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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 3 | The CELLULOSE-SYNTHASE LIKE C (CSLC) Family of Barley Includes Members that Are Integral Membrane Proteins Targeted to the Plasma Membrane显示文摘纤维素象 SYNTHASE 一样 C (CSLC ) 家庭是在被认为在苔藓和脉管的植物的分叉前产生了的 CELLULOSE SYNTHASE/CELLULOSE 象 SYNTHASE 一样(CESA/CSL ) 多糖 synthase 总科以内的一个古老的系。作为在 flowering 植物的研究, Arabidopsis 建议了合成( 1,4 )-- xyloglucan ( XyG )的 glucan 脊梁,,拴住邻近的纤维素 microfibrils 到对方的墙多糖为 CSLC 的可能的功能, CSLC 功能在大麦( Hordeum vulgare L.)被调查,有在它的墙中的 XyG 的低数量的种。四大麦 CSLC 基因被识别(指明的 HvCSLC14 ) 。种系发生的分析在 flowering 植物揭示 CSLC 的三很好支持的 clades,与有在二这些 clades 的代表的大麦。四大麦 CSLC 在各种各样的纸巾被表示,与,包括有主要、第二等的房间墙的房间在在所有房间检测抄本的 situ PCR coleoptile 和根打字。合作表示分析证明 HvCSLC3 并列地与通常认为的 XyG xylosyltransferase 基因被表示。两免疫 -- 他们和膜分别证明 HvCSLC2 位于大麦的血浆膜暂停有教养的房间并且不在象 endoplasmic 那样的内部膜蜂窝胃或 Golgi 仪器。基于我们多糖合成的亚 cellular 地点的当前的知识,我们断定 CSLC 家庭可能包含多糖 synthase 的超过一种类型。 | Fenny M. Dwivany Dina Yulia Rachel A, Burton Neil J. Shirley Sarah M. Wilson Geoffrey B, Fincher Antony Bacic Ed Newbigin Monika S. Doblin | 2009 | Molecular Plant2009，2，5： | 2 |
| 4 | Genetics of macrovascular complications in type 2 diabetes显示文摘Type 2 diabetes mellitus(T2DM)is a metabolic disorder that currently affects more than 400 million worldwide and is projected to cause 552 million cases by the year 2030.Long-term vascular complications,such as coronary artery disease,myocardial infarction,stroke,are the leading causes of morbidity and mortality among diabetic patients.The recent advances in genome-wide technologies have given a powerful impetus to the study of risk markers for multifactorial diseases.To date,the role of genetic and epigenetic factors in modulating susceptibility to T2DM and its vascular complications is being successfully studied that provides the accumulation of genomic knowledge.In the future,this will provide an opportunity to reveal the pathogenetic pathways in the development of the disease and allow to predict the macrovascular complications in T2DM patients.This review is focused on the evidence of the role of genetic variants and epigenetic changes in the development of macrovascular pathology in diabetic patients. | Ziravard N Tonyan Yulia A Nasykhova Maria M Danilova Andrey S Glotov | 2021 | World Journal of Diabetes2021，12，8： | 2 |
| 5 | Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes显示文摘Type 2 diabetes(T2D)mellitus is a common complex disease that currently affects more than 400 million people worldwide and has become a global health problem.High-throughput sequencing technologies such as whole-genome and whole-exome sequencing approaches have provided numerous new insights into the molecular bases of T2D.Recent advances in the application of sequencing technologies to T2D research include,but are not limited to:(1)Fine mapping of causal rare and common genetic variants;(2)Identification of confident genelevel associations;(3)Identification of novel candidate genes by specific scoring approaches;(4)Interrogation of disease-relevant genes and pathways by transcriptional profiling and epigenome mapping techniques;and(5)Investigation of microbial community alterations in patients with T2D.In this work we review these advances in application of next-generation sequencing methods for elucidation of T2D pathogenesis,as well as progress and challenges in implementation of this new knowledge about T2D genetics in diagnosis,prevention,and treatment of the disease. | Yulia A Nasykhova Yury A Barbitoff Elena A Serebryakova Dmitry S Katserov Andrey S Glotov | 2019 | World Journal of Diabetes2019，10，7： | 2 |
| 6 | Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells显示文摘 | Galina V Larisa Z Yulia A | 2004 | BMC Cancer2004，4，8： | 1 |
| 7 | Oxidative stress following traumatic brain injury in rats显示文摘 | VLADIMIR A TYURIN YULIA Y | 2000 | Journal of Neurochemistry2000，75，5： | 1 |
| 8 | Effects of gelatinous plankton on Black Sea and Sea of Azov fish and their food resources显示文摘 | Shiganova T A Yulia V B | 2000 | ICES Journal of Marine Science2000，57，： | 1 |
| 9 | Copper nanoparticles as active catalysts in hydroxylation of phenol by hydrogen peroxide显示文摘 | Karakhanov Edward A Maximov Anton L Kardasheva Yulia S | 2010 | Applied Catalysis A: General2010，385，： | 1 |
| 10 | Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity显示文摘 | Shvedova Anna A Fabisiak James P Kisin Elena R Murray Ashley R Roberts Jenny R Tyurina Yulia Y Antonini James M Feng Wei Hong Kommineni Choudari Reynolds Jeffrey Barchowsky Aaron Castranova Vince Kagan Valerian E | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，5： | 1 |
| 11 | Hydroxylation of phenol by hydrogen peroxide catalyzed by copper( Ⅱ ) and iron(Ⅲ) complexes: the structure of ligand and the selectivity of ortho- hydroxylation显示文摘 | Karakhanov Edward A Maximov Anton L Kardasheva Yulia S | 2010 | Ind Eng Chem Res2010，49，： | 1 |
| 12 | Myometrial oxytocin receptor exp- ression and intracellular pathways显示文摘 | Yulia A Johnson MR | 2014 | Minerva Ginecol2014，66，3： | 1 |
| 13 | Involvement of Notch1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines 显示文摘 | Yulia N Cheng P Y Melissa A | 2004 | Blood2004，103，9： | 1 |
| 14 | Oxida- tive lipidomics of γ-irradiation-induced intestinal injury 显示文摘 | Yulia Y T Vladimir A T Michael W E | 2008 | 44(3) :299-3142008，44，3： | 1 |
| 15 | Poten- tial 18F-labeled biomarkers for epidermal growth factor receptor tyro- sine kinase 显示文摘 | Bonasem Thomas A Ortua Giuseppina Rozen Yulia | 2001 | Nuclear Medicine and Biology2001，28，： | 1 |
| 16 | Cadmium and Copper Uptake and Translocation in Five Willow Species 显示文摘 | YULIA A KUZOVKINA MICHAEL KNEE | 2004 | International Journal of Phytoremediation2004，6，3： | 1 |
| 17 | Involvement of Notch-1 signaling in bone marrow stroma mediated denovo drug resistance of myeloma and other malignant lymphoid cell lines显示文摘 | Yulia N Pingyan C Melissa A | 2004 | Blood2004，103，： | 1 |
| 18 | Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality显示文摘Background:In vitro production of bovine embryos is a well-established technology,but the in vitro culture(IVC)system still warrants improvements,especially regarding embryo quality.This study aimed to evaluate the effect of extracellular vesicles(EVs)isolated from oviductal(OF)and uterine fluid(UF)in sequential IVC on the development and quality of bovine embryos.Zygotes were cultured in SOF supplemented with either BSA or EVs-depleted fetal calf serum(dFCS)in the presence(BSA-EV and dFCS-EV)or absence of EVs from OF(D1 to D4)and UF(D5 to D8),mimicking in vivo conditions.EVs from oviducts(early luteal phase)and uterine horns(mid-luteal phase)from slaughtered heifers were isolated by size exclusion chromatography.Blastocyst rate was recorded on days 7-8 and their quality was assessed based on lipid contents,mitochondrial activity and total cell numbers,as well as survival rate after vitrification.Relative mRNA abundance for lipid metabolism-related transcripts and levels of phosphorylated hormonesensitive lipase(pHSL)proteins were also determined.Additionally,the expression levels of 383 miRNA in OF-and UF-EVs were assessed by qRT-PCR.Results:Blastocyst yield was lower(P<0.05)in BSA treatments compared with dFCS treatments.Survival rates after vitrification/warming were improved in dFCS-EVs(P<0.05).EVs increased(P<0.05)blastocysts total cell number in dFCS-EV and BSA-EV compared with respective controls(dFCS and BSA),while lipid content was decreased in dFCSEV(P<0.05)and mitochondrial activity did not change(P>0.05).Lipid metabolism transcripts were affected by EVs and showed interaction with type of protein source in medium(PPARGC1B,LDLR,CD36,FASN and PNPLA2,P<0.05).Levels of pHSL were lower in dFCS(P<0.05).Twenty miRNA were differentially expressed between OF-and UF-EVs and only bta-miR-148b was increased in OF-EVs(P<0.05).Conclusions:Mimicking physiological conditions using EVs from OF and UF in sequential IVC does not affect embryo development but improves blastocyst quality regarding survival rate after vitrification/warming,total cell number,lipid content,and relative changes in expression of lipid metabolism transcripts and lipase activation.Finally,EVs miRNA contents may contribute to the observed effects. | Cláudia Lima Verde Leal Karina Canón-Beltrán Yulia N.Cajas Meriem Hamdi Aracelli Yaryes María Gemma Millán de la Blanca Paula Beltrán-Brena Rosane Mazzarella Juliano Coelho da Silveira Alfonso Gutiérrez-Adán Encina M González Dimitrios Rizos | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 19 | 通过图像分析、临床评估和消费者评估的方法评价唇部产品的性能显示文摘结合临床评估、消费者评估,通过图像分析方法建立可以客观量化的唇部外观指数(LAI),使其应用于唇部产品的性能评价。招募30名成年女性自愿者参加研究,定期使用口红,在不同时间点收集相关数据,用于LAI指数模型的建立和验证。使用6个参数(a*:肤色红度,ENT:熵,CU:肤色均匀度,IDM:逆差矩,ASM:角二阶矩,C:对比度)构建出LAI指数计算公式,并通过LAI值与TEWL、消费者感官评估的关联性验证,证明了LAI指数构建成功。 | Yulia A Park 曲镝 廖峰 | 2015 | 日用化学品科学2015，38，8： | 0 |
| 20 | Taxonomic Composition and Spatial Distribution of Meiofauna Community from a Sandy Intertidal Zone in Sishili Bay, Yellow Sea Coast (Northern China)显示文摘The meiofauna composition and trophic groups of the nematode communities have been studied at a sandy intertidal zone in Sishili Bay along the Yantai coast(Yellow Sea,China).Nematoda was dominant among the 11 groups of meiofauna.The meiofaunal densities were low,ranging between 111±47 and 542±131 ind./10 cm^(2).Results obtained from the correlation analysis made it possible to determine several factors that influence species composition and distribution.Generally,sediment granulometry significantly affected the communities.The highest abundance was found in fine-grained sediments(318.77±126 ind./10 cm^(2))com-pared to coarse-grained sediments(175±82 ind./10 cm2).Nematodes were predominant in all studied sites.A total of 70 species be-longing to 52 genera and 18 families were identified in the study area.There was a significant difference in nematode abundance(ANOVA,F=2.38,P<0.05)between the three sites.Nematode communities were characterized by a high level of species diversity in sediments composed mainly of very-fine sands(>63μm),with dominant species belonging to the genus Bathylaimus,Ptycho-laimellus,Spirinia,and Sabatieria.The trophic groups were dominated by non-selective deposit feeders(40.7%)and epistrate feed-ers(41.29%).In contrast,the species composition in medium grain sands was characterized by a low species diversity index and a high Simpson dominance index.Nematode communities showed similar dominant species compositions belonging to a single genus Bathylaimus,Enoplolaimus,and Oncholaimus,and in terms of trophic structure-representatives of deposit feeders(46.15%),preda-tors,and omnivores(64.71%)prevailed.The divergence of meiofaunal community structures can be explained by abiotic factors such as sediment grain size,salinity,and organic carbon content.Specifically,sediment particle size can explain the diversity of nematodes at the level of in abundance,diversity indices,and trophic structure.The highest nematode density and diversity coincided with the highest percentage of very fine sands. | PAVLYUK Olga N TREBUKHOVA Yulia A SHCHERBAKOV Ilya A TARASOVA Tatiana S LUTAENKO Konstantin A CHEN Linlin SONG Bo LI Xiaojing LI Baoquan | 2022 | Journal of Ocean University of China2022，21，5： | 0 |
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