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| 1 | Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia显示文摘AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter(UES) abnormality, and clinical and manometric profiles were compared.Correlation between UES abnormality and sub-type(i.e.,hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also evaluated.RESULTS: Among all 41 patients, 24(58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response compared to those with no UES abnormality(P = 0.017).CONCLUSION: The presence of UES abnormalities in patients with achalasia significantly predicted poorer treatment response as compared to those with normal UES function. | Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John O Clarke Ellen Stein Bani Chander Roland | 2014 | World Journal of Clinical Cases2014，2，9： | 5 |
| 2 | A Full Compensating System for General Loads, Based on a Combination of Thyristor Binary Compensator, and a PWM-IGBT Active Power Filter显示文摘 | Juan Dixon Yamille del Valle Micah Ortuzar | 2003 | IEEE Transactions on Industrial Electronics2003，50，5： | 1 |
| 3 | Functional evaluation of human CLC-2 chloride channel mutations associated with idiopathic generalized epilepsies 显示文摘 | Maria IN Yamil RY Isabel C | 2004 | Physiol Genomics2004，19，1： | 1 |
| 4 | Clinic-based ultrasound can predict malignancy in pediatric thyroid nodules显示文摘 | Melanie G Stephan S G Yamile S | 2012 | Thyroid2012，22，8： | 1 |
| 5 | Particle swarm optimization: Basic concepts, variants and applications in power systems显示文摘 | Yamille del Valle Ganesh Kumar Venayagamoorthy Salman Mohagheghi | 2008 | IEEE Trans on Evolutionary Computation2008，12，2： | 1 |
| 6 | Hybrid hard- and soft-modeling of spectrophotometric data for monitoring of ciprofloxacin and its main photodegradation products at different pH values显示文摘 | Mariela Razuc Mariano Garrido Yamile S. Caro Carla M. Teglia Héctor C. Goicoechea Beatriz S. Fernández Band | 2013 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2013，，： | 1 |
| 7 | A proportional-integrator type adaptive critic design-based neurocontroller for a static compensator in a multimachine power system显示文摘 | Salman Mohagheghi Yamille del Valle Ganesh Kumar Venayagamoorthy | 2007 | IEEE Transactions on Industrial Electronics2007，54，1： | 1 |
| 8 | Immunization of mice with a Mycobacterium tuberculosis ge nomic expression library results in lower bacterial load in lungs after challenge with BCG 显示文摘 | Yamile L H Daniel Y C Sergio S R | 2006 | Tuberculosis2006，86，： | 1 |
| 9 | Particle swarm optimization: basic concepts, variants and applications in power systems 显示文摘 | Yamille D V Ganesh K V | 2008 | IEEE Transactions on Evolutionary Computation2008，12，2： | 1 |
| 10 | Particle swarm optimization: basic concepts, variants and applications in power systems显示文摘 | Yamille del Valle Ganesh Kumar Venayagamoorthy Salman Mohagheghi | 2008 | IEEE Transactions on Evolutionary Computation2008，12，2： | 1 |
| 11 | A propor- tional-integrator type adaptive critic design-based neuro- controller for a static compensator in a multimaehine power system 显示文摘 | Salman M Yamille D V Ganesh K V | 2007 | IEEE Transactions on Industrial Elec- tronics2007，54，1： | 1 |
| 12 | NOTES Is Successful for Vertebral Spinal Interventions with Significant Advantages for Anterior Spinal Procedures显示文摘 | Priscilla Magno Manuel a. Mas Yamil Rivera Samuel a. Giday Jonathan M. Buscaglia Eun Ji Shin Sergey V. Kantsevoy Xavier Dray Anthony N. Kalloo | 2008 | Gastrointestinal Endoscopy2008，，5： | 1 |
| 13 | Development of a germination protocol for blueberry seeds (Vaccinium meridionale Swartz)显示文摘 | Camilo Castro Yamile Olart Leidy Rach | 2012 | Agronomia Colombiana2012，30，2： | 1 |
| 14 | Particle swarm optknization: basic concepts,variants and applicatiom in power sys- tems显示文摘 | Yamille D V Ganesh K V | 2008 | IEEE Tramactions on Evolutionary Computa- tion2008，12，2： | 1 |
| 15 | Soft tissue sarcoma with metastasis to the stomach: A case report显示文摘Soft tissue sarcomas are unusual malignancies comprising 1% of cancer diagnoses in the United States. Undifferentiated pleomorphic sarcoma accounts for approximately 5% of sarcomas occurring in adults. The most common site of metastasis is the lung, with other sites being bone, the brain, and the liver. Metastasis to the gastrointestinal tract has rarely been documented. We present an unusual case of high-grade pleomorphic sarcoma with metastasis to the stomach, complicated by upper gastrointestinal bleeding. | Lemuel Leon Dent Cesar Yamil Cardona Michael Clause Buchholz Roosevelt Peebles Julie Denise Scott Derrick Jerome Beech Billy Ray Ballard | 2010 | World Journal of Gastroenterology2010，16，40： | 1 |
| 16 | Particle Swarm Optimization:Basic Concepts,Variants and Applications in Power Systems显示文摘 | Yamille D V Ganesh K V | | 0，，12： | 1 |
| 17 | Immunization of mice with a Mycobacterium tuberculosis genomic expression library results in lower bacterial load in lungs after challenge with BCG显示文摘 | Yamile L H Daniel Y C Sergio S R | 2006 | Tuberculosis2006，86，： | 1 |
| 18 | A Proportional Integrator Type Adaptive Critic Design-Based Neurocontroller for a Static Compensator in a Multimachine Power System显示文摘 | Salman Mohagheghi Yamille del Valle Ganesh Kumar Venayagamoorthy | 2007 | IEEE Transactions on Industrial Electronics2007，54，1： | 1 |
| 19 | Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23显示文摘Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain unclear.Our goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron utilization.Hypoxia-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was suppressed.An inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor cells.Integrative genomics also revealed increased prolyl hydroxylase Egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte differentiation.In mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this model.Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1αblockade.In vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 or-3.In sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable iron.Further,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing. | Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White | 2023 | Bone Research2023，11，1： | 1 |
| 20 | Comparacion de dos tratamientos: propoleos y lugol, en pacientes concervicitis aguda显示文摘 | Tania Yamile Quintana RiveronMiguel A Lugones BotellElizabeih Gonzalez OramasTamara Rodriguez Labaut | 2013 | Revista Cubana de Medicina General Integral2013，3，： | 1 |
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