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| 1 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 2 | Densification and anticorrosion performances of vacuum evaporated aluminium coatings on NdFeB magnets显示文摘Al coated NdFeB magnets obtained by vacuum evaporation technique were densified by high energy ball milling method.The surface morphology,metal composition and micro structure of the coatings were characterized by scanning electron microscopy,X-ray diffraction and X-ray photoelectron spectroscopy,respectively.The anticorrosive properties were investigated by potentiodynamic polarization curves and neutral salt spray test.The pores in the Al coatings of columnar crystals(Al) induced by the evaporation technique,were apparently filled in the following ball milling process,leading to the densification of Al coatings and the evident improvement of the anticorrosive performances.When treated with ball milling for 30 min,the sample achieves the best anticorrosive performances with the self-corrosion potential of-0.87 V,self-corrosion current density of 1.65 μA/cm^(2) and the neutral salt spray(NSS) time of 144 h(red rust).The improvement of the anticorro sive performances of vacuum evaporated Al coating mainly lies in the densification effect of the coating,which depends on different loading conditions of ball milling process. | Jun Huang Qing Liu Zhenyu Yang Guangqing Xu Pengjie Zhang Jun Lv Wei Sun Bingshan Li Dongmei Wang Yucheng Wu | 2021 | Journal of Rare Earths2021，39，10： | 3 |
| 3 | A finite-time 3D guidance law based on fixed-time convergence disturbance observer显示文摘In order to achieve accurate interception of high-speed maneuvering targets,this paper presents a relative Line-of-Sight(LOS)velocity based finite-time three-dimensional guidance law design framework,and discusses the application of fixed-time convergence disturbance observer in this framework.Firstly,a simple Lyapunov function is provided to show that the coupled terms in the relative kinematics can be ignored in the proposed guidance law design framework.Secondly,the realizations of several classical guidance laws are analyzed with the proposed framework,including TPN guidance law,finite-time Input-to-State Stability(ISS)guidance law,and sliding mode guidance law.Thirdly,fixed-time convergence disturbance observers are introduced to design the composite finite-time 3D guidance law,and Lyapunov method is employed to show the stability of the guidance system.Numerical simulations with different scenarios show that the proposed generalized guidance law performs high interception accuracy. | Feng YANG Guangqing XIA | 2020 | Chinese Journal of Aeronautics2020，33，4： | 2 |
| 4 | Burial of organic carbon in Holocene sediments of the Zhujiang (Pearl River) and Changjiang (Yangtze River) estuaries 显示文摘 | Yang Shouye Tang Min Yim W W S Zong Yongqiang Huang Guangqing Switzer A D Saito Y | 2011 | Mar Chem2011，123，14： | 1 |
| 5 | Cost-efficient and flexible fabrication of rectangular-shaped microlens arrays with controllable aspect ratio and spherical morphology显示文摘 | Yang Hu Qing Yang Feng Chen Hao Bian Zefang Deng Guangqing Du Jinhai Si Feng Yun Xun Hou | 2013 | Applied Surface Science2013，，： | 1 |
| 6 | Behaviour of geo- grid reinforced soil retaining wall with concrete-rigid facing 显示文摘 | Yang Guangqing Zhang Baojian Lti Peng | 2009 | Geotextiles and Geomembranes2009，27，： | 1 |
| 7 | Behaviour of geogrid reinforced soil retaining wall with concrete-rigid facing显示文摘 | Yang Guangqing Zhang Baojian Lit Peng | 2009 | Geotextiles and Geomembranes2009，27，5： | 1 |
| 8 | Deformation Mechanisms and Safe Drilling Fluids Density in Extremely Thick Salt Formations显示文摘Hydrocarbons are very often associated with salt structures. The oil and gas industry is often required to drill along and through long salt sections to reach and recover hydrocarbons. The unique physical properties of salt require special techniques to ensure borehole stability and adequate casing design. This paper assumed that the mechanical behavior of salt is regulated by the magnitude of mean stress and octahedral shear stress and under the influence of different stress conditions,the deformation of rock salt can be represented by three domains,i.e. compression domain,volume unchanged domain,and dilatancy domain,which are separated by a stress dependent boundary. In the compression domain,the volume of salt decreases until all microcracks are closed,with only elastic deformation and pure creep; in the volume unchanged domain the deformation is considered steady incompressible flow controlled by pure creep; and in the dilatancy domain the volume of salt increases during deformation due to micro-cracking,causing damage and accelerating 'creep' until failure. This paper presents a hypothesis that the borehole is stable only when the magnitude of octahedral shear stress is below the dilatancy boundary. It gives the design method for determining drilling fluids density,and calculates the closure rate of borehole with the recommended drilling fluids density. If the closure rate of the borehole is less than 0.1%,the drilling fluids density window can be used during drilling through extremely thick salt formations. | Yang Henglin Chen Mian Zhang Guangqing | 2007 | Petroleum Science2007，4，4： | 1 |
| 9 | Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface‐Functionalized Gold Nanoparticles显示文摘 | Libo Du Siqingaowa Suo Guangqing Wang Hongying Jia Ke Jian Liu Baolu Zhao Yang Liu | 2012 | Chem Eur J2012，，4： | 1 |
| 10 | Energy transfer and photoluminescence of BaMgAl10 O17 co-doped with Eu2+ and Mn2+ 显示文摘 | Yang Ping Yao Guangqing Lin Jianhua | 2004 | Optical Materials2004，26，： | 1 |
| 11 | 显示文摘 | Yang Ping Yao Guangqing Lin Jianhua | 2004 | Optical Materials2004，26，： | 1 |
| 12 | Geochemical composition of inner shelf Quaternary sediments in the northern South China Sea with implications for provenance discrimination and paleoenvironmental reconstruction 显示文摘 | Yang Shouye Yim W W S Huang Guangqing | 2008 | Global Planet Change2008，60，34： | 1 |
| 13 | The Game Analysis on Financing Strategy and Product Innovation in Oligopoly Competition显示文摘 | Yang guangqing Jiang luquan Wang Huanchen | 2005 | Proceedings of 2005 International Conference on Management Science & Engineering2005，，： | 1 |
| 14 | Seismic Response of Multi-tiered Reinforced Soil Retaining Walls显示文摘 | LIU Huabei YANG Guangqing LING HoeI | 2014 | Soil Dynamics and Earthquake Engineering2014，，6162： | 1 |
| 15 | Energy transfer and photoluminescence of BaMgAl10O17co - doped with Eu^2+ and Mn^2+ 显示文摘 | Yang ping Yao Guangqing Lin jianhua | 2004 | Optical Materials2004，26，3： | 1 |
| 16 | Pijx confers broad-spectrum seedling and panicle blast resistance by promoting the degradation of ATP β subunit and OsRbohC-mediated ROS burst in rice显示文摘Rice blast,caused by the fungal pathogen Magnaporthe oryzae,is one of the most important diseases of rice.Utilization of blast-resistance genes is the most economical,effective,and environmentally friendly way to control the disease.However,genetic resources with broad-spectrum resistance(BSR)that is effective throughout the rice growth period are rare.In this work,using a genome-wide association study,we identify a new blast-resistance gene,Pijx,which encodes a typical CC-NBS-LRR protein.Pijx is derived from a wild rice species and confers BSR to M.oryzae at both the seedling and panicle stages.The functions of the resistant haplotypes of Pijx are confirmed by gene knockout and overexpression experiments.Mechanistically,the LRR domain in Pijx interacts with and promotes the degradation of the ATP synthase β subunit(ATPb)via the 26S proteasome pathway.ATPb acts as a negative regulator of Pijx-mediated panicle blast resistance,and interacts with OsRbohC to promote its degradation.Consistently,loss of ATPb function causes an increase in NAPDH content and ROS burst.Remarkably,when Pijx is introgressed into two japonica rice varieties,the introgression lines show BSR and increased yields that are approximately 51.59%and 79.31%higher compared with those of their parents in a natural blast disease nursery.In addition,we generate PPL^(Pijx Pigm) and PPL^(Pijx Piz-t) pyramided lines and these lines also have higher BSR to panicle blast compared with Pigm-or Piz-t-containing rice plants.Collectively,this study demonstrates that Pijx not only confers BSR to M.oryzae but also maintains high and stable rice yield,providing new genetic resources and molecular targets for breeding rice varieties with broad-spectrum blast resistance. | Ning Xiao Yunyu Wu Xiaoxiang Zhang Zeyun Hao Zichun Chen Zefeng Yang Yue Cai Ruyi Wang Ling Yu Zhiping Wang Yue Lu Wei Shi Cunhong Pan Yuhong Li Changhai Zhou Jianju Liu Niansheng Huang Guangqing Liu Hongjuan Ji Shuhao Zhu Shuai Fang Yuese Ning Aihong Li | 2023 | Molecular Plant2023，16，11： | 0 |
| 17 | Identification of in vivo interaction between rabbit hemorrhagic disease virus capsid protein and minor structural protein显示文摘We investigated the ability of the rabbit hemorrhagic disease virus(RHDV) capsid protein(VP60) to interact specifically with the minor structural protein VP10,using an in vivo cell-based CheckMate Mammalian Two-Hybrid System.RHDV VP60 protein interacted specifically with VP10.Immunofluorescence analysis and co-immunoprecipitation with specific antibodies revealed the existence of biologically important VP60/VP10 complexes.However,when VP60 was divided into two fragments,the interaction between VP60 and VP10 was impaired dramatically.These results will be helpful for further investigating the mechanism of RHDV particle assembly. | YANG ZongWei NI Zheng YUN Tao CHEN ZongYan LI ChuanFeng LIU GuangQing | 2012 | Chinese Science Bulletin2012，57，30： | 0 |
| 18 | Mup-knockout mice generated through CRISPR/ Cas9-mediated deletion for use in urinary protein analysis显示文摘主要尿蛋白质(MUP ) 是在老鼠尿的最丰富的蛋白质种类,为超过 90% 全部的蛋白质内容的财务。21 Mup 基因和 21 pseudogenes 在染色体 4 上在约 2 megabase 对(Mbp ) 的一个区域被聚类。一个 Mup 大美人老鼠模型将极大地在老鼠尿的 proteomic 分析的领域里便于研究。这里,我们用 CRISPR/Cas9 系统报导 2.2 Mbp 的 Mup 基因簇的成功的大美人。同型结合的 Mup 大美人老鼠幸存到成人生活并且没展出明显的缺点。non-MUP 的 proteomes 的模式在同型结合的 Mup 大美人老鼠的尿蛋白质类似于钠 dodecyl 硫酸盐 polyacrylamide 胶化电气泳动判定的野类型的老鼠的那些。连接酶的 immunosorbent 试金的敏感显著地在 Mup 大美人提高了老鼠检测尿蛋白质是的 non-MUP。简言之,我们开发了一个 Mup 大美人老鼠模型。这个老鼠模型将是有用的因为测试那的尿 biomarker 的研究可以为人有关联。 | Haixia Yang Wei Zhang Shan Lu Guangqing Lu Hongjuan Zhang Yinghua Zhuang Yue Wang Mengqiu Dong Yu Zhang Xingang Zhou Peng Wang Lei Yu Fengchao Wang Liang Chen | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 0 |
| 19 | Rare earth passivation and corrosion resistance of zinc coated NdFeB magnets显示文摘Rare earth passivation was conducted on Zn coated NdFeB magnets by chemical reaction to enhance the corrosion resistance performance.Morphologies,micro structures and compositions of different passivated coatings were studied by X-ray diffraction,field emission scanning electron microscopy,and X-ray photoelectron spectroscopy,respectively.The corrosion behavior was evaluated by electrochemical measurement and neutral salt spray test.The results show that the rare earth passivation can enhance the corrosion resistance of Zn coated NdFeB magnets.When the concentration of cerium nitrate is 5 g/L,the passivated specimens can achieve the longest NSS time of 360 h,which is 144 h longer than that of the pristine Zn/NdFeB magnets.The passivation layer on the Zn coating surface contributes to the enhancement of the magnets’corrosion resistance. | Jing Chen Hongyi Yang Guangqing Xu Pengjie Zhang Jun Lv Wei Sun Bingshan Lidi Jun Huang Dongmei Wang Xia Shu Yucheng Wu | 2022 | Journal of Rare Earths2022，40，2： | 0 |
| 20 | 中国北京地区部分医院患者疼痛现状调查(英文)显示文摘Objective:This study aimed to survey the characteristics and treatments of cancer pain in Beijing hospitals,China.Methods:At 20:00 on December 22,2009,there conducted a questionnaire survey in 2238 patients with malignant tumors of 26 hospitals in Beijing,and the survey results were statistically analyzed.Results:The 531 cases in 2238 patients had pained and 121 cases (22.79%) had outbreak pain with one week.At 20:00 on December 22,2009,199 cases (38%) in the above-mentioned 531 pain patients suffered the moderate to severe pain (pain scores ≥ 4).The number of pain (pain scores ≥ 4) patients in the consecutive three days from December 20 to December 22 were 150.Conclusion:In the 531 cancer pain patients of the surveyed hospitals,38% of the patients were not satisfied with the pain control.Doctors believed that the main reason for pain not controlled was the non-standard treatment,but patients considered to be afraid of addiction. | Shikai Wu Fang Li Pingping Li Jian Luo Xiaoming Wu Heling Shi Xiaohong Ning Yufei Yang Huangying Tan Ping Yang Guangqing Zhu Jianhua Zhu Guoqing Liao Huoming Chen Dapeng Lv Ye Fang Hong Dai Xiaoming Xi Xiuhua Li Yuan Qin Li Feng Su Wang Xiaoyan Chen Hongyong Wang Hongyan Li Duanqi Liu | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
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