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| 1 | Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B显示文摘Aim: To examine the effects ofAstragalus polysaccharide (APS), a component of an aqueous extract ofAstragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor (IR) signal transduction, and its potential role in the amelioration of insulin resistance. Methods: Ten-week-old fat-fed streptozotocin (STZ)-treated rats, an animal model of type Ⅱ diabetes mellitus (TIIDM), were treated with APS (400 mg/kg po) for 5 weeks. Insulin sensitivity was identified by the insulin-tolerance test. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle and liver were performed by immunoprecipitation or Western blotting. PTP1B activity was measured by an assay kit. Results: The diabetic rats responded to APS with a significant decrease in body weight, plasma glucose, and improved insulin sensitivity. The activity and expression of PTP1B were elevated in the skeletal muscle and liver of TIIDM rats. Thus the insulin signaling in target tissues was diminished. APS reduced both PTP1B protein level and activity in the muscle, but not in the liver of TIIDM rats. Insulin-induced tyrosine phosphorylation of the IR β-subunit and insulin receptor substrate-1 (IRS-1) were increased in the muscle, but not in the liver of APS-treated TIIDM rats. There was no change in the activity or expression of PTP1B in APS-treated normal rats, and blood insulin levels did not change in TIIDM rats after treatment with APS. Conclusion: APS enables insulin-sensitizing and hypoglycemic activity at least in part by decreasing the elevated expression and activity of PTP1B in the skeletal muscles of TIIDM rats. | YongWU Jing-pingOU-YANG KeWU YaWANG Yun-fengZHOU Chong-yuanWEN | 2005 | Acta Pharmacologica Sinica2005，26，3： | 58 |
| 2 | ZnPcS_2P_2-based Photodynamic Therapy Induces Mitochondria-dependent Apoptosis in K562 Cells显示文摘Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumor chemotherapeutic and other toxic agents. Photodynamic therapy (PDT) exerts significant cellular killing efficacy through either an apoptotic or necrotic cell death pathway. This study investigated the mechanism underlying the killing effects of a novel amphipathic photosensitizer [di-sulfonated di-phthalimidomethy lphthalocyanine zinc (ZnPcS2P2)]-mediated photodynamic therapy (ZnPcS2P2-PDT) on K562 cells. Apoptosis was evident in the post-PDT cells through the TdT-mediated dUTP nick end labeling (TUNEL) method and DNA fragmentation assay. After ZnPcS2P2-PDT, K562 cells underwent mitochondria-dependent apoptosis as evidenced by the release of cytochrome c from mitochondria into cytosol, accompanied by mitochondrial membrane potential (A^m) reduction, indicating the opening of the mitochondrial permeability transition pore (PTP). The activities of protease from the caspase family and caspase-3 were also significantly elevated. Furthermore, ZnPcS2P2-PDT down-regulated the expression of chimaeric Bcr-Abl oncoprotein, which is the molecular hallmark of chronic myelogenous leukemia (CML). | Hui-FangHUANG Yuan-ZhongCHEN YongWU | 2005 | Acta Biochimica et Biophysica Sinica2005，37，7： | 7 |
| 3 | Optimal Decision Rule of the inventory Problem for Deteriorating items with Shortages and Time-varying Demand | ZHOU Yongwu(Hefei University of Technology Helei, 230009, China) | 1996 | Systems Science and Systems Engineering1996，6，2： | 7 |
| 4 | Research on the molecular scale material removal mechanism in chemical mechanical polishing显示文摘This paper investigates a novel molecular scale material removal mechanism in chemical mechanical polishing (CMP) by incorporating the order-of-magnitude calculations,particle adhesion force,defect of wafer,thickness of newly formed oxidized layer,and large deformation of pad/particle not discussed by previous analysis. The theoretical analysis and experimental data show that the indentation depth,scratching depth and polishing surface roughness are on the order of molecular scale or less. There-fore,this novel mechanism has gained the support from wide order-of-magnitude calculations and experimental data. In addition,with the decrease in the particle size,the molecular scale removal mechanism is plausibly one of the most promising removal mechanisms to clarify the CMP polishing process. The results are useful to substantiating the molecular-scale mechanism of the CMP material removal in addition to its underlying theoretical foundation. | WANG YongGuang ZHAO YongWu | 2008 | Chinese Science Bulletin2008，53，13： | 7 |
| 5 | Recombinant fibronectin polypeptide antagonizes hepatic failure induced by endotoxin in mice显示文摘AIM: To study the preventive effect of recombinant human fibronectin (rhFN) polypeptide on hepatic failure in- duced by endotoxin in mice. METHODS: A cDNA fragment coding for Ile1363-Tyr1725 of human FN was inserted into the PinPoint Xa-3 plasmid, and the constructed plasmid was transformed into E coli BL21 (DE3) cells, and then the expression of rhFN polypeptide in DE3 cells was identified through SDS-PAGE. The target protein from the supernatant of bacteria lysate was purified through biotin-affinity chromatography. The bioactivity of the purified rhFN polypeptide was determined with cell adhesiveactivity. The survival rate was observed in endotoxemia mice injected with rhFN polypeptide. The tissue damage in hepatocyte was detected using histology, ultrastructure, and DNA fragmentation assay. RESULTS: The expression of rhFN polypeptide reached approximately 20 % of the total cellular protein. The adhesion ability of rhFN polypeptide was concentration-dependent. The value of EC50 was 0.8 nmol/L. The survival rate of endotoxemia mice sensitized by D-galactosamine (D-GalN) was 60 % in rhFN polypeptide treated group, while that of endotoxemia mice sensitized by D-GalN was 20 % in the control group (P<0.01). Histopathology showed that less necrosis occurred on the hepatocyte of endotoxemia mice in- jected with rhFN polypeptide compared with saline control. Ultrastructure and DNA fragmentation assay showed that no apoptotic hepatocyte was observed in the liver of rhFN-treated endotoxemia mice. CONCLUSION: Re- combinant fibronectin polypeptide antagonizes hepatic failure induced by endotoxin in mice. | YongWU Yuan-zhongCHEN Hui-fangHUANG PingCHEN | 2004 | Acta Pharmacologica Sinica2004，25，6： | 7 |
| 6 | PI3K/AKT Mediated p53 Down-Regulation Participates in CpG DNA Inhibition of Spontaneous B Cell Apoptosis显示文摘unmethylated CpG DNA 能阻止 B 房间的自发的 apoptosis。然而, CpG DNA 由堵住 apoptosis 的精确机制仍然保持不清楚。在这研究,我们证明 B 房间 apoptosis 被 CpG DNA 的增加显著地禁止。CpG DNA 的处理能减少 caspase 的表示 3,增加国际机场和 Bcl-xL 表情,并且禁止水平在 B 房间被增加的 p53 蛋白质表示在 24 h 的自发的 apoptosis。AKT kinase 活动与 CpG DNA 的孵化被增加。wortmannin 和 Ly294002 能由 CpG DNA 从 apoptosis 废除 B 房间的保护。当由特定的禁止者 Ly294002 堵住 PI3K 时,由 CpG DNA 的 Bci-xL 和国际机场的起来规定没被禁止,当由 CpG DNA 的 p53 的抑制能被 Ly294002 堵住时。这些结果证明由 CpG DNA 的自发的 B 房间 apoptosis 的抑制被相关到 p53 和 caspase 的 Bci-xL,国际机场和下面规定的起来规定 3。p53 的 CpG DNA 抑制通过 PI3K/AKT 发信号被调停。细胞与分子的免疫学。2009; 6 (3 ): 175-180。 | Yongxin Zhou Huiling Zhen Yunqing Mei Yongwu Wang Jing Feng Shuchang Xu Xiaoying Fu | 2009 | Cellular & Molecular Immunology2009，6，3： | 3 |
| 7 | Pricing and Service Strategies for Two-sided Platforms显示文摘Nowadays,more and more transactions or interactions like online dating and shopping are completed on two-sided platforms involving two groups of agents.On these two-sided platforms,there often exist cross-network effects,i.e., the benefits that agents at one side receive are positively related to the number of agents at the other side,and vice versa.This paper considers such two-sided platforms,where the platforms offer a certain service to attract agents of both sides to join the platforms,and then charge agents who join the platforms a lump-sum fee to gain the profit.We present service and pricing strategies for both monopolistic and duopolistic platforms,respectively.We also investigate the impact of platforms'life cycle on their service and pricing strategies.Some managerial implications are shown. | Xiaogang Lin Chuanying Chen Zhaozhan Lin Yongwu Zhou | 2019 | Journal of Systems Science and Systems Engineering2019，28，3： | 2 |
| 8 | Synthesis,structure and property of one porous Zn(salen)-based metal-metallosalen framework显示文摘Chiral Schiff-base ligand L was synthesized through six steps in good overall yield from readily available 2-tert-butylphenol and was used to construct one chiral porous metal-metallosalen framework,[Zn5(μ3-OH)2(ZnL)4(H2O)2]·18H2O(1,L=5′,5″-(1E,1′E)-(1R,2R)-cyclohexane-1,2-diylbis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)bis(3′-tert-butyl-4′-hydroxybiphenyl-4-carboxylic acid),under mild reaction conditions.1 was characterized by IR,TGA,CD,UV,PL,single-crystal and powder X-ray crystallography.The structure of 1 displays a 3-fold interpenetrating 3D framework with 1D channel of 1.14 nm×0.58nm and imparts unique Zn(salen)units on the surface of the pore,in which(ZnL)2dimer acts as multi-functionlized metalloligand.1 is thermally robust with network decomposition temperature of 400oC and it also exhibits strong photoluminescence in the visible region. | PENG YongWu ZHU ChengFeng CUI Yong | 2014 | Science China Chemistry2014，57，1： | 2 |
| 9 | How time-inconsistent preferences influence venture capital exit decisions?A new perspective for grandstanding显示文摘Considering that the assumption of time consistency does not adequately reveal the mechanisms of exit decisions of venture capital(VC),this study proposes two kinds of time-inconsistent preferences(i.e.,time-flow inconsistency and time-point incon-sistency)to advance research in this field.Time-flow inconsistency is in line with the previous time inconsistency literature,while time-point inconsistency is rooted in the VC fund’s finite lifespan.Based on the assumption about the strategies guiding future behaviors,we consider four types of venture capitalists:time-consistent,time-point-inconsistent,naïve,and sophisticated venture capitalists,of which the latter three are time-inconsistent.We derive and compare the exit thresholds of these four types of venture capitalists.The main results include:(1)time-inconsistent preferences acceler-ate the exits of venture capitalists;(2)the closer the VC funds expiry dates are,t`he more likely time-inconsistent venture capitalists are to accelerate their exits;and(3)future selves caused by time-flow inconsistency weaken the effect of time-point inconsist-ency.Our study provides a behavioral explanation for the empirical fact of young VCs’grandstanding. | Yanzhao Li Ju-e Guo Shaolong Sun Yongwu Li | 2022 | Financial Innovation2022，8，1： | 2 |
| 10 | Platform Competition for Advertisers and Viewers in Media Markets with Endogenous Content and Advertising显示文摘In this paper,we investigate two competing pay-tv platforms or free-to-air media platforms that consist of two groups of agents:viewers and advertisers.The pay-tv platforms can receive revenues from charging viewers pay-per-view prices and advertising,while the free-to-air platforms can only obtain all incomes from advertising.We discuss and compare advertising intensities and program content provisions of the two competing media platforms.Our findings show that if the extent to which viewers dislike advertising(the nuisance for advertising)is more massive than the marginal benefit that advertisers receive from an additional viewer,the pay-tv stations tend to maximally differentiate their program content and charge the viewers higher pay-per-view prices.If the nuisance approaches to the marginal benefit,however,both stations should offer similar program content,and charge the viewers lower prices under certain conditions.Particularly,if both platforms provide duplicated content,they should subsidize the viewers.In contrast,we show that the free-to-air media platforms never duplicate program content with a positive nuisance for advertising,and tend to offer maximal differentiated content if the nuisance is sufficiently large.Moreover,we reveal that if the viewers greatly dislike advertising(care less about advertising),the advertising volume of the pay-tv platforms is lower(higher)than that of the free-to-air platforms.Finally,we extend our base model to the case in which a pay-tv platform competes against a free-to-air station,and numerically show that the profit of the pay-tv platform may be larger or smaller than that of the free-to-air station. | Xiaogang Lin Rui Hou Yongwu Zhou | 2020 | Journal of Systems Science and Systems Engineering2020，29，1： | 2 |
| 11 | Optimal production and shipment models for a single-vendor-single-buyer integrated system显示文摘 | ZHOU Yongwu | 2007 | European Journal of Operational Research2007，180，： | 1 |
| 12 | Optimal production and shipment models for a single-vendor-single-buyer in- tegrated system 显示文摘 | Zhou Yongwu Wang Shengdong | 2007 | European Journal of Operational Research2007，180，1： | 1 |
| 13 | Coordinating ordering,pricing and advertising policies for a supply chain with random demand and two production modes显示文摘 | Wang Shengdong Zhou Yongwu Wang JunPing | | 0，，02： | 1 |
| 14 | A New Continuous-Production Lot-Size Model with Increasing Time-Varying Demand and Variable Rate of Production Considering Shortages | ZHOU Yongwu Hefei University of Technology, Hefei,Anhui,230009, P.R.China | 1998 | Systems Science and Systems Engineering1998，8，1： | 1 |
| 15 | A comparison of different quantity discount pricing poli- cies in a two echelon channel with stochastic and asymmetric demand and information显示文摘 | Zhou Yongwu | 2007 | European Journal of Operational Research2007，181，5： | 1 |
| 16 | A stochastic and asymmetric-information framework for a dominant-manufacturer supply chain显示文摘 | LAU A H L LAU H S ZHOU Yongwu | 2007 | European Journal of Operational Research2007，176，1： | 1 |
| 17 | Two-echelon style-goods Supply Chain Models Considering Duopolistic Retailers' Different Competitive Behaviors 显示文摘 | Yang Shanlin Zhou Yongwu | 2006 | International Journal of Production Economics (S0925-5273)2006，103，1： | 1 |
| 18 | Anasperity microcontact model incorporating the transitionfrom elastic deformation to fully plastic flow显示文摘 | ZHAO Yongwu MAIETTA D M CHANG L | 2000 | Transactions of the ASME Journal of Tribology2000，122，1： | 1 |
| 19 | An optimal replenishment policy for items with inventory-level-dependent demand and fixed lifetime under the LIFO policy显示文摘 | Zhou Yongwu Yang Shanlin | 2003 | Journal of the Operational Research Society2003，54，： | 1 |
| 20 | A model of asperityinteractions in elastic-plastic contact of rough surfaces显示文摘 | ZHAO Yongwu CHANG L | 2001 | Transactions of the ASME Journal of Tribology2001，123，4： | 1 |
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