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| 1 | Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits显示文摘OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF. | Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 2 | Processing and properties of MWNT/HDPE composites显示文摘 | Yaobang Zou Yongcheng Feng Lu Wang Xiaobo Liu | 2004 | Carbon2004，42，： | 1 |
| 3 | Radical-scavenging activities of marine-derived xyloketals and related chromanes显示文摘Xyloketals,a new type of antioxidants from a marine mangrove fungus,have potential pharmacological properties.In this paper,the radical-scavenging activities of a series of synthetic xyloketals and related chromanes toward 2,2-diphenyl-1-picrylhydrazyl(DPPH)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)were evaluated by absorption spectrometry.One of the compounds(compound 10)displayed significant antioxidative action against DPPH and ABTS.A structure-activity analysis showed that the reactive sites on these compounds correlated with a hydroxygroup and also with ketal or aromatic H substituents.Based in part on a density functional theory(DFT)calculation of compound 10,the antioxidant mechanism of this chromane was deduced as a possible radical-scavenging mechanism by a sequential proton loss electron-transfer(SPLET)process. | Zhongliang Xu Bingtai Lu Qi Xiang Yiying Li Shichang Li Yongcheng Lin Jiyan Pang | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 1 |
| 4 | A Norsesquiterpene Lactone and a Benzoic Acid Derivative from the Leaves of Cyclocarya paliurus and their Glucosidase and Glycogen Phosphorylase Inhibiting Activities显示文摘 | Jun Li Yuanyuan Lu Xiaojian Su Fu Li Zhigang She Xingcun He Yongcheng Lin | 2008 | Planta Med2008，，： | 1 |
| 5 | High sintering and dielectric performance:The improved(Mg,Zn)_(3)B_(2)O_(6) ceramics with the help of the DFT calculation显示文摘With the help of the first principle calculation,the solid-state reaction experiment was conducted to investigate the alteration in the sintering and the microwave dielectric properties of Mg_(3)B_(2)O_(6)ceramic with many Zn^(2+)substitutions.These properties were characterized using the scanning electron microscopy,network analyzer,X-ray diffraction,Raman spectroscopy,energy-dispersive spectroscopy,and thermomechanical and differential-thermal analyses.The coexistence of Mg_(3)B_(2)O_(6),Mg_(2)B_(2)O_(5)and ZnO ceramics could be observed with increasing Zn^(2+)addition,and the lattice distortion occurred in the Mg_(2)B_(2)O_(5)and Mg_(3)B_(2)O_(6)ceramics due to the substitution of Mg^(2+)with Zn^(2+).The electron density and the bond property of the MgO_(6)octahedron changed,and a quantitative method was used to discuss the variation in sintering,substitution and phase formation properties.The densification window was decreased to 1100℃,and the dielectric properties improved with the formation of a three-phase borate solid solution(dielectric constant=6.73,quality factor=112,000 GHz at 16 GHz(Q=7000),temperature coefficient of resonant frequency=-61.2 ppm℃^(-1),and relative density=97.0%). | Rui Peng Yongcheng Lu Liang Shi Guoliang Yu Yuanming Lai Gang Wang Yuanxun Li Hua Su Huaiwu Zhang | 2023 | Journal of Magnesium and Alloys2023，11，6： | 0 |
| 6 | All-dielectric terahertz metasurface for linearly-polarized multichannel transmission and superposition states of spherical and vortex waves显示文摘Compared to pure vortex waves,the superposition state of spherical waves and vortex waves has enough degrees of freedom to upgrade applications in particle manipulation,information encryption,and large-capacity communications.Here,we propose a new scheme to achieve superposition states and multichannel transmission of vortex and spherical waves.Two transmissive all-silicon metasurfaces that enable mutual interference between linearly polarized(LP)waves in the terahertz region are demonstrated.Type A can achieve interference between x and y polarized waves,while type B can achieve interference between x(or y)and x(or y)polarized waves.The multichannel transmission and superposition states of topological charges of+3,+2,and+4 are designed and demonstrated from theoretical,simulative,and experimental perspectives at 1.1 THz.In addition,the objective fact that the focused superposition state must be observed close to the focal plane is also revealed.The measured results are in good agreement with the theoretical and simulative results.This work provides an idea for the design of ultrathin terahertz devices and could be applied in the fields of information encryption and highfrequency communications. | FUYU LI YUANXUN LI TINGTING TANG YONGCHENG LU XINYAN LIU YULONG LIAO QIYE WEN | 2023 | Photonics Research2023，11，3： | 0 |
| 7 | Amelioration of sintering and multi-frequency dielectric properties of Mg_(3)B_(2)O_(6):A mechanism study of nickel substitution using DFT calculation显示文摘With the support of density functional theory(DFT)calculation,the amelioration of sintering and dielectric properties of the Mg_(3)B_(2)O_(6)(MBO)ceramic was realized through the substitution of magnesium with nickel.The TE-mode cylindrical cavity method was used to measure the dielectric properties at different frequencies.The thermo-mechanical analysis and simultaneous thermal analysis were used to characterize the chemical and mechanical properties.The phase composition was determined through the X-ray diffraction(XRD)and Raman spectrum.The microstructure was investigated using the scanning electron microscopy(SEM).Magnesium substitution with nickel(4 mol%)could ionize the B-0 bond of BO3,modify the vibration mode,improve the order degree,densify the microstmcture,decrease the intrinsic densification temperature,and ameliorate the dielectric properties of the MBO ceramics.The maximum values were achieved for the ceramics with 4 mol%nickel and sintered at 1175℃,that is,97.2%for relative density,72,600 GHz(10 GHz),75,600 GHz(11.4 GHz),and 92,200 GHz(15 GHz)for Q×f,7.1(10 GHz),7.01(11.4 GHz),and 6.91(15 GHz)for£r,and-56.3 ppm/℃ for if. | Rui PENG Yongcheng LU Qin ZHANG Yuanming LAI Guoliang YU Xiaohui WU Yuanxun LI Hua SU Huaiwu ZHANG | 2021 | Journal of Advanced Ceramics2021，10，6： | 0 |
| 8 | All-electrical switching of a topological non-collinear antiferromagnet at room temperature显示文摘Non-collinear antiferromagnetic Weyl semimetals,combining the advantages of a zero stray field and ultrafast spin dynamics,as well as a large anomalous Hall effect and the chiral anomaly of Weyl fermions,have attracted extensive interest.However,the all-electrical control of such systems at room temperature,a crucial step toward practical application,has not been reported.Here,using a small writing current density of around 5×10^(6)A·cm^(-2),we realize the all-electrical current-induced deterministic switching of the non-collinear antiferromagnet Mn_(3)Sn,with a strong readout signal at room temperature in the Si/SiO_(2)/Mn_(3)Sn/AlO_(x)structure,and without external magnetic field or injected spin current.Our simulations reveal that the switching originates from the current-induced intrinsic non-collinear spin-orbit torques in Mn_(3)Sn itself.Our findings pave the way for the development of topological antiferromagnetic spintronics. | Yongcheng Deng Xionghua Liu Yiyuan Chen Zongzheng Du Nai Jiang Chao Shen Enze Zhang Houzhi Zheng Hai-Zhou Lu Kaiyou Wang | 2023 | National Science Review2023，10，2： | 0 |
| 9 | Correlation analysis of intestinal flora and pathological process of type 2 diabetes mellitus显示文摘Objective: To observe the relationship between the different stages of type 2 diabetes mellitus(T2DM)and the intestinal flora and verify its underlying mechanism.Methods: T2DM rats were generated by high-fat diet(HFD) combined with intraperitoneal streptozotocin(STZ) injection. The rats were divided into four groups: the control group(fed with normal feed for1 month), the HFD group(fed with HFD for 1 month), the T2DM group(HFD combined with STZ and blood glucose ≥11.1 m M), and the unformed T2DM model(Un-mod) group(HFD combined with STZ and blood glucose <11.1 m M). Feces were collected, and bacterial communities in the fecal samples were analyzed by 16S r RNA gene sequencing. The content of short-chain fatty acids(SCFAs) in feces was measured by gas chromatography. Western blot and quantitative real-time polymerase chain reaction were used to detect the expression of G protein-coupled receptor 41(GPR41) and GPR43.Results: At different stages of T2DM, the intestinal flora and SCFAs content of rats were significantly decreased(all P <.05). Our results indicated that g__Prevotella had a significant negative correlation, and g__Ruminococcus_torques_group and g__lachnoclastic had a significant positive correlation with blood glucose. The content of SCFAs, in particular acetate and butyrate, in rat feces of different stages of T2DM were significantly reduced, as well as GPR41 and GPR43 expression. The results in the Un-mod group were similar to the T2DM group, and the expression of GPR41 and GPR43 proteins were significantly higher than those in the T2DM group(both P <.001).Conclusion: The intestinal flora-SCFAs-GPR41/GPR43 network may be important in the development of T2DM. Decreasing blood glucose levels by regulating the intestinal flora may become a new therapeutic strategy for T2DM, which has very important clinical and social values. | Yongcheng An Yuhui Duan Hongyu Dai Chen Wang Lu Shi Changhao He Yinglan Lv Huimin Li Shuhang Dai Baosheng Zhao | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，2： | 0 |
| 10 | Metabolomics characterization of Qingwei San on oral ulcer in db/db mice with stomach heat pattern显示文摘Objective:To characterize the effects of Qingwei San(QWS)on diabetic oral ulcer(OU)mice with stomach heat pattern through metabolomic analysis.Methods:A stomach heat pattern mouse model was established by treating C57BLKS/J Leprdb/db(db/db)mice with dried Zingiber officinale Rosc.rhizome(Z.officinale,Gan Jiang)decoction by gavage.All model mice had blood glucose levels of≥11.1 m M.Subsequently,OU was induced by Na OH cauterization.After 1 week of administration of QWS,non-targeted metabolomic analysis of serum was conducted using ultra high performance liquid chromatography coupled with mass spectrometry(UHPLC-MS/MS).Results:The non-targeted metabolomics results indicated that tryptophan metabolism,2-oxocarboxylic acid metabolism,serotonergic synapses,amino sugar and nucleotide sugar metabolism,and amino acid biosynthesis were involved in the therapeutic effects of QWS,with tryptophan metabolism playing a predominant role.Conclusion:QWS treatment can significantly improve the pathological status of diabetic OU mice with stomach heat pattern.QWS may regulate the release of inflammatory factors through the tryptophan metabolism pathway. | Huimin Li Chen Wang Yinglan Lyu Lu Shi Changhao He Yongcheng An Huilin Zhang Hongbin Zhao Yonghua Zhao Baosheng Zhao | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，3： | 0 |
| 11 | A theoretical study of the proton transfer process in the spin-forbidden reaction 1~HNO(1~A')+OH^-→3~NO^-(3~Σ^-)+H_2O显示文摘The spin-forbidden reaction 1HNO(1A')+OH-→3NO-(3Σ-)+H2O has been extensively explored using various CASSCF active spaces with MP2 corrections in several basis sets. Natural bond orbital (NBO) analysis, together with the NBO energetic (deletion) analysis, indicates that the two isomers have nearly equal total energy and could compete with each other in the title reaction. More significantly, the singlet/triplet surface crossing regions have been examined and the spinorbit coupling (SOC) and energetics have been computed. The computational results indicate that the SOC is very large at the crossing point T1/S0 trans (ca.40.9 cm-1). Moreover, the T1/S0 trans has a low energy of 10.67 kcal/mol relative to that of trans-S0. Therefore, the surface crossing to the triplet state seems much more efficient at the T1/S0 trans region along the minimum energy path (MEP), However, The values of single (P1ISC) and double (P2ISC) passes estimated at T1/S0 trans show that the ISC occurs with a little probability. | LU LingLing WANG XiaoFang WANG YongCheng DAI GuoLiang | 2008 | Chinese Science Bulletin2008，53，10： | 0 |
| 12 | An Improved Method for Correction of Air Temperature Measured Using Different Radiation Shields显示文摘The variation of air temperature measurement errors using two different radiation shields(DTR502B Vaisala, Finland,and HYTFZ01, Huayun Tongda Satcom, China) was studied. Datasets were collected in the field at the Daxing weather station in Beijing from June 2011 to May 2012. Most air temperature values obtained with these two commonly used radiation shields were lower than the reference records obtained with the new Fiber Reinforced Polymers(FRP) Stevenson screen. In most cases, the air temperature errors when using the two devices were smaller on overcast and rainy days than on sunny days; and smaller when using the imported rather than the Chinese shield. The measured errors changed sharply at sunrise and sunset, and reached maxima at noon. Their diurnal variation characteristics were, naturally, related to changes in solar radiation. The relationships between the record errors, global radiation, and wind speed were nonlinear. An improved correction method was proposed based on the approach described by Nakamura and Mahrt(2005)(NM05), in which the impact of the solar zenith angle(SZA) on the temperature error is considered and extreme errors due to changes in SZA can be corrected effectively. Measurement errors were reduced significantly after correction by either method for both shields.The error reduction rate using the improved correction method for the Chinese and imported shields were 3.3% and 40.4%higher than those using the NM05 method, respectively. | CHENG Xinghong SU Debin LI Deping CHEN Lu XU Wenjing YANG Meilin LI Yongcheng YUE Zhizhong WANG Zijing | 2014 | Advances in Atmospheric Sciences2014，31，6： | 0 |
| 13 | Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy显示文摘Despite recent advances in tumor treatment, reactive oxygen species(ROS)-mediated therapy, such as photodynamic therapy(PDT) and chemical dynamic therapy(CDT), remains challenging mainly due to hypoxia in tumor microenviroment. Relieving the hypoxia of tumor tissue has been considered as an attractive strategy for enhancing efficacy of ROS-based cancer treatment.Herein, one cascaded platform was developed to overcome tumor hypoxia and synergistically enhance the effect of ROSmediated therapy. This platform is based on cleavable bimetallic metal organic polymers(DOX@Fe/Mn-THPPTK-PEG). As an efficient Fenton-like material, it could not only produce cytotoxic ·OH by catalyzing the decomposition of intracellular H2O2, but also generate O2 to alleviate tumor hypoxia. In addition, the DOX-loaded metal organic polymers(MOPs could be disrupted after being exposed to laser irradiation or/and treated with H2O2, and then release the DOX for chemotherapy. Overall, 3 therapies(hypoxia-relieved PDT, photo-enhanced CDT, and ROS-mediated chemotherapy) could be achieved simultaneously by such a smart platform. Furthermore, T1-weighted MRI imaging ability of the MOPs could be greatly improved under H2O2 treatment.Therefore, total four robust functions were realized in a simple platform. These findings demonstrate great clinical potentials of the MOPs for cancer theranostics. | Haozhe He Lihua Du Min Tan Yali Chen Liejing Lu Yongcheng An Yong Wang Xiaoxia Li Bo Li Jun Shen Jun Wu Xintao Shuai | 2020 | Science China Chemistry2020，63，7： | 0 |
| 14 | Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway显示文摘Mulberry (Morus alba L.) leaf is a well-established traditional Chinese botanical and culinary resource. It has found widespread application in the management of diabetes. The bioactive constituents of mulberry leaf, specifically mulberry leaf flavonoids (MLFs), exhibit pronounced potential in the amelioration of type 2 diabetes (T2D). This potential is attributed to their ability to safeguard pancreatic β cells, enhance insulin resistance, and inhibit α-glucosidase activity. Our antecedent research findings underscore the substantial therapeutic efficacy of MLFs in treating T2D. However, the precise mechanistic underpinnings of MLF’s anti-T2D effects remain the subject of inquiry. Activation of brown/beige adipocytes is a novel and promising strategy for T2D treatment. In the present study, our primary objective was to elucidate the impact of MLFs on adipose tissue browning in db/db mice and 3T3-L1 cells and elucidate its underlying mechanism. The results manifested that MLFs reduced body weight and food intake, alleviated hepatic steatosis, improved insulin sensitivity, and increased lipolysis and thermogenesis in db/db mice. Moreover, MLFs activated brown adipose tissue (BAT) and induced the browning of inguinal white adipose tissue (IWAT) and 3T3-L1 adipocytes by increasing the expressions of brown adipocyte marker genes and proteins such as uncoupling protein 1 (UCP1) and beige adipocyte marker genes such as transmembrane protein 26 (Tmem26), thereby promoting mitochondrial biogenesis. Mechanistically, MLFs facilitated the activation of BAT and the induction of WAT browning to ameliorate T2D primarily through the activation of AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling pathway. These findings highlight the unique capacity of MLF to counteract T2D by enhancing BAT activation and inducing browning of IWAT, thereby ameliorating glucose and lipid metabolism disorders. As such, MLFs emerge as a prospective and innovative browning agent for the treatment of T2D. | CHENG Long SHI Lu HE Changhao WANG Chen LV Yinglan LI Huimin AN Yongcheng DUAN Yuhui DAI Hongyu ZHANG Huilin HUANG Yan FU Wanxin SUN Weiguang ZHAO Baosheng | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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