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| 1 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 2 | Influence of Na^+,K^+,Mg^(2+),Ca^(2+),and Fe^(3+) on filterability and settleability of drilling sludge显示文摘Solid–liquid separation is a vital step in drilling sludge disposal, and the filterability and settleability of drilling sludge are the main evaluating indicators for the separation process. The influence of Na^+,K^+,Mg^(2+),Ca^(2+),and Fe^(3+) on drilling sludge filterability and settleability was investigated in our research. The water content,filtration rate, supernatant volume and supernatant turbidity were measured to evaluate the filterability and settleability of drilling sludge. Meanwhile, the zeta potential, specific surface area of sludge flocs, particle size distribution and Fourier-transformed infrared spectra were employed to clarify the influencing mechanism.The experimental results showed that the filterability and settleability of drilling sludge were related to concentration and types of cations. Mg^(2+),Ca^(2+),and Fe^(3+) performed better than Na^+, K^+, and the cations with smaller hydrated radius got superior solid–liquid separation behavior at same valence. Finally, the spectra indicated that no chemical adsorption occurred between inorganic cations and drilling sludge flocs. The variation of surface charge and flocs growth after adding different inorganic cations were the reasons for the changes of the filterability and settleability. | Liyan Liu Hao Yan Wei Tan Guorui Zhu | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 4 |
| 3 | Fast cone-beam CT image reconstruction using GPU hardware显示文摘 | Yan Guorui Tian Jie Zhu Shouping | 2008 | Journal of X-Ray Science and Technology2008，16，： | 1 |
| 4 | Fabrication of Cd 1? x Zn x S/TiO 2 heterostructures with enhanced photocatalytic activity显示文摘 | Guorui Yang Qian Zhang Wei Chang Wei Yan | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 5 | Fast cone-beam CT image reconstruction显示文摘 | Guorui Yan | 2008 | Journal of X-Ray Science and Technology2008，16，： | 1 |
| 6 | Single-spinneret electrospin- ning fabrication of CoMn204 hollow nanofibers with excellent per- formance in lithium-ion batteries 显示文摘 | Yang Guorui Xu Xin Yan Wei | 2014 | Electrochimica Acta2014，137，： | 1 |
| 7 | Mathematical Foundation of Visual Query Languageon Spatial Information显示文摘Visual Query Language on Spatial Information (SIVQL) is one kind of visual query language based on the extension of Query by Example (QBE). It is a visual operation based on graphics or media object, such as point, line and area elements. In this paper, the relation calculation and query function of SIVQL have been studied and discussed by using set theory and relation algebra. The theory foundation of SIVQL has been investigated by the mathematical method. Finally, its application examples are also given with the specific information system. | Wang Jianhua Guo Jingjun Yan Huiwu Zhu Guorui Wu Hehai | 2000 | Journal of Systems Engineering and Electronics2000，11，4： | 0 |
| 8 | Recent advances in the mechanics of 2D materials显示文摘The exceptional physical properties and unique layered structure of two-dimensional(2D)materials have made this class of materials great candidates for applications in electronics,energy conversion/storage devices,nanocomposites,and multifunctional coatings,among others.At the center of this application space,mechanical properties play a vital role in materials design,manufacturing,integration and performance.The emergence of 2D materials has also sparked broad scientific inquiry,with new understanding of mechanical interactions between 2D structures and interfaces being of great interest to the community.Building on the dramatic expansion of recent research activities,here we review significant advances in the understanding of the elastic properties,in-plane failures,fatigue performance,interfacial shear/friction,and adhesion behavior of 2D materials.In this article,special emphasis is placed on some new 2D materials,novel characterization techniques and computational methods,as well as insights into deformation and failure mechanisms.A deep understanding of the intrinsic and extrinsic factors that govern 2D material mechanics is further provided,in the hopes that the community may draw design strategies for structural and interfacial engineering of 2D material systems.We end this review article with a discussion of our perspective on the state of the field and outlook on areas for future research directions. | Guorui Wang Hongyu Hou Yunfeng Yan Ritesh Jagatramka Amir Shirsalimian Yafei Wang Binzhao Li Matthew Daly Changhong Cao | 2023 | International Journal of Extreme Manufacturing2023，5，3： | 0 |
| 9 | A Reactive Oxygen Species-Tyrosinase Cascade-Activated Prodrug for Selectively Suppressing Melanoma显示文摘“Off-target effect”is one of the obstacles for targeted prodrugs in chemotherapy.To circumvent this issue,herein we propose a dual biomarker cascadeactivated prodrug strategy based on high levels of reactive oxygen species(ROS)and tyrosinase(TYR)in melanoma cells.A representative prodrug,Coumarin-Quinazolinone-phenylBoronic acid pinacol ester(CQB),was prepared.The prodrug contained Coumarin-Quinazolinone(CQ)as mitochondria targeting and monitoring moiety and phenylboronic acid pinacol ester as a cascade-activated prowarhead.After activation by the endogenous ROS and subsequent TYR in melanoma cells,CQB can be converted to the final active reagent Coumarin-Quinazolinone-o-Quinone(CQQ)that contains o-quinone group as the reactive species.CQQ may interact with cellular nucleophiles to exert its genotoxic effect and disrupt the cellular redox balance.This enables CQB to selectively suppress melanoma.CQB accumulates in the mitochondria and causes mitochondrial dysfunction via affecting mitochondrial DNA integrity.This cascade-activated prodrug may provide a precise strategy for melanoma theranostics. | Guorui Li Yi Yang Yaya Zhang Peiling Huang Jiangyu Yan Zhibin Song Quan Yuan Jing Huang | 2022 | CCS Chemistry2022，4，5： | 0 |
| 10 | Dual Diomarkers Triggered Prodrugs for Precise Treatment of Melanoma:Design,Synthesis and Activities显示文摘Targeted prodrug strategy,which utilizes the endogenous biomarkers in cancer cells as activators to release the active drug,has been well established either in the fundamental research or the clinical treatment.However,many prodrugs suffer from safety concern due to“off-target activation”.Dual or multiple biomarkers triggered prodrug may provide an effective strategy to overcoming the“off-target effect”.Melanoma cells have both high levels of reactive oxygen species(ROS)and tyrosinase(TYR),which makes them significantly different from other tumor cells and normal cells.Here we reported a series of quinazolinone-aryl boronic acid/ester-based prodrugs,which can be activated by the cascade of ROS and TYR and selectively kill melanoma cells.The structure-activity relationship(SAR)analysis revealed that mitochondria-targeting property was vital for their cytotoxicity and the dual activated effector played a significant role in their selectivity towards melanoma cells.Among these candidates,compound 4b showed the highest toxicity to B16,leading to an imbalance of the redox system in melanoma cells,causing mitochondrial DNA damage,and then promoting melanoma cells death. | RUAN Yawen HUANG Peiling YAN Jiangyu LI Guorui HUANG Jing | 2022 | Chemical Research in Chinese Universities2022，38，4： | 0 |
| 11 | A boronic acid conjugation integrates antitumor drugs into albumin-binding prodrugs-based nanoparticles with robust efficiency for cancer therapy显示文摘Despite great therapeutic effect of Abraxane®,complex preparation technology and unfavorable pharmacokinetics still restricted the clinical application of albumin-based paclitaxel(PTX)nanoparticles(NPs).Herein,we reported that an albumin-binding prodrug,phenylboronic acid-conjugated PTX(P-PTX),can form the uniform NPs with the diameters around 100 nm with the help of albumin via simple one-step nano-precipitation method.The albumin-based nanomedicines were stabilized by the integration of a single boronic acid with PTX due to the increased affinity based on multiple intermolecular interactions.We found that albumin-based P-PTX NPs exhibited superior colloidal stability over albumin-based PTX NPs through one-step nanoprecipitation approach,achieving longer in vivo circulation time and higher concentration in tumor than those of the marketed Abraxane®.Furthermore,the albumin-based P-PTX NPs with great stability and enhanced intratumoral enrichment,increased the maximum tolerated dose of PTX,remarkably suppressed the growth of breast tumor and lung metastasis,prolonged survival of melanoma tumors-bearing mice.Such a convenient and effective system gains an insight into the impact of phenylboronic acid group on the albumin-based PTX NPs,provides potent strategy for the rational design of albumin-based antitumor nanomedicines. | Weiyue Ban Qiuhua Luo Chengda Yan Xiaoying Fan Guorui Zhu Maosheng Cheng Zhonggui He Mengchi Sun Jin Sun | 2023 | Nano Research2023，16，5： | 0 |
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