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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 1型糖尿病患者的血糖控制,心脏自身免疫和心血管病的长期风险显示文摘血糖控制不佳与1型糖尿病(type 1diabetes mellitus,T1DM)患者的心血管病风险增加有关;然而,对T1DM的特异性机制知之甚少。在T1DM中,心肌损伤可诱发持续的心脏自身免疫。慢性高血糖症引起心肌损伤,高血糖诱导的心脏自身免疫可能导致长期心血管病并发症的可能性。 | Sousa GR Pober D Galderisi A Lv H Yu L Pereira AC Doria A Kosiborod M Lipes MA 刘莉 叶鹏 | 2019 | 中华高血压杂志2019，27，1： | 8 |
| 3 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 4 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 5 | Novel amphiphilie diblock and triblock liquid-crystalline eopolymers with well-defined structures prepared by atom transfer radical polymerization显示文摘 | Shishido A Ikeda T | 2005 | Macmmol Rapid Commun2005，26，： | 1 |
| 6 | Layered Copper Metagermanate Nanobelts: Hydrothennal Synthesis, Structure, and Magnetic Properties显示文摘 | Song R Q Xu A W Yu S H | 2007 | J Am Chem Soc2007，129，14： | 1 |
| 7 | Inertially coupled galloping of iced conductors 显示文摘 | Yu P Shah A H Popplewell N | 1992 | ASME Journal of Applied Mechanics1992，59，1： | 1 |
| 8 | Factors affecting Agrobactcrium-mediated transformation and regeneration of sweet orange and citrange 显示文摘 | Yu C H Huang S Chen C X Deng Z A Ling P and Gmitter F O J | 2002 | Plant Cell Tissue and Organ Culture2002，71，： | 1 |
| 9 | Inertially Coupled Galloping of Iced Conductors显示文摘 | Yu P Shah A H Popplewell N | 1992 | Journal of Applied Mechanics Transactions ASME1992，59，1： | 1 |
| 10 | The roleof uterine artery Doppler in predicting adverse pregnancy outcome显示文摘 | Papageorghiou A T Yu C K Nicolaides K H | 2004 | Best Pract Res Clin Obstet Gynaecol2004，18，3： | 1 |
| 11 | Potential magnesium alloys for high temperature die cast automotive applications: a review 显示文摘 | Hu H Yu A Li N | 2003 | Materials and ManufacturingProcesses2003，18，5： | 1 |
| 12 | Pharmaceutical contamina- tion in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan 显示文摘 | Lin A Y C Yu T H Lin C F | 2008 | Chemosphere2008，74，1： | 1 |
| 13 | The effects of supply chain integration on customer satisfaction and financial performance : An organizational learning perspective 显示文摘 | YU W T JACOBS M A SALISBURY W D ENNS H | 2013 | International Journal of Production Economies2013，146，1： | 1 |
| 14 | Molecular structures and metabolic characteristics of protein in brown and yellow flaxseed with altered nutrient traits显示文摘 | KHAN N A BOOKER H YU P | 2014 | J Agric Food Chem2014，62，28： | 1 |
| 15 | A novel DSP-based current-controlled PWM strategy for single phase grid connected inverters显示文摘 | Kojabadi H M Bin Yu Gadoura I A | 2006 | IEEE Transactions on Power Electronics2006，21，4： | 1 |
| 16 | Numerical simulation of the gasparticle flow in a fluidized bed by combining discrete particle method with computational fluid dynamics 显示文摘 | XU B H YU A B | 1997 | Chemical Engineering Science1997，52，： | 1 |
| 17 | Growth factors and extracellular ma-trix of liver precursor cell proliferation and differentiation显示文摘 | Qin A Zhou X Q Yu H | 2004 | ChineseJournal of Hepatology2004，12，7： | 1 |
| 18 | High quality CeO2 nanocrystals stabilized by a double hydrophilic block copolymer显示文摘 | YU Shuhong COLFEN H FISCHER A | 2004 | Colloids and Surfaces A: Physicochem2004，243，： | 1 |
| 19 | Natural at- tenuation, biostimulation and bioaugmentation on biodegrada tion of polycyclic aromatic hydrocarbons (PAHs) in man- grove sediments显示文摘 | YU K S H WONG A H Y YAU K W Y | 2005 | Marine Pollution Bulletin2005，51，89101112： | 1 |
| 20 | Gene selection from microarray data for cancer classification-a machinelearning approaeh显示文摘 | YU WANG IGOR V T MARK A H | 2005 | Computational Biology and Chemistry2005，，： | 1 |
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