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| 1 | Contemporary crustal movement of continental China obtained by global positioning system(GPS) measurements显示文摘We obtain a unified horizontal velocity field of continental China and vicinity through measurements at 81 GPS stations provided by the National Key Infrastructure Project, Crustal Movement Observation Network of China. The velocity field delineates patterns of movements and deformation of active crustal blocks in continental China under the Eurasia-fixed reference frame. The space-based geodesy also clearly shows for the first time the horizontal movementand deformation of continental China induced by indentation of the Indian plate. The data provide kinematic constraints for simulating dynamic process of continental litho-spheric deformation. | MA Zongjin, CHEN Xinlian, YE Shuhua, LAI Xian, WEI Ziqing, CHEN Junrong, NING Jinsheng, XU Huoze & DING Guoyu1. Insitute of Geology, China Seismological Bureau, Beijing 100029, China (e-mail: disgroup@publi.bta.net.cn)2. Center for Analysis and Prediction, China Seismological Bureau, Beijing 100036, China 3. Shanghai Astronomic Observatory, Chinese Academy of Sciences, Shanghai 200030, China 4. Institute of Seismology, China Seismological Bureau, Wuhan 430077, China 5. Institute of Survey and Mapping, Xi’an 710054, China 6. National Bureau of Survey and Mapping, Beijing 100830, China 7. Wuhan University, Wuhan 430077, China 8. Institute of Geodesy and Geophysics, Wuhan 430077, China 9. China Seismological Bureau, Beijing 100036, China | 2001 | Chinese Science Bulletin2001，46，18： | 34 |
| 2 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 3 | Hydrogen sulfide regulates abiotic stress tolerance and biotic stress resistance in Arabidopsis显示文摘Hydrogen sulfide(H_2S) is an important gaseous molecule in various plant developmental processes and plant stress responses.In this study,the transgenic Arabidopsis thaliana plants with modulated expressions of two cysteine desulfhydrases,and exogenous H_2S donor(sodium hydrosulfide,NaHS) and H_2S scavenger(hypotaurine,HT) pre-treated plants were used to dissect the involvement of H_2S in plant stress responses.The cysteine desulfhydrases overexpressing plants and NaHS pre-treated plants exhibited higher endogenous H_2S level and improved abiotic stress tolerance and biotic stress resistance,while cysteine desulfhydrases knockdown plants and HT pre-treated plants displayed lower endogenous H_2S level and decreased stress resistance.Moreover,H_2S upregulated the transcripts of multiple abiotic and biotic stress-related genes,and inhibited reactive oxygen species(ROS) accumulation.Interestingly,MIR393-mediated auxin signaling including MIR393a/b and their target genes(TIR1,AFB1,AFB2,and AFB3) was transcriptionally regulated by H_2S,and was related with H_2S-induced antibacterial resistance.Moreover,H_2S regulated 50 carbon metabolites including amino acids,organic acids,sugars,sugar alcohols,and aromatic amines.Taken together,these results indicated that cysteine desulfhydrase and H_2S conferred abiotic stress tolerance and biotic stress resistance,via affecting the stress-related gene expressions,ROS metabolism,metabolic homeostasis,and MIR393-targeted auxin receptors. | Haitao Shi Tiantian Ye Ning Han Hongwu Bian Xiaodong Liu Zhulong Chan | 2015 | Journal of Integrative Plant Biology2015，57，7： | 26 |
| 4 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 5 | Prevention of hepatocellular carcinoma in mice by IL-2 and B7-1 genes co-transfected liver cancer cell vaccines显示文摘AIM: To study the immunoprotective effect of liver cancer vaccine with co-transfected IL-2 and B7-1 genes on hepatocarcinogenesis in mice.METHODS: The murine liver cancer cell line Hepal-6 was transfected with IL-2 and/or B7-1 gene via recombinant adenoviral vectors and the liver cancer vaccines were prepared. C57BL/6 mice were immunized with these vaccines and challenged with the parental Hepal-6 cells afterwards.The immunoprotection was investigated and the reactive T cell line was assayed.RESULTS: The immunoprotection of the tumor vaccine was demonstrated. The effect of IL-2 and B7-1 genes cotransfected Hepal-6 liver cancer vaccine (Hep6-IL2/B7vaccine) on the onset of tumor formation was the strongest.When attacked with wild Hepal-6 cells, the median survival period of the mice immunized with Hep6-IL2/B7 vaccine was the longest (68 days, χ2=7.70-11.69, P<0.05) and the implanted tumor was the smallest (z =3.20-44.10, P<0.05).The effect of single IL-2 or B7-1 gene-transfected vaccine was next to the IL2/B7 gene co-transfected group, and the mean survival periods were 59 and 54 days, respectively.The mean survival periods of wild or enhanced green fluorescence protein gene modified vaccine immunized group were 51 and 48 days, respectively. The mice in control group all died within 38 days and the implanted tumor was the largest (z=3.20-40.21, P<0.05). The cellular immunofunction test and cytotoxicity study showed that the natural killer (NK) cell, lymphokine activated killer (LAK) cell and cytotoxic T lymphocyte (CTL) activities were significantly increased in mice immunized with the Hep6-IL2/B7 vaccine, (29.5±2.5%,65.0±2.9%, 83.1±1.5% respectively, compared with other groups, P<0.05).CONCLUSION: The Hep6-IL2/B7 liver cancer vaccines can induce the mice to produce activated and specific CTL against the parental tumor cells, and demonstrate stronger effect on the hepatocarcinogenesis than single gene modified or the regular tumor vaccine. Therefore, the vaccines may become a novel potential therapy for recurrence and metastasis of HCC. | Ning-Ling Ge Sheng-Long Ye Ning Zheng Rui-Xia Sun Yin-Kun Liu Zhao-You Tang, Liver Cancer Institute of Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China | 2003 | World Journal of Gastroenterology2003，9，10： | 19 |
| 6 | Effects of cryopreservation and phenylacetate on biological characters of adherent LAK cells from patients with hepatocellular carcinoma显示文摘AIM: To improve the preparation of adherent lymphokine-activated killer (A-LAK) cells and to study the effects ofcryopreservation and phenylacetate (PA) on biologicalcharacters of A-LAK cells.METHODS: A-LAK cells were obtained from peripheral bloodmononuclear cells (PBMCs) of the patients withhepatocellular caminoma (HCC) by using L-phenylalaninemethyl ester ( PME ) to deplete immunosuppressivermonocytes. Proliferative activity of SMMC7721 cell line aftertreatment with phenylacetate (PA) was observed. A-LAKcells were treated with the supernatant of SMMC7721 cellsthat had been pretreated with PA. The changes ofproliferation, cytotoxicity and phenotype of A-LAK cellswere investigated after cryopreservstion.RESULTS: The expansion of A-LAK cells (96.79± 69.10 foldson Day 14 ) was significantly higher then that of non-adherent LAK (NA-LAK) cells (22.77 ± 13.20) as well asconventional LAK cells (4. 64 ± 0. 91 ). PA significantlysuppressed the growth of SMMC7721 cells, and the inhibitorratio was 46 %. rite supernatant of cultured tumor cellsintensively suppressed the proliferation and cytotoxicity ofA-LAK cells, but the suppressive effect of the supernatantwas previously decreased after treatment with PA.Impairments in proliferation and cytotoxicity of A-LAK cellsimmediately after thawing of cryopreservation and recoveryafter reincubation with IL-2 were observed. The cytotoxicltyof thawed A-LAK cells on Day 5 was significantly higher thanthat of fresh A-LAK before freezing (54.8 ± 10.2 % vs 40.5 ±6. 4 %). No significant change in the percentage oflymphocyte subsets was identified in frozen A-LAK cells ascompared with that in the fresh control cells.CONCLUSION: A-LAK cells can he simply prepared by usingPME, and showed a synergistic anti-tumor effect with thecombination of PA. Cryopreseration can increase theimmunoactivities of A-LAK cells from the patients withhepatocellular caminoma . | Ning Zheng Sheng-Long Ye Rui-Xia Sun Yan Zhao Zhao-You Tang,Liver Cancer Institute and Zhongshan Hospital,Fudan University,Shanghai 200032,China | 2002 | World Journal of Gastroenterology2002，8，2： | 16 |
| 7 | Generation of male germ cells from induced pluripotent stem cells (iPS cells): an in vitro and in vivo study显示文摘最近的研究报导了从老鼠和人的房间能区分进初发的细菌房间的那导致的 pluripotent 茎(iPS ) 。然而, iPS 房间是否能够生产男细菌房间,不被知道。这研究的目的进 spermatogonial 干细胞和迟了阶段的男细菌房间的老鼠 iPS 房间是调查区别潜在的。我们使用了在 vitro 区别并且在 vivo 移植联合的一条途径。胚胎植物或动物身体(EB ) 用白血球过多症禁止者因素(LIF ) 从 iPS 房间被获得免费媒介。量的 PCR 表明在 Oct4 表示的减少和 Stra8 的增加和在 EB 的 Vasa mRNA 源于 iPS 房间。iPS 导出房间的 EB 被区分进 spermatogonial 干细胞(SSC ) ,,的酸由他们 VASA,以及 CDH1 和 GFRα 的表示证实了的 retinoic 导致; 1,它是 SSC 的标记。而且,从 iPS 房间导出的这些细菌房间被移植进与 busulfan 被预先对待的老鼠的接受者睾丸。尤其是, iPS 导出房间的 SSC 能区分进从 spermatogonia 到圆 spermatids,由 VASA 和 SCP3 表示出现的男细菌房间。这研究证明 iPS 房间有潜力区分进迟了阶段的男细菌房间。从 iPS 房间的男细菌房间的推导在男不孕的处理有潜在的应用程序并且为揭开提供一个模型位于男细菌房间开发下面的分子的机制。 | Yong Zhu Hong-Liang Hu Peng Li Shi Yang Wei Zhang Hui Ding Ru-Hui Tian Ye Ning Ling-Ling Zhang Xi-Zhi Guo Zhan-Ping Shi Zheng Li Zuping He | 2012 | Asian Journal of Andrology2012，14，4： | 13 |
| 8 | Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects显示文摘VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects,as well as the effect of food on the pharmacokinetics and safety of VV116.Three studies were launched sequentially:Study 1(single ascending-dose study,SAD),Study 2(multiple ascending-dose study,MAD),and Study 3(food-effect study,FE).A total of 86 healthy subjects were enrolled in the studies.VV116 tablets or placebo were administered per protocol requirements.Blood samples were collected at the scheduled time points for pharmacokinetic analysis.116-N1,the metabolite of VV116,was detected in plasma and calculated for the PK parameters.In SAD,AUC and Cmax increased in an approximately dose-proportional manner in the dose range of 25–800 mg.T_(1/2)was within 4.80–6.95 h.In MAD,the accumulation ratio for Cmax and AUC indicated a slight accumulation upon repeated dosing of VV116.In FE,the standard meal had no effect on Cmax and AUC of VV116.No serious adverse event occurred in the studies,and no subject withdrew from the studies due to adverse events.Thus,VV116 exhibited satisfactory safety and tolerability in healthy subjects,which supports the continued investigation of VV116 in patients with COVID-19. | Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu | 2022 | Acta Pharmacologica Sinica2022，43，12： | 13 |
| 9 | Estimation of the Effects of Maize Straw Return on Soil Carbon and Nutrients Using Response Surface Methodology显示文摘Straw incorporation is generally considered an effective agricultural management practice that improves nutrient cycling and maintains soil fertility. To study the interactive effects of straw returning factors on soil organic carbon and available nutrients, a17-month(May 6, 2016 to October 6, 2017) experiment was conducted on straw incorporation by using response surface methodology under a three-factor(straw length, amount, and burying depth), five-level quadratic orthogonal rotation experimental design. Weight was assigned to each indicator for soil carbon and nutrients and then a comprehensive indicator was established. Then, a second-order polynomial model of the three straw returning factors was established using response surface methodology. Results indicated that17 months after straw incorporation, straw amount and burying depth had significant effects on the comprehensive indicator of soil carbon and nutrients. Straw length and the interactions of straw amount and burying depth showed no significant effects on the comprehensive indicator of soil carbon and nutrients. It was concluded that 17 months after straw incorporation, the highest value of the comprehensive indicator of soil carbon and nutrients was achieved when the straw length, amount, and burying depth were approximately 17–20 cm, 740–840 g m^(-2), and 9–13 cm, respectively, which can be recommended as the most suitable parameters for use in straw returning in the study area. | ZHOU Dongxing SU Ye NING Yucui RONG Guohua WANG Guangdong LIU Di LIU Liyan | 2018 | Pedosphere2018，28，3： | 12 |
| 10 | Giant submucosal lipoma located in the descending colon: A case report and review of the literature显示文摘Colonic lipoma is an uncommon tumor of the gastrointestinal tract.Most cases are asymptomatic,with a small tumor size,and do not need any special treatment.However,we encountered one patient with a giant submucosal lipoma,with a maximum diameter of 8.5 cm,which exhibited symptoms such as intermittent lower abdominal pain,changes in bowel habits with passage of fresh blood and mucus per rectum,abdominal distension,anorexia and weight loss.Unfortunately,the possibility of colonic malignancy could not be precluded and left hemicolectomy was planned.The exact diagnosis of this special case was accomplished by intraoperative pathology.In the end,local resection was performed instead of left hemicolectomy.To the best of our knowledge,colonic lipoma exceeding 8 cm in diameter has not been previously reported.We,therefore,present this case and discuss age and sex factors,clinical and histopathological findings,diagnostic methods and treatment by reviewing the available literature,to serve as a reminder that colonic lipoma can also exist in patients with significant symptoms.In addition,intraoperative pathology should be investigated in those doubtful cases,so as to guide the exact diagnosis and treatment plan. | Li Jiang Li-Sheng Jiang Fu-Yu Li Hui Ye Ning Li Nan-Sheng Cheng Yong Zhou | 2007 | World Journal of Gastroenterology2007，13，42： | 11 |
| 11 | Mitosin/CENP-F is a conserved kinetochore protein subjected to cyto plasmic dynein-mediated poleward transport显示文摘Mitosin/CENP-F is a human nuclear protein transiently associated with the outer kinetochore plate in M phase and is involved in M phase progression. LEK1 and CMF1, which are its murine and chicken orthologs, however, are implicated in muscle differentiation and reportedly not distributed at kinetochores.We therefore conducted several assays to clarify this issue. The typical centromere staining patterns were observed in mitotic cells from both human primary culture and murine, canine, and mink cell lines. A C-terminal portion of LEK1 also conferred centromere localization. Our analysis further suggests conserved kinetochore localization of mammalian mitosin orthologs. Moreover, mitosin was associated preferentially with kinetochores of unaligned chromosomes. It was also constantly transported from kinetochores to spindle poles by cytoplasmic dynein. These properties resemble those of other kinetochore proteins important for the spindle checkpoint, thus implying a role of mitosin in this checkpoint. Therefore, mitosin family may serve as multifunctional proteins involved in both mitosis and differentiation. | ZHEN YE YANG, JING GUO, NING LI, MIN QIAN, SHENG NIAN WANG, XUE LIANG ZHULaboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China | 2003 | Cell Research2003，13，4： | 11 |
| 12 | Circulating DNA level is negatively associated with the long-term survival of hepatocellular carcinoma patients显示文摘瞄准:确定在从有肝细胞癌(HCC ) 并且到的病人的血浆的传播 DNA 评估它的预示的价值。方法:血样品在操作,有肝肝硬化的 20 个病人,和 20 个健康志愿者前与 HCC 从 79 个病人被收集。传播 DNA 从血浆被提取并且确定。在传播 DNA 水平和 HCC 病人的预后之间的协会被评估。结果:与健康志愿者相比(17.6 +/- 9.5 ng/mL ) ,重要更高的传播 DNA 水平与 HCC 在病人被发现(47.1 +/- 43.7 ng/mL, P = 0.000 ) 或与肝肝硬化(30.0 +/- 13.3 ng/mL, P = 0.002 ) 。传播 DNA 水平仔细与肿瘤尺寸被联系(P = 0.008 ) 并且 TNM 舞台(P = 0.040 ) ,否定地与 3 年的没有疾病的幸存(DFS ) 联系了(P = 0.017 ) 并且全面幸存(OS )(P = 0.001 ) 。结论:大或侵略的肿瘤可以释放更多的传播 DNA,并且传播 DNA 的高水平可以与 HCC 病人的差的预后被联系。 | Ning Ren Qing-Hai Ye Lun-Xiu Qin Bo-Heng Zhang Yin-Kun Liu Zhao-YouTang | 2006 | World Journal of Gastroenterology2006，12，24： | 10 |
| 13 | Kinetics of Hydrogen Absorption in Hydrogen Storage Alloy显示文摘Hydrogenation kinetics of MLNi3.8(Co,Mn,Al)1.2 and MLNi3.7(Co,Mn,Al)1.2Cu0.1 alloy in α + β phase at the temperatUre range of 30 ~70 ℃ has been studied. The kinetic mechanism of hydrogen absorption is not affected by initial hydrogen pressure. Temperature does not influence the rate of hydrogen absorption obviously. In the prior and later period of hydrogen absorption the rate-controlling step is chemical reaction and hydrogen diffusion in the hydride phase respectively for MLNi3.8(Co,Mn,Al)1.2 alloy. Adding Cu, the rate-controlling step changes from chemical reaction to the nucleation and growth of β phase in the prior period and the process of hydrogen absorption still controlled by diffusion in the later period. | LIN Qin CHEN Ning YE Wen LIU Renmin(Applied Science School, USTB, Beijing 100083, China) (General Research Institute of Non-Ferrous Metals Beijing, 100088) | 1997 | International Journal of Minerals,Metallurgy and Materials1997，11，2： | 10 |
| 14 | Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats显示文摘超载锻练(OE ) 通过导致 autophagy 和 apoptosis 引起心肌的损害。在这研究,我们检验了 autophagy 禁止者 3-methyladenine (3 麻省) 是否能减轻导致 OE 的心脏的损害。老鼠与 3 麻省被注射(15 mg/kg, iv ) 或在前盐使遭到了到 OE 的各种各样的紧张包括没有游泳(控制) , 2 h 游泳(温和紧张的锻练, MIE ) ,有 2.5% 身体重量超载的 2 h 游泳(中等 OE;MOE ) , 5% 超载(集中的 OE;IOE ) 或 2.5% 过载直到用尽(彻底的 OE;EOE ) 。在 OE 以后,心被收获为词法并且 biochemiacal 分析。心脏的形态学, autophagosomes 和 apoptosis 与 H&E 染色,传播电子显微镜学和 TUNEL 分析被检验分别地。Autophagy 相关的蛋白质到(LC3-II/I 和 Beclin-1 ) 并且 apoptosis 相关的蛋白质(Bcl-2/Bax ) 用西方的弄污被估计。我们的结果证明与控制相比, MIE 没改变展出了未经触动的心肌的纤维并且干净地安排了 cardiomyocytes 的心纸巾的词法结构。然而, IOE 导致了 cardiomyocytes 的不规则的安排并且显著地增加了 cardiomyocytes 的宽度,而 EOE 引起了更肿、平的破坏 cardiomyocytes。与增加的 OE 紧张同时(MOE, IOE, EOE ) , cardiomyocyte autophagy 和 apoptosis 变得越来越突出,象增加的 apoptotic 房间和减少的 Bcl-2/Bax 比率一样由 autophagosomes 的增加的数字和 LC3-II/I 和 Beclin-1 的表示层次证实了。3 麻省管理显著地在 MOE, IOE 和 EOE 老鼠稀释了 cardiomyocytes 以及所有 autophagy 相关、 apoptosis 相关的畸形的导致 OE 的词法变化。因此, autophagy 禁止者 3 麻省能在老鼠减轻导致 OE 的心损害。 | Hua LIU Hui LEI Yue SHI Jin-ju WANG Ning CHEN Zhang-hua LI Yan-fang CHEN Qi-fa YE Yi YANG | 2017 | Acta Pharmacologica Sinica2017，38，7： | 10 |
| 15 | Influence of aquatic plants on the hydrogen isotope composition of sedimentary long-chain n-alkanes in the Lake Qinghai region, Qinghai-Tibet Plateau显示文摘The hydrogen isotopic composition(δD) of leaf wax long-chain n-alkanes(C27, C29, and C31) from lacustrine sediments has been widely applied to reconstruct terrestrial paleoclimatic and paleohydrological changes. However, few studies have addressed whether the aquatic-derived n-alkanes can affect the δD values of lake sedimentary long-chain n-alkanes, which are usually regarded as a recorder of the terrestrial hydrological signals. Here we systematically investigated δD values of long-chain n-alkanes from modern aquatic plants, both near-shore and off-shore surface sediments, surrounding terrestrial plant litters, as well as river water and lake water in Lake Qinghai and its satellite lakes on the northeastern Qinghai-Tibet Plateau. Our data showed that(i) δD values of long-chain n-alkanes from aquatic plants varied from-184‰ to-132‰ for n-C27, from-183‰ to-138‰ for n-C29, and from-189‰ to-130‰ for n-C31, respectively, with no significant differences among the three n-alkanes homologues;(ii) δD values of long-chain n-alkanes from aquatic plants were generally more positive than those from surrounding terrestrial plants, possibly because that they recorded the D-enrichment of lake water in this semi-arid region;(iii) δD values of long-chain n-alkanes from surface sediments showed significant differences among the three n-alkanes homologues, due to the larger aquatic input of n-C27 to the sedimentary lipid pool than that of n-C31, and(iv) n-C27 δD values of near-shore aquatic plants and near-shore sediments are more negative than those from off-shore as a result of lower δD values of near-shore lake water. Our findings indicate that in this region(i) the offset between sedimentary n-C27 and n-C31 δD values(ΔδDC27-C31) could potentially be used to evaluate if sedimentary long-chain n-alkanes are derived from a single source;(ii) while δD values of n-C27 may be influenced by lake water hydrological changes, sedimentary n-C31 is derived predominantly from terrestrial plants and thus its δD can serve as a relatively reliable indicator for terrestrial paleoclimatic and paleohydrological reconstructions. | LIU Wei Guo YANG Hong WANG Huan Ye YAO Yuan WANG Zheng CAO Yun Ning | 2016 | Science China Earth Sciences2016，59，7： | 10 |
| 16 | Activation of p38 mitogen-activated protein kinase contribute to BMP4-induced alkaline phosphatase expression in MC3T3-E1 preosteoblast显示文摘 | YUAN Ye Wu Zhi-jun YAO Hui-yu YU Xiao-dan GUO Zi-kuan CHEN Xiao-san TANG Pei-xian MAO Ning | 2006 | Chinese Medical Journal2006，，4： | 9 |
| 17 | Plate/shell topological optimization subjected to linear buckling constraints by adopting composite exponential filtering function显示文摘In this paper, a model of topology optimization with linear buckling constraints is established based on an independent and continuous mapping method to minimize the plate/shell structure weight. A composite exponential function(CEF) is selected as filtering functions for element weight, the element stiffness matrix and the element geometric stiffness matrix, which recognize the design variables, and to implement the changing process of design variables from'discrete' to 'continuous' and back to 'discrete'. The buckling constraints are approximated as explicit formulations based on the Taylor expansion and the filtering function. The optimization model is transformed to dual programming and solved by the dual sequence quadratic programming algorithm. Finally, three numerical examples with power function and CEF as filter function are analyzed and discussed to demonstrate the feasibility and efficiency of the proposed method. | Hong-Ling Ye Wei-Wei Wang Ning Chen Yun-Kang Sui | 2016 | Acta Mechanica Sinica2016，32，4： | 9 |
| 18 | Effect of a Traditional Chinese Medicine combined therapy on adolescent idiopathic scoliosis:a randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness of a combined Traditional Chinese Medicine(TCM) therapy versus conventional treatment on adolescent idiopathic scoliosis.METHODS:One hundred twenty outpatients with mild and moderate adolescent idiopathic scoliosis were randomly divided into a TCM group(TCMG)and a brace group(CG).TCMG patients underwent Daoyin,Tuina,and acupotomology therapies.CG patients were treated with a Milwaukee brace.Each patient's Cobb angle was measured after 12 and 24 months of treatment,and pulmonary function was determined after 12 months of treatment.Average electromyogram(AEMG) ratio of the surface electromyogram was measured after 6 and 12 months of treatment and followed-up after 18 and 24 months.RESULTS:The Cobb angle significantly decreased in both groups after 12 months of treatment compared with before treatment(P< 0.05).The percentages of original Cobb angle in TCMG and CG were51.4%and 47.8%(P > 0.05) after 12 months and62.5%and 34.7%(P < 0.05) after 24 months,respectively.Pulmonary function significantly improved after 12 months in TCMG(P < 0.05) but significantly decreased in CG(P < 0.05).The AEMG ratio was significantly lower(P < 0.01) and tended to remain at1 after stopping treatment in TCMG,but increased in CG(P<0.05).CONCLUSION:TCM combined therapy can prevent the progression of scoliosis.The AEMG ratio is a promising index that could replace radiography in the evaluation of treatment effect and progression in scoliosis. | Wei Hui Xu Jinyuan Jiang Zhong Ye Shuliang Song Hongquan Ning Xitao Huang Huanmin Chen Wei Pei Jianwei Jiang Nengyi Chen Shao Du Honggen | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 9 |
| 19 | Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice显示文摘Metabolic syndrome is a clustering of metabolic disorder with unclear molecular mechanism.Increasing studies have found that the pathogenesis and progression of metabolic syndrome are closely related to inflammation.Here,we report celastrol,a traditional Chinese medicine,can improve high fat diet-induced metabolic syndrome through suppressing resistin-induced inflammation.Mechanistically,celastrol binds to adenylyl cyclase associated protein 1(CAP1)and inhibits the interaction between CAP1 and resistin,which restrains the cyclic adenylate monophosphate(cAMP)-protein kinase A(PKA)-nuclear factor kappa-B(NF-kB)signaling pathway and ameliorates high fat diet-induced murine metabolic syndrome.Knockdown of CAP1 in macrophages abrogated the resistin-mediated inflammatory activity.In contrast,overexpression of CAP1 in macrophages aggravated inflammation.Taken together,our study identifies celastrol,which directly targets CAP1 in macrophages,might be a promising drug candidate for the treatment of inflammatory metabolic diseases,such as metabolic syndrome. | Yuyu Zhu Ning Wan Xinni Shan Guoliang Deng Qiang Xu Hui Ye Yang Sun | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 9 |
| 20 | Dishevelled interacts with p65 and acts as a repressor of NF-KB-mediated transcription显示文摘 | Ning Deng Yanger Ye Wei Wang Lin Li | 2010 | Cell Research2010，20，10： | 7 |
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