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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 3 | Hydrodynamics of spouted and spout-fluidized beds at high temperature 显示文摘 | Ye B Lim C J Grace J R | 1992 | The Canadian Journal of Chemical Engineering1992，70，5： | 2 |
| 4 | Wireless tracing and locating system for in-pipe robot 显示文摘 | QI H M YE J R ZHANG X H | 2010 | Sensors and Actuators A2010，159，： | 1 |
| 5 | Molecular dynamics simulation of nanoscale machining of copper显示文摘 | YE Y Y BISWAS R MORRIS J R | 2003 | Nanotechnology2003，14，： | 1 |
| 6 | Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide 显示文摘 | Ye R Han J Kong X | 2008 | Biol Pharm Bull2008，31，10： | 1 |
| 7 | Neuroprotective effects of ginsen-oside Rd against oxygen - glucose deprivation in cultured hippocampalneurons显示文摘 | Ye R D Li N L Han J L | 2009 | Neuroscience Research2009，64，： | 1 |
| 8 | Influence of different diffuser angle on sedan’s aerodynamic characteristics显示文摘 | Hu X J Zhang R Ye J | 2011 | Physics Procedia2011，22，： | 1 |
| 9 | Extremely high prevalence of neural tube defects in a 4 - county area in Shanxi Province, China 显示文摘 | Li Z Ren A Zhang L Ye R Li S Zheng J Hong S Wang T Li Z | 2006 | Birth Defects Res A Clin Mol Teratol2006，76，4： | 1 |
| 10 | Uv-light induces p38MAPK- dependent phosphorylation of Bell0显示文摘 | Boder A J Ye R Lees-Miller S P | 2003 | Biochemical and Bio- physical Research Communcations2003，301，4： | 1 |
| 11 | Involvement of heine oxygenaser - 1 in delayed cardio - protection induced by monophosphcol lipid A in rats显示文摘 | Ru R Peng J Ye F | 2002 | Acta Pharmacol Sin2002，23，1： | 1 |
| 12 | A small sphere and large margin approach for novelty detection using training data with outliers 显示文摘 | Wu M R Ye J P | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 13 | Preparation,preliminary characterization,antioxidant,hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant显示文摘 | XU R J YE H SUN Y | 2012 | Food and Chemical Toxicology2012，50，： | 1 |
| 14 | Dynamic behavior of cable-stayed beam with localized damage显示文摘 | Zhu J Ye G R Xiang Y Q | 2011 | Journal of Vibration and Control2011，17，7： | 1 |
| 15 | The heme oxygenaser- 1 pathway invoved in calcitonin gene- related peptide- mediated delayed cardioprotection induced by monophosphoryl lipid A in rats显示文摘 | Peng J Ru R Ye F | 2002 | Regul Pept2002，103，1： | 1 |
| 16 | Exact three- dimensional solutions of laminated orthotropic piezoelectric rectangular plates featuring interlaminar bonding imperfections modeled by a general spring layer 显示文摘 | Chen W Q Cai J B Ye G R Wang Y F | 2004 | International Journal of Solids and Structures2004，41，1819： | 1 |
| 17 | 查看详情显示文摘 | R Q Ye B Q Han E J Lavernia | | 0，，： | 1 |
| 18 | Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways显示文摘 | Fels D R Ye J Segan A T | 2008 | Cancer Res2008，68，22： | 1 |
| 19 | Proteolysis of chimeric β-amyloid precursorproteins containing the Notch transmembrane domain yields amyloid β-1ike peptides 显示文摘 | Zhang J Ye W Wang R | 2002 | JBiol Chem2002，277，15： | 1 |
| 20 | Behavior of ground vibrations induced by trains moving on embankments with rail roughness显示文摘 | JU S H LIAO J R YE Y L | | 0，，： | 1 |
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