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| 1 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 2 | A systematic review of metabolomic profiling of gastric cancer and esophageal cancer显示文摘Objective:Upper gastrointestinal(UGI)cancers,predominantly gastric cancer(GC)and esophageal cancer(EC),are malignant tumor types with high morbidity and mortality rates.Accumulating studies have focused on metabolomic profiling of UGI cancers in recent years.In this systematic review,we have provided a collective summary of previous findings on metabolites and metabolomic profiling associated with GC and EC.Methods:A systematic search of three databases(Embase,PubMed,and Web of Science)for molecular epidemiologic studies on the metabolomic profiles of GC and EC was conducted.The Newcastle–Ottawa Scale(NOS)was used to assess the quality of the included articles.Results:A total of 52 original studies were included for review.A number of metabolites were differentially distributed between GC and EC cases and non-cases,including those involved in glycolysis,anaerobic respiration,tricarboxylic acid cycle,and protein and lipid metabolism.Lactic acid,glucose,citrate,and fumaric acid were among the most frequently reported metabolites of cellular respiration while glutamine,glutamate,and valine were among the most commonly reported amino acids.The lipid metabolites identified previously included saturated and unsaturated free fatty acids,aldehydes,and ketones.However,the key findings across studies to date have been inconsistent,potentially due to limited sample sizes and the majority being hospital-based case-control analyses lacking an independent replication group.Conclusions:Studies on metabolomics have thus far provided insights into etiological factors and biomarkers for UGI cancers,supporting the potential of applying metabolomic profiling in cancer prevention and management efforts. | Sha Huang Yang Guo Zhexuan Li Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li | 2020 | Cancer Biology & Medicine2020，17，1： | 11 |
| 3 | A newly Found Biotite Syenogranite in the Huangshaping Polymetallic Deposit, South China: Insights into Cu Mineralization显示文摘The W-Sn-Mo-Cu-Pb-Zn polymetallic mineralization in the Huangshaping Deposit is associated with different types of Jurassic granitic intrusions such as quartz porphyry, granophyre and granite porphyry. In this study, we carried out detailed mineralogical, petrological, geochemical, zircon U-Pb geochronological and Hf isotopic studies on a newly found, Cu-mineralization-related finegrained biotite syenogranite at Huangshaping. This syenogranite is mainly composed of quartz(40%), K-feldspar(30%), plagioclase(15%) and biotite(5%), enriching in SiO_2(75.58 wt.%–76.02 wt.%), K_2O(5.24 wt.%–5.78 wt.%), Al_2O_3(12.23 wt.%–12.46 wt.%), Rb(405 ppm–504 ppm), U(18.5 ppm–40.7 ppm), Th(47 ppm–52.3 ppm), Nb(49.6 ppm–57.5 ppm), and Cu(54 ppm–288 ppm) whereas depleting in P_2O_5(0.01 wt.%), TiO_2(0.05 wt.%–0.06 wt.%), Ba(5 ppm–13.1 ppm), Sr(6.8 ppm–23.9 ppm) and Eu(0.04 ppm–0.05 ppm), with A1-type alkaline granite characteristics. Magmatic and hydrothermal zircons were separated from a Cu-mineralized syenogranite sample and yielded the 206 Pb/238 U concordant ages of 156.5±1.8 and 154.4±2.9 Ma, representing the intrusive age of the pluton and probable Cu-mineralization time at the Huangshaping Deposit, respectively. Zircon Hf isotopes suggest a crust-derived(partial melting of Paleoproterozoic basement) magma for the syenogranite, with some degree of crust-mantle interaction. We infer that the syenogranite is a transitional phase between the granophyre and the granite porphyry, not only contributed greatly to the Cu mineralization but also provided W-Sn polymetallic ore-forming metals for the Huangshaping Deposit. | Weicheng Jiang Huan Li Jinghua Wu Zhekai Zhou Hua Kong Jingya Cao | 2018 | Journal of Earth Science2018，29，3： | 7 |
| 4 | Improving the performance of solid oxide electrolysis cell with gold nanoparticles-modified LSM-YSZ anode显示文摘Gold, as the common current collector in solid oxide electrolysis cell(SOEC), is traditionally considered to be inert for oxygen evolution reaction at the anode of SOEC. Herein, gold nanoparticles were loaded onto conventional strontium doped lanthanum manganite-yttria stabilized zirconia(LSM-YSZ) anode, which evidently improved the performance of oxygen evolution reaction at 800 °C. The current densities at 1.2 V and 1.4 V increased by 60.0% and 46.9%, respectively, after loading gold nanoparticles onto the LSM-YSZ anode. Physicochemical characterizations and electrochemical measurements suggested that the improved SOEC performance was attributed to the accelerated electron transfer of elementary process in anodic polarization reaction and the newly generated triple phase boundaries in gold nanoparticles-loaded LSMYSZ anode. | Yuefeng Song Xiaomin Zhang Yingjie Zhou Houfu Lv Qingxue Liu Weicheng Feng Guoxiong Wang Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 5 | Helicobacter pylori antibody responses in association with eradication outcome and recurrence: a population-based intervention trial with 7.3-year follow-up in China显示文摘Objective:To identify serum biomarkers that may predict the short or long term outcomes of anti-Helicobacter pylori(H.pylori)treatment,a follow-up study was performed based on an intervention trial in Linqu County,China.Methods:A total of 529 subjects were selected randomly from 1,803 participants to evaluate total anti-H.pylori immunoglobulin G(Ig G)and 10 specific antibody levels before and after treatment at 1-,2-and 7.3-year.The outcomes of anti-H.pylori treatment were also parallelly assessed by 13C-urea breath test at 45-d after treatment and 7.3-year at the end of follow-up.Results:We found the medians of anti-H.pylori Ig G titers were consistently below cut-off value through 7.3years in eradicated group,however,the medians declined in recurrence group to 1.2 at 1-year after treatment and slightly increased to 2.0 at 7.3-year.While the medians were significantly higher(>3.0 at 2-and 7.3-year)among subjects who failed the eradication or received placebo.For specific antibody responses,baseline seropositivities of Fli D and Hpa A were reversely associated with eradication failure[for Fli D,odds ratio(OR)=0.44,95%confidence interval(95%CI):0.27–0.73;for Hpa A,OR=0.32,95%CI:0.17–0.60].The subjects with multiple positive specific antibodies at baseline were more likely to be successfully eradicated in a linear fashion(Ptrend=0.006).Conclusions:Our study suggested that total anti-H.pylori Ig G level may serve as a potential monitor of longterm impact on anti-H.pylori treatment,and priority for H.pylori treatment may be endowed to the subjects with multiple seropositive antibodies at baseline,especially for Fli D and Hap A. | Tianyi Wang Yang Zhang Huijuan Su Zhexuan Li Lian Zhang Junling Ma Weidong Liu Tong Zhou Weicheng You Kaifeng Pan | 2017 | Chinese Journal of Cancer Research2017，29，2： | 3 |
| 6 | A Study on Detonation Safety of Some Hydrocarbon-air Mixtures显示文摘 | Fan Weicheng Zhou Xiaodong | 2000 | Process Safety Progress2000，19，2： | 1 |
| 7 | Propofol prevents lung injury after intestinal ischemia-reperfusion by inhibiting the interaction between mast cell activation and oxidative stress显示文摘 | Weicheng Zhao Shaoli Zhou Weifeng Yao Xiaoliang Gan Guangjie Su Dongdong Yuan Ziqing Hei | 2014 | Life Sciences2014，，： | 1 |
| 8 | Construction and characterization of a live, attenuated apxIICA inactivation mutant of Actinobacillus pleuropneumoniae lacking a drug resistance marker显示文摘 | Weicheng Bei Qigai He Lin Yan Liurong Fang Yadi Tan Shaobo Xiao Rui Zhou Meilin Jin Aizhen Guo Jianqiang Lv Hongliang Huang Huanchun Chen | 2004 | FEMS Microbiology Letters2004，，1： | 1 |
| 9 | Modeling pyrolysis of charring material in fire显示文摘A modified model of pyrolysis for charring materials in fire has been proposed in this note. In this model some special factors which show the effect on pyrolysis are considered, i.e. heat loss by convection and radiation caused by surface temperature rise and shrinkage of char surface are considered. Experimental device is designed specially for validating the reliability of the model. Effects of density of materials and heat radiation on pyrolysis of materials have also been investigated. | Lizhong Yang Xiaojun Chen Xiaodong Zhou Qing’an Wang Weicheng Fan | 2002 | Chinese Science Bulletin2002，47，5： | 1 |
| 10 | Synthesis and anti- bacterial effect of new alkylenedibiguandines 显示文摘 | WANG YI YOU QIDONG ZHOU WEICHENG | 2002 | Journal of Chinese Pharmaceulical Sciences2002，11，2： | 1 |
| 11 | Overview of HL-2A Experiment Results显示文摘 | YANG Qingwei LIU Yong DING Xuantong YAN Longwen LIU Dequan XUAN Weiming CHEN Liaoyuan RAO Jun SONG Xianming CAO Zeng ZHANG Jinhua DUAN Xuru MAO Weicheng ZHOU Caipin PAN Chuanhong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 1 |
| 12 | A leap by the rise of solid-state electrolytes for Li-air batteries显示文摘Li-air batteries have attracted extensive attention because of their ultrahigh theoretical energy density. However, the potential safety hazard of flammable organic liquid electrolytes hinders their practical applications. Replacing liquid electrolytes with solidstate electrolytes(SSEs) is expected to fundamentally overcome the safety issues. In this work, we focus on the development and challenge of solid-state Li-air batteries(SSLABs). The rise of different types of SSEs, interfacial compatibility and verifiability in SSLABs are presented. The corresponding strategies and prospects of SSLABs are also proposed. In particular, combining machine learning method with experiment and in situ(or operando)techniques is imperative to accelerate the development of SSLABs. | Kecheng Pan Minghui Li Weicheng Wang Shuochao Xing Yaying Dou Shasha Gao Zhang Zhang Zhen Zhou | 2023 | Green Energy & Environment2023，8，4： | 0 |
| 13 | Concepts, models, and indicator systems for urban safety resilience: A literature review and an exploration in China显示文摘Safety resilient city is a frontier concept of urban safety development and a hot topic in the field of urban safety research. In this paper, the relevant research results of domestic and foreign scholars are reviewed from the perspectives of concepts and models, the evaluation indicator system of urban safety resilience is compared in terms of risk types, evaluation objects, evaluation dimensions and quantitative methods, and the development of international standards for resilient cities is discussed. Based on the literature review, the connotation of the triangular theoretical model of urban safety resilience is explained, and an urban safety resilience evaluation index system applicable to Chinese cities is proposed, which provides support for the development of the national standard “Guide for safety resilient city evaluation” (GB/T 40947-2021). It is applied to six representative cities as examples for evaluation to explore the direction of Chinese urban safety resilience improvement. The pathway for improving the safety resilience of Chinese cities is discussed. | Hong Huang Ruiqi Li Wan Wang Tingxin Qin Rui Zhou Weicheng Fan | 2023 | Journal of Safety Science and Resilience2023，4，1： | 0 |
| 14 | Divertor Experiments with MBI and Strong Gas Puffing on HL-2A显示文摘 | DUAN Xuru DING Xuantong YANG Qingwei YAN Longwen YAO Lianghua HONG Wenyu XUAN Weiming LIU Dequan CHEN Liaoyuan SONG Xianming ZHANG Jinhua CAO Zeng CUI Zhengying LI Wei LIU Yi PAN Yudong PAN Li ZHENG Yinjia ZHOU Yan MAO Weicheng LIU Yong 无 | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
| 15 | Effect of Radiative Heat Transfer on Indoor-Fire显示文摘The importance of radiative heat transfer in the simulation of indoor-fire has been studied.Computer codes have been developed based on four-flux model and discrete transfer model,respectively.Evaluation of the codes against exact analytic solution and experimental data shows that the discrete transfer model gives numerical results with acceptable accuracy while the four-flux model underpredicts the heat fluxes although the general trend is reasonable.Numerical studies have been performed of two-dimensional,axisymmetric turbulent,buoyancy-controlled indoor,fire.The computational results show that neglecting radiation in the simulation can causs overprediction of 500K in the maximum temperature and less uniform velocity fleld compared to the prediction by discrete transfer model.The four-flux method has been found to produce less uniform velocity and temperature values than discrete transfer model,but is more economic in computation. | Fan Weicheng Zhou Hong Department of Engineering Thermophysics,University of Science and Technology of China,Hefei,Anhui 230026,China | 1992 | Journal of Thermal Science1992，1，1： | 0 |
| 16 | Multimaterial Embedded 3D Printing of Composite Reinforced Soft Actuators显示文摘Soft pneumatic actuators(SPAs)have attracted enormous attention in the growing field of robotics.Among different SPAs,composite reinforced actuators(CRAs)are widely used because of their simple structure and high controllability.However,multistep molding,a time-consuming method,is still the predominant fabrication method.Here,we propose a multimaterial embedded printing method(ME3P)to fabricate CRAs.In comparison with other 3-dimensional printing methods,our method improves fabrication flexibility greatly.Via the design and fabrication of the reinforced composites’patterns and different geometries of the soft body,we demonstrate actuators with programmable responses(elongation,contraction,twisting,bending,and helical and omnidirectional bending).Finite element analysis is employed for the prediction of pneumatic responses and the inverse design of actuators based on specific actuation needs.Lastly,we use tube-crawling robots as a model system to demonstrate our ability to fabricate complex soft robots for practical applications.This work demonstrates the versatility of ME3P for the future manufacturing of CRA-based soft robots. | Zhenhua Wang Boyu Zhang Qu He Hao Chen Jizhe Wang Yuan Yao Nanjia Zhou Weicheng Cui | 2023 | Research2023，，4： | 0 |
| 17 | Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study显示文摘Objective:This study aimed at examining the alterations in metabolomic profiles caused by treatment of H.pylori infection,and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up after treatment.Methods:An intervention trial was performed in 183 participants,117 of whom were H.pylori positive participants receiving treatment for H.pylori infection.H.pylori positive participants were prospectively followed for 182 to 1,289 days.Untargeted metabolomics assays were conducted on plasma samples collected at baseline,6 months after treatment,and during continued follow-up.Results:We identified 59 metabolites with differential posttreatment changes between participants with successful and failed H.pylori eradication,17 metabolites significantly distinguished participants with successful vs.failed eradication.Two metabolites[PC(18:1(11Z)/14:1(9Z))and(2S)-6-amino-2-formamidohexanamide]showed posttreatment changes positively associated with successful H.pylori eradication,and were inversely associated with the risk of gastric lesion progression among participants with successful eradication.In contrast,9-decenoic acid showed posttreatment changes inversely associated with successful eradication:its level was positively associated with the risk of gastric lesion progression among participants with successful eradication.Although the identified metabolites showed a temporary but significant decline after treatment,the trend generally reversed during continued follow-up,and pretreatment levels were restored.Conclusions:Treatment of H.pylori infection significantly altered plasma metabolic profiles in the short term,and key metabolites were capable of distinguishing participants with successful vs.failed eradication,but might not substantially affect metabolic regulation in the long term.Several plasma metabolites were differentially associated with the risk of gastric lesion progression among participants with successful or failed eradication. | Wenhui Wu Zongchao Liu Zhexuan Li Weidong Liu Lanfu Zhang Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 18 | Simultaneously improving mechanical properties and oxidation resistance of Ti-bearing high-entropy superalloys at intermediate temperature via silicon addition显示文摘Ti-bearing high-entropy superalloys(HESAs)often suffer from severe intergranular embrittlement and terrible oxidation degradation at intermediate temperatures.Here we showcase that minor Si addition can effectively mitigate the intergranular embrittlement and improve the oxidation resistance of the a(Ni_(2)Co_(2)FeCr)_(92) Ti_(4)Al_(4) HESA at 700℃ simultaneously.Experimental analysis revealed that the intergranu-lar G phase induced by 2 at%Si addition can effectively suppress the inward diffusion of oxygen along grain boundaries at 700℃,thus enhancing the tensile ductility of the alloy from∼8.3%to∼13.4%.Be-sides,the 2 at%Si addition facilitated the formation of a continuous Al_(2)O_(3) layer during oxidation,con-tributing to a remarkable reduction in the growth rate of the oxide scale to a quarter of the Si-free HESA.Our results demonstrate that Si can be a favorable alloying element to design advanced HESAs with syn-ergistically improved thermal-mechanical performance. | Shaofei Liu Weicheng Xiao Bo Xiao Jiang Ju Yinghao Zhou Yilu Zhao Zengbao Jiao Junhua Luan Qian Li Jinxiong Hou Ji-jung Kai Tao Yang | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
| 19 | Efficacy of repeated intravenous esketamine in adolescents with anxious versus non-anxious depression显示文摘Background Patients with anxious major depressive disorder(MDD)are more likely to have poorer outcomes than those with non-anxious MDD.However,the effect of esketamine on adolescents with anxious versus non-anxious MDD has remained unknown.Aims We compared the efficacy of esketamine in adolescents with MDD and suicidal ideation,both anxious and non-anxious.Methods Fifty-four adolescents with anxious(n=33)and non-anxious(n=21)MDD received three infusions of esketamine 0.25mg/kg or active-placebo(midazolam 0.045 mg/kg)over 5 days,with routine inpatient care and treatment.Suicidal ideation and depressive symptoms were assessed using the Columbia Suicide Severity Rating Scale and the Montgomery-Asberg Depression Rating Scale.Multiple-sample proportional tests were used to compare the differences between groups on treatment outcomes 24 hours after the final infusion(day 6,primacy efficacy endpoint)and throughout the 4-week post-treatment(days 12,19 and 33).Results In subjects who received esketamine,a greater number of patients in the non-anxious group than the anxious group achieved antisuicidal remission on day 6(72.7%vs 18.8%,p=0.015)and day 12(90.9%vs 43.8%,p=0.013),and the non-anxious group had a higher antidepressant remission rate compared with the anxious group on day 33(72.7%vs 26.7%,p=0.045).No significant differences in treatment outcomes were observed between the anxious and non-anxious groups at other time points.Conclusions Three infusions of esketamine as an adjunct to routine inpatient care and treatment had a greater immediate post-treatment antisuicidal effect in adolescents with non-anxious MDD than in those with anxious MDD;however,this benefit was temporary and was not maintained over time. | Xiaofeng Lan Chengyu Wang Fan Zhang Haiyan Liu Ling Fu Weicheng Li Yanxiang Ye Zhibo Hu Siming Mai Yuping Ning Yanling Zhou | 2023 | General Psychiatry2023，36，3： | 0 |
| 20 | Nebkhas play important roles in desertification control and biodiversity protection in arid and semi-arid regions of China显示文摘Nebkhas are isolated mounds vegetated with burial-tolerant desert plants that trap windborne sediment within their canopies.Nebkhas are critical to desertification control and biodiversity protection of oases in arid and semi-arid regions of China,as they(ⅰ)trap windborne sediments and ensure oasis security;(ⅱ)as“fertile islands,”nebkhas can trap and provide a suitable micro-environment for seeds,birds,and small soil animals,and increase biodiversity;(ⅲ)increase the soil surface roughness and significantly reduce soil erosion following heavy rain.However,the establishment of sand-fixing vegetation and over-grazing significantly limits the development and accelerate the degradation of nebkhas,threatening oasis ecosystems.We provide background and recommendations for protective measures for nebkha landscapes in arid and semi-arid areas of China to aid managers in oasis protection. | Weicheng Luo Wenzhi Zhao Bing Liu Hai Zhou | 2020 | Ecosystem Health and Sustainability2020，6，1： | 0 |
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