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| 1 | Genetics of macrovascular complications in type 2 diabetes显示文摘Type 2 diabetes mellitus(T2DM)is a metabolic disorder that currently affects more than 400 million worldwide and is projected to cause 552 million cases by the year 2030.Long-term vascular complications,such as coronary artery disease,myocardial infarction,stroke,are the leading causes of morbidity and mortality among diabetic patients.The recent advances in genome-wide technologies have given a powerful impetus to the study of risk markers for multifactorial diseases.To date,the role of genetic and epigenetic factors in modulating susceptibility to T2DM and its vascular complications is being successfully studied that provides the accumulation of genomic knowledge.In the future,this will provide an opportunity to reveal the pathogenetic pathways in the development of the disease and allow to predict the macrovascular complications in T2DM patients.This review is focused on the evidence of the role of genetic variants and epigenetic changes in the development of macrovascular pathology in diabetic patients. | Ziravard N Tonyan Yulia A Nasykhova Maria M Danilova Andrey S Glotov | 2021 | World Journal of Diabetes2021，12，8： | 2 |
| 2 | Externalization of endogenous annexin A5 participates in apoptosis of rat cardiomyocytes 显示文摘 | Virginie M Yulia B Gueorgul K | 2004 | Cardio Res2004，64，3： | 1 |
| 3 | The digestion of phosphate ore in phosphoric acid显示文摘 | Sietse van der S Yulia M Wim G J | 1987 | Ind Eng Chem Res1987，26，： | 1 |
| 4 | Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin H A( MYH9 protein) in human podocytes 显示文摘 | Sima B Michelle M Yulia Z | 2011 | Pediatr Nephro12011，26，7： | 1 |
| 5 | Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity显示文摘 | Shvedova Anna A Fabisiak James P Kisin Elena R Murray Ashley R Roberts Jenny R Tyurina Yulia Y Antonini James M Feng Wei Hong Kommineni Choudari Reynolds Jeffrey Barchowsky Aaron Castranova Vince Kagan Valerian E | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，5： | 1 |
| 6 | Evaluation of cancer treatment in the abdomen: Trends and advances显示文摘Response evaluation in Oncology has relied primarily on change in tumor size. Inconsistent results in the prediction of clinical outcome when size based criteria are used and the increasing role of targeted and locoregional therapies have led to the development of new methods of response evaluation that are unrelated to change in tumor size. The goals of this review are to expose briefly the size based criteria and to present the non-size based approaches that are currently applicable in the clinical setting. Other paths that are still being explored are not discussed in details. | Silanath Peungjesada Hubert H Chuang Srinivasa R Prasad Haesun Choi Evelyne M Loyer Yulia Bronstein | 2013 | World Journal of Radiology2013，5，3： | 1 |
| 7 | Calcineurin A_ Is Central to the Expression of the Renal Type Ⅱ Na/PiCo-transporter Gene and to the Regulation of Renal Phosphate Transport显示文摘 | Yulia M Ronen L | 2004 | J Am Soc Nephrol2004，15，： | 1 |
| 8 | ITO-free flexible organic solar cells with printed cur- rent collecting grids 显示文摘 | Yulia Galagan Jan-EricJ M Rubingh Ronn Andriessen Chia-Chen Fan Paul W M Blom Sjoerd C Veenstra Jan M Kroon | 2011 | Solar Energy Materials & Solar Cells2011，95，： | 1 |
| 9 | Pd nanoparticles in dendrimers immobilized on silica-polyamine composites as catalysts for selective hydrogenation显示文摘 | EDWARD K ANTON M YULIA K al et | 2014 | ACS Applied Materials & Interfaces2014，6，11： | 1 |
| 10 | A dual-axis tilt acquisition geometry for digital musculoskeletal tomosynthesis显示文摘 | Yulia M Levakhina Robert L Duschka Florian M Vogt Joerg Barkhausen Thorsten M Buzug | 2013 | Physics in Medicine and Biology2013，，14： | 1 |
| 11 | Identification of some naturally occurring alkylsubstituted phenols in cashew-nut shell liquid by chromatographic techniques显示文摘 | YULIA M NGUYAN B T FAIKA S | 1968 | Journal of Chromatography A1968，32，4： | 1 |
| 12 | The effect of manipulation of the center of pressure of the foot during gait on the activation patterns of the lower limb musculature 显示文摘 | Yulia G Eytan M D Amir H | 2011 | J Electromyogr Kinesiol2011，21，2： | 1 |
| 13 | Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality显示文摘Background:In vitro production of bovine embryos is a well-established technology,but the in vitro culture(IVC)system still warrants improvements,especially regarding embryo quality.This study aimed to evaluate the effect of extracellular vesicles(EVs)isolated from oviductal(OF)and uterine fluid(UF)in sequential IVC on the development and quality of bovine embryos.Zygotes were cultured in SOF supplemented with either BSA or EVs-depleted fetal calf serum(dFCS)in the presence(BSA-EV and dFCS-EV)or absence of EVs from OF(D1 to D4)and UF(D5 to D8),mimicking in vivo conditions.EVs from oviducts(early luteal phase)and uterine horns(mid-luteal phase)from slaughtered heifers were isolated by size exclusion chromatography.Blastocyst rate was recorded on days 7-8 and their quality was assessed based on lipid contents,mitochondrial activity and total cell numbers,as well as survival rate after vitrification.Relative mRNA abundance for lipid metabolism-related transcripts and levels of phosphorylated hormonesensitive lipase(pHSL)proteins were also determined.Additionally,the expression levels of 383 miRNA in OF-and UF-EVs were assessed by qRT-PCR.Results:Blastocyst yield was lower(P<0.05)in BSA treatments compared with dFCS treatments.Survival rates after vitrification/warming were improved in dFCS-EVs(P<0.05).EVs increased(P<0.05)blastocysts total cell number in dFCS-EV and BSA-EV compared with respective controls(dFCS and BSA),while lipid content was decreased in dFCSEV(P<0.05)and mitochondrial activity did not change(P>0.05).Lipid metabolism transcripts were affected by EVs and showed interaction with type of protein source in medium(PPARGC1B,LDLR,CD36,FASN and PNPLA2,P<0.05).Levels of pHSL were lower in dFCS(P<0.05).Twenty miRNA were differentially expressed between OF-and UF-EVs and only bta-miR-148b was increased in OF-EVs(P<0.05).Conclusions:Mimicking physiological conditions using EVs from OF and UF in sequential IVC does not affect embryo development but improves blastocyst quality regarding survival rate after vitrification/warming,total cell number,lipid content,and relative changes in expression of lipid metabolism transcripts and lipase activation.Finally,EVs miRNA contents may contribute to the observed effects. | Cláudia Lima Verde Leal Karina Canón-Beltrán Yulia N.Cajas Meriem Hamdi Aracelli Yaryes María Gemma Millán de la Blanca Paula Beltrán-Brena Rosane Mazzarella Juliano Coelho da Silveira Alfonso Gutiérrez-Adán Encina M González Dimitrios Rizos | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
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