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| 1 | Acute development of collateral circulation and therapeutic prospects in ischemic stroke显示文摘In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic transformation.We have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is achieved.Contrary to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact arteries.We believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein. | Eri Iwasawa Masahiko Ichijo Satoru Ishibashi Takanori Yokota | 2016 | Neural Regeneration Research2016，11，3： | 19 |
| 2 | 一种从XML数据中发现关系信息的方法显示文摘提出了一种发现蕴藏在不同XML文档嵌套结构中的关系信息及其出现模式的新方法.可根据用户兴趣,发现描述不同实体之间联系的关系信息,抽取关系实例及其在文档中的出现模式.具体解决方案是:首先识别和收集包含用户感兴趣的实体的XML文档片段:然后根据文档片段标签的语义和文档片段的结构计算文档片段的相似度,并采用自适应阈值方法按相似度聚类文档片段.使得包含同一种关系的文档片段聚集在同一个片段簇:最后从XML文档片段簇中抽取关系实例及其出现模式.实验结果表明,对于包含有意义标签的各种XML文档,该方法能够准确地识别和抽取出描述指定实体之间联系的各种关系信息. | 吴扬扬 雷庆 陈锻生 YOKOTA Harou | 2008 | 软件学报2008，19，6： | 10 |
| 3 | Preparation and Application of Ultra Fine Particles显示文摘UFPs are formed using gas evaporation methods. In the gas evaporation methods, configuration of UFPs are controlled to form chain-like shape, complex, and isolated UFP. UFP films can be formed through the gas deposition method, where formed UFPs are ejected out of a nozzle and deposited on a substrate, forming | M.Oda K.Setoguchi E.Fuchita and C.Hayashi(UFP Division, Vacuum Metallurgical Co., Ltd., 516 Yokota, Sanbu-cho, Sanbu-gun, Chiba-pref., Japan 289-12) | 1997 | Journal of Materials Science & Technology1997，13，4： | 9 |
| 4 | Confirming Stereochemical Structures of Strigolactones Produced by Rice and Tobacco显示文摘主要 strigolactones (SL ) 由米饭生产了(Oryza sativa L。cv。Nipponbare ) 并且烟草(Nicotiana tabacum L。cv。Michinoku 号码 1 ) 被净化,他们的 stereochemical 结构被在 ESILC/MS 和 GCMS 为他们的 NMR 和 CD 数据和保留时间和集体破碎与光学地纯的合成标准作比较决定。从米饭植物的根流出物净化的 SL 是 orobanchol, orobanchyl 醋酸盐,和 ent-2-epi-5-deoxystrigol。除了这些 SL, 7-oxoorobanchyl 醋酸盐并且通常认为三 methoxy-5-deoxystrigol 异构体被最小公倍数 /MS 检测。7-oxoorobanchyl 醋酸盐的生产似乎发生在早生长阶段,当它仅仅在在孵化的第一个星期期间收集的根流出物被检测。烟草的根流出物包含了至少 11 SL,包括其结构尚待被澄清的通常认为的 didehydro-orobanchol 的 solanacol, solanacyl 醋酸盐, orobanchol, ent-2-epi-orobanchol, orobanchyl 醋酸盐, ent-2-epi-orobanchyl 醋酸盐, 5-deoxystrigol, ent-2-epi-5-deoxystrigol,和三异构体。而且,二 sorgolactone 异构体然而并非 sorgolactone 被最小公倍数 /MS 分析作为次要的 SL 检测。注意米饭植物生产了仅仅 orobanchol 类型 SL 是吸引人的,源于 ent-2-epi-5-deoxystrigol,而是 orobanchol 类型和 strigol 类型 SL,源于 5-deoxystrigol 在烟草植物被检测。 | Xiaonan Xie Kaori Yoneyama Takaya Kisugi Kenichi Uchida Seisuke Ito Kohki Akiyama Hideo Hayashi Takao Yokota Takahito Nomura Koichi Yoneyama | 2013 | Molecular Plant2013，6，1： | 9 |
| 5 | Laparoscopic approach to suspected T1 and T2 gallbladder carcinoma显示文摘AIM To evaluate a laparoscopic approach to gallbladder lesions including polyps, wall-thickening lesions, and suspected T1 and T2 gallbladder cancer(GBC).METHODS We performed 50 cases of laparoscopic whole-layer cholecystectomy(LCWL) and 13 cases of laparoscopic gallbladder bed resection(LCGB) for those gallbladder lesions from April 2010 to November 2016. We analyzed the short-term and long-term results of our laparoscopic approach. RESULTS The median operation time was 108 min for LCWL and 211 min for LCGB. The median blood loss was minimal for LCWL and 28 ml for LCGB. No severe morbidity occurred in either procedure. Nine patients who underwent LCWL and 7 who underwent LCGB were postoperatively diagnosed with GBC. One of these patients had undergone LCGB for pathologically diagnosed T2 GBC after LCWL. All of the final surgical margins were negative. Three of these 15 patients underwent additional open surgery. The mean follow-up period was 26 mo, and only one patient developed recurrence.CONCLUSION LCWL and LCGB are safe and useful procedures that allow complete resection of highly suspected or earlystage cancer and achieve good short-term and longterm results. | Yusuke Ome Kazuki Hashida Mitsuru Yokota Yoshio Nagahisa Michio Okabe Kazuyuki Kawamoto | 2017 | World Journal of Gastroenterology2017，23，14： | 8 |
| 6 | 4气门直喷式柴油机的涡流形成过程显示文摘降低排气污染是柴油机一项迫切而重要的任务。每缸4气门的布置方案是实现该目标而采取的一项先进技术。阐述了使用稳态气流装置。通过试验方法2气门和4气门缸盖的缸内空气运动的形成过程。试验时,分别使用示踪激光片技术(TLS)和激光多普勒测速仪(LDV)进行显像和测速。采用示踪激光片技术和激光多普勒测速仪进行显像并测量了2气门和4气门缸盖的缸内空气运动。2气门气缸盖主要依靠螺旋气道来的强旋涡产生涡流运动。当涡流向下流过气缸时,同时由气缸中心向气缸周边扩散。与此相反,4气门气缸盖则主要依靠切向和螺旋气道来的、沿气缸周边处的强气流产生涡流运动。随着气流的继续流动,外部气流不断影响内部气流。当诸如2气门与4气门缸盖间的气流图像变化很大时,最好采用脉动式涡流计而不是叶片式涡流计来测量总涡流强度。 | Aoyagi Y Yokota H Sugihara H 瞿俊鸣 | 1996 | 国外内燃机1996，28，1： | 8 |
| 7 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 8 | Biliary drainage strategy of unresectable malignant hilar strictures by computed tomography volumetry显示文摘AIM:To identify criteria for predicting successful drainage of unresectable malignant hilar biliary strictures(UMHBS) because no ideal strategy currently exists.METHODS:We examined 78 patients with UMHBS who underwent biliary drainage.Drainage was considered effective when the serum bilirubin level decreased by ≥ 50% from the value before stent placement within 2 wk after drainage, without additional intervention.Complications that occurred within 7 d after stent placement were considered as early complications.Before drainage, the liver volume of each section(lateral and medial sections of the left liver and anterior and posterior sections of the right liver) was measured using computed tomography(CT) volumetry.Drained liver volume was calculated based on the volume of each liver section and the type of bile duct stricture(according to the Bismuth classification).Tumor volume, which was calculated by using CT volumetry, was excluded from the volume of each section.Receiver operating characteristic(ROC) analysis was performed to identify the optimal cutoff values for drained liver volume.In addition, factors associated with the effectiveness of drainage and early complications were evaluated.RESULTS:Multivariate analysis showed that drained liver volume [odds ratio(OR) = 2.92, 95%CI:1.648-5.197; P < 0.001] and impaired liver function(with decompensated liver cirrhosis)(OR = 0.06, 95%CI:0.009-0.426; P = 0.005) were independent factors contributing to the effectiveness of drainage.ROC analysis for effective drainage showed cutoff values of 33% of liver volume for patients with preserved liver function(with normal liver or compensated livercirrhosis)and 50%for patients with impaired liver function(with decompensated liver cirrhosis).The sensitivity and specificity of these cutoff values were82%and 80%for preserved liver function,and 100%and 67%for impaired liver function,respectively.Among patients who met these criteria,the rate of effective drainage among those with preserved liver function and impaired liver function was 90%and 80%,respectively.The rates of effective drainage in both groups were significantly higher than in those who did not fulfill these criteria(P<0.001 and P=0.02,respectively).Drainage-associated cholangitis occurred in 9 patients(12%).A smaller drained liver volume was associated with drainage-associated cholangitis(P<0.01).CONCLUSION:Liver volume drainage≥33%in patients with preserved liver function and≥50%in patients with impaired liver function correlates with effective biliary drainage in UMHBS. | Ei Takahashi Mitsuharu Fukasawa Tadashi Sato Shinichi Takano Makoto Kadokura Hiroko Shindo Yudai Yokota Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 9 | 用1Hz GPS观测数据推导中强震震源过程的能力:2008年日本岩手—宫城内陆地震例子显示文摘通过反演研究2008年日本岩手—宫城内陆地震(M~6.9),说明了用1Hz全球定位系统(GPS)观测数据推导中强震(M6级)震源过程的能力。比较了此次地震采样率为1Hz的GPS观测波形,发现与强震仪记录波形有很好的一致性。由于震源区及其周围有足够多的GPS台站很好地记录到了地面运动,因而使我们仅仅采用1Hz的GPS观测数据就可进行波形反演。反演的结果与大地测量和强震仪数据联合反演的结果相当一致,如地震矩(Mw~6.9)、累积滑动量分布和破裂传播等。这种一致性证明,采样率为1Hz的GPS观测数据不仅能用来推导M6级中强震破裂过程的动态特征,而且能用来推导其持久(或静态)的滑动。 | Y. Yokota K. Koketsu K. Hikima S. Miyazaki 邵玉平(译) 许健生(校) | 2009 | 世界地震译丛2009，40，5： | 5 |
| 10 | 低排放柴油机燃烧的新概念显示文摘为了降低柴油机NO_x和颗粒排放,用数值模拟发动机试验和观察燃烧过程方法研究了柴油机燃烧的一种新概念。该概念(HiMICS:均质合理的多次喷射燃烧系统)为预混合压缩着火燃烧与多次喷射相结合的方式。用与标准的单次喷射和先导喷射的比较方法研究了HiMICS方式的燃烧特性。HiMICS方式要求在从进气行程早期到压缩行程中期这一时期内完成预先喷油形成预混合气。采用改进的KIVA-Ⅱ程序分析了每一种喷油模式对发动机性能和排放量的影响。模拟结果表明,HiMICS燃烧系统的燃油耗与NO_x排放量之间的折衷关系可获得显著的改进。为了证实模拟计算的结论,在一台装有共轨喷油系统的单缸试验机上完成了发动机试验。与模拟计算结论相反,试验表明,在正常喷油定时范围内,与标准喷油系统或先导喷油系统比较,HiMICS燃烧系统的NO_x和燃油耗之间以及NO_x和炭烟排放之间的折衷关系更为恶化。然而,从另一方面来说,当喷油定时相当大地推迟时,HiMICS燃烧系统在燃油耗和炭烟排放方面占优势,同时NO_x排放也相当低。需进一步解决的问题:预混合不够均匀,预混合气着火过早以及HC和CO排放量偏高。 | Haruyuki Yokota Yugo Kudo Hiroshi Naka jima 杨寿藏 | 1998 | 国外内燃机1998，30，3： | 5 |
| 11 | Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids显示文摘We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid(ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury,and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa,from the rectum to the anus,and this is the first description of a case that developed a severe liver disorder after this treatment; hence,an analysis of future cases as they accumulate is desirable. | Kenichi Yoshikawa Reimi Kawashima Yuki Hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Akiyoshi Kinoshita Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Masayuki Saruta | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 12 | Study on Targeting and in vitro Anti-oxidation of Baicalin Solid Lipid Nanoparticles显示文摘Objective To prepare liver-targeted baicalin solid lipid nanoparticles(BSLNs) and to study their in vitro anti-oxidative activity.Methods BSLNs were prepared by emulsification ultrasonic dispersion method and characterized by transmission electron microscopy and laser particle size distribution;The tissue in vivo distribution was detected by pharmacokinetics;In vitro anti-superoxide dismutase(SOD) activity and reduction capacity of BSLNs were determined;The ability of removing hydroxyl radical was determined by phenanthroline-Fe2+ oxidation.Results The best prescription was baicalin-soybean lecithin-glyceryl monostearate-poloxamer 188(1:5:15:30);The encapsulation efficiency and drug loading were 84.7% and 5.65%,respectively,mean size of particles was(68.6 ± 8) nm,Zeta potential was 22.13 mV;The in vitro anti-oxidant results showed that BSLNs had a significant inhibitory effect on SOD and a strong reducing capacity as well as a removing hydroxide radical ability.The targeting rate of BSLNs was 6.931 for liver.Conclusion The results demonstrate that BSLNs could enhance the liver targeting ability and in vitro anti-oxidative activity significantly. | MIYAMURA Mitsuhiko YOKOTA Junko YOSHIOKA Saburo | 2012 | Chinese Herbal Medicines2012，4，4： | 4 |
| 13 | 颈椎压缩性骨折伴脊髓损伤保守治疗后的局部后凸进展显示文摘颈椎屈曲压缩性骨折常伴有小关节面明显移位、颈椎力线偏移以及灾难性的神经功能障碍,因此建议及时施行外科手术。但是,一些患者的小关节面尚能维持平整,颈椎力线可,此外,由于伤后可能同时存在多发性损伤和/或失血性休克,常无法施行手术,因此保守治疗仍是可取的选择。目前鲜有报道评估保守治疗颈椎屈曲压缩性骨折伴脊髓损伤的长期疗效。本研究回顾性分析此类患者的临床特征、影像学表现和远期治疗结果,同时探讨患者损伤后局部后凸进展的潜在危险因素。 | Yokota K Maeda T Kawano 白朝晖 王建华 | 2019 | 中国骨科临床与基础研究杂志2019，11，3： | 4 |
| 14 | Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion显示文摘Osteocytes are mechanosensitive bone cells, but little is known about their effects on tumor cells in response to mechanical stimulation. We treated breast cancer cells with osteocyte-derived conditioned medium(CM) and fluid flow-treated conditioned medium(FFCM) with 0.25 Pa and 1 Pa shear stress. Notably, CM and FFCM at 0.25 Pa induced the mesenchymal-to-epithelial transition(MET), but FFCM at 1 Pa induced the epithelial-to-mesenchymal transition(EMT). This suggested that the effects of fluid flow on conditioned media depend on flow intensity. Fluorescence resonance energy transfer(FRET)-based evaluation of Src activity and vinculin molecular force showed that osteopontin was involved in EMT and MET switching. A mouse model of tumorinduced osteolysis was tested using dynamic tibia loadings of 1, 2, and 5 N. The low 1 N loading suppressed tumor-induced osteolysis, but this beneficial effect was lost and reversed with loads at 2 and 5 N, respectively. Changing the loading intensities in vivo also led to changes in serum TGFβ levels and the composition of tumor-associated volatile organic compounds in the urine.Collectively, this study demonstrated the critical role of intensity-dependent mechanotransduction and osteopontin in tumorosteocyte communication, indicating that a biophysical factor can tangibly alter the behaviors of tumor cells in the bone microenvironment. | Yao Fan Aydin Jalali Andy Chen Xinyu Zhao Shengzhi Liu Meghana Teli Yunxia Guo Fangjia Li Junrui Li Amanda Siegel Lianxiang Yang Jing Liu Sungsoo Na Mangilal Agarwal Alexander G.Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota | 2020 | Bone Research2020，8，2： | 4 |
| 15 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis显示文摘 | Nozomu Yanaihara Natasha Caplen Elise Bowman Masahiro Seike Kensuke Kumamoto Ming Yi Robert M. Stephens Aikou Okamoto Jun Yokota Tadao Tanaka George Adrian Calin Chang-Gong Liu Carlo M. Croce Curtis C. Harris | 2006 | Cancer Cell2006，，3： | 4 |
| 16 | 高性能发动机活塞销衬套材料的研制显示文摘近年来,柴油机要求更高的性能和更长的寿命。由于气缸爆发压力高,活塞销衬套的工作负荷和温度变得更高。因此要求活塞销衬套具有高承载能力、耐磨性和耐腐蚀性。为了改善铜衬套材料的耐腐蚀性,研究了铜合金中添加元素的效果。研究发现,在铜中加入镍可降低铜合金的硫腐蚀。此外,还得知可以通过传统的烧结方法来生产铜镍合金。尝试在铜基体中加入硬颗粒来提高耐磨性。研究的首要目标是确定硬颗粒对耐磨性和切削加工工艺性的影响。研究发现,在铜基体中加入一种硬颗粒时耐磨性有所提高,但切削加工性却变差。为了解决这个问题,试验同时添加两种硬颗粒,细的AIN和Fe3P颗粒。结果是成功地提高了耐磨性,又不使切削加工性变差。在本研究的基础上成功地开发了活塞销衬套新材料,有效地提高了高性能柴油机活塞销衬套的耐磨性和耐腐蚀性。 | Kira T Yokota H Kamiya S 顾如龙 | 2000 | 国外内燃机2000，32，4： | 3 |
| 17 | Efficacy of additional treatment with azathioprine in a patient with prednisolone-dependent gastric sarcoidosis显示文摘Gastric sarcoidosis with noncaseating granuloma is rare. Although corticosteroid produces a dramatic clinical response, it is unknown whether azathioprine show efficacy in prednisolone-dependent cases. Here, we report a case of gastric sarcoidosis in a 25-year-old man with severe epigastlargia. Gastroendoscopy revealed multiple map-like ulcerations. Histological examination showed multiple noncaseating granulomatous lesions in gastric mucosa, which were incompatible with diagnoses of Crohn's disease or tuberculosis. He was started on prednisolone at 30 mg/d, and his symptoms improved within 7-d. The prednisolone was gradually tapered by 5 mg every 2-wk, but oral azathioprine at 50 mg was added after symptoms recurred at tapered dose of 10 mg. Endoscopy 4-wk later showed healing ulcers, and, lymphocytic infiltration was absent. The efficacy of additional azathioprine in gastric sarcoidosis is not well defined. Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases. | Masaki Murata Mitsushige Sugimoto Yoshihiro Yokota Hiromitsu Ban Osamu Inatomi Shigeki Bamba Ryoji Kushima Akira Andoh | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 18 | Early neurological deterioration represents recurrent attack in acute small non-lacunar stroke显示文摘 | Noriko Matsumoto Kazumi Kimura Chiaki Yokota Kiminobu Yonemura Kuniyasu Wada Makoto Uchino Kazuo Minematsu | 2003 | Journal of the Neurological Sciences2003，，2： | 3 |
| 19 | A Brief Review of Bone Adaptation to Unloading显示文摘Weight-bearing bone is constantly adapting its structure and function to mechan-ical environments. Loading through routine exercises stimulates bone formation and prevents bone loss, but unloading through bed rest and cast immobilization as well as exposure to weightlessness during spaceflight reduces its mass and strength. In order to elucidate the mechanism underlying unloading-driven bone adaptation, ground-based in vitro and in vivo analyses have been conducted using rotating cell culturing and hindlimb suspension. Focusing on gene expression studies in osteoblasts and hindlimb suspension studies, this minireview introduces our recent understanding on bone homeostasis under weightlessness in space. Most of the existing data indicate that unloading has the opposite effects to loading through common signaling pathways. However, a question remains as to whether any path-way unique to unloading (and not to loading) may exist. | Kazunori Hamamura Hiroki Yokota | 2008 | Genomics, Proteomics & Bioinformatics2008，6，1： | 3 |
| 20 | Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma显示文摘We report the first use of endoscopic submucosal dissection(ESD) for the treatment of a patient with adenoid cystic carcinoma of the esophagus(EACC). An 82-year-old woman visited our hospital for evaluation of an esophageal submucosal tumor. Endoscopic examination showed a submucosal tumor in the middle third of the esophagus. The lesion partially stained with Lugol's solution,and narrow band imaging with magnification showed intrapapillary capillary loops with mild dilatation and a divergence of caliber in the center of the lesion. Endoscopic ultrasound imaging revealed a solid 8 mm × 4.2 mm tumor,primarily involving the second and third layers of the esophagus. A preoperative biopsy was non-diagnostic. ESD was performed to resect the lesion,an 8 mm submucosal tumor. Immunohistologically,tumor cells differentiating into ductal epithelium and myoepithelium were observed,and the tissue type was adenoid cystic carcinoma. There was no evidence of esophageal wall,vertical stump or horizontal margin invasion with p T1 b-SM2 staining(1800 μm from the muscularis mucosa). Further studies are needed to assess the use of ESD for the treatment of patients with EACC. | Kenichi Yoshikawa Akiyoshi Kinoshita Yuki Hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Haruka Kaneyama Keiichi Ikeda Masayuki Saruta | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
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