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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 3 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 4 | Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model显示文摘 | Si-qi FENG Nan AA Jian-liang GENG Jing-qiu HUANG Run-bin SUN Chun GE Zhi-jian YANG Lian-sheng WANG Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，11： | 12 |
| 5 | Distribution of tetraether lipids in surface sediments of the northern South China Sea:Implications for TEX_(86) proxies显示文摘Archaea 有能习惯于的类脂化合物开发的唯一的甘油 dialkyl 甘油 tetraether (GDGT ) paleotemperature 代理象 TEX86 那样。这研究是在华南海(SCS ) 为 paleotemperature 决心验证建议 GDGT 代理。样品在北 SCS 从核心顶沉积(05 厘米) 被收集。全部的类脂化合物被提取获得核心 GDGT,它被识别并且确定了使用液体层析团 spectrometry (最小公倍数) 。许多 isoprenoidal GDGT (iGDGTs ) 从 271.5 ng/g 干燥沉积到 1266.3 ng/g,弄干沉积分叉的 GDGT (bGDGTs ) ,据说源于陆上的来源,从 22.2 ng/g 干燥沉积到 56.7 ng/g 干燥沉积。导出 TEX86 的海表面温度从 20.9 牡敧挠湯瑳畲瑣潩獮椠 ? 散瑮慲? 湡 ? 潳瑵敨湲匠湩楡沈 ? 沈吗?? | Huangmin Ge Chuanlun L.Zhang Hongyue Dang Chun Zhu Guodong Jia | 2013 | Geoscience Frontiers2013，4，2： | 10 |
| 6 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 7 | Bartonella Species Detected in the Plateau Pikas(Ochotona curzoiae) from Qinghai Plateau in China显示文摘Bartonella 种类能感染许多哺乳动物的主人并且在人引起许多疾病,但是在那里有不是在 Ochotonidae 的 Bartonella 感染的报告。这是第一研究在 Qinghai 高原在高原一种短耳野兔检测 Bartonella,提供为对在这个区域的人的 Bartonella 感染的风险评价的基线数据。我们与 18.99% 的积极的率在 Qinghai 的 Binggou 和 Maixiu 区域从 79 只一种短耳野兔获得了 15 Bartonella 紧张。基于基因定序的 Bartonella 柠檬酸盐 synthase (gltA ) 的种系发生的分析,大多数紧张是仔细与 B 有关。taylorii (3/15 ) 和 B。grahamii (12/15 ) 。后者是在人的病原的紧张。我们的结果建议相应预防和控制策略应该在 Qinghai 省被考虑。 | RAO Hua Xiang YU Juan GUO Peng MA Yong Cheng LIU Qi Yong JIAO Ming MA Zhong Wen GE Hua WANG Chun Xiang SONG Xiu Ping SHI Yan LI Dong Mei | 2015 | Biomedical and Environmental Sciences2015，28，9： | 8 |
| 8 | Histone Deacetylase HDA9 and WRKY53 Transcription Factor Are Mutual Antagonists in Regulation of Plant Stress Response显示文摘Epigenetic regulation of gene expression is important for plant adaptation to environm ental changes.Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is known to function in repressing plant response to stress in Arabidopsis.However,how HDA9 targets to specific chromatin loci and controls gene expression netw orks involved in plant response to stress remains largely unclear.Here,we show that HDA9 represses stress tolerance response by interacting with and regulating the DNA binding and transcriptional activity of WRKY53,which functions as a high-hierarchy positive regulator of stress response.We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites,some of which are removed by HDA9,resulting in inhibition of WRKY53 transcription activity.Conversely,WRKY53 negatively regulates HDA9 histone deacetylase activity.Collectively,our results indicate that HDA9 and WRK53 are reciprocal negative regulators of each other's activities,illustrating how the functional interplay between a chromatin regulator and a transcription factor regulates stress tolerance in plants. | Yu Zheng Jingyu Ge Chun Bao Wenwen Chang Jingjing Liu Jingjie Shao Xiaoyun Liu Lufang Su Lei Pan Dao-Xiu Zhou | 2020 | Molecular Plant2020，13，4： | 6 |
| 9 | A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples显示文摘Surface molecularly imprinted polymers(SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support.The physical and morphological characteristics of the polymers were investigated by scanning electron microscope(SEM),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),elemental analysis and nitrogen adsorption–desorption test.The obtained results showed that the SMIPs displayed great adsorption capacity(13.5 μg/mg),high recognition ability(the imprinted factor is 3.2) and good binding kinetics for ampicillin sodium.Finally,as solid phase extraction adsorbents,the SMIPs coupled with HPLC method were validated and applied for the enrichment,purification and determination of ampicillin sodium in real milk and blood samples.The averages of spiked accuracy ranged from 92.1% to 107.6%.The relative standard deviations of intra- and inter-day precisions were less than 4.6%.This study provides a new and promising method for enriching,extracting and determining ampicillin sodium in complex biological samples. | Ningli Wu Zhimin Luo Yanhui Ge Pengqi Guo Kangli Du Weili Tang Wei Du Aiguo Zeng Chun Chang Qiang Fu | 2016 | Journal of Pharmaceutical Analysis2016，6，3： | 6 |
| 10 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 4 |
| 11 | Nanoscale inhibition of polymorphic and ambidextrous lAPP amyloid aggregation with small molecules显示文摘 | Aleksandr Kakinen Jozef Adamcik Bo Wang Xinwei Ge Raffaele Mezzenga Thomas P. Davis Feng Ding Pu Chun Ke | 2018 | Nano Research2018，11，7： | 4 |
| 12 | Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules显示文摘Xuezhikang 囊(XZK ) 是为 hyperlipidemia 治疗包含 lovastatin (Lv ) 的繁体中文药,尽管它比 Lv 有更少副作用。然而,贡献它的不同功效的 pharmacokinetic 机制和低副作用是不清楚的。老鼠被喂为 6 个星期到的一本高脂肪的食谱(HFD ) 导致 hyperlipidemia。我们首先在跟随 Lv 的口头的管理的 HFD 鼠标进行了 pharmacokinetic 研究( 10mg/kg , i.g )并且发现那 HFD 显著地减少了 Lv 的活跃形式( lovastatin 酸, LvA )在发行量系统的暴露特别在指向的机关肝,与到 LvA 的从 Lv 的拒绝的变换,而 Lv (为 myotoxicity 负责)在肌肉的暴露显著地增加了。然后,我们在 XZK 的口头的管理以后在 HFD 老鼠比较了 Lv 的 pharmacokinetic 侧面(1200mg/kg, i.g ) 或 Lv 的相等的剂量(10mg/kg, i.g ) 。LvA 的更高的暴露和 Lv 的更低的暴露在 XZK 管理以后被观察,建议在 XZK 的一些成分的一个 pharmacokinetic 相互作用。进一步的研究表明 HFD 支持了发炎并且禁止了 carboxylesterase (CES ) 在肠和肝的活动,因此贡献 Lv 的更低的转变进 LvA。相反, XZK 在肠和肝禁止了发炎和 upregulated CES。最后,我们评估了 monacolins 和 phytosterols 的效果, isoflavones 的部分摘录在煽动性的 LS174T 或 HepG2 房间上,它证明 isoflavones 禁止了发炎, upregulated CES,并且显著地提高了 Lv 的变换进 LvA。第一次,我们提供在 XZK 的 isoflavones 和 Lv 在音乐会扮演提高功效并且减少 Lv 的副作用的证据。 | Dong feng Chun Ge Zhao-yi Tan Jian-guo Sun Yuan Xie Lan Yao Cai-xia Yan Ji-ye Aa Guang-ji Wang | 2018 | Acta Pharmacologica Sinica2018，39，11： | 4 |
| 13 | Catalytic oxidation of 4-tert-butyltoluene over Ti-MCM-41显示文摘The surface-grafted titanium MCM-41 materials were prepared by anchoring titanocene onto the inner walls of MCM-41. The materials were characterized by powder X-ray diffraction (XRD), N2 adsorption-desorption isotherm and diffuse reflectance UV-visible (UV-vis) spectroscopies. The catalytic properties of Ti-MCM-41 were tested in oxidation of 4-tert-butyltoluene with tert-butylhydroperoxide (TBHP) in liquid phase. MCM-41 with loading 4.8 mol% Ti gave the maximal conversions of 23.6% of 4-tert-butyltoluene with a complete selectivity to 4-tert-butylbenzaldehyde. | Wei Hua Yu Chun Hui Zhou Xiang Sheng Xu Zhong Hua Ge | 2007 | Chinese Chemical Letters2007，18，3： | 3 |
| 14 | Protocol of Jidong Women Health Cohort Study: Rationale, Design, and Baseline Characteristics显示文摘Objective The Jidong Women Health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause and risks of cardiovascular disease(CVD). Methods The study includes 4,179 female participants with an age of older than 18 years from Caofeidian district, Tangshan city, northern China. Baseline information on female-specific characteristics and potential cardiovascular risk factors was collected and all the participants underwent a physical examination with blood samples collected in 2013. To establish a better risk assessment tool of female CVD, updated information from questionnaire investigation, physical examinations and occurrence of outcome events will be collected through a longitudinal follow-up annually up to the year 2024. Results At baseline, Mean age of the participants was 42.3 ± 12.8 years. Reproduction occurred in 2,948 participants(70.5%), menopausal transition in 173(4.3%), and postmenopause in 1,058(25.3%). The incidence of arterial hypertension, dyslipidemia, and diabetes showed significant difference across different groups stratified by Stage of Reproductive Aging Workshop(STRAW) system(P < 0.05). Conclusion The Jidong Women Health Cohort Study will contribute to the scientific evidence on association between female-specific characteristics and cardiovascular risks, and will also be helpful to provide a new path for early detection and prevention of CVD. | QIU Meng Si WANG Xian Wei YAO Yan GE Si Qi LIU Hua Min DAI Ying Chun ZHOU Yong | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
| 15 | Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells显示文摘目的: 戊糖磷酸盐小径(PPP ) 涉及 glucose-6-phosphate 脱氢酶(G6PD ) 和 NADPH 的产生的活动,它在药新陈代谢起一个关键作用。这研究的目的是在 vitro 在药新陈代谢能力上调查 PPP 的调整的效果。 | Wen-jing XIAO Ting MA Chun GE Wen-juan XIA Yong MAO Run-bin SUN Xiao-yi YU Ji-ye AA Guang-ji WANG | 2015 | Acta Pharmacologica Sinica2015，36，2： | 3 |
| 16 | Anti-cancer Effect of 20(S)-Ginsenoside-Rh2 on Oral Squamous Cell Carcinoma Cells via the Decrease in ROS and Downregulation of MMP-2 and VEGF显示文摘Squamous cell carcinoma(SCC) is the most common in oral and maxillofacial regions and occupy more than 90% of the malignant lesions in the oral cavity[1]. The complex anatomy of the head and neck region gives rise to intricate patterns of local invasion and regional spread, which makes primary tumors more difficult to eradicate. | ZHANG Bao Ping LI Bo CHENG Jing Yang CAO Rui GAO Shu Ting HUANG Chun Juan LI Rui Ping NING Jing LIU Bin LI Zhi Ge | 2020 | Biomedical and Environmental Sciences2020，33，9： | 3 |
| 17 | Pharmacokinetic interactions between 20(S)- ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo显示文摘 | Jian SHI Bei CAO Wei-bin ZHA Xiao-lan WU Lin-sheng LIU Wen-jing XIAO Rong-rong GU Run-bin SUN Xiao-y YU Tian ZHENG Meng-jie LI Xin-wen WANG Jun ZHOU Yong MAO Chun GE Ting MA Wen-juan XIA Ji-ye AA Guang-ji WANG Chang-xiao LIU | 2013 | Acta Pharmacologica Sinica2013，34，10： | 3 |
| 18 | Anti-free radical,anti-oxidative ability and anti-fatigue effects of Huanshaodan An experiment of aging mice显示文摘BACKGROUND: In the theory of traditional Chinese medicine,aging is mainly thought renal deficiency caused renal failure,mainly involving decline of kidney-Yang and deficiency of kidney-essence. Huanshaodan,a Chinese traditional preparation for kidney-replenishing essence,was used to be the preparation for reinforcing renal deficiency and preventing aging for aged people. OBJECTIVE: To observe the effects of Huanshaodan on swimming durance and the abilities of catalase (CAT) in serum and monoamine oxidase-B (MAO-B) in brain tissue as well as in vitro anti-oxidative ability of aging mouse. DESIGN: A controlled animal experiment. SETTING: College of Basic Medicine,Hunan University of Traditional Chinese Medicine. MATERIALS: Fifty-four healthy NIH mice,aged 18 months old,of either gender,weighing (48.9±5.4)g,and one SD male rat,aged 16 months old,weighing 51.7 g,were provided by Animal Experimental Center,Hunan University of Traditional Chinese Medicine. Thirty NIH mice were randomly chosen for swimming test,and divided into experimental group and control group,with 15 in each; The other 24 NIH mice were used for enzyme activity assay,and also divided into experimental group and control group,with 12 in each. SD rat was used for in vitro anti-oxidative ability test. Huanshaodan water decoction was composed of Cheqianzi,Wuweizi,Huaishan,Danggui,Huangbai,Shudi,Baizhi,Niuxi,Baishen,Tusizi,Buguzhi,Roucongrong and Heshouwu 13 Chinese herbs. METHODS: This study was carried out in the Second Laboratory,Department of Biochemistry,Hunan University of Traditional Chinese Medicine in June 2006. Swimming and enzyme activity assay: Mice in the two experimental groups were intragastrically administrated with 10 μL/ g Huanshaodan water decoction. Mice in the two control groups were intragastrically administrated with the same amount of normal saline. All the mice were intragastrically administrated for 5 days,and they were free to access to medicine in the other 2 days in a week. Each mouse was administrated for 8 weeks. MAIN OUTCOME MEASURES: ① Forty days after administration,mice in the experimental group and control group for swimming test were loaded at tails and allowed to swim in the water-tank. Swimming durance was recorded. ② Following the method of Chen Qi,the activities of CAT in serum and MAO-B in brain tissue as well as the inhibitory rate of each medicine on malonaldehyde (MDA) content in the in vitro rat hepatic tissue were determined; Meanwhile,the inhibitory rate of different doses of Tusizi liquid to MDA content in the rat hepatic tissue in vitro was also assayed. RESULTS: Fifty-four NIH mice and one SD rat were recruited in this experiment. Three mice died in the swimming test,and all the other animals were involved in the final analysis. ① Swimming durance of mice in the experimental group was significantly longer than that in the control group (t =7.502,P < 0.01). The activity of CAT in serum of mice in the experimental group was significantly higher than that in the control group (t =13.307,P < 0.01). ② The activity of MAO-B in brain tissue of mice in the experimental group was significantly lower than that in the control group (t =13.27,P < 0.01). ③ The inhibitory rate of Cheqianzi,Wuweizi,Huaishan,Danggui,Huangbai,Shudi,Baizhi,Niuxi,Baishen,Tusizi,Buguzhi,Roucongrong and Heshouwu 13 Chinese herbs of Huanshaodan to MDA in the rat hepatic tissue in vitro was –62.9,–95.1,–34.9,–65.1,–99.1,–87.2,–94.1,–20.0,–67.0,–83.7,–91.0,–98.4,–93.0,respectively. ④ The inhibitory rate of low to high dose of Tusizi liquid to MDA content in the rat hepatic tissue in vitro was –3.41,–18.1,–26.6,–83.7,respectively. CONCLUSION: Huanshaodan enhances swimming endurance,anti-oxygen free radical and anti-oxidativeabilities,and thus,it can delay aging. | Xiao shu Ge Qun liang Liu Feng Tan Yi Zhang Mei Hu Ke chun Zhang | 2007 | Neural Regeneration Research2007，2，10： | 3 |
| 19 | O-glycosyltransferases from Homo sapiens contributes to the biosynthesis of Glycyrrhetic Acid 3-O-mono-β-D-glucuronide and Glycyrrhizin in Saccharomyces cerevisiae显示文摘Glycyrrhizin(GL)and Glycyrrhetic Acid 3-O-mono-β-D-glucuronide(GAMG)are the typical triterpenoid glycosides found in the root of licorice,a popular medicinal plant that exhibits diverse physiological effects and pharmacological manifestations.However,only few reports are available on the glycosylation enzymes involved in the biosynthesis of these valuable compounds with low conversion yield so far.In mammals,glycosyltransferases are involved in the phase II metabolism and may provide new solutions for us to engineer microbial strains to produce high valued compounds due to the substrate promiscuity of these glycosyltransferases.In this study,we mined the genomic databases of mammals and evaluated 22 candidate genes of O-glycosyltransferases by analyzing their catalytic potential for O-glycosylation of the native substrate,glycyrrhetinic acid(GA)for its glycodiversification.Out of 22 selected glycosyltransferases,only UGT1A1 exhibited high catalytic performance for biosynthesis of the key licorice compounds GL and GAMG.Molecular docking results proposed that the enzymatic activity of UGT1A1 was likely owing to the stable hydrogen bonding interactions and favorite conformations between the amino acid residues around substrate channels(P82~R85)and substrates.Furthermore,the complete biosynthesis pathway of GL was reconstructed in Saccharomyces cerevisiae for the first time,resulting in the production of 5.98±0.47 mg/L and 2.31±0.21 mg/L of GL and GAMG,respectively. | Ke Xu Yu-jia Zhao Nadeem Ahmad Jing-nan Wang Bo Lv Ying Wang Jun Ge Chun Li | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 3 |
| 20 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science . 2013 (6146)2013，，： | 2 |
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