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| 1 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 2 | THz Channel Modeling: Consolidating the Road to THz Communications显示文摘For the sake of meeting the demand of data rates at terabit(Tbit)per second scale in future networks,the terahertz(THz)band is widely accepted as one of the potential key enabling technologies for next generation wireless communication systems.With the progressive development of THz devices,regrading THz communications at system level is increasing crucial and captured the interest of plenty of researchers.Within this scope,THz channel modeling serves as an indispensable and fundamental element.By surveying the latest literature findings,this paper reviews the problem of channel modeling in the THz band,with an emphasis on molecular absorption loss,misalignment fading and multipath fading,which are major influence factors in the THz channel modeling.Then,we focus on simulators and experiments in the THz band,after which we give a brief introduction on applications of THz channel models with respects to capacity,security,and sensing as examples.Finally,we discuss some key issues in the future THz channel modeling. | Shanyun Liu Xianbin Yu Rongbin Guo Yajie Tang Zhifeng Zhao | 2021 | China Communications2021，18，5： | 2 |
| 3 | In Vivo Two-photon Calcium Imaging in Dendrites of Rabies Virus-labeled V1 Corticothalamic Neurons显示文摘Monitoring neuronal activity in vivo is critical to understanding the physiological or pathological functions of the brain.Two-photon Ca^(2+)imaging in vivo using a cranial window and specific neuronal labeling enables realtime,in situ,and long-term imaging of the living brain.Here,we constructed a recombinant rabies virus containing the Ca^(2+)indicator GCaMP6 s along with the fluorescent protein DsRed2 as a baseline reference to ensure GCaMP6 s signal reliability.This functional tracer was applied to retrogradely label specific V1-thalamus circuits and detect spontaneous Ca^(2+)activity in the dendrites of V1 corticothalamic neurons by in vivo two-photon Ca^(2+)imaging.Notably,we were able to record single-spine spontaneous Ca2+activity in specific circuits.Distinct spontaneous Ca^(2+)dynamics in dendrites of V1 corticothalamic neurons were found for different V1-thalamus circuits.Our method can be applied to monitor Ca^(2+)dynamics in specific input circuits in vivo,and contribute to functional studies of defined neural circuits and the dissection of functional circuit connections. | Yajie Tang Liang Li Leqiang Sun Jinsong Yu Zhe Hu Kaiqi Lian Gang Cao Jinxia Dai | 2020 | Neuroscience Bulletin2020，36，5： | 2 |
| 4 | In vivo fiber photometry of neural activity in response to optogenetically manipulated inputs in freely moving mice显示文摘In vito fber photometry is a powerful technique to analyze the dy namics of population neurons during fiunctional study of neuroscience.Here,we introduced a detailed protocol for fiber photometry-based calciun reording in freely moving mice,covering from virus injection,fiber stub insertion,optogenetical stimulation to data procurement and analysis.Furthemnore,we applied this protocol to explore neuronal activity of mice latenal-posterior(LP)thalaric nucleus in response to optogenetical stimulation of primary visual cortex(V1)neurons,and explore axon clusters activity of optogenetically evoked V1 neurons.Final confirmation of virus-based protein expression in V1 and precise fber insertion indicated that the surgery procedure of this protocol is reliable for functional calcium recording.The scripts for data analysis and some tips in our protocol are provided in details.Together,this protocol is simple,low-cost,and effective for neuronal activity detection by fiber photometry,which will hep neuroscience researchers to carry out fiunctional and behavioral study in vivo. | Liang Li Yajie Tang Leqiang Sun Khaista Rahman Kai Huang Weize Xu Jinsong Yu Jinxia Dai Gang Cao | 2017 | Journal of Innovative Optical Health Sciences2017，，5： | 1 |
| 5 | Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus, Ganoderma lucidum, grown on lactose in a bioreactor显示文摘 | TANG Yajie ZHONG Jiangjiang | 2002 | Biotechnology Letters2002，24，： | 1 |
| 6 | Trace elements (Mn, Cr, Pb, Se, Zn, Cd and Hg) in emissions from a pulverized coal boiler显示文摘 | Yaji Huang Baosheng Jin Zhaoping Zhong Rui Xiao Zhiyong Tang Huifeng Ren | 2003 | Fuel Processing Technology2003，，1： | 1 |
| 7 | Significance of inoculation density and carbon source on the mycelial growth and Tuber polysaccharides production by submerged fermentation of Chinese truffle Tuber显示文摘 | TANG Yajie ZHU Lingli LI Dongsheng | 2008 | Process Biochemistry2008，43，5： | 1 |
| 8 | Inactivated Pseudomonas PE(△Ⅲ)exotoxin fused to neutralizing epitopes of PEDV S proteins produces a specific immune response in mice显示文摘Porcine epidemic diarrhea(PED)caused by the porcine epidemic diarrhea virus(PEDV),is a severe infectious and devastating swine disease that leads to serious economic losses in the swine industry worldwide.An increased number of PED cases caused by variant PEDV have been reported in many countries since 2010.S protein is the main immunogenic protein containing some B-cell epitopes that can induce neutralizing antibodies of PEDV.In this study,the construction,expression and purification of Pseudomonas aeruginosa exotoxin A(PE)without domain Ⅲ(PE△Ⅲ)as a vector was performed for the delivery of PEDV S-A or S-B.PE(△Ⅲ)PEDV S-A and PE(△Ⅲ)PEDV S-B recombinant proteins were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis.The immunogenicity of PEDV S-A and PEDV S-B subunit vaccines were evaluated in mice.The results showed that PEDV-S-B vaccine could not only induce specific humoral and Th1 type-dominant cellular immune responses,but also stimulate PEDV-specific mucosal immune responses in mice.PEDV-S-B subunit vaccine is a novel candidate mucosal vaccine against PEDV infection. | Leqiang Sun Yajie Tang Keji Yan Huanchun Chen Huawei Zhang | 2021 | Animal Diseases2021，1，3： | 1 |
| 9 | Significance of fungal elicitors on the production of ganoderic acid and Ganoderma polysaccharides by the submerged culture of medicinal mushroom Ganoderma lucidum显示文摘 | ZHU Liwen ZHONG Jianjiang TANG Yajie | 2008 | Process Biochemistry2008，43，12： | 1 |
| 10 | A self-crosslinking,double-functional group modified bacterial cellulose gel used for antibacterial and healing of infected wound显示文摘Cellulose/chitosan composite,as a mature commercial antibacterial dressing,is an important type of wound repair material.However,how to achieve the perfect compound of two components and improve antibacterial activity is a major,lingering issue.In this study,a bifunctional group modified bacterial cellulose(DCBC)was prepared by carboxymethylation and selective oxidation.Further,the chitosan(CS)was compounded in the network of DCBC by self-crosslinking to form dialdehyde carboxymethyl bacterial cellulose/chitosan composites(S-DCBC/CS).The aldehyde group can react with amino of CS by Schiff base reaction.The carboxyl group of DCBC and the amorphous distribution of CS molecular chains increase the antimicrobial properties of com-posites.The bacteriostatic rate of composites could be higher than 95%.Bacteria can be attracted onto the surface of composites,what we call it“directional adhesion antibacterial effects”.In particular,a kind of large animal wound model,deep II degree infected scald of Bama miniature pig,was used to research the antimicrobial and healing properties of materials.The S-DCBC/CS can effectively inhibit bacterial proliferation of wound and kill the bacteria.The wound healing rate of S-DCBC/CS was up to 80%after three weeks.The composites show better antibacterial and promoting concrescence effects than traditional chitosan dressings. | Yajie Xie Kun Qiao Lina Yue Tao Tang Yudong Zheng Shihui Zhu Huiyi Yang Ziyuan Fang | 2022 | Bioactive Materials2022，7，11： | 1 |
| 11 | Submerged culture of mushrooms in bioreactors: Challenges, current state-of-the-art, and future prospects显示文摘 | TANG Yajie ZHU Liwen LI Hongmei | 2007 | Food Technol Biotechnol2007，45，3： | 1 |
| 12 | Prospects and Challenges of THz Precoding显示文摘Terahertz(THz) communications are considered as very promising for the sixth-generation(6 G) ultra-dense wireless networks. However, THz signals suffer from well-known severe path loss, which consequently shortens the coverage of THz communication systems. To deal with this issue, precoding technique is expected to be beneficial to extend the limited coverage by providing directional beams with ultra large number of antenna arrays. In this paper, we overview the state-ofthe-art developments of THz precoding techniques such as reconfigurable intelligent surface based precoding, hybrid digital-analog precoding and delay-phase precoding. Based on the survey, we summarize several open issues remaining to be addressed, and discuss the prospects of a few potential research directions on THz precoding, such as one-bit precoding, precoding for hardware impairments and THz security precoding. This overview will be helpful for researchers to study innovative solutions of THz precoding in the future 6 G wireless communications. | GUO Rongbin TANG Yajie ZHANG Changming LIU Shanyun ZHAO Zhifeng | 2022 | Chinese Journal of Electronics2022，31，3： | 0 |
| 13 | Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles显示文摘Indolylarylsulfones(IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors(NNRTIs) with a unique scaffold and possess potent antiviral activity.To address the high cytotoxicity and improve safety profiles of IASs,we introduced various sulfonamide groups linked by alkyl diamine chain to explore the entrance channel of non-nucleoside inhibitors binding pocket.48 compounds were designed and synthesized to evaluate their anti-HIV-1 activities and reverse transcriptase inhibition activities.Especially,compound R_(10)L_(4) was endowed with significant inhibitory activity towards wild-type HIV-1(EC_(50(WT))=0.007μmol/L,SI=30,930) as well as a panel of single-mutant strains exemplified by L100I(EC_(50)=0.017μmol/L,SI=13,055),E138K(EC_(50)=0.017μmol/L,SI=13,123) and Y181C(EC_(50)=0.045μmol/L,SI=4753) which were superior to Nevirapine and Etravirine.Notably,R_(10)L_(4) was characterized with significantly reduced cytotoxicity(CC_(50)=216.51μmol/L) and showed no remarkable in vivo toxic effects(acute and subacute toxicity).Moreover,the computer-based docking study was also employed to characterize the binding mode between R_(10)L_(4) and HIV-1 RT.Additionally,R_(10)L_(4) presented an acceptable pharmacokinetic profile.Collectively,these results deliver precious insights for next optimization and indicate that the sulfonamide IAS derivatives are promising NNRTIs for further development. | Shenghua Gao Letian Song Yusen Cheng Fabao Zhao Dongwei Kang Shu Song Mianling Yang Bing Ye Wei Zhao Yajie Tang Erik De Clercq Christophe Pannecouque Peng Zhan Xinyong Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 14 | A Strategy to Find Novel Candidate DKAs Inhibitors Using Modified QSAR Model with Favorable Druggability Properties显示文摘The study dealed with quantitative structure-activity relationship(QSAR)to explore the important features of diketo acid(DKA)derivatives for exerting potent HIV-1 integrase inhibitors activity.A three-step screening method was proposed to choose descriptors.Then,additional descriptors were used in the CoMFA and CoMSIA.Lastly,a modified CoMSIA m7 model,constructed by adding Csp^2_03_F descriptor,showed better predictive ability.Validation parameters(Q^2 and R^2)for the models were 0.722 and 0.925,respectively.In addition,external validation for the models using a test group revealed R^2pred=0.892.Contour maps analysis defined favored and disfavored regions of the compounds,and two new compounds with the descriptor structure were designed with better activities than Raltegravir(RAL),well drug-likeness and low toxicity.The research provides a base for further DKA development. | ZHANG Xiaoyi NIU Wenling TANG Tang HOU Chengfei GUO Yajie KONG Ren | 2019 | Chemical Research in Chinese Universities2019，35，6： | 0 |
| 15 | Three putative DIMA replication/repair elements encoding genes confer self-resistance to distamycin in Streptomyces显示文摘Distamycin(DST)is a well-characterized DNA minor groove binder with antivirus activity and anti tumor potency.Two separate gene clusters(a 28-kb cluster and a 7-kb cluster)have recently been identified to coordinately encode the biosynthetic machinery of DST in Streptomyces netropsis.Here we report a gene cassette,which is linked to the aforementioned smaller dst gene cluster and plays an important role in the self-resistance to DST in S.netropsis.This cassette consists of three uncharacterized genes that might be implicated in DNA replication/repair.Knockout of the cassette led to the decrease in the production of DST,while heterologous expression of part of the cassette in S.lividans made it become resistant to both DST and mitomycin C,another DNA-bmding agent.More interestingly,homologs of these three genes were found in genomes of other actinomyces that produce DNA-binding antibiotics,suggesting that a novel common mechanism in addition to pumping may enable these strains to resist the cytotoxic metabolites they produced. | Lie Ma Siyao Sun Ziyu Yuan Zixin Deng Yajie Tang Yi Yu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 0 |
| 16 | The levels of osteopontin in human milk of Chinese mothers and its associations with maternal body composition显示文摘Objective:This study explored the content and change trend of osteopontin(OPN)in breast milk and analyzed the relationship between OPN in breast milk and maternal body composition.Methods:Breast-feeding mothers were recruited in Xinhua Hospital to collect breast milk and provide pertinent information.The content of OPN in breast milk was determined by enzyme-linked immunosorbent assay(ELISA).Determination of protein content in human milk was performed via the BCA method.The maternal body composition was determined by the bioelectrical impedance method.Serum glucocorticoid receptorα,adiponectin,insulin,and leptin were determined by ELISA.SPSS 25 was used for statistical analysis.Results:In the longitudinal cohort,106 mothers provided 318 milk samples at different lactation periods.The results indicate that the OPN showed dynamic changes.OPN levels were(343.2±163.5)mg/L during 1-14 days postpartum,(228.4±121.5)mg/L during 2-4 months postpartum,and(204.8±100.6)mg/L during 5-7 months postpartum.The content of OPN was very high in the first 1-14 days postpartum and then decreased.Compared with early postpartum milk,the OPN content of mature milk showed a significant relationship with maternal weight-related parameters.Additional body composition analysis was performed in 88 women at the mature milk phase.The results show that the OPN in milk is related to the mother’s body composition,especially the content of skeletal muscle mass,but not to relevant humoral factors.Conclusions:The levels of OPN in human milk of Chinese mothers showed dynamic changes with the extension of lactation time.The OPN in human milk was related to the mother’s body composition but not related to related humoral factors. | Huijuan Ruan Qingya Tang Xuan Zhao Yajie Zhang Xuelin Zhao Yi Xiang Wei Geng Yi Feng Wei Cai | 2022 | Food Science and Human Wellness2022，11，5： | 0 |
| 17 | Conductance of a single molecule C_(60)-SnPc heterojunction显示文摘Geometries of molecule-molecule interfaces strongly influence the current passing from one molecule to another. The contact conductance of molecule-molecule junctions which consist of fullerene and tin phthalocyanine molecules is investigated with a low-temperature scanning tunneling microscope. Two types of molecules are deposited onto Cu(111). Fullerene molecules are transferred to tips through controlled contact of STM tips on molecules. The molecule-molecule junctions are formed by approaching fullereneterminated tips to tin phthalocyanine molecules on Cu(111). Our experimental method can be extended to study the intermolecular charge transport of a range of molecular junctions. | Yifan Wang Mingjun Zhong Jie Li Hao Tang Richard Berndt Yajie Zhang Shimin Hou Yongfeng Wang | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 18 | Rearranged 19-nor-7,8-seco-labdane diterpenoids and Diels-Alder cycloadducts from the Chinese liverwort Pallavicinia ambigua:Structural elucidation,photoinduced rearrangement,and cytotoxic activity显示文摘Two distinctive rearranged 19-nor-7,8-seco-labdane diterpenoids(1 and 2)with a novel tetracyclo[5.2.1.0^(2,5.)0^(4,10)]decane skeleton,a derivative of the open tetrahydrofuran ring(7),three dimeric compounds(8-10),and four revised homologs(3-6)were obtained from Chinese liverwort Pallavicinia ambigua.Their structures were identified via combined analysis of their spectroscopic data,single-crystal X-ray diffraction patterns,and ECD calculations.The light-driven conversion of compound 5 to compounds 1-4 demonstrated that photochemically induced postmodification involved in biosynthesis is an important way to diversify natural structures.A preliminary cytotoxicity assay revealed that compound 5 showed significant inhibition in the human prostate cancer(PC-3)cell line via an apoptotic pathway. | Chunyang Zhang Yuelan Li Zhaojun Chu Shuangzhi Yuan Yanan Qiao Jiaozhen Zhang Lin Li Yueqing Zhang Ruifeng Tian Yajie Tang Hongxiang Lou | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 19 | Boost photothermal theranostics via self-assembly-induced crystallization(SAIC)显示文摘Owing to the intrinsic advantages of spatiotemporal selectivity,photothermal theranostics have become the advancing edge of precision medicine for cancer.Developing photothermal transduction agents(PTAs)with near-infrared(NIR)absorption,high photothermal conversion efficiency,robust photothermal stability,and good accumulation in tumors,is particularly valuable.Herein,we report a new concept,self-assembly-induced crystallization(SAIC),which can serve as a mechanism that dramatically boosts photothermal behaviors of PTA in NIR region.As a proof of concept,three heptamethine cyanine molecules with internal degrees of freedom(geometry and intramolecular interaction)are designed to fine-tune their crystallinity.Notably,Cy7-TCF-EMBI molecules with rigid and planar skeletons self-assemble into a crystalline state to maximize their packing density and improve the charge transfer,both of which contribute to nonradiative decay for energy dissipation as heat.The high packing density also renders an ideal scaffold for controlling intermolecular interactions to exhibit better photothermal stability,and endows an anisotropic three-dimensional architecture for passive tumor targeting.This“SAIC”strategy may offer a conceptually novel,practically simple but effective approach to unveil the structure–property relationship that could provide some general rules in rational design of PTAs,and paves the way for a next generation of supramolecular medicine for photothermal theranostics. | Xueluer Mu Fapu Wu Ying Tang Rui Wang Yajie Li Kaixuan Li Chunfeng Li Yingxi Lu Xianfeng Zhou Zhibo Li | 2022 | Aggregate2022，3，5： | 0 |
| 20 | Longitudinal changes in body weight of breastfeeding mothers in the first year after delivery and its relationship with human milk composition:a combined longitudinal and cross-sectional cohort study显示文摘Objective:Postpartum weight retention(PPWR)is a common problem among women after childbirth.The main objectives of this study are to understand the changes in body weight of breastfeeding mothers during long-term follow-up and preliminarily explore the relationship between maternal body weight and human milk composition,including macronutrients,leptin,and adiponectin.Methods:The study included a longitudinal cohort(122 mothers),and a cross-sectional cohort(37 mothers).The human milk,maternal weight,and dietary surveys were collected in the longitudinal cohort at different follow-up time points(1-14 days postpartum,2-4 months postpartum,5-7 months postpartum,and 12-17 months postpartum).The maternal body weight was analyzed using the responses in the survey questionnaires.A milk analyzer based on the mid-infrared spectroscopy(MIRS)was used to determine milk composition,and nutrition analysis software evaluated dietary intakes.In the cross-sectional cohort,participating mothers were asked to provide blood and human milk samples and pertinent information related to maternal body composition.Maternal body composition was measured by bioelectrical impedance analysis(BIA),while ELISA analyzed leptin and adiponectin in milk and serum.Results:At 5-7 months postpartum,the PPWR of breastfeeding mothers was(2.46±3.59)kg.At 12-17 months postpartum,the PPWR was(0.98±4.06)kg.PPWR was found to be negatively correlated with milk fat content within 14 days postpartum and positively correlated at 2-4 months postpartum.In addition,the maternal weight and body muscle mass were positively correlated with leptin and adiponectin in milk.Plasma leptin was positively correlated with the mother’s body weight,body mass index(BMI),FAT percentage,and body fat mass,while plasma adiponectin did not correlate with any parameter.The results also indicate that the PPWR did not correlate with leptin and adiponectin in plasma or milk.Conclusions:Breastfeeding mothers may retain considerable weight gain one year after delivery.Human milk composition may be related to changes in maternal body weight.Leptin and adiponectin in breast milk and leptin in plasma are associated with the maternal body composition.This study supports the notion that maternal nutritional status may affect offspring health through lactation,and future research should focus on exploring weight management of postpartum mothers. | Huijuan Ruan Yajie Zhang Qingya Tang Xuan Zhao Xuelin Zhao Yi Xiang Wei Geng Yi Feng Wei Cai | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
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