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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Comparison and im- provement of the high rate perform of different types of LiMn204 spinels显示文摘 | DENG B H NAKAMURA H YOSHIO M | 2005 | Power Sources2005，141，1： | 1 |
| 3 | Capacity fading with oxygen loss for manganese spinels upon cycling at elevated temperatures 显示文摘 | Deng B Nakamura H Yoshio M | 2008 | Journal of Power Sources2008，180，： | 1 |
| 4 | Systemic inflammatory respnse syndrome and organ dysfunction following gastrointestinal surgery显示文摘 | Yoshio H Toru B Kouihi D | 1997 | Crit Clin Med1997，25，： | 1 |
| 5 | Comparison and improvement of the high rate performance of different types of LiMn2O4 spinels显示文摘 | Deng B H Nakamura H Yoshio M | 2005 | J Power Sources2005，141，1： | 1 |
| 6 | Comparison and improvement of high rate performance of types of LiMn2 04 spinels显示文摘 | Deng B H Nakamura H Yoshio M | 2005 | J Power Sources2005，141，1： | 1 |
| 7 | Clinical features of prognosis of japanese patients with anomalous origin of the coronary artery 显示文摘 | Shimizu M Yoshio H | 1996 | Jpn Circ J1996，60，10： | 1 |
| 8 | Cerium phosphate nanotubes: synthesis, valence state, and optical properties显示文摘 | Tang C C Yoshio B Dmitri G | 2005 | Angewandte Chemie International Edition2005，44，57： | 1 |
| 9 | Capacity fading with oxygen loss for manganese spinels upon cycling at elevated temperatures显示文摘 | Deng B Nakamura H Yoshio M | | 0，，02： | 1 |
| 10 | Nature of the acidic protons in H-mordenite and H-MCM-22 as studied by variable temperature 1H MAS NMR显示文摘 | Toshihide B Norito K Yoshio O | 1998 | Microporous and Mesoporous Materials1998，22，123： | 1 |
| 11 | Comparison and improvement of the high rate performance of different types of LiMn2O4 spinels显示文摘 | Deng B H Nakamura H Yoshio M | 2005 | J Power Sources2005，141，1： | 1 |
| 12 | The role of zirconium to improve strength and stress-corrosion resistance of AI-Zn-Mg and A1-Zn-Mg-Cu alloys 显示文摘 | HIDEO Y YOSHIO B | 1982 | Transactions of the Japan Institute of Metals1982，23，10： | 1 |
| 13 | Nanotubes of magnesium borate 显示文摘 | RENZHI M YOSHIO B DMITRI G | 2003 | Angewandte Chemic International E- dition2003，42，16： | 1 |
| 14 | Comparison and improvement of the high rate perform ance of diferent types of LiMn2O4 spinels显示文摘 | Deng B H Nakamura H Yoshio M | 2005 | Power Sources2005，141，1： | 1 |
| 15 | Carbonylation of ophenylenediamine and o-aminophphenol with dimethyl carbonate using lead compounds as catalysts显示文摘 | YUE Fu TOSHIHIDE B YOSHIO O | 2001 | Journal of Catalysis2001，197，1： | 1 |
| 16 | Capacity fading withoxygen loss for manganese spinels upon cycling at ele-vated temperatures显示文摘 | Deng B Nakamura H Yoshio M | 2008 | Journal of Power Sources2008，180，： | 1 |
| 17 | Comparison and improvement of the high rate performance of different types of LiMn2O4 spinels显示文摘 | Deng B H Nakamura H Yoshio M | 2005 | J Power Sources2005，141，1： | 1 |
| 18 | New boron nitride whisk- ers showing strong ultraviolet and visible light luminescene显示文摘 | ZHU Y C YOSHIO B XUE D F | 2004 | Journal of Physical Chemistry: B2004，108，20： | 1 |
| 19 | Comparison and improvement of the high rate performance of different types of LiMn2 04 spinels显示文摘 | DENG B H Nakamura H Yoshio M | 2005 | Journal of Power Sources2005，141，1： | 1 |
| 20 | High purity single crystalline boron carbide nanowires显示文摘 | Ma R Z Yoshio B | 2002 | Chemical Physics Letters2002，364，： | 1 |
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