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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | Identification of the metab- olites of baicalein in rat serum 显示文摘 | YANG L GUO XY WANG QF | 2011 | J Chin Pharm Sci2011，20，3： | 1 |
| 3 | Plasma level of growth arrest- speciffc 6 (GAS 6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome显示文摘 | Jiang L Liu CY Yang QF | 2009 | Am J Olin Pathol2009，15，5： | 1 |
| 4 | Discrimination of type 2 diabetic patients from healthy controls by using metabonomits method based on their serum fatty acid profiles 显示文摘 | Yang J Xu GW Hong QF | 2004 | J Chromatogr B2004，813，12： | 1 |
| 5 | Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome显示文摘 | Jiang L Liu CY Yang QF | 2009 | Am J Clin Pathol2009，131，： | 1 |
| 6 | Protective effects of adenoviral cardiotrophin-1 gene transfer on rubrospinal neurons after spinal cord injury in adult rats显示文摘 | Zhang ZF Liao WH Yang QF | 2003 | Neurotox Res2003，5，7： | 1 |
| 7 | Enhanced chilling tolerance in Zoysia matrella by pre-treatment with salicylic acid, calcium chloride, hydrogen peroxide or 6-benzylaminopurine 显示文摘 | Y WANG ZM YANG QF ZHANG | 2009 | Biologia Plantarum2009，53，： | 1 |
| 8 | Prognostic value of thymidine phosphorylase expression in breast carcinoma 显示文摘 | Yang QF Barbareschi M Mori I | 2002 | Int J Cancer2002，97，4： | 1 |
| 9 | Peritoneal reflections of left perihepatic region:radiologic-anatomic study显示文摘 | Min PQ Yang ZG Lei QF | 1992 | Radiology1992，182，2： | 1 |
| 10 | Peritoneal reflections of left perihepatic region:radiologic-anatomic study显示文摘 | Min PQ Yang ZG Lei QF | 1992 | Radiology1992，182，： | 1 |
| 11 | Two-Hit inactivation of FI-IIT by loss of heterozygosity and hypermethylation in breast cancer 显示文摘 | Yang QF Nakamura M Nakamura Y | 2002 | Clin Cancer Res2002，8，9： | 1 |
| 12 | Prognostic value of thymidine phosphorylase expression in breast carcinoma显示文摘 | Yang QF Barbareschi m Mori I | 2002 | Int J Cancer2002，97，4： | 1 |
| 13 | Association of tumor-associated fibroblasts with progression of hepatocellular carcinoma显示文摘 | Yang XY Zhang D Zou QF | 2013 | Med Oncol2013，30，3： | 1 |
| 14 | Mycobacterium vaccae as adjuvant therapy to anti-tuberculosis chemotherapy in never-treated tuberculosis patients:a meta-analysis显示文摘 | Yang XY Chen QF Li YP | 2011 | PLo S One2011，6，23： | 1 |
| 15 | Plasma level of growth arrest- specific 6 ( GAS6 ) protein and genetic variations in the GAS6 Gene in patients with acute coronary syndrome 显示文摘 | JIANG L LIU CY YANG QF | 2009 | Am J Clin Pathol2009，131，5： | 1 |
| 16 | Lanthanum chloride impairs memory, decreases pCaMK IV, pMAPK and pCREB expression of hippocampus in rats 显示文摘 | Yang JH Liu QF Zhang LF | 2009 | Toxicology Letters2009，190，： | 1 |
| 17 | Prevalence of polycys- tic ovary syndrome in women in China:a large community- based study显示文摘 | LI R ZHANG QF YANG D | 2013 | Hum Reprod2013，28，9： | 1 |
| 18 | Plasma level of growth arrest- specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome显示文摘 | JIANG L LIU CY YANG QF | 2009 | Am J Clin Pathol2009，131，5： | 1 |
| 19 | Expression of Bcl-2 but not Bax or P53 correlates with in vitro resistance to a series of anticancer drugs in breast carcinoma显示文摘 | Yang QF Sakurai T Yoshimura G | 2000 | Breast Cancer Res Treat2000，61，3： | 1 |
| 20 | Determination of trace lead, cadmium and mercury by on-line column enrichment followed by RP-HPLC as metaltetra-(4-bromophenyl)-porphyrin chelates显示文摘 | Hu QF Yang GY Yin JY | 2002 | Talanta2002，57，： | 1 |
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