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| 1 | A New Cluster Validity for Data Clustering显示文摘 | Xulei Yang Qing Songl Aize Cao | 2006 | Neural Processing Letters2006，，23： | 1 |
| 2 | Effect of Puerarin on the pro- liferation and differentiation of osteoblasts in the regulation of estro- gen receptor promoteramethylation显示文摘 | Lu Haihong Yang Xulei Fu Songbo | 2015 | Journal of Hebei Medical U- niversity2015，4，： | 1 |
| 3 | A weighted support vector machine for data classification显示文摘 | Yang Xulei | 2007 | International Journal of Pattern Recognition and Artificial Intelligence2007，21，5： | 1 |
| 4 | A robust deterministic annealing algorithm for data clustering显示文摘 | Yang Xulei Song Qing Wu Yilei | 2007 | Data & Knowledge Engineering2007，62，： | 1 |
| 5 | A new cluster validity for data clustering显示文摘 | Yang Xulei Song Qing Cao Aize | 2006 | Neural Processing Letters2006，23，3： | 1 |
| 6 | Kernel-based Deterministic Annealing Algorithm for Data Clustering显示文摘 | Yang Xulei Song Qing | 2006 | IEE Proceedings of Vision Image and Signal Processing2006，153，5： | 1 |
| 7 | Systemic antibiotics increase microbiota pathogenicity and oral bone loss显示文摘Periodontitis is the most widespread oral disease and is closely related to the oral microbiota.The oral microbiota is adversely affected by some pharmacologic treatments.Systemic antibiotics are widely used for infectious diseases but can lead to gut dysbiosis,causing negative effects on the human body.Whether systemic antibiotic-induced gut dysbiosis can affect the oral microbiota or even periodontitis has not yet been addressed.In this research,mice were exposed to drinking water containing a cocktail of four antibiotics to explore how systemic antibiotics affect microbiota pathogenicity and oral bone loss.The results demonstrated,for the first time,that gut dysbiosis caused by long-term use of antibiotics can disturb the oral microbiota and aggravate periodontitis.Moreover,the expression of cytokines related to Th17 was increased while transcription factors and cytokines related to Treg were decreased in the periodontal tissue.Fecal microbiota transplantation with normal mice feces restored the gut microbiota and barrier,decreased the pathogenicity of the oral microbiota,reversed the Th17/Treg imbalance in periodontal tissue,and alleviated alveolar bone loss.This study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis.A Th17/Treg imbalance might be related to this relationship.Importantly,these results reveal that the periodontal condition of patients should be assessed regularly when using systemic antibiotics in clinical practice. | Xulei Yuan Fuyuan Zhou He Wang Xinxin Xu Shihan Xu Chuangwei Zhang Yanan Zhang Miao Lu Yang Zhang Mengjiao Zhou Han Li Ximu Zhang Tingwei Zhang Jinlin Song | 2023 | International Journal of Oral Science2023，15，1： | 0 |
| 8 | Graphene oxide/gallium nanoderivative as a multifunctional modulator of osteoblastogenesis and osteoclastogenesis for the synergistic therapy of implant-related bone infection显示文摘Currently,implant-associated bacterial infections account for most hospital-acquired infections in patients suffering from bone fractures or defects.Poor osseointegration and aggravated osteolysis remain great challenges for the success of implants in infectious scenarios.Consequently,developing an effective surface modification strategy for implants is urgently needed.Here,a novel nanoplatform(GO/Ga)consisting of graphene oxide(GO)and gallium nanoparticles(GaNPs)was reported,followed by investigations of its in vitro antibacterial activity and potential bacterium inactivation mechanisms,cytocompatibility and regulatory actions on osteoblastogenesis and osteoclastogenesis.In addition,the possible molecular mechanisms underlying the regulatory effects of GO/Ga nanocomposites on osteoblast differentiation and osteoclast formation were clarified.Moreover,an in vivo infectious microenvironment was established in a rat model of implant-related femoral osteomyelitis to determine the therapeutic efficacy and biosafety of GO/Ga nanocomposites.Our results indicate that GO/Ga nanocomposites with excellent antibacterial potency have evident osteogenic potential and inhibitory effects on osteoclast differentiation by modulating the BMP/Smad,MAPK and NF-κB signaling pathways.The in vivo experiments revealed that the administration of GO/Ga nanocomposites significantly inhibited bone infections,reduced osteolysis,promoted osseointegration located in implant-bone interfaces,and resulted in satisfactory biocompatibility.In summary,this synergistic therapeutic system could accelerate the bone healing process in implant-associated infections and can significantly guide the future surface modification of implants used in bacteria-infected environments. | Ying Yang Min Li Bixia Zhou Xulei Jiang Dou Zhang Hang Luo | 2023 | Bioactive Materials2023，，7： | 0 |
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