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| 1 | Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats显示文摘 | Ji-ye AA Guang-ji WANG Hai-ping HAO Qing HUANG Yi-hong LU Bei YAN Wei-bin ZHA Lin-sheng LIU An KANG | 2010 | Acta Pharmacologica Sinica2010，31，8： | 14 |
| 2 | Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules显示文摘Xuezhikang 囊(XZK ) 是为 hyperlipidemia 治疗包含 lovastatin (Lv ) 的繁体中文药,尽管它比 Lv 有更少副作用。然而,贡献它的不同功效的 pharmacokinetic 机制和低副作用是不清楚的。老鼠被喂为 6 个星期到的一本高脂肪的食谱(HFD ) 导致 hyperlipidemia。我们首先在跟随 Lv 的口头的管理的 HFD 鼠标进行了 pharmacokinetic 研究( 10mg/kg , i.g )并且发现那 HFD 显著地减少了 Lv 的活跃形式( lovastatin 酸, LvA )在发行量系统的暴露特别在指向的机关肝,与到 LvA 的从 Lv 的拒绝的变换,而 Lv (为 myotoxicity 负责)在肌肉的暴露显著地增加了。然后,我们在 XZK 的口头的管理以后在 HFD 老鼠比较了 Lv 的 pharmacokinetic 侧面(1200mg/kg, i.g ) 或 Lv 的相等的剂量(10mg/kg, i.g ) 。LvA 的更高的暴露和 Lv 的更低的暴露在 XZK 管理以后被观察,建议在 XZK 的一些成分的一个 pharmacokinetic 相互作用。进一步的研究表明 HFD 支持了发炎并且禁止了 carboxylesterase (CES ) 在肠和肝的活动,因此贡献 Lv 的更低的转变进 LvA。相反, XZK 在肠和肝禁止了发炎和 upregulated CES。最后,我们评估了 monacolins 和 phytosterols 的效果, isoflavones 的部分摘录在煽动性的 LS174T 或 HepG2 房间上,它证明 isoflavones 禁止了发炎, upregulated CES,并且显著地提高了 Lv 的变换进 LvA。第一次,我们提供在 XZK 的 isoflavones 和 Lv 在音乐会扮演提高功效并且减少 Lv 的副作用的证据。 | Dong feng Chun Ge Zhao-yi Tan Jian-guo Sun Yuan Xie Lan Yao Cai-xia Yan Ji-ye Aa Guang-ji Wang | 2018 | Acta Pharmacologica Sinica2018，39，11： | 4 |
| 3 | Berberine reverses LPS-induced repression of CYP7A1 through an anti-inflammatory effect显示文摘Objective: To evaluate the anti-inflammatory effect of berberine(BBR) on the lipopolysaccharide(LPS)-induced acute phase response and its modulation of the altered bile acid metabolism induced by LPS treatment.Methods: An acute phase response was induced by intraperitoneal injection of LPS(5 mg/kg, ip) in C57 BL/6 J mice, and the BBR treatment group was orally administered with BBR(200 mg/ky, ig). The levels of TNFα, IL-1β and IL-6 in the serum were measured using an ELISA kit, and their expression levels in the liver were measured using q RT-PCR. The bile acid pool was measured using a commercial bile acid kit, and the expression levels of enzymes involved in bile acid metabolism were measured by q RTPCR. The expression levels of CYP7 A1, p65 NF-κ B and the MAPK signaling pathway was measured using Western blotting.Results: LPS treatment suppressed the expression of CYP7 A1 and CYP8 B1, and the total bile acid pool was also reduced. Pretreatment with BBR inhibited the pro-inflammatory biomarkers TNFα and IL-1β in the serum, as well as the expression of TNFα, IL-1β and i NOS mRNA in the liver. BBR treatment did not affect the reduction in the bile acid pool size induced by LPS, but significantly increased the concentration of bile acids in the liver, which was consistent with the upregulated expression of CYP7 A1 and CYP8 B1. The MAPK signaling pathway was activated by BBR treatment, while the p65 NF-κ B signaling pathway was inhibited.Conclusion: BBR can offer an anti-inflammatory effect and reverse the inhibition of CYP7 A1 and CYP8 B1 expression caused by LPS treatment, as well as induce the production of bile acids in liver, probably via MAPK signaling;However, treatment with BBR had no effect on the size of total bile acid pool. | Bei Cao Run-bin Sun Geng Yan Guang-yu Yang Ji-ye Aa Juan Li | 2019 | Chinese Herbal Medicines2019，11，3： | 3 |
| 4 | Segmentation of volumetric MRA images by using capillary active contour显示文摘 | Yan PK Kassim AA | | 0，，03： | 1 |
| 5 | Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer:a comparison of intensity modulated radiation therapy(IMRT),3D conformal radiation,and elective nodal irradiation显示文摘 | Grills IS Yan D Martinez AA | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 6 | Improvement in dose escalation using the process of adaptive radiotherapy combined with threedimensional conformal or intensity-modulated beams for prostate canc- er显示文摘 | Martinez AA Yan D Lockman D | 2001 | Int J Radiat Oncol Biol Phys2001，50，5： | 1 |
| 7 | A new meaningful secret sharing scheme based on random grids,error diffusion and chaotic encryption显示文摘 | Abd El-Latif Yan AA Wang XH | 2013 | Optics&Laser Technology2013，54，30： | 1 |
| 8 | Potential for reduced toxicity and dose esealation in the treatment of inoperable non- small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation显示文摘 | Grills IS Yan D Martinez AA | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 9 | Potential for reduced toxicity and dose escalation in the treat ment of inoperable non-small cell lung cancer:a comparison of intensity-modulated radiationtherapy(IM-RT),3D conformal radiation,and elective nodal irradiation显示文摘 | Yan D Martinez AA | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 10 | Potential for reduced toxicity and dose escalation in the treatment of inoperable non - small - cell lung cancer: a comparison of intensity- modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation显示文摘 | Grills IS Yan D Martinez AA Vicini FA | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 11 | Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer:a comparison of intensity-modulated radiation therapy(IMRT),3D conformal radiation,and elective nodal irradiation显示文摘 | Grills IS Yan D Martinez AA | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 12 | Improvement in dosw escalation using the process of adaptive radiotherapy combined with three-dimen-sional conformal or intensity-modulated beams for prostare cancer 显示文摘 | Martinez AA Yan D Loekman D | 2001 | Int J Radiat Oneol Biol Phys2001，50，5： | 1 |
| 13 | lmprowmmnt in dose escalation using Ihe process off adaptive radio- therapy conllfined with three-dimensional conlbrmal or interlsilv-modhdated beams for prostate cancer 显示文摘 | Marlinez AA Yan D l ockman D el al | 2001 | lnl J Radial Oncol Biol Phvs2001，50，5： | 1 |
| 14 | Improvement in dosw escalation using the process of adaptive radiotherapy combined with three-dimen-sional conformal or intensity-modulated beams for prostate cancer显示文摘 | Martinez AA Yan D Lockman D | 2001 | Int J Radiat Oncol Biol Phys2001，50，： | 1 |
| 15 | Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer:a comparison of intensity-modulated radiation therapy(IMRT),3D conformal radiation,and elective nodal irradiation显示文摘 | Grills IS Yan D Martinez AA | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 16 | Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensitymodulated beams for prostate cancer显示文摘 | Martinez AA Yan D Lockman D | | 0，，05： | 1 |
| 17 | Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer:a comparison of intensity-modulated radiation therapy(IMRT),3D conformal radiation,and elective nodal irradiation显示文摘 | Grills IS Yan D Martinez AA | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 18 | Human sperm telomere-binding complex involves histone H2B and secures telomere membrane attachment 显示文摘 | Gineitis AA Zalenskaya IA Yan PM | 2000 | J Cell Biol2000，151，7： | 1 |
| 19 | Protein phosphorylation:technologies for the identification of phosphoamino acids显示文摘 | Yan JX Packer NH Gooley AA | 1998 | J Chromatogr A1998，808，12： | 1 |
| 20 | Rapid responses to anakinra in patients with refractory adult-onset Still’s disease显示文摘 | Fitzgerald AA Leclercq SA Yan A | | 0，，06： | 1 |
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