003 | Arch Environ Health2003，58，4： | 1 |
| 10 | Possible pathophysiological roles of Mitogen - Activated Protein Kinases(MAPKs) in endometriosis显示文摘 | Osamu Y Yutaka O Yasushi H | 2004 | Am J Reprod Immunol2004，52，5： | 1 |
| 11 | Fundamental combustion characteristics of palm methyl ester (PME) as alternative fuel for gas turbines显示文摘 | Nozomu H Yasushi O Noriyuki M | | 0，，15： | 1 |
| 12 | Control of smoke flow in tunnel fires显示文摘 | Yasushi O Graham T A | 1995 | Fire Safety Journal1995，25，： | 1 |
| 13 | Stereotactic hypofractionated high-dose irradiation for patients with stage I non-small cell lung carcinoma:clinical outcomes in 241 cases of a Japanese multi-institutional study显示文摘 | Yasushi N Hiroki S | 2003 | (Abstr) Int J Radiat Oncol Biol Phys2003，57，： | 1 |
| 14 | The polymerase L528M mutation cooperates with nucleotide binding - site mutations, increasing hepatitis B virus replication and drug resistance显示文摘 | NAOYA K YASUSHI S | 2001 | The Journal of Clinical Investigation2001，107，4： | 1 |
| 15 | Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb-Williams Maze task显示文摘 | Satoru K Yasushi O Susumu A | 2002 | Journal of Neuroscience Research2002，70，2： | 1 |
| 16 | Molecular hydrogen attenu- ates neuropathic pain in mice显示文摘 | Masanori K Yasushi S Yukiko O | 2014 | PLoS One2014，9，10： | 1 |
| 17 | Elevated sensitivity to gibberellin by vernalization in the vegetative rosette plants of Eustoma grandiflorum and Arabidopsis thaliana 显示文摘 | Mariko O Yasushi T Masaaki I | 2001 | Plant Science2001，160，： | 1 |
| 18 | Fire properties in near field of square fire source with longitudinal ventilation in tunnels显示文摘 | HITOSHI K YASUSHI O HIROOMI S | 2003 | Fire Safety Journal2003，38，： | 1 |
| 19 | Total cadmium intake andmortality among residents in the Jinzu River Basin,Japan显示文摘 | KAORI M ETSUKO K YASUSHi O | 2003 | Arch Environ Health2003，58，4： | 1 |
| 20 | In situ preconcentration method for iron(Ⅱ) in environmental water samples using solid extraction followed by specteophotometric determination显示文摘 | MINORU O YASUSHI S KAORU F | 1997 | Analytical Sciences1997，13，： | 1 |
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