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| 1 | Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B显示文摘Aim: To examine the effects ofAstragalus polysaccharide (APS), a component of an aqueous extract ofAstragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor (IR) signal transduction, and its potential role in the amelioration of insulin resistance. Methods: Ten-week-old fat-fed streptozotocin (STZ)-treated rats, an animal model of type Ⅱ diabetes mellitus (TIIDM), were treated with APS (400 mg/kg po) for 5 weeks. Insulin sensitivity was identified by the insulin-tolerance test. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle and liver were performed by immunoprecipitation or Western blotting. PTP1B activity was measured by an assay kit. Results: The diabetic rats responded to APS with a significant decrease in body weight, plasma glucose, and improved insulin sensitivity. The activity and expression of PTP1B were elevated in the skeletal muscle and liver of TIIDM rats. Thus the insulin signaling in target tissues was diminished. APS reduced both PTP1B protein level and activity in the muscle, but not in the liver of TIIDM rats. Insulin-induced tyrosine phosphorylation of the IR β-subunit and insulin receptor substrate-1 (IRS-1) were increased in the muscle, but not in the liver of APS-treated TIIDM rats. There was no change in the activity or expression of PTP1B in APS-treated normal rats, and blood insulin levels did not change in TIIDM rats after treatment with APS. Conclusion: APS enables insulin-sensitizing and hypoglycemic activity at least in part by decreasing the elevated expression and activity of PTP1B in the skeletal muscles of TIIDM rats. | YongWU Jing-pingOU-YANG KeWU YaWANG Yun-fengZHOU Chong-yuanWEN | 2005 | Acta Pharmacologica Sinica2005，26，3： | 58 |
| 2 | Impacts of low level aflatoxin in feed and the use of modified yeast cell wall extract on growth and health of nursery pigs显示文摘This study was to investigate the effect of corn naturally contaminated with aflatoxins(AF)under the regulatory level on the growth performance and health of nursery pigs,and the efficiency of yeast cell wall based feed additive(YC)mainly composed ofβ-glucans and mannan oligosaccharide(MOS)(Integral A+,Alltech,Lexington,KY)in prevention of mycotoxicosis.Pigs(60 barrows and 60 gilts at 6.02 ± 0.83kg BW)were randomly allotted to 4 treatments in a randomized complete block design based on a 2×2 factorial arrangement with 10 pens(5 barrow and 5 gilt pens)per treatment and 3 pigs per pen.Pigs were fed experimental diets for 5 wk.First factor was AF(0 or 20 mg/kg in feed)and the second factor was YC(0 or 2 g/kg in feed).Feed intake and body weight were measured weekly,and blood samples were used to measure blood cell counts,immunoglobulin G(Ig G),tumor necrosis factor-a(TNF-a),oxidative damage status,and serological evaluation related to liver health.Aflatoxin decreased(P<0.05)the number of platelet count(247.4 to 193.5×10~3/μL),and it also tended to increase the level of albumin(P=0.055,3.46 to 3.63 g/d L),albumin:globulin ratio(P=0.050,2.09 to 2.37),and Ca(P=0.080,10.79 to 10.97 mg/d L).Yeast cell wall based feed additive increased(P < 0.05)ADG(493 to 524 g/d),and ADFI(796 to 846 g/d)of pigs whereas G:F was not affected,and it also tended to increase(P=0.055)albumin level(3.46 to 3.63 g/d L).Interactions(P < 0.05)on hemoglobin,hematocrit,and platelet count indicated that YC further increased their levels when pigs were eating AF contaminated feed.Interactions(P < 0.05)on urea nitrogen and blood urea N to creatinine ratio indicated that YC further decreased their levels when feed were contaminated with AF.In conclusion,low level of 20 mg AF/kg under the regulatory level had minor effects on hematology without affecting growth performance,however the supplementation of 2 g/kg YC as a source ofβ-glucans and MOS in feed can improve feed intake and therefore the growth of pigs. | Yawang Sun Inkyung Park Jiyao Guo Alexandra C.Weaver Sung Woo Kim | 2015 | Animal Nutrition2015，，3： | 8 |
| 3 | Intestinal challenge with enterotoxigenic Escherichia coli in pigs,and nutritional intervention to prevent postweaning diarrhea显示文摘Gut health of nursery pigs immediately after weaning is tightly associated with their growth performance and economic values. Postweaning diarrhea(PWD) is one of the major concerns related to gut health of nursery pigs which often is caused by infections of enterotoxigenic Escherichia coli(ETEC),mainly including F4(K88)^+ and F18^+ E. coli. The main virulence factors of ETEC are adhesins(fimbriae or pili) and enterotoxins. The common types of fimbriae on ETEC from PWD pigs are F18^+ and F4^+. Typically, PWD in pigs is associated with both F18^+ and F4^+ ETEC infections whereas pre-weaning diarrhea in pigs is associated with F4+ ETEC infection. Enterotoxins including heat-labile enterotoxins(LT) and heatstable peptide toxins(ST) are associated with causing diarrhea in pigs. At least 109 to 1010 ETEC are required to induce diarrhea in nursery pigs typically lasting 1 to 5 days after ETEC infection. Antibiotics used to be the most effective way to prevent PWD, however, with the increased bacterial resistance to antibiotics, alternatives to the use of antibiotics are urgently needed to prevent PWD. Immunopropylaxis and nutritional intervention of antimicrobial minerals(such as zinc oxide and copper sulfate), organic acids, functional feedstuffs(such as blood plasma and egg yolk antibodies), direct fed microbials, phytobiotics, and bacteriophage can potentially prevent PWD associated with ETEC. Some other feed additives such as nucleotides, feed enzymes, prebiotic oligosaccharides, and clay minerals can enhance intestinal health and thus indirectly help with preventing PWD. Numerous papers show that nutritional intervention using selected feed additives can effectively prevent PWD. | Yawang Sun Sung Woo Kim | 2017 | Animal Nutrition2017，，4： | 4 |
| 4 | 日粮中添加微生态制剂对断奶仔猪生长性能、肠道健康和由F18^+大肠杆菌引起的仔猪腹泻的影响显示文摘本研究旨在检测F18^+产肠毒素大肠杆菌(ETEC)对新生断奶仔猪生长性能和肠道健康的影响以及饲喂直接饲喂型微生物添加剂DFM(百猛灵,明星实验室/美国饲料研究公司)对F18^+ETEC引起的断奶仔猪腹泻的影响。试验选择日龄和体重相近、健康状况良好的三元杂交断奶仔猪32头(公母各半,体重6.99 kg±0.33 kg),随机分成4组(2×2因子试验)。试验期25 d:分0~9 d和10 d^25 d两个阶段。第一影响因子:断奶后第13天F18^+ETEC攻毒(0或2×10~9 CFU);第二影响因子:DFM(第一、二阶段添加量分别为0.15%和0.10%)。在第5、9、13、19和25天称量断奶仔猪体重和采食量。第2、3、5、9、12和13天检测粪样得分。第19和24天颈静脉采血收集血液样品。在第25天屠宰将所有仔猪处以安乐死并收集空肠、回肠和脾脏,检测空肠、回肠和结肠内容物的p H。血清和肠道组织用于检测肿瘤坏死因子(TNFα)和丙二醛(MDA)。肠道组织用于组织学评价。结果显示,E.coli口服攻毒后,空肠隐窝深度显著降低(241μm^221μm),回肠隐窝深度显著增加(255μm^284μm),粪样分数显著增加(0.45~1.03)。13 d^25 d的仔猪腹泻数明显增加1头~6头。DFM显著可增加断奶仔猪体重(11.8 kg^14.7 kg)、平均日增重(193 g/d^308 g/d)和平均日采食量(193 g/d^308 g/d),但对料重比无影响。DFM显著增加了空肠隐窝深度。绒毛高度和绒毛高度与隐窝深度比值(VCR)的交互作用表明,当猪受E.coli攻毒后,DFM可进一步增加绒毛高度和VCR值。第19天的血清TNFα浓度显示当猪只E.coli攻毒后DFM可进一步减少TNFα。由此可见,E.coli口服攻毒可增加仔猪腹泻发生率,引起肠道形态的轻微改变。DFM可通过增加平均日增重和平均日采食量来改善生长性能。 | 李亚雄(译) 仇正兴(译) 何闪(图) Sung Woo Kim Yawang Sun | 2016 | 国外畜牧学(猪与禽)2016，36，4： | 3 |
| 5 | Changes in dendritic cells and dendritic cell subpopulations in peripheral blood of recipients during acute rejection after kidney transplantation显示文摘 | Ma Linlin Liu Yong Wu Junjie Xu Xiuhong Liu Fen Feng Lang Xie Zelin Tang Yawang Sun Wen Guo Hongbo Zhang Lei Lin Jun Tian Ye | 2014 | Chinese Medical Journal2014，，8： | 3 |
| 6 | 产肠毒素大肠杆菌主要毒力因子介绍显示文摘肠道是猪消化系统的主要组成部分,同时也是免疫系统的最大组成部分。肠道的功能在于消化食物、吸收营养,同时还负责保护机体免受毒素和病原的侵袭,所以保持猪尤其是保育猪的肠道健康是保证猪群健康生产的基础。而肠道致病菌感染引发的腹泻对猪的肠道健康是一个巨大的挑战,同时也是全球养猪业发展的巨大挑战。 | 费文涛(摘译) 张晨飞(摘译) 张配配(审) Yawang Sun Sung WooKim | 2018 | 国外畜牧学(猪与禽)2018，38，12： | 2 |
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