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| 1 | Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants显示文摘As shown in our previous study, two alternatively spliced androgen receptor(AR) variants, which are exclusively expressed in the granulosa cells of patients with polycystic ovary syndrome, exhibit retarded nuclear translocation compared with wild-type AR. However, researchers have not yet determined whether these abnormalities correlate with heat shock protein 90(HSP90)and importin α(the former is a generally accepted co-chaperone of AR, and the latter is a component of classical nuclear import complexes). Here, these two variants were mainly retained in cytoplasm with HSP90 and importin α in the presence of dihydrotestosterone(DHT), and their levels in nucleus were significantly reduced, according to the immunofluorescence staining. The binding affinity of two AR variants for importin α was consistently decreased, while it was increased in WT-AR following DHT stimulation, leading to reduced nuclear import, particularly for the insertion-AR(Ins-AR). However, the binding affinities of two AR variants for HSP90 were increased in the absence of DHT compared with WT-AR, which functioned to maintain spatial structural stability, particularly for the deletion-AR(Del-AR). Therefore, the retarded nuclear translocation of two AR variants is associated with HSP90 and importin α, and the abnormal binding affinities for them play critical roles in this process. | Ye Liu Yinyu Wang Fangfang Wang Jiexue Pan Jingjing Xu Jingyi Li Chengliang Zhou Guolian Ding Yanting Wu Xinmei Liu Jianzhong Sheng Hefeng Huang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 2 | On a homogeneous algorithm for the monotone complementarity problem显示文摘 | Erling D Andersen Yinyu Ye | 1999 | Math Prog1999，84，： | 2 |
| 3 | A novel molecular distance edge vector as applied to chemical modeling of quantitative structure-retention relationships:Various gas chromatographic retention behaviors of polychlorinated dibenzofurans on different polarity-varying stationary phases显示文摘Based on the identical group as a pseudo atom instead of a typical atom, a novel modified molecular dis-tance-edge (MDE) vector μ was developed in our laboratory to characterize chemical structure of polychlorinated diben-zofurans (PCDFs) congeners and/or isomers. Quantitative structure-retention relationships (QSRRs) between the new VMDE parameters and gas chromatographic (GC) retention behavior of PCDFs were then generated by multiple linear regression (MLR) method for non-polar, moderately polar, and polar stationary phases. Four excellent models with high correlation coefficients, R=0.984-0.995, were proposed for non-polar columns (DB-5, SE-54, OV-101). For the moder-ately polar columns (OV-1701), the correlation coefficient of the developed good model is only 0.958. For the polar col-umns (SP-2300), the QSRR model is poor with R=0.884. Then cross validation with leave-one out of procedure (CV) is performed in high correlation with the non-polar (Rcv=992-0.974) and weakly polar (Rcv=921) columns and in little cor-relation (Rcv=0.834) with the polar columns. These results show that the new μ vector is suitable for describing the re-tention behaviors of PCDFs on non-polar and moderately polar stationary phases and not for the various gas chroma-tographic retention behaviors of PCDFs on the different po-larity-varying stationary phases. | DENG Hong HUANG Ping HU Yinyu YE Nancy LI Zhiliang | 2005 | Chinese Science Bulletin2005，50，16： | 2 |
| 4 | An O(n 3 L) potential reduction algorithm for linear programming显示文摘 | Yinyu Ye | 1991 | Mathematical Programming (-)1991，，1： | 1 |
| 5 | Convergence behavior of interior-point algorithms显示文摘 | Osman Güler Yinyu Ye | 1993 | Mathematical Programming (-)1993，，1： | 1 |
| 6 | Newsvendor opti mization with limited distribution information显示文摘 | Zhu Zhisu Zhang Jiawei Ye Yinyu | 2013 | Op- timization Methods and Software2013，28，3： | 1 |
| 7 | Theory of Semidefite Programming for Sensor Network Localization 显示文摘 | Man-Cho So A Ye Yinyu | 2007 | Math Program2007，109，： | 1 |
| 8 | Improved combinatorial approximation algorithms for the k-level facility location problem显示文摘 | Ageev A Ye Yinyu Zhang Jiawei | 2004 | SIAM Journal on Discrete Mathematics2004，18，1： | 1 |
| 9 | An O(√nL)-Iteration Homogenous and Self-dual Linear Programming Algorithm 显示文摘 | YE Yinyu Todd M J Mizuno S | 1994 | Math Oper Res1994，19，1： | 1 |
| 10 | An O(n 3 L) potential reduction algorithm for linear programming显示文摘 | Yinyu Ye | 1991 | Mathematical Programming (-)1991，，1： | 1 |
| 11 | Approximation algorithms for metric facility location problems显示文摘 | Mahdian M Ye Yinyu Zhang Jiawei | 2006 | SIAM Journal on Computing2006，36，2： | 1 |
| 12 | Blind Channel Equalization and e-Approximation Algorithms 显示文摘 | Qingyu Li Er-Wei Bai Yinyu Ye | 2001 | IEEE Trans Signal Processing2001，49，11： | 1 |
| 13 | Solving large-scale sparse semidefinite programs for combina- torial optimization显示文摘 | Benson Steven J Ye Yinyu Zhang Xiong | 1998 | SIAM Journal on Optimiza- tion1998，10，1： | 1 |
| 14 | Blind Channel Equalization and - approximation Algorithms 显示文摘 | Li Qingyu Bai Erwei Ye Yinyu | 2001 | IEEE Trans on Signal Processing2001，49，11： | 1 |
| 15 | On affine scaling algorithms for nonconvex quadratic programming显示文摘 | Yinyu Ye | 1992 | Mathematical Programming (-)1992，，1： | 1 |
| 16 | DSDP5:Software for semidefinite programming显示文摘 | Steven J Benson Yinyu Ye | | ACM Transactions on Mathematical Software0，，： | 1 |
| 17 | Likelihood ro- bust optimization for data-driven problems 显示文摘 | Wang Zizhou Glynn P W Ye Yinyu | 2016 | Com- putational Management Science2016，13，2： | 1 |
| 18 | Convergence behavior of interior-point algorithms显示文摘 | Osman Güler Yinyu Ye | 1993 | Mathematical Programming (-)1993，，1： | 1 |
| 19 | On affine scaling algorithms for nonconvex quadratic programming 显示文摘 | Yinyu Ye | 1992 | Math Prog1992，56，： | 1 |
| 20 | Approximation of Dense-n/2-Subgraph and the Complement of Min-Bisection显示文摘 | Yinyu Ye Jiawei Zhang | 2003 | Journal of Global Optimization2003，，1： | 1 |
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