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| 1 | Change in arterial tumor perfusion is an early biomarker of lenvatinib efficacy in patients with unresectable hepatocellular carcinoma显示文摘BACKGROUND Lenvatinib is one of the first-line tyrosine kinase inhibitors used for unresectable hepatocellular carcinoma(HCC). In the present study, we evaluated the potential of early changes in the time-intensity curve(TIC) of arterial phase on contrastenhanced ultrasound(CEUS) as early imaging biomarkers of lenvatinib efficacy.AIM To evaluate the potential of the early changes in the TIC of CEUS as early imaging biomarkers of lenvatinib efficacy in patients with unresectable HCC.METHODS We analyzed 20 consecutive patients with unresectable HCC treated with lenvatinib from March to November 2018. Tumor response at 8 wk was assessed by computed tomography using the modified Response Evaluation Criteria in Solid Tumors(m RECIST). CEUS was performed at baseline before treatment(Day 0) and on day 7(Day 7), and the images were analyzed in the arterial phase for 20 seconds after the contrast agent arrived at the target tumor. Three perfusion parameters were extracted from the TICs: the slope of wash-in(Slope),time to peak(TTP) intensity, and the total area under the curve(AUC) during wash-in. The rate of change in the TIC parameters between Day 0 and Day 7 was compared between treatment responders and non-responders based on m RECIST.RESULTS The rate of change for all TIC parameters showed significant differences between the responders(n = 9) and non-responders(n = 11)(Slope, P = 0.025; TTP, P =0.004; and AUC, P = 0.0003). The area under the receiver operating curve values for slope, TTP, and AUC for the prediction of responders were 0.805, 0.869, and0.939, respectively.CONCLUSION CEUS may be useful for the early prediction of tumor response to lenvatinib therapy in patients with unresectable HCC. | Hidekatsu Kuorda Tamami Abe Yudai Fujiwara Takuya Okamoto Miki Yonezawa Hiroki Sato Kei Endo Takayoshi Oikawa Kei Sawara Yasuhiro Takikawa | 2019 | World Journal of Gastroenterology2019，25，19： | 8 |
| 2 | E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance显示文摘AIM: To examine the role of E-cadherin and beta- catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs). METHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins. RESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequentlyin EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV- GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% CI, 0.11-0.93). CONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. | Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan Suguru Yonezawa Yoshito Eizuru | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 3 | 香港红山茶个体内ITS多态性及物种鉴定的应用显示文摘核糖体DNA的内转录间隔区(ITS)一直被作为一种重要的分子标记,却很难用于山茶物种中。通过对1个疑似香港红山茶(Camellia hongkongensis)的样本进行ITS区域的扩增、克隆和测序,从中获得74种不同序列。研究结果表明,其ITS区域具有高度的多态性,其中76%的序列为假基因。系统发育分析显示,超过半数的假基因源自同一祖先。这些假基因在经历多次基因重复后分化成至少5个谱系,且每个谱系中的序列非常相似,这表明一些假基因不但未被剔除,反而通过快速复制事件幸存下来。由于山茶物种个体内ITS的高度多态,使用这个区域区分山茶物种可能导致错误。然而,通过比较香港红山茶中的1个种间特异性r DNA假基因,确定该样本属于香港红山茶。 | 范文 徐颖 许汀 徐晶 Takahiro Yonezawa 高继银 张文驹 | 2015 | 植物学报2015，50，2： | 5 |
| 4 | Discovery of a high-altitude ecotype and ancient lineage of Arabidopsis thaliana from Tibet显示文摘Arabidopsis thaliana(A.thaliana)has long been a model species for dicotyledon study,and was the first flowering plant to get its genome completed sequenced[1].Although most wild A.thaliana are collected in Europe,several studies have found a rapid A.thaliana west-east expansion from Central Asia[2].The Qinghai-Tibet Plateau(QTP)is close to Central Asia and known for its high alti- | Liyan Zeng Zhuoya Gu Min Xu Ning Zhao Weidong Zhu Takahiro Yonezawa Tianmeng Liu Lha Qiong Tashi Tersing Lingli Xu Yang Zhang Rongyan Xu Ningyu Sun Yanyan Huang Jiankun Lei Liang Zhang Feng Xie Fang Zhang Hongya Gu Yupeng Geng Masami Hasegawa Ziheng Yang M. James C. Crabbe Fan Chen Yang Zhong | 2017 | Science Bulletin2017，62，24： | 3 |
| 5 | Environmentally assisted crack growth in one-dimensionally cold worked Alloy 690TT in primary water显示文摘 | Q.J. Peng J. Hou T. Yonezawa T. Shoji Z.M. Zhang F. Huang E.-H. Han W. Ke | 2012 | Corrosion Science2012，，： | 2 |
| 6 | Sensing and tracking enhanced by quantum squeezing显示文摘Quantum sensing, along with quantum communications and quantum computing, is commonly considered as the most important application of quantum optics. Among the quantum-sensing experiments, schemes based on squeezed states of light are popular choices due to their natural quadrature components. Since the first experimental demonstration of quantum-squeezing-enhanced phase measurement beyond the shot-noise limit in 1987, quantum-squeezing techniques toward practical sensing and tracking have been extensively investigated. In this paper, we briefly review the recent developments of quantum squeezing and its applications in several advanced systems for measurements of position, rotation, dynamic motion, magnetic fields, and gravitational waves. We also introduce the recent experimental efforts to combine the quantum-squeezing lights into fiber sensing systems. | CHUAN XU LIDAN ZHANG SONGTAO HUANG TAXUE MA FANG LIU HIDEHIRO YONEZAWA YONG ZHANG MIN XIAO | 2019 | Photonics Research2019，7，6： | 2 |
| 7 | Comparative analysis of gastric bacterial microbiota in Mongolian gerbils after long-term infection with Helicobacter pylori显示文摘 | Takako Osaki Takahiro Matsuki Takashi Asahara Cynthia Zaman Tomoko Hanawa Hideo Yonezawa Satoshi Kurata Timothy Derg-hoong Woo Koji Nomoto Shigeru Kamiya | 2012 | Microbial Pathogenesis2012，，1： | 2 |
| 8 | Li ion conduction in LiLnSiO4 (Ln=La, Nd, Sm, Eu, Gd and Dy) sinters 显示文摘 | Matsumoto H Yonezawa K Iwahra H | 1998 | Solid State Ionics1998，1131，15： | 2 |
| 9 | Dielectric spectroscopy of biological cells显示文摘 | ASAMI K YONEZAWA T WAKAMATSU H | 1996 | Bioelectroch Bioener1996，40，2： | 1 |
| 10 | The effects of cognitive rehabilitation on social knowledge in patients with schizophrenia显示文摘 | Matsui M ArM H Yonezawa M | 2009 | Appl Neuropsychol2009，16，3： | 1 |
| 11 | Decorrelation of SAR data uban damages caused by the 1995 Hyogoken-nanbu earthquake 显示文摘 | Takeuchi S | 2001 | International Journal of Remote Sensing2001，22，8： | 1 |
| 12 | Mechanistic consideration of formation of polymer - protected nanoscopic bimetallic clusters 显示文摘 | YONEZAWA T TOSHIMA N | 1995 | J Chem Soc Fara Trans1995，91，22： | 1 |
| 13 | Expression of mucin core proteins in extramammary Paget's disease显示文摘 | Yoshii N Kitajima S Yonezawa S | 2002 | Pathol Int2002，52，56： | 1 |
| 14 | Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo 显示文摘 | Ha BG Nagaoka M Yonezawa T | 2012 | Nutr Biochem2012，23，： | 1 |
| 15 | The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms显示文摘 | Suguru Yonezawa Akiko Nakamura Michiko Horinouchi Eiichi Sato | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，3： | 1 |
| 16 | On tile Seasonal and Nonseasonal Annual Variations and the Semiannual Variation in the Noon and Midnight Electron Densities of the F2 Layer in Middle Latitudes显示文摘 | Yonezawa T Arima Y | 1959 | Radio Research Laboratories1959，6，25： | 1 |
| 17 | Evaluation of rapidly disintegrating tablets prepared by a direct compression 显示文摘 | Bi YX Sunada H Yonezawa Y | 1999 | Drug Dev Ind Pharm1999，25，5： | 1 |
| 18 | Rapidly disintegrating tablets prepared by the wet compression method: mechanism and optimization显示文摘 | Bi Yo Yonezawa Y Sunada H | 1999 | J Pharm Sci1999，88，10： | 1 |
| 19 | Comparative effects of type angiotensinⅡ receptor blockade with angiotensin-corverting-enzyme inhibitor on left ventricular distensibility and collage metabolism in spontaneously hypertensive rats显示文摘 | Yonezawa T Umemoto S Fujii A | 1996 | J Cardiovase Pharmacol1996，27，： | 1 |
| 20 | Regulation of eIF-4E BPI phosphorylation by mTOR显示文摘 | Hara K Yonezawa K Kozlowski M | 1997 | J Biol Chem1997，272，26： | 1 |
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