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| 1 | High Thermoelectric Performance of Cu-Doped PbSe-PbS System Enabled by High-Throughput Experimental Screening显示文摘Recent advances in high-throughput(HTP)computational power and machine learning have led to great achievements in exploration of new thermoelectric materials.However,experimental discovery and optimization of thermoelectric materials have long relied on the traditional Edisonian trial and error approach.Herein,we demonstrate that ultrahigh thermoelectric performance in a Cu-doped PbSe-PbS system can be realized by HTP experimental screening and precise property modulation.Combining the HTP experimental technique with transport model analysis,an optimal Se/S ratio showing high thermoelectric performance has been efficiently screened out.Subsequently,based on the screened Se/S ratio,the doping content of Cu has been subtly adjusted to reach the optimum carrier concentration.As a result,an outstanding peak zT~1:6 is achieved at 873 K for a 1.8 at%Cu-doped PbSe_(0.6)S_(0.4) sample,which is the superior value among the n-type Te-free lead chalcogenides.We anticipate that current work will stimulate large-scale unitization of the HTP experimental technique in the thermoelectric field,which can greatly accelerate the research and development of new high-performance thermoelectric materials. | Li You Zhili Li Quanying Ma Shiyang He Qidong Zhang Feng Wang Guoqiang Wu Qingyi Li Pengfei Luo Jiye Zhang Jun Luo | 2020 | Research2020，，1： | 4 |
| 2 | 2D materials for conducting holes from grain boundaries in perovskite solar cells显示文摘Grain boundaries in organic-inorganic halide perovskite solar cells(PSCs)have been found to be detrimental to the photovoltaic performance of devices.Here,we develop a unique approach to overcome this problem by modifying the edges of perovskite grain boundaries with flakes of high-mobility two-dimensional(2D)materials via a convenient solution process.A synergistic effect between the 2D flakes and perovskite grain boundaries is observed for the first time,which can significantly enhance the performance of PSCs.We find that the 2D flakes can conduct holes from the grain boundaries to the hole transport layers in PSCs,thereby making hole channels in the grain boundaries of the devices.Hence,2D flakes with high carrier mobilities and short distances to grain boundaries can induce a more pronounced performance enhancement of the devices.This work presents a cost-effective strategy for improving the performance of PSCs by using high-mobility 2D materials. | Peng You Guanqi Tang Jiupeng Cao Dong Shen Tsz-Wai Ng Zafer Hawash Naixiang Wang Chun-Ki Liu Wei Lu Qidong Tai Yabing Qi Chun-Sing Lee Feng Yan | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 3 | Growth Inhibitory Effect of GGAsOn Experimental Tumor in Mice and Human Tumor Cell Cultured in vitro显示文摘 | WU Zhaoqiu GUO Qinglong YOU Qidong | 2003 | Chin J NatMed2003，1，2： | 1 |
| 4 | 3D-QSAR studies of arylcarboxamides with inhibitory activity on InhA using pharmacophore-based alignment 显示文摘 | LU Xiaoyun CHEN Yadong YOU Qidong | 2010 | Chem Biol Drug Des2010，75，2： | 1 |
| 5 | VI-14, a novel flavonoid derivative, inhibits migration and invasion of human breast cancer cells显示文摘 | Fanni Li Chenglin Li Haiwei Zhang Zhijian Lu Zhiyu Li Qidong You Na Lu Qinglong Guo | 2012 | Toxicology and Applied Pharmacology2012，，： | 1 |
| 6 | A novel bicyclic ketolide derivative显示文摘 | Zhao Ying You Qidong Shen Wenbin | 2003 | J Bioorg Med Chem Lett2003，13，： | 1 |
| 7 | Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression显示文摘 | Zhang Kun Guo Qinglong You Qidong | | 0，，04： | 1 |
| 8 | Synthesis and local anesthetic activity of fluoro-substituted imipramine and its analogues显示文摘 | Li Wen You Qidong | 2007 | Bioorg Med Chem Lett2007，17，13： | 1 |
| 9 | Synthesis and anti- bacterial effect of new alkylenedibiguandines 显示文摘 | WANG YI YOU QIDONG ZHOU WEICHENG | 2002 | Journal of Chinese Pharmaceulical Sciences2002，11，2： | 1 |
| 10 | Non-small molecule PROTACs(NSM-PROTACs):Protein degradation kaleidoscope显示文摘The proteolysis targeting chimeras(PROTACs)technology has been rapidly developed since its birth in 2001,attracting rapidly growing attention of scientific institutes and pharmaceutical companies.At present,a variety of small molecule PROTACs have entered the clinical trial.However,as small molecule PROTACs flourish,non-small molecule PROTACs(NSM-PROTACs)such as peptide PROTACs,nucleic acid PROTACs and antibody PROTACs have also advanced considerably over recent years,exhibiting the unique characters beyond the small molecule PROTACs.Here,we briefly introduce the types of NSM-PROTACs,describe the advantages of NSM-PROTACs,and summarize the development of NSM-PROTACs so far in detail.We hope this article could not only provide useful insights into NSM-PROTACs,but also expand the research interest of NSM-PROTACs. | Sinan Ma Jianai Ji Yuanyuan Tong Yuxuan Zhu Junwei Dou Xian Zhang Shicheng Xu Tianbao Zhu Xiaoli Xu Qidong You Zhengyu Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 1 |
| 11 | Advances and applications of machine learning and intelligent optimization algorithms in genome‑scale metabolic network models显示文摘Due to the increasing demand for microbially manufactured products in various industries,it has become important to find optimal designs for microbial cell factories by changing the direction of metabolic flow and its flux size by means of metabolic engineering such as knocking out competing pathways and introducing exogenous pathways to increase the yield of desired products.Recently,with the gradual cross-fertilization between computer science and bioinformatics fields,machine learning and intelligent optimization-based approaches have received much attention in Genome-scale metabolic network models(GSMMs)based on constrained optimization methods,and many high-quality related works have been published.Therefore,this paper focuses on the advances and applications of machine learning and intelligent optimization algorithms in metabolic engineering,with special emphasis on GSMMs.Specifically,the development history of GSMMs is first reviewed.Then,the analysis methods of GSMMs based on constraint optimization are presented.Next,this paper mainly reviews the development and application of machine learning and intelligent optimization algorithms in genome-scale metabolic models.In addition,the research gaps and future research potential in machine learning and intelligent optimization methods applied in GSMMs are discussed. | Lidan Bai Qi You Chenyang Zhang Jun Sun Long Liu Hengyang Lu Qidong Chen | 2023 | Systems Microbiology and Biomanufacturing2023，3，2： | 0 |
| 12 | Influence of Ag substitution on thermoelectric properties of the quaternary diamond-like compound Zn_(2)Cu_(3)In_(3)Te_(8)显示文摘The quaternary diamond-like compounds,A_(2)Cu_(3)In_(3)Te_(8)(A=Cd,Zn,Mn,Mg),are a new class of thermoelectric materials recently proposed by complex structure design.Among them,the Zn_(2)Cu_(3)In_(3)Te_(8) compound possesses reasonable electrical transport properties but relatively high lattice thermal conductivity.Herein,the effects of Ag substitution on the phase stability and thermoelectric properties of Zn_(2)Cu_(3)In_(3)Te_(8) compound are reported.It is revealed that only the In sites show an appreciable tolerance for Ag doping.Ag substitution at the In sites introduces extra holes and thus results in improved electrical transport properties.Furthermore,the introducing of Ag lowers the sound velocities and enhances the phonon scattering of the Zn_(2)Cu_(3)In_(3)Te_(8) compound,which leads to a substantially reduction in lattice thermal conductivity.Finally,in virtue of the optimization in both electrical and thermal transport properties,the maximal zT value of Zn_(2)Cu_(3)In_(2.8)Ag_(0.2)Te_(8) sample reaches 0.62 at 823 K,which is 43%higher than the pristine sample. | Qidong Zhang Lili Xi Jiye Zhang Chenyang Wang Li You Shanshan Pan Kai Guo Zhili Li Jun Luo | 2021 | Journal of Materiomics2021，7，2： | 0 |
| 13 | Pharmacophore Modeling and in Silico Screening Studies to Design Potential KDR Kinase Inhibitors显示文摘为 KDR kinase 的一个新奇基于 ligand 的 pharmacophore 模型根据 30 个 KDR kinase 禁止者的化学特征被产生。这个 pharmacophore 模型由一个氢契约领受人,一个氢契约施主和二个恐水病的组组成。几个方法被用来验证模型,建议它能用作为便于新奇 KDR 禁止者的发现的虚拟屏蔽的一个可靠工具。模型然后从国家癌症研究所(NCI ) 数据库被用作数据库搜索质问让合理设计识别新点击化合物。 | Xu, Dan Sun, Haopeng Chen, Yadong Sun, Liping You, Qidong | 2011 | Chinese Journal of Chemistry2011，29，6： | 0 |
| 14 | Visualization of Ferroelectric Domains in Thin Films of Molecular Materials Using Confocal Micro-Raman Spectroscopy显示文摘Ferroelectrics are an important class of functional materials.Among all their unique properties,the study of their ferroelectric domains and domain walls is of great interest due to their importance in ferroelectric applications.There are many methods to characterize ferroelectric domains,namely,scanning probe microscopy,optical microscopy,electron microscopy,etc.Currently,newly emerged molecular ferroelectrics are attracting much attention from chemists,physicists and researchers in material sciences due to their structural flexibility,light mass,simple fabrication,etc.However,for the characterization of molecular ferroelectric domains,most conventional methods require either a complicated preparation process or direct contact between physical probes and material surfaces,limiting the development of molecular ferroelectric materials.In this report,we have demonstrated that confocal micro-Raman spectroscopy,as a nondestructive and noncontact in-situ method,is very suitable for studying the ferroelectric polarization and structures of domains in molecular ferroelectrics.Taking recently reported molecular ferroelectric trimethylchloromethyl ammonium trichlorocadmium(II)(TMCM-CdCl_(3))as an example,the non-180°domains have been characterized and visualized at different temperatures.Such a simple and extendable method requires minimum sample preparation,which would further benefit the research of molecular ferroelectric domain engineering and promote the miniaturization and integration of molecular ferroelectric films. | ZHOU Wenqin FENG Zijie XIONG Yuan DU Guowei LIN Xiumei SU Qidong LOU Yuheng AN Shili YOU Yumeng | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
| 15 | Docking Study and Three-Dimensional Quantitative Structure- Activity Relationship (3D-QSAR) Analyses and Novel Molecular Design of a Series of 4-Aminoquinazolines as Inhibitors of Aurora B Kinase显示文摘曙光蛋白质为 anticancer 治疗是主要有丝分裂的事件和吸引人的目标的批评管理者。3D-QSAR 研究在 40 4-aminoquinazolines 混合物的数据集上基于分子的停靠被执行。CoMSIA 模型比 CoMFA 模型生产了显著地更好的结果,与 q2=0.652 和 r2=0.991。轮廓分析为禁止曙光 B 为 4-aminoquinazolines 关于结构的要求提供有用信息。支架跳跃方法被用来基于训练和测试集合混合物的最大的普通基础产生新结构。ADMET 性质,有约束力的亲密关系和新设计混合物的禁止的活动分别地被预言。最后, 16 混合物为曙光 B kinase 作为新奇禁止者被识别。 | Sun, Haopeng Zhu, Jia Chen, Yadong Sun, Yuan Zhi, Huijing Li, Hao You, Qidong | 2011 | Chinese Journal of Chemistry2011，29，9： | 0 |
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