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| 1 | Curculigoside isolated from Curculigo orchioides prevents hydrogen peroxide-induced dysfunction and oxidative damage in calvarial osteoblasts显示文摘反应的氧种类(ROS ) 包括 H2O2,在骨质疏松症的 pathophysiology 起一个关键作用。因此,能禁止 ROS 生产的代理人或抗氧化剂在骨质疏松症的治疗有高临床的价值。Curculigoside (杂种狗) ,酉分的混合物从 Curculigo orchioides Gaertn 的根茎孤立的主要 bioactive 之一,被报导有有势力抗氧化剂和 anti-osteoporotic 性质。然而,没有直接证据与观察 anti-osteoporotic 效果连接杂种狗的抗氧化剂能力,并且相关分子的机制仍然保持不清楚。因此,我们在 calvarial 造骨细胞对氧化应力调查了杂种狗的保护的效果并且讨论了相关机制。造骨细胞生存能力在 48-h 暴露以后显著地减少了到 H2O2 的 400 M,这被发现,与对待车辆的房间相比,并且 H2O2 的细胞毒素的效果显著地被颠倒什么时候有杂种狗的 0.110 M 的 pretreated (P < 0.05 ) 。有杂种狗的 0.110 M 的预告的处理减少了 ROS 生产和类脂化合物 peroxidation,并且增加了抗氧化剂酶的活动,例如 superoxide,在造骨细胞的 dismutase 和谷胱甘肽 peroxidase 由 H2O2 导致了。另外,象碱的磷酸酶,钙免职,和 Runx2 水平那样的区别标记的导致 H2O2 的减小显著地面对杂种狗被恢复。杂种狗也颠倒了细胞外的调整信号的 kinase 1/2,并且原子 factor-B 发信号和 p38 的抑制的导致 H2O2 的刺激激活 mitogen 的蛋白质 kinase 激活。这些结果通过减少 ROS 的生产提供新卓见进杂种狗的造骨细胞保护的机制,建议那条杂种狗可以作为为骨质疏松症和另外的骨头相关的人的疾病的预防和处理的一个对简历安全的代理人被开发。 | Ying Wang Lu Zhao Yin Wang Jinlong Xu Yah Nie Yuanhui Guo Yongtao Tong Luping Qin Qiaoyan Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 15 |
| 2 | A New Epidithiodioxopiperazine Metabolite Isolated from Gliocladium roseum YMF1.00133显示文摘Glioclatine,a novel epidithiodioxopiperazine was isolated from wheat solid-substrate fermentation of Gliocladium roseum YMF1.00133. Its structure was elucidated by HRESI-MS and NMR spectra. | Jin Yah DONG Wei ZHOU Lei LI Guo Hong LI Ya Jun LIU Ke Qing ZHANG | 2006 | Chinese Chemical Letters2006，17，7： | 4 |
| 3 | Late Mesozoic Thermotectonic Evolution of the Jueluotage Range,Eastern Xinjiang,Northwest China:Evidence from Apatite Fission Track Data显示文摘摘要:尽管许多作者强调了变丑的新生代历史,发掘并且在与印度亚洲碰撞有关的 Tianshan 区域冷却,几乎不对压缩的中生代历史被知道并且在 Tianshan 以内高举。以便关于中生代发掘历史和在东方 Tianshan 冷却的进程获得信息,磷灰石上的分裂磁道方法被使用。采样在 Jueluotage 范围被做。三件样品(Z001-Z003 ) 在 Yandong pluton 的地上凿穿 ZK6301 从花岗石被拿;从比是的 pluton 年龄年轻得多的 97.0 ~ 87.6 妈的年龄范围在 334 点由 U-Pb 锆石标明日期 ????????? Y ?? 霈吗?? | ZHU Wenbin WAN Jinglin SHU Liangshu ZHANG Zhiyong SU Jinbao SUN Yah GUO Jichun ZHANG Xueyun | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 4 |
| 4 | Heterotrophie nitrification and aerobic denitrification by a novel Halomonas eampisalis 显示文摘 | Yah Guo Zhou Xuemei Yuguang Lit | 2013 | Biotechnology Letters2013，8，： | 1 |
| 5 | Phase 2 reentry as a trigger to initiate ventrieular fibrillation during early acute myocardial ischemia 显示文摘 | Yah GX Joshi A Guo D | 2004 | Circalation2004，110，9： | 1 |
| 6 | Cognitive Alterations in Motor Imagery Process after Left Hemispheric Ischemie Stroke显示文摘 | Yah J Guo X Jin Z | 2012 | PLoS ONE2012，7，8： | 1 |
| 7 | Soluble MHC I and soluble MIC molecules: potential therapeutic targets for cancer 显示文摘 | Zhao JR Guo Y Yah Z | 2011 | Int Rev Immunol2011，30，1： | 1 |
| 8 | Preparation of Multiwall Carbon Nanotubes-supported High Loading Platinum for Vehicular PEMFC Application显示文摘Multiwall carbon nanotube-supported Pt (Pt/MWNTs) catalysts with high dispersion and high loading of Pt were prepared by chemical reduction method and the loading of Pt got to 40 wt%. The average diameter of Pt nanoparticles on MWNTs was about 3.5 nm. When the hydrogen and air were used as reactant gases for PEMFC, Pt/MWNTs catalysts showed significantly higher performance than the Pt/XC-72 (carbon black) catalysts. | Bing ZHANG Li Juan CHEN Kai Yong GE Yah Chuan GUO Bi Xian PENG | 2005 | Chinese Chemical Letters2005，16，11： | 1 |
| 9 | Monoclonal antibody and porcine antisera recognized B cell epitopes of Nsp2 protein of a Chinese strain of porcine reproductive and respiratory syndrome virus显示文摘 | Yah Y L Guo X Yang H C H | 2007 | Virus Res2007，126，： | 1 |
| 10 | Solvent-free production of 1,3-diglyceride of CLA: Strategy consideration and protocol design显示文摘 | GUO Zheng SUN Yah | 2007 | Food Chemistry2007，100，3： | 1 |
| 11 | miR-429 regulation of osmotic stress transcription factor 1 ( OSTF1 ) in tilapia during osmotic stress显示文摘 | Yah B Zbao LH Guo JT | 2012 | Biochem Biophys Res Commun2012，426，3： | 1 |
| 12 | Separation and simultaneous determination of four artificial sweeteners in food and beverages by ion chromatography 显示文摘 | ZHU Yah GUO Yingying YE Mingli | 2005 | J Chromatogr A2005，1085，： | 1 |
| 13 | Graphene/carbon cloth anode for high performonce mediatorless microbial fuel cells显示文摘 | Liu Jing Qiao Yah Guo Chunxian etal | 2012 | Bioresource Technology2012，114，1： | 1 |
| 14 | MnO2 film with three-dimen- sional structure prepared by hydrothermal process for super- capacitor 显示文摘 | Yah D L Guo Z L Zhu G S | 2012 | J Power Sources2012，199，： | 1 |
| 15 | Melamine residues in tissues of broilers fed diets containing graded levels of melamine 显示文摘 | Lu M B Yah L Guo J Y | 2009 | Pouh Sci2009，88，10： | 1 |
| 16 | (-)-Epigalloeatechin-3- gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells 显示文摘 | Tang GQ Yah TQ Guo W | 2010 | J Cancer Res Clin Oncol2010，136，8： | 1 |
| 17 | A H∞ Control Method of the Bullwhip Effect for a Class of Supply Chain Systems 显示文摘 | Huang X Yah N Guo H | 2007 | Int J of Production Research ( S0020-7543 )2007，45，1： | 1 |
| 18 | Multi-detector row CT as a 'one- stop' examination in the preoperative evaluation of the morpholo- gy and function of living renal donors: preliminary study显示文摘 | Su C Yah CG Guo Y | 2011 | Ab- dora Imaging2011，36，1： | 1 |
| 19 | Waffle-cone technique using solitaire AB stent for en- dovaseular treatment of complex and wide-necked bifurcation cerebral aneur- ysms 显示文摘 | Guo XB Yah BJ Guan S | 2014 | J Neumimagiug2014，24，6： | 1 |
| 20 | Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia 显示文摘 | Yah GX Joshi A Guo D | 2004 | Circulation2004，110，： | 1 |
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