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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Binding interaction of gatifloxacin with bovine serum albumin显示文摘 | Guo M Zou J W Yi G | 2004 | Anal Lett2004，20，： | 1 |
| 3 | Preliminary results of a phase Ⅰ/ Ⅱ study of simultaneous modulated accelerated radiotherapy for nondisseminated nasophar yngeal carcinoma显示文摘 | Lee S W Back G M Yi B Y | 2006 | Int J Radiat Oncol Biol Phys2006，65，1： | 1 |
| 4 | Coherent integration for ma- neuvering target detection based on Radon-Lv' s distribution 显示文摘 | Li X L Cui G L Yi W | 2015 | IEEE Signal Processing2015，22，9： | 1 |
| 5 | Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis显示文摘 | Yi W Fischer J Krewer G | 2005 | Agricult Food Chem2005，53，18： | 1 |
| 6 | Response of ammonia oxidizing microbes to the stresses of arsenic and copper in two acidic alfisols显示文摘 | Subrahmanyam G Hu YI W Zheng Y M | 2014 | Applied Soil Ecology2014，77，： | 1 |
| 7 | Effects of RE-A1 additions andaustenitising time on structural variations of medium carbon Fe-Bcast alloy 显示文摘 | Yi D W Xing D J Fu H G | 2010 | Materials Science and Technology2010，26，7： | 1 |
| 8 | ZnO nanoneedles grown vertically on Si substrates by non-catalytic vapor-phase epitaxy显示文摘 | PARK W I YI G C KIM M | 2002 | Advanced Materials2002，14，24： | 1 |
| 9 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 10 | ZnO Nanorods:Synthesis,Characterization and Applications显示文摘 | Yi G Wang C Park W | 2005 | Semiconductor Science and Technology2005，20，4： | 1 |
| 11 | Preliminary results of a phase / study of simultaneous modulated accelerated radiotherapy for non-disseminated nasopharyngeal carcinoma显示文摘 | Lee S W Bark G M Yi B Y | 2006 | Int J Radiat Oncol Biol Phys2006，65，1： | 1 |
| 12 | Stigma development and receptiv- ity in almond ( Prunus dulcis) 显示文摘 | Yi W G Law S E Mccoy D | 2006 | Annals of Botany2006，97，1： | 1 |
| 13 | The effects of the concentration of individual reactants on Fe-Ni-P-B nanoparticles fabricated by chemical reduction显示文摘 | Yi G Zhang B W | 2001 | Journal of Materials Proce ss Technology2001，117，12： | 1 |
| 14 | Suppression of cancer growth in mice by adeno-associated virns vector-mediated IFN-β expression driven by hTERT promoter显示文摘 | Ling F H Yi G W Tian X | 2009 | Volume2009，286，228： | 1 |
| 15 | Priori-ty- Based Traffic Scheduling and Utility Optimization for Cognitive Radio Communication Infrastructure-Based Smart Grid 显示文摘 | JING F H HONG G W YI Q A | 2013 | IEEE Transactions on Smart Grid2013，4，1： | 1 |
| 16 | The mathematical description of uniformity and related theorems显示文摘 | LUO C W YI C D WANG G | 2009 | Chaos Solitons andFractals2009，42，： | 1 |
| 17 | Modeling and experimental studies on absorption of CO2 by Benfield solution in rotating packed bed显示文摘 | Yi F Zou H K Chu G W | 2009 | Chemical Engineering Journal2009，145，3： | 1 |
| 18 | 显示文摘 | Park W I Yoo J K Yi G C | 2005 | J Korean Phys Soc2005，46，5： | 1 |
| 19 | Stigma development and receptivity in amond (Prunus dulcis)显示文摘 | Yi W G Law S E Mc Coy D | 2006 | Annals of Botany2006，97，1： | 1 |
| 20 | Electroluminescence in n-ZnO nanorod arrays vertically grown on p-GaN显示文摘 | Park W I Yi G C | 2004 | Adv Mater2004，16，1： | 1 |
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