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| 1 | Association of Dietary Pattern during Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study in Northern China显示文摘Objective To examine the association of maternal dietary patterns during pregnancy with gestational diabetes mellitus(GDM) in northern China.Methods The dietary intakes of pregnant women were recorded twice by 24‐hour dietary recalls for three days prior to having been diagnosed with GDM, at 5‐15 and 24‐28 gestational weeks, respectively.GDM was diagnosed, and serum glycosylated hemoglobin(HbA1c) was measured at 24‐28 weeks.Dietary patterns were assessed by factor analysis. The association of the dietary pattern with GDM and HbA1c was examined by multiple logistic models.Results Of 753 participants, 64(8.5%) were diagnosed with GDM. Four dietary patterns were identified: Western pattern(dairy, baked/fried food and white meat), traditional pattern(light‐colored vegetables, fine grain, red meat and tubers), mixed pattern(edible fungi, shrimp/shellfish and red meat)and prudent pattern(dark‐colored vegetables and deep‐sea fish). Compared with the prudent pattern,both the Western pattern and the traditional pattern were associated with an increased risk of GDM(a OR = 4.40, 95% CI: 1.58‐12.22; a OR = 4.88, 95% CI: 1.79‐13.32) and a high level of HbA1c(a OR = 12.37,95% CI: 1.47‐103.91; a OR = 26.23, 95% CI: 2.54‐270.74). Compared to the lowest quartile(Q), Q3 of the Western pattern scores and Q3‐Q4 of the traditional pattern scores were associated with a higher risk of GDM.Conclusion The consumption of the Western pattern or the traditional pattern during pregnancy may increase the risk of GDM. | DU Hong Yi JIANG Hong O Karmin CHEN Bo XU Lin Ji LIU Shu Ping YI Jian Ping HE Geng Sheng QIAN Xu | 2017 | Biomedical and Environmental Sciences2017，30，12： | 16 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 4 | Antioxidant Activity of Grape Extracts in a Lecithin Liposome System显示文摘 | Yi O S Meyer A S Frankel E N | 1997 | JAOCS1997，74，10： | 1 |
| 5 | External and endoscopic dacryocystorhinostomy in chronic dacryocystitis:comparison of results显示文摘 | Yi(g)it O Samancioglu M Taskin U | 2007 | Eur Arch Otorhinolaryngol2007，264，8： | 1 |
| 6 | The oneofetal protein lMP3:a novel biomarker for endometrial serous carcinoma显示文摘 | Zheng W Yi X Fadare O | 2007 | Am J Surg Pathol2007，，： | 1 |
| 7 | The effect of bicanalicular silicone tube implantation on the success rate of endoscopic dacryocystorhinostomy显示文摘 | Yi(g)it O Uzun H Han T | 2005 | Kulak Burun Bogaz Ihtis Derg2005，14，34： | 1 |
| 8 | Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs显示文摘 | Yi R O'Carroll D Pasolli HA | 2006 | Nature Genet2006，38，3： | 1 |
| 9 | The oncofetal protein IMP3:a novel biomarker for endometrial serous carcinoma显示文摘 | Zheng W Yi X Fadare O | 2008 | Am J Surg Pathol2008，32，2： | 1 |
| 10 | The oncofetal protein IMP3:a novel biomarker for endometrial serous carcinoma显示文摘 | Zheng W Yi X Fadare O | | 0，，02： | 1 |
| 11 | Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs显示文摘 | Yi R O’Carroll D Pasolli HA | 2006 | Nat Genet2006，38，35： | 1 |
| 12 | Expression of vascular endothelial growth factor (VEGF) and its receptors during embryonic implantation in the golden hamster (Mesocricetus auratus)显示文摘 | X. J. Yi H. Y. Jiang K. K. H. Lee W. S. O P. L. Tang P. H. Chow | 1999 | Cell & Tissue Research1999，，2： | 1 |
| 13 | The influence of SrSO4 on the tribological properties of NiCr-Al2O3 cermet at ele- vated temperatures 显示文摘 | Liu F Yi O W Wang W Z | 2014 | Ceramics International2014，40，2： | 1 |
| 14 | A renewable lignin-lactide copolymer and application in biobased compo- sites显示文摘 | Yi Linchung Johan V O Russell J L | 2013 | Sustainable Chemistry Engineering2013，1，10： | 1 |
| 15 | A Dynamic Logistics Coordination Model for Evacuation and Support in Disaster Response Activities显示文摘 | Wei Yi Linet O Zdamar | 2007 | European Journal of Operational Research2007，179，3： | 1 |
| 16 | Techincal and oncologic safety of robotic thyroid surgery显示文摘 | Yi O Yoon J H Lee | 2013 | Ann Surg Oncol2013，20，： | 1 |
| 17 | IL-10 is required for human CD4+ CD25+ regulatory T cell-mediated suppression of xenogeneie prolif- eration显示文摘 | Sun L Yi S O'Connell PJ | 2010 | Immunol Cell Biol2010，88，4： | 1 |
| 18 | Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands显示文摘 | Heather M. O’Hagan Wei Wang Subhojit Sen Christina DeStefano Shields Stella S. Lee Yang W. Zhang Eriko G. Clements Yi Cai Leander Van Neste Hariharan Easwaran Robert A. Casero Cynthia L. Sears Stephen B. Baylin | 2011 | Cancer Cell2011，，5： | 1 |
| 19 | Exercise pro- tects against high-fat diet-induced hypothalamie inflammation 显示文摘 | YI C X AL-MASSADI O DONELAN E | 2012 | Physiol Behav2012，106，4： | 1 |
| 20 | Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3 显示文摘 | Seal R P Akil O Yi E | 2008 | Neuron2008，57，2： | 1 |
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